Theodore W. Laetsch, MD

faculty photo
Associate Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Attending Physician, Division of Oncology, Children's Hospital of Philadelphia
Inaugural Director, Very Rare Malignant Tumors Program, Children's Hospital of Philadelphia
Director, Developmental Therapeutics Program, Children's Hospital of Philadelphia
Co-Leader, Pediatric Oncology Program, Abramson Cancer Center, University of Pennsylvania
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
HUB for Clinical Collaboration
3500 Civic Center Blvd; Office 3527
Philadelphia, PA 19104
Education:
BS (Agriculture and Biosystems Engineering)
University of Arizona, Tucson, 2001.
MD
University of California, San Francisco, 2005.
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Selected Publications

Dholaria H, Tsetlina V, Simpson SK, Gillies E, Eswaran N, Rodriguez-Galindo C, Schultz KAP, Chen KS, Wu CC, Krasin MJ, Roemer T, Christiansen H, Piao J, Laetsch TW, Pashankar F, Kontny U, Gartrell RD: One-Two Punch: Combining Chemotherapy and Immunotherapy to Decrease Radiation Dose and Related Toxicity in Children and Adolescents with Nasopharyngeal Carcinoma. Clinical Cancer Research Page: doi: 10.1158, Jul 2025 Notes: epub ahead of print.

Yang AT, Lai ST, Laetsch TW, Bhatti T, Baloch Z, Surrey LF, Franco AT, Ricarte-Filho JCM, Mostoufi-Moab S, Adzick NS, Kazahaya K, Bauer AJ: Molecular landscape and therapeutic strategies in pediatric differentiated thyroid carcinoma. Endocrine Rev 46(3): 397-417, May 2025.

Drillon A, Hong DS, Orbach D, Tan DSW, Lin JJ, Georger B, Italino a, Kummar S, Lassen UN, McDermott R, Xu RH, Qi C, Burcoveanu DL, Brega N, Chaturvedi S, Shen K, Zheng H, Neu N, Van Tilburg CM, Laetsch TW: Larotrectinib resistance in TRK fusion cancers: analysis of a tumor-agnostic, global clinical trial dataset. American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL - Poster Presentation May 2025.

Yang AT, Lai ST, Laetsch TW, Bhatti T, Baloch Z, Surrey LF, Franco AT, Ricarte-Filho JCM, Mostoufi-Moab S, Adzick NS, Kazahaya K, Bauer AJ.: Molecular landscape and therapeutic strategies in pediatric differentiated thyroid carcinoma. Endocr Rev 46(3): 397-417, May 2025.

Oberoi S, Meade J, Rudzinski ER, Funkhouser A, Cottrel CE, Hawkins DS, Khan J, Mardis ER, Ramirez NC, Laetsch TW, Xue W, Smith MA, Barr FG, Linardic CM, Jagu S, Weiss AR, Venkatramani R, Reaman G, Shern JF: Integrated Molecular Characterization of Pediatric Soft Tissue Sarcomas: A Report from the COG and CCDI Molecular Characterization Initiative. American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago IL - Abstract May 2025.

Dela Cruz FS, Fox E, DuBois SG, Friedman GK, Croop JM, Kim A, Morgenstern DA, Balis FM, Macy ME, Pressey JG, Watt T, Krystal JI, Vo KT, Mody R, Laetsch TW, Weigel BJ, O'Hara K, He CS, Aluri J, Okpara CE, Glade Bender JL: A Phase 1/2 Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric and Young Adult Solid Tumors. Pediatric Blood & Cancer 72(7): e31692, May 2025.

Hong DS, Xu RH, Shen L, Dierselhuis MP, Orbach D, McDermott R, Italiano A, Tahara M, Bernard-Gauthier V, Neu N, Mussi CE, De La Cuesta E, Laetsch TW, Drilon A: Efficacy and safety of larotrectinib as first-line treatment for patients with TRK fusion cancer. ESMO Open 10(6): 105110, May 2025.

Xu RH, Hong DS,2 Van Tilburg CM, Orbach D, Tan DSW,7 Lin JJ, Geoerger B, Italiano A, Kummar S, Lassen UN, McDermott R, Burcoveanu DI, Brega N, Neu N, Laetsch TW, Qi C, Drilon A: Efficacy and safety of larotrectinib in patients with non-primary central nervous system TRK fusion cancer: an updated analysis. American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL - Poster Presentation May 2025.

Slotkin EK, Casanova M, Van Tine BA, Strauss S, Gennatas S, Arakawa A, Chishlom JC, Valverde Morales CM, Bertuzzi AF, Kothari A, Flor Oncala MJ, McCabe M, Hettmer S, Laetsch TW, Dirksen U, Oba U, Kordes UR, Kusi A, Pradhan K, Ferrari A, CAMPFIRE Study Team: Ramucirumab in Pediatric and Young Adult Patients with Relapsed/Refractory (R/R) Desmoplastic Small Round Cell Tumor (DSRCT) or Synovial Sarcoma (SS): Results from the CAMPFIRE Study: American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL - Poster Presentation May 2025.

Gaze MN, Handkiewicz-Junak D, Hladun R, Laetsch TW, Sorge C, Sparks R, Wan S, Ceraulo A, Kluczewska-Galka A, Gámez-Cenzano C, States LJ, El Khouli R, Aimone P, Perraud K, Kollar G, Khanshan F, Blumenstein L, Brouri F, Giraudet AL: Safety and dosimetry of [177Lu]Lu-DOTA-TATE in adolescent patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumours, or pheochromocytomas and paragangliomas: Primary analysis of the Phase II NETTER-P study. Eur J Nucl Med Mol Imaging 5(14): doi: 10.1007, Apr 2025 Notes: epub.

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Last updated: 07/03/2025
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