David A Mankoff, MD, PhD
Matthew J. Wilson Professor of Research Radiology
Active Medical Staff - Radiologist, Chester County Hospital
Active Physician, Penn Presbyterian Medical Center
Active Physician, Pennsylvania Hospital
Attending, Department of Radiology, Hospital of the University of Pennsylvania
Vice-Chair of Research, Department of Radiology, University of Pennsylvania
Associate Director of Education and Research, Abramson Cancer Center
Department: Radiology
Graduate Group Affiliations
Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine, University of Pennsylvania
1 Donner, HUP
3400 Spruce Street
Philadelphia, PA 19104
Department of Radiology
Perelman School of Medicine, University of Pennsylvania
1 Donner, HUP
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-746-4062
Fax: 215-349-5843
Fax: 215-349-5843
Education:
B.S. (Physics)
Yale University, 1981.
M.D. (Medicine)
University of Pennsylvania, 1988.
Ph.D. (Bioengineering)
University of Pennsylvania, 1988.
Permanent linkB.S. (Physics)
Yale University, 1981.
M.D. (Medicine)
University of Pennsylvania, 1988.
Ph.D. (Bioengineering)
University of Pennsylvania, 1988.
Description of Clinical Expertise
Nuclear Medicine/PETRadionuclide Therapy
Thyroid Cancer
Description of Other Expertise
Susan G. Komen ScholarDescription of Research Expertise
Molecular ImagingBreast Cancer
Quantitative Cancer Imaging and Image Analysis
Translational Clinical Trials
Selected Publications
Sreekumar, A., Blankemeyer, E., Sterner, C. J., Pan, T. C., Pant, D. K., Acolatse, S., Turkistani, H., Belka, G. K., Nayak, A., Carlin, S. D., Assenmacher, C. A., Sellmyer, M. A., Mankoff, D. A., Chodosh, L. A.: Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy. Cancer Discov 16(4): 781-799, 2026.Lee, H., Sarkar, S., Xu, K., Martorano, P., Pham, J., Park, P. S. U., King, A. P., Lee, H. S., Mankoff, D. A., Pryma, D. A., Sellmyer, M. A.: Influence of Subcellular Localization on the Cytotoxicity of Targeted alpha-Therapy. J Nucl Med 67(3): 429-437, 2026.
Chen, A. W., Zeballos Torrez, C. R., Peterson, L. M., Muzi, M., Specht, J. M., Cohen, E. A., Linden, H. M., Kontos, D., Mankoff, D. A.: Novel 4D radiomics applied to dynamic FES PET images to improve prediction of breast cancer response to ER-targeted therapy. Eur J Nucl Med Mol Imaging 53(5): 3128-3139, 2026.
Choi, H., Gupta, M., Sengupta, A., Furth, E. E., Hensley, C., Weljie, A. M., Lee, H., Lu, Y. T., Pantel, A., Mankoff, D., Zhou, R.: Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export. Neoplasia 61: 101136, 2025.
Hensley, C. T., Padakanti, P., Damani, R., Dulal, C., Choi, H., Li, S., Cao, J., Lee, H., Pantel, A., Li, E., Mankoff, D., Zhou, R.: L-5-[(11)C]-glutamine PET of breast cancer: Preclinical studies in mouse models. Nucl Med Biol 150-151: 109092, 2025.
Kwon, D., Li, E. J., Dulal, C., Daube-Witherspoon, M., Viswanath, V., Young, A. J., Damani, R. A., Hou-Liu, J., McDonald, E. S., Mankoff, D. A., Karp, J. S., Pantel, A. R.: Dual-Tracer Imaging on a Long-Axial-Field-of-View PET: A Proof-of-Principle Study with [(18)F]FGln and [(18)F]FDG. J Nucl Med 66(7): 1149-1152, 2025.
Mankoff, D., Balogova, S., Dunnwald, L., Dehdashti, F., DeVries, E., Evangelista, L., Van Kruchten, M., Vaz, S. C., Fowler, A., Linden, H., Ulaner, G. A.: Summary: SNMMI Procedure Standard/EANM Practice Guideline for Estrogen Receptor Imaging of Patients with Breast Cancer Using 16alpha-[(18)F]Fluoro-17beta-Estradiol PET. J Nucl Med 65(2): 221-223, 2024.
Zhou, R., Choi, H., Cao, J., Pantel, A., Gupta, M., Lee, H. S., Mankoff, D.: (18)F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med 64(1): 131-136, Jan 2023 Notes: DOI: 10.2967/jnumed.122.264152.
Pantel, A. R., Gitto, S. B., Makvandi, M., Kim, H., Medvedv, S., Weeks, J. K., Torigian, D. A., Hsieh, C. J., Ferman, B., Latif, N. A., Tanyi, J. L., Martin, L. P., Lanzo, S. M., Liu, F., Cao, Q., Mills, G. B., Doot, R. K., Mankoff, D. A., Mach, R. H., Lin, L. L., Simpkins, F.: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study. Clin Cancer Res 29(8): 1515-1527, Apr 2023 Notes: DOI: 10.1158/1078-0432.CCR-22-1602.
McDonald, E. S., Doot, R. K., Pantel, A. R., Farwell, M. D., Mach, R. H., Maxwell, K. N., Mankoff, D. A.: Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol April 2020.