Brian Litt, MD
Perelman Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology
Graduate Group Affiliations
Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Fax: (215)-349-5733
Email:
littb@pennmedicine.upenn.edu
littb@pennmedicine.upenn.edu
Publications
Links
Search PubMed for articles
Penn Neuroengineering Research Lab
Lab Web Page
Institute of Neurological Sciences Faculty
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
Penn Center for Health, Devices & Technology (Penn Health-Tech)
Center for Neuroengineering and Therapeutics
PennBrain
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Search PubMed for articles
Penn Neuroengineering Research Lab
Lab Web Page
Institute of Neurological Sciences Faculty
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
Penn Center for Health, Devices & Technology (Penn Health-Tech)
Center for Neuroengineering and Therapeutics
PennBrain
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Education:
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Permanent linkA.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Description of Research Expertise
Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.Description of Clinical Expertise
Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEGDescription of Other Expertise
Entrepreneurship:I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000
I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.
I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).
I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)
I have participated in helping bring several implantable NeuroDevices to market.
Selected Publications
John M Bernabei, Adam Li, Andrew Y Revell, Rachel J Smith, Kristin M Gunnarsdottir, Ian Z Ong, Kathryn A Davis, Nishant Sinha, Sridevi Sarma, Brian Litt: Quantitative approaches to guide epilepsy surgery from intracranial EEG. BRAIN advanced online, January 2023.TC Arnold, CW Freeman, B Litt, JM Stein: Low‐field MRI: Clinical promise and challenges. Journal of Magnetic Resonance Imaging 57(1): 25-44, January 2023.
Erin C Conrad, Andrew Y Revell, Adam S Greenblatt, Ryan S Gallagher, Akash R Pattnaik, Nicole Hartmann, James J Gugger, Russell T Shinohara, Brian Litt, Eric D Marsh, Kathryn A Davis: Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy. Epilepsia online ahead of print, December 2022.
Brian Litt: Engineers drive new directions in translational epilepsy research. BRAIN 145(11): 3725-3726, November 2022.
TC Arnold, D Tu, S Okar, G Nair, S By, K Kawatra, T Roberts-Fitzgerald, L Desiderio, M Schindler, B Litt, R Shinohara, D Reich, J Stein: Assessing lesion sensitivity and brain atrophy using portable low-field MRI in multiple sclerosis. The Multiple Sclerosis Journal 10: 975-976, October 2022.
Rory J Piper, R Mark Richardson, Gregory Worrell, David W Carmichael, Torsten Baldeweg, Brian Litt, Timothy Denison, Martin M Tisdall: Towards network-guided neuromodulation for epilepsy. BRAIN 145(10): 3347-3362, October 2022.
Barbara M Decker, Alexandra Turco, Jian Xu, Samuel W Terman, Nikitha Kosaraju, Alisha Jamil, Kathryn A Davis, Brian Litt, Colin A Ellis, Pouya Khankhanian, Chloe E Hill: Development of a natural language processing algorithm to extract seizure types and frequencies from the electronic health record. Seizure 101: 48-51, October 2022.
Erin C Conrad, John M Bernabei, Nishant Sinha, Nina J Ghosn, Joel M Stein, Russell T Shinohara, Brian Litt: Addressing spatial bias in intracranial EEG functional connectivity analyses for epilepsy surgical planning. Journal Of Neural Engineering 19(5): 056019, September 2022.
Arian Ashourvan, Sérgio Pequito, Maxwell Bertolero, Jason Z Kim, Danielle S Bassett, Brian Litt: External drivers of BOLD signal’s non-stationarity. Plos One 17(9): e0257580, September 2022.
Erin C Conrad, Russell T Shinohara, James J Gugger, Andrew Y Revell, Sandhitsu Das, Joel M Stein, Eric D Marsh, Kathryn A Davis, Brian Litt: Implanting intracranial electrodes does not affect spikes or network connectivity in nearby or connected brain regions. Network Neuroscience 6(3): 834-849, July 2022.