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Gerald B. W. Wertheim, MD, PhD
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Associate Professor of Clinical Pathology and Laboratory Medicine
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Hematopathologist, Hospital of the University of Pennsylvania
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Assistant Director, Division of Genomic Diagnostics
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Children's Hospital of Philadelphia
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Director of Hematopathology, The Children's Hospital of Philadelphia
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Department: Pathology and Laboratory Medicine
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Contact information
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Department of Pathology and Laboratory Medicine
2b Children's Hospital of Philadelphia
1b 5199B Main Building
11 5th Floor
3e 3401 Civic Center Boulevard
Philadelphia, PA 19104
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2b Children's Hospital of Philadelphia
1b 5199B Main Building
11 5th Floor
3e 3401 Civic Center Boulevard
Philadelphia, PA 19104
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Office: 267-970-5918
32 Fax: 215-590-1736
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32 Fax: 215-590-1736
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Email:
wertheimg@email.chop.edu
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wertheimg@email.chop.edu
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Education:
21 7 BS 16 (Chemistry) c
36 Yale University, New Haven CT, 1994.
21 8 PhD 1b (Cancer Biology) c
46 University of Pennsylvania School of Medicine, 2004.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2005.
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Permanent link21 7 BS 16 (Chemistry) c
36 Yale University, New Haven CT, 1994.
21 8 PhD 1b (Cancer Biology) c
46 University of Pennsylvania School of Medicine, 2004.
21 7 MD 15 (Medicine) c
46 University of Pennsylvania School of Medicine, 2005.
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257 Myers RM, DiNofia AM, Li Y, Diorio C, Liu H, Wertheim GB, Fraietta JA, Gonzalez V, Plesa G, Siegel DL, Iannone E, Shinehouse L, Brogdon JL, Taylor C, Jadlowsky JK, Hexner EO, Engels B, Baniewicz D, Callahan C, Ruella M, Aplenc R, Barz Leahy A, McClory SE, Rheingold SR, Wray L, June CH, Maude SL, Frey NV, Grupp SA: CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy. Science Translational Medicine April 2025.
220 Newman H, Clark ME, Wong D, Wu J, Brodeur GM, Hunger SP, Tasian SK, Olson T, Warren JT, Teachey DT, Bona K, Schubert J, Golenberg N, Patel M, Denenberg EH, Fanning EA, Chen J, Luke T, Charles S, Gallo D, Cao K, Fu W, Fan Z, Surrey LF, Wertheim GB, Luo M, MacFarland SP, Li MM, Zhong Y: Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing. Haematologica September 2024.
17f Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L: Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression. Cancer Discovery 14(8), August 2024.
1bd Luo M, Wong D, Zelley K, Wu J, Schubert J, Denenberg EH, Fanning EA, Chen J, Gallo D, Golenberg N, Patel M, Conlin LK, Maxwell KN, Wertheim GB, Surrey LF, Zhong Y, Brodeur GM, MacFarland SP, Li MM: Identification of TP53 Germline Variants in Pediatric Patients Undergoing Tumor Testing: Strategy and Prevalence. J Natl Cancer Inst August 2024 Notes: Online Ahead of Print.
1e1 Myers RM, Devine K, Li Y, Lawrence S, Barz Leahy A, Liu H, Vernau L, Callahan C, Baniewicz D, Kadauke S, McGuire R, Wertheim GB, Kulikovskaya I, Gonzalez VE, Fraietta JA, DiNofia Am, Hunger SP, Rheingold SR, Aplenc R, June CH, Grupp SA, Wray L, Maude SL: Reinfusion of CD19 CAR T Cells for Relapse Prevention and Treatment in Children With Acute Lymphoblastic Leukemia. Blood Adv 14(8): 2182-2192, May 2024.
191 Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L: Condensate-promoting ENL Mutation Drives Tumorigenesis in Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression. Cancer Discov April 2024 Notes: Online Ahead of Print.
19f Placek A, Lockhart B, Miller KP, Wertheim GB, Maude SL, Wood BL, Kovach AE: Maturational Dyssynchrony in Benign B-cell Precursors Following Lymphocyte Depleting Chemotherapy: A potential Pitfall for B-lymphoblastic Leukemia Minimal/Measurable Residual Disease (MRD) Flow Cytometry Analysis. Cytometry B Clin Cytom 106(2): 138-141, March 2024.
190 Sung PJ, Selvam M, Riedel SS, Xie HM, Bryant K, Manning B, Wertheim GB, Kulej K, Pham L, Bowman RL, Peresie J, Nemeth MJ, Levine RL, Garcia BA, Meyer SE, Sidoli S, Bernt KM, Carroll M: FLT3 Tyrosine Kinase Inhibition Modulates PRC2 and Promotes Differentiation in Acute Myeloid Leukemia. Leukemia 38(2): 291-301, February 2024.
