Cassie Kline, MD, MAS

Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Director, Neuro-Oncology Clinical Research, Children’s Hospital of Philadelphia
Pediatric Neuro-Oncology Consortium Site PI, Children’s Hospital of Philadelphia
Department: Pediatrics
Contact information
Children’s Hospital of Philadelphia
The Hub for Clinical Collaