Theodore W. Laetsch, MD
Associate Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Attending Physician, Division of Oncology, Children's Hospital of Philadelphia
Inaugural Director, Very Rare Malignant Tumors Program, Children's Hospital of Philadelphia
Director, Developmental Therapeutics Program, Children's Hospital of Philadelphia
Co-Leader, Pediatric Oncology Program, Abramson Cancer Center, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
HUB for Clinical Collaboration
3500 Civic Center Blvd; Office 3527
Philadelphia, PA 19104
HUB for Clinical Collaboration
3500 Civic Center Blvd; Office 3527
Philadelphia, PA 19104
Email:
laetscht@chop.edu
laetscht@chop.edu
Publications
Education:
BS (Agriculture and Biosystems Engineering)
University of Arizona, Tucson, 2001.
MD
University of California, San Francisco, 2005.
Permanent linkBS (Agriculture and Biosystems Engineering)
University of Arizona, Tucson, 2001.
MD
University of California, San Francisco, 2005.
Selected Publications
Englum BR, Piao J, Younis L, Baertschiger RM, Chen KS, Christison-Lagay E, Dholaria H, Gartrell R, Hicks MJ, Kamihara J, Mitchell SG, Orjuela-Grimm M, Pashankar F, Potter SL, Aldrink JH, Rosenblum J, Sargen MR, Schultz KAP, Seynnaeve BKN, Wedekind M, Laetsch TW: Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee. Pediatr Blood Cancer Feb 2026 Notes: doi: 10.1002/pbc.32164.Bastianelli WE, Wu J, Ahsan MU, Szepessy AM, Schubert J, Balamuth NJ, Chan J, Denenberg EH, Luo M, Pollock AN, Russo PA, Rybacki K, Xu F, Zhong Y, Surrey LF, Wang K, Laetsch TW, Li MM: Molecular Characterization of a Complex PDGFRB Structural Variation in Infantile Myofibroma With Complete Response to Imatinib. JCO Precis Oncol Jan 2026 Notes: doi: 10.1200/PO-25-00943.
Ródon J, Arkenau HT, Funchain P, Hervieu A, Anthony K, Chawla SP, Laetsch TW, Murciano-Goroff YR, Singer CF, He Y, Mina M, Wacheck V, Delaloge S: A phase II study of the AKT inhibitor TAS-117 in patients with advanced solid tumors and germline PTEN mutations. ESMO Open Jan 2026 Notes: doi: 10.1016/j.esmoop.2025.105932.
Crane JN, Xue W, Qumseya A, Barkauskas DA, Chau K, Tan SY, Hiniker S, Dasgupta R, Venkatramani R, Spunt SL, Weiss AR, Laetsch TW: Malignant peripheral nerve sheath tumors: a report from children's oncology group study ARST0332. J Natl Cancer Inst. Dec 2025 Notes: DOI: 10.1093/jnci/djaf359.
Yang AT, Laetsch TW, Busch CM, Li Y, Mcclory SE, Olson TS, Balis FM: Pilot Study of Scaling Busulfan dose to Body Surface Area in Children Undergoing Hematopoietic Stem Cell Transplant Conditioning. Alex's Lemonade Stand (ALSF) Summit, Philadelphia, PA Dec 2025.
Vaile JR, Tipps JA, Hurley R, Struble SL, Allen BE, Surrey LF, Finn LS, Balis FM, Laetsch TW, Mendenhall SD: Infantile Fibrosarcoma of the Hand: Limb-Sparing Treatment With Modern Targeted Oral Chemotherapy and Conservative Surgical Resection. J Hand Surg Glob Online Dec 2025 Notes: doi: 10.1016/j.jhsg.2025.
McNerney KO, Kwon S, Naik S, Fabrizio V, Llaurador Caraballo G, Sanchez-Pinto LN, Talleur AT, Zeng X, Baggott C, Vatsayan A, Verneris MR, Prabhu S, Rossoff J, Pacenta HL, Phillips CL, Talano JA, Moskop A, Myers D, Karras N A, Bonifant C, Qayed M, Satwani P, Temple W, Krupski C, Keating AK, Baumeister S, Egeler E, Mavroukakis S, Curran KJ, Mackall CL, Laetsch TW, Gardner R, Schultz LM: Overlap of post-CAR T HLH toxicity definitions and their prognostic significance in children and young adults with B-acute lymphoblastic leukemia. American Society of Hematology (ASH) Annual Meeting, Orlando FL - Abstract December 2025.
Federman N, van Tilburg CM, Orbach D, Qi C, DuBois SG, Mascarenhas L, Dierselhuis MP, Albert CM, Blattman C, Geoerger B, Toledano H, Burcoveanu D-I, Neu N, Brega N, de la Cuesta E, Drilon A, Laetsch TW, Xu RH: Efficacy and Safety of Larotrectinib in Patients with TRK Fusion Sarcomas. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
Hurley R, Huang K, Gutstein L, Segers B, Caradonio O, Maple E, Rivera D, Robinson J, Szepessy A, Bastianelli W, Trivedi H, Reilly M, Liu A, Crane J, Laetsch TW: Describing the Characteristics and Treatment of Synovial Sarcoma in the Recurrent Setting. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
Huang K, Gutstein L, Segers B, Caradonio O, Maple E, Rivera D, Robinson J, Szepessy A, Bastianelli W, Trivedi H, Reilly M, Liu A, Crane J, Laetsch TW, Hurley R: Evaluating Front-Line Therapy Accordance With Current Synovial Sarcoma Guidelines. Connective Tissue Oncology Society (CTOS) Annual Meeting, Boca Raton, FL - Poster Presentation Nov 2025.
