Matthew J. O'Connor, M.D.
Professor of Clinical Pediatrics (Cardiology)
Attending Physician, Children's Hospital of Philadelphia
Section Chief, Heart Function, Heart Transplant, and Mechanical Circulatory Support Program, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Cardiology
3401 Civic Center Blvd
Philadelphia, PA 19104
Division of Cardiology
3401 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-426-2882
Email:
oconnorm@email.chop.edu
oconnorm@email.chop.edu
Education:
B.S. (Chemistry)
College of William and Mary , 2000.
M.D.
University of Virginia, 2004.
M.L.
University of Pennsylvania Carey Law School, 2023.
Permanent linkB.S. (Chemistry)
College of William and Mary , 2000.
M.D.
University of Virginia, 2004.
M.L.
University of Pennsylvania Carey Law School, 2023.
Selected Publications
Edelson JB, O'Connor MJ, Zhang X, Tomlinson AZ, Rossano JW.: Expedited organ placement is rare in pediatric heart transplantation: a UNOS registry analysis. Circ Heart Fail Dec 2025.Kauffman H, Convery MJ, Matsubara D, Miller KE, O'Connor MJ, Quartermain MD, Banerjee A.: Fully automated evaluation of left ventricular global longitudinal strain in normal hearts: an assessment of accuracy in the pediatric population. Pediatr Cardiol Nov 2025.
Liversedge M, Wang J, Boustany M, Sharova A, Lin KY, O'Connor MJ, Danziger-Isakov L, Ryan TD, Downes KJ, Otto WR.: Epidemiology of invasive fungal disease in pediatric heart transplant recipients. J Pediatric Infect Dis Soc Nov 2025.
Catalano MA, Shin M, Toubat O, Rastogi R, Beqaj H, Iyengar A, Smood BF, Toomey N, Edelson JB, Rossano JW, O'Connor MJ, Ahmed H, Gaynor JW, Maeda K, Mavroudis CD: Listing for pediatric donation after circulatory death heart transplantation is associated with improved waitlist outcomes. J Am Heart Assoc 14: e041633, October 2025.
Edelson JB, Amdani S, Rosenthal DN, Kroslowitz B, Morray B, Law S, Joong A, Wilkens S, Peng DM, Ploutz M, Murray J, Lantz J, Esch JJ, Iqbal M, Lancaster T, VanderPluym C, Jeewa A, Shugh S, Absi M, Shezad M, O'Connor MJ, Lorts A, Tume S: Multi-institutional outcomes of Impella use in pediatric patients: A brief communication from the ACTION Network. J Heart Lung Transplant 44: 1668-1671, October 2025.
O'Connor MJ, Vu C, Zhang X, Bennett L, Ahmed H, Edwards JJ, Lin KY, Li Y, Maeda K, Marcellus B, Monos D, Rossano JW, Wittlieb-Weber CA, Edelson JB.: Allosensitization status predicts excess mortality in pediatric congenital heart disease transplant recipients in the current era: an analysis of the United Network for Organ Sharing database. JHLT Open 10: 100406, Oct 2025.
Chaudhary AA, Srinivasan C, Maeda K, DeWitt AG, Montgomery C, Rastogi R, O'Connor MJ, Edwards JJ, Ahmed H, Lin KY, Rossano JW, Wittlieb-Weber C, Edelson JB: Cardiac resynchronization therapy to aid ventricular assist device explantation in infants with cardiomyopathy and left bundle branch block. Pediatr Cardiol September 2025.
Schumacher KR, Rosenthal DN, Batazzi A, Yu S, Reichle G, Bano M, Deshpande SR, O'Connor M, Ahmed H, Chen S, Wright LK, Kindel SJ, Joong A, Ploutz M, Feingold B, Godown J, Mao CY, Lorts A, Simpson KE, Ybarra A, Richmond ME, Amdani S, Conway J, Blume ED, Cousino MK: The impact of Fontan circulatory failure on heart transplant survival: a 20-center retrospective cohort study. Circulation 152: 508-518, August 2025.
Masood IR, Wang L, Stanley HM, Edwards JJ, Ahmed H, Lin KY, Wittlieb-Weber CA, O'Connor MJ, Rossano JW, O'Malley S, Paridon SM, Tam VW, Edelson JB: Impact of neighborhood factors on exercise capacity in children With hypertrophic cardiomyopathy. Circ Heart Fail 18: e012501, July 2025.
Townsend M, O'Connor MJ, Spinner JA, Amdani S, Conway J: Practice variation in thromboprophylaxis management of outpatient pediatric cardiomyopathy patients: survey of ACTION providers. J Card Fail 31: 1090-1092, July 2025.