Brian Litt, MD

faculty photo
Perelman Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology
Graduate Group Affiliations
Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Email: littb@pennmedicine.upenn.edu
Publications

Search PubMed for articles
Links
Search PubMed for articles
 Penn Center for Health, Devices & Technology (Penn Health-Tech)
Penn Neuroengineering Research Lab
PennBrain
Institute of Neurological Sciences Faculty
Lab Web Page
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Center for Neuroengineering and Therapeutics
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
Education:
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
 M.D. ( )
Johns Hopkins University School of Medicine, 1986.
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Description of Research Expertise

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Description of Clinical Expertise

Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEG

Description of Other Expertise

Entrepreneurship:

I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000


I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.

I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).

I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)

I have participated in helping bring several implantable NeuroDevices to market.

Selected Publications

Chen Y, Litt B, Vitale F, Takano H.: On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy. bioRxiv Oct 2024.

 Galer PD, McKee JL, Ruggiero SM, Kaufman MC, McSalley I, Ganesan S, Ojemann WKS, Gonzalez AK, Cao Q, Litt B, Helbig I, Conrad EC.: Quantitative EEG Spectral Features Differentiate Genetic Epilepsies and Predict Neurologic Outcomes. medRxiv Oct 2024.

 Gallagher RS, Sinha N, Pattnaik AR, Ojemann WKS, Lucas A, LaRocque JJ, Bernabei JM, Greenblatt AS, Sweeney EM, Cajigas I, Chen HI, Davis KA, Conrad EC, Litt B.: The sixth sense: how much does interictal intracranial EEG add to determining the focality of epileptic networks? Brain Commun 6: fcae320, Sep 2024.

 Conrad EC, Lucas A, Ojemann WKS, Aguila CA, Mojena M, LaRocque JJ, Pattnaik AR, Gallagher R, Greenblatt A, Tranquille A, Parashos A, Gleichgerrcht E, Bonilha L, Litt B, Sinha SR, Ungar L, Davis KA.: Interictal intracranial EEG asymmetry lateralizes temporal lobe epilepsy. Brain Commun 6: fcae284, Aug 2024.

 Shi H, Pattnaik AR, Aguila C, Lucas A, Sinha N, Prager B, Mojena M, Gallagher R, Parashos A, Bonilha L, Gleichgerrcht E, Davis KA, Litt B, Conrad EC.: Utility of intracranial EEG networks depends on re-referencing and connectivity choice. Brain Commun 6: fcae165, May 2024.

 Lucas A, Campbell Arnold T, Okar SV, Vadali C, Kawatra KD, Ren Z, Cao Q, Shinohara RT, Schindler MK, Davis KA, Litt B, Reich DS, Stein JM.: Multi-contrast high-field quality image synthesis for portable low-field MRI using generative adversarial networks and paired data. Radiology in revision, May 2024.

 Xie K, Ojemann WKS, Gallagher RS, Lucas A, Hill CE, Hamilton RH, Johnson KB, Roth D, Litt B, Ellis CA.: Disparities in seizure outcomes revealed by large language models. Journal Am Med Inform Assoc. 13(ocae047): 1348-1355, March 2024 Notes: doi: 10.1093/jamia/ocae047.

 Farach LS, Richard MA, Wulsin AC, Bebin EM, Krueger DA, Sahin M, Porter BE, McPherson TO, Peters JM, O'Kelley S, Taub KS, Rajaraman R, Randle SC, McClintock WM, Koenig MK, Frost MD, Werner K, Nolan DA, Wong M, Cutter G, Northrup H, Au KS; PREVeNT Study Group.: Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial. Pediatr Neurol 2024.

 Galer PD, Parthasarathy S, Xian J, McKee JL, Ruggiero SM, Ganesan S, Kaufman MC, Cohen SR, Haag S, Chen C, Ojemann WKS, Kim D, Wilmarth O, Vaidiswaran P, Sederman C, Ellis CA, Gonzalez AK, Boßelmann CM, Lal D, Sederman R, Lewis-Smith D, Litt B, Helbig I.: Clinical signatures of genetic epilepsies precede diagnosis in electronic medical records of 32,000 individuals. Genet Med 2024.

 Lucas A, Scheid BH, Pattnaik AR, Gallagher R, Mojena M, Tranquille A, Prager B, Gleichgerrcht E, Gong R, Litt B, Davis KA, Das S, Stein JM, Sinha N.: iEEG-recon: A Fast and Scalable Pipeline for Accurate Reconstruction of Intracranial Electrodes and Implantable Devices. Epilepsia Dec 2023.
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Last updated: 04/02/2025
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