Brian Litt, MD
Perelman Professor of Neurology
Attending Neurologist, Hospital of the University of Pennsylvania
Co-Director, Master's Degree Program, University of Pennsylvania, Department of Bioengineering
Director, Penn Epilepsy Center, Hospital of the University of Pennsylvania
Director, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Co-Director, Penn Center for Health, Devices and Technology, University of Pennsylavania
Department: Neurology
Graduate Group Affiliations
Contact information
Hospital: HUP
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
3 West Gates / 4283
34th Spruce Street
Lab: 301 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104
Office: (215) 746-4850
Fax: (215)-349-5733
Fax: (215)-349-5733
Email:
littb@pennmedicine.upenn.edu
littb@pennmedicine.upenn.edu
Publications
Links
Search PubMed for articles
Penn Center for Health, Devices & Technology (Penn Health-Tech)
Penn Neuroengineering Research Lab
PennBrain
Lab Web Page
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
Institute of Neurological Sciences Faculty
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Center for Neuroengineering and Therapeutics
Search PubMed for articles
Penn Center for Health, Devices & Technology (Penn Health-Tech)
Penn Neuroengineering Research Lab
PennBrain
Lab Web Page
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System
Institute of Neurological Sciences Faculty
News & Publications, Perelman School of Medicine/University of Pennsylvania Health System, “See-Through, One-Atom-Thick, Carbon Electrodes are a Powerful Tool for Studying Epilepsy, Other Brain Disorders, Penn Study Finds”
Center for Neuroengineering and Therapeutics
Education:
A.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Permanent linkA.B.
Harvard University Cum Laude, Engineering and Applied Sciences, 1982.
M.D. ( )
Johns Hopkins University School of Medicine, 1986.
Description of Research Expertise
Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.Description of Clinical Expertise
Epilepsy, Status epilepticus, Epilepsy Surgery, EEG, Clinical Neurophysiology, Intraoperative Monitoring, Antiepileptic Drugs, Functional brain mapping, brain stimulation, electrocorticography, evoked potentials, EEG, MEGDescription of Other Expertise
Entrepreneurship:I have helped found the following companies:
1. IntelliMedix, Inc. Atlanta, GA ~1997
2. Bioquantix, Inc, Atlanta, GA ~2000
I consult or have consulted for the following other companies:
1. NeuroVista, Inc.
2. MC10 (agreement under review)
3. Medtronic, Inc.
4. KCI, Inc.
I am on the Scientific Advisory Board of the following companies:
1. NeuroVista, Inc.
2. MC10 (agreement pending).
I have licensed technology to the following companies:
1. NeuroPace, Inc.
2. MC10, Inc.
3. NeuroVista (under potential review)
I have participated in helping bring several implantable NeuroDevices to market.
Selected Publications
Galer PD, McKee JL, Ruggiero SM, Kaufman MC, Ojemann WKS, McSalley I, Ganesan S, Gonzalez AK, Cao Q, Litt B, Helbig I, Conrad EC.: Quantitative EEG Biomarkers in the Genetic Epilepsies and Associations With Neurologic Outcomes. Neurology 105: e214148, Oct 2025.Vizcarra JA, Hefter K, Lafontant DE, Duong MT, Ertefaie A, Litt B, Bassett DS, Siderowf A; Parkinson’s Progression Markers Initiative.: Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross-Sectional Analysis. medRxiv Sep 2025.
Sheybani L, Vivekananda U, Sinha N, Conrad E, Litt B, Burgess N, Bush D, Walker MC.: Dynamic Interplay Between Wake Slow Waves and Epileptiform Discharges in the Epileptogenic Zone. Neurology 105: e214001, Sep 2025.
Ojemann WKS, Armstrong C, Pattnaik A, Petillo N, Josyula M, Daum A, Zhou DJ, LaRocque J, Korzun J, Kulick-Soper CV, Cornblath EJ, Damaraju S, Shinohara RT, Marsh ED, Davis KA, Litt B, Conrad EC.: Can electrical stimulation replace spontaneous seizures in epilepsy surgery? medRxiv Sep 2025.
Ghosn NJ, Walsh K, Xie K, Aguila C, Pattnaik A, Ma D, Krieger A, Conrad E, Litt B.: Inter-ictal spike rates are not modulated by anti-seizure medication taper in the epilepsy monitoring unit: a tale of two confounders. J Neural Eng Sep 2025.
Xie K, Korzun J, Zhou DJ, Chang E, Ghosn NJ, Lavelle S, Oganisian A, Acton EK, Gelfand MA, Roth D, Litt B, Ellis CA.: Comparative effectiveness of anti-seizure medications in emulated trials using medical informatics. Brain Jul 2025.
Xu Z, Scheid BH, Conrad EC, Davis KA, Ganguly T, Gelfand MA, Gugger JJ, Jiang X, LaRocque JJ, Ojemann WKS, Sinha SR, Waldman GJ, Wagenaar J, Sinha N, Litt B.: Annotating neurophysiologic data at scale with optimized human input. J Neural Eng 22: 046003, Jul 2025.
Lamberta LK, Asmar M, Fredwall MM, Ahrens SM, Bai S, Eisner M, Lado FA, Schuele SU, Clarke DF, Abdelmoity AT, Davis KA, Hopp JL, Koubeissi MZ, Bensalem Owen MK, Herman ST, Ostendorf AP; NAEC Center Director Study Group.: Status Epilepticus Protocol Variation Across Accredited National Association of Epilepsy Centers Members. Neurology 104: e213689, Jun 2025.
Ojemann WKS, Xie K, Liu K, Chang E, Roth D, Litt B, Ellis CA.: Zero-Shot Extraction of Seizure Outcomes from Clinical Notes Using Generative Pretrained Transformers. J Healthc Inform Res 9: 380-400, Apr 2025.
Aguila CA, Lucas A, Lavelle S, Pattnaik AR, Kim J, Ojemann WKS, Ma D, Josyula M, Petillo N, LaRocque JJ, Sinha SR, Ellis CA, Parashos A, Gleichgerrcht E, Davis KA, Litt B, Conrad EC.: Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy. Epilepsia 2025.