23f Newman H, Egan Clark M, Wong D, Wu J, Brodeur GM, Hunger SP, Tasian SK, Olson T, Warren JT, Teachey DT, Bona K, Schubert J, Golenberg N, Patel M, Denenberg EH, Fanning EA, Chen J, Luke T, Charles S, Gallo D, Cao K, Fu W, Fan Z, Surrey LF, Wertheim G, Luo M, MacFarland SP, Li MM, Zhong Y: Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing. Haematologica February 2024 Notes: Online Ahead of Print.
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Selected Publications
d6 Shah B, Wertheim GB: Giant cytoplasmic inclusions (Alder-Reilly bodies) in Hurler syndrome (mucopolysaccharidosis type 1H). Blood April 2025.257 Myers RM, DiNofia AM, Li Y, Diorio C, Liu H, Wertheim GB, Fraietta JA, Gonzalez V, Plesa G, Siegel DL, Iannone E, Shinehouse L, Brogdon JL, Taylor C, Jadlowsky JK, Hexner EO, Engels B, Baniewicz D, Callahan C, Ruella M, Aplenc R, Barz Leahy A, McClory SE, Rheingold SR, Wray L, June CH, Maude SL, Frey NV, Grupp SA: CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy. Science Translational Medicine April 2025.
220 Newman H, Clark ME, Wong D, Wu J, Brodeur GM, Hunger SP, Tasian SK, Olson T, Warren JT, Teachey DT, Bona K, Schubert J, Golenberg N, Patel M, Denenberg EH, Fanning EA, Chen J, Luke T, Charles S, Gallo D, Cao K, Fu W, Fan Z, Surrey LF, Wertheim GB, Luo M, MacFarland SP, Li MM, Zhong Y: Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing. Haematologica September 2024.
17f Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L: Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression. Cancer Discovery 14(8), August 2024.
1bd Luo M, Wong D, Zelley K, Wu J, Schubert J, Denenberg EH, Fanning EA, Chen J, Gallo D, Golenberg N, Patel M, Conlin LK, Maxwell KN, Wertheim GB, Surrey LF, Zhong Y, Brodeur GM, MacFarland SP, Li MM: Identification of TP53 Germline Variants in Pediatric Patients Undergoing Tumor Testing: Strategy and Prevalence. J Natl Cancer Inst August 2024 Notes: Online Ahead of Print.
1e1 Myers RM, Devine K, Li Y, Lawrence S, Barz Leahy A, Liu H, Vernau L, Callahan C, Baniewicz D, Kadauke S, McGuire R, Wertheim GB, Kulikovskaya I, Gonzalez VE, Fraietta JA, DiNofia Am, Hunger SP, Rheingold SR, Aplenc R, June CH, Grupp SA, Wray L, Maude SL: Reinfusion of CD19 CAR T Cells for Relapse Prevention and Treatment in Children With Acute Lymphoblastic Leukemia. Blood Adv 14(8): 2182-2192, May 2024.
191 Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L: Condensate-promoting ENL Mutation Drives Tumorigenesis in Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression. Cancer Discov April 2024 Notes: Online Ahead of Print.
19f Placek A, Lockhart B, Miller KP, Wertheim GB, Maude SL, Wood BL, Kovach AE: Maturational Dyssynchrony in Benign B-cell Precursors Following Lymphocyte Depleting Chemotherapy: A potential Pitfall for B-lymphoblastic Leukemia Minimal/Measurable Residual Disease (MRD) Flow Cytometry Analysis. Cytometry B Clin Cytom 106(2): 138-141, March 2024.
190 Sung PJ, Selvam M, Riedel SS, Xie HM, Bryant K, Manning B, Wertheim GB, Kulej K, Pham L, Bowman RL, Peresie J, Nemeth MJ, Levine RL, Garcia BA, Meyer SE, Sidoli S, Bernt KM, Carroll M: FLT3 Tyrosine Kinase Inhibition Modulates PRC2 and Promotes Differentiation in Acute Myeloid Leukemia. Leukemia 38(2): 291-301, February 2024.
23f Newman H, Egan Clark M, Wong D, Wu J, Brodeur GM, Hunger SP, Tasian SK, Olson T, Warren JT, Teachey DT, Bona K, Schubert J, Golenberg N, Patel M, Denenberg EH, Fanning EA, Chen J, Luke T, Charles S, Gallo D, Cao K, Fu W, Fan Z, Surrey LF, Wertheim G, Luo M, MacFarland SP, Li MM, Zhong Y: Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing. Haematologica February 2024 Notes: Online Ahead of Print.
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