Theodore W. Laetsch, MD
Associate Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Attending Physician, Division of Oncology, Children's Hospital of Philadelphia
Inaugural Director, Very Rare Malignant Tumors Program, Children's Hospital of Philadelphia
Director, Developmental Therapeutics Program, Children's Hospital of Philadelphia
Co-Leader, Pediatric Oncology Program, Abramson Cancer Center, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
HUB for Clinical Collaboration
3500 Civic Center Blvd; Office 3527
Philadelphia, PA 19104
HUB for Clinical Collaboration
3500 Civic Center Blvd; Office 3527
Philadelphia, PA 19104
Email:
laetscht@chop.edu
laetscht@chop.edu
Publications
Education:
BS (Agriculture and Biosystems Engineering)
University of Arizona, Tucson, 2001.
MD
University of California, San Francisco, 2005.
Permanent linkBS (Agriculture and Biosystems Engineering)
University of Arizona, Tucson, 2001.
MD
University of California, San Francisco, 2005.
Selected Publications
Crane JN, Xue W, Qumseya A, Barkauskas DA, Chau K, Tan SY, Hiniker S, Dasgupta R, Venkatramani R, Spunt SL, Weiss AR, Laetsch TW: Malignant peripheral nerve sheath tumors: a report from children's oncology group study ARST0332. J Natl Cancer Inst. Dec 2025 Notes: DOI: 10.1093/jnci/djaf359.Yang AT, Laetsch TW, Busch CM, Li Y, Mcclory SE, Olson TS, Balis FM: Pilot Study of Scaling Busulfan dose to Body Surface Area in Children Undergoing Hematopoietic Stem Cell Transplant Conditioning. Alex's Lemonade Stand (ALSF) Summit, Philadelphia, PA Dec 2025.
McNerney KO, Kwon S, Naik S, Fabrizio V, Llaurador Caraballo G, Sanchez-Pinto LN, Talleur AT, Zeng X, Baggott C, Vatsayan A, Verneris MR, Prabhu S, Rossoff J, Pacenta HL, Phillips CL, Talano JA, Moskop A, Myers D, Karras N A, Bonifant C, Qayed M, Satwani P, Temple W, Krupski C, Keating AK, Baumeister S, Egeler E, Mavroukakis S, Curran KJ, Mackall CL, Laetsch TW, Gardner R, Schultz LM: Overlap of post-CAR T HLH toxicity definitions and their prognostic significance in children and young adults with B-acute lymphoblastic leukemia. American Society of Hematology (ASH) Annual Meeting, Orlando FL - Abstract December 2025.
Federman N, van Tilburg CM, Orbach D, Qi C, DuBois SG, Mascarenhas L, Dierselhuis MP, Albert CM, Blattman C, Geoerger B, Toledano H, Burcoveanu D-I, Neu N, Brega N, de la Cuesta E, Drilon A, Laetsch TW, Xu RH: Efficacy and Safety of Larotrectinib in Patients with TRK Fusion Sarcomas. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
Crane JN, Dagalakis U, Gartrell RD, Schultz KAP, Laetsch TW: Rare but not forgotten: Therapeutic advancements for rare childhood cancers. Mol Ther Oncol Nov 2025 Notes: doi: 10.1016/j.omton.2025.201084.
Pannucci A, Mukherjee E, Daley J, Ganapathi S, Levine E, Surrey L, Gutstein L, Azar P, Delacruz F, Pavisic J, Stockfisch E, Neyaz A, John I, Picarsic J, Tanaka Y, Gillani R, Crompton B, Janeway K, Taroni J, Davis J, Reed D, Shlien A, Laetsch TW, Mody R, Lawlor ER, Grohar P, Hawkins A, Cillo AR, Bailey KM: The Sean Karl Cohort: A National Collaborative Single-Cell RNASEQ Study of Paired Patient Ewing Sarcoma Specimens. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Abstract Nov 2025.
Shulman DS, Sala A, Bhushan K, Blair E, McManus JM, Cavanaugh KL, Garland J H, Divirgilio R, Sexton S, Field J, Garcia S, Carrozza S, Hohos MB, Murphy M M, Wagner M, Crane J, Sabnis A, Michlitsch J, Laetsch TW, Livingston JA, Gill JB, Chen N, Klega K, Clinton C, Crompton BD, Balis FM, London WB, DuBois SG: Phase 1/2 trial to evaluate the safety and efficacy of PEEL-224 in combination with vincristine and temozolomide in adolescents and young adults with relapsed or refractory sarcomas. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
Trent J, Wang H, Watt T, Choi W, Schilling F, Glade Bender J, Kasenda B, Tabatabai G, Burcoveanu DI, Neu N, Carrasco CP, Hong DS, Laetsch TW: Real-world study of larotrectinib in patients with TRK fusion solid tumors: interim analysis of ON-TRK. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
Hurley R, Huang K, Gutstein L, Segers B, Caradonio O, Maple E, Rivera D, Robinson J, Szepessy A, Bastianelli W, Trivedi H, Reilly M, Liu A, Crane J, Laetsch TW: Describing the Characteristics and Treatment of Synovial Sarcoma in the Recurrent Setting. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
Huang K, Gutstein L, Segers B, Caradonio O, Maple E, Rivera D, Robinson J, Szepessy A, Bastianelli W, Trivedi H, Reilly M, Liu A, Crane J, Laetsch TW, Hurley R: Evaluating Front-Line Therapy Accordance With Current Synovial Sarcoma Guidelines. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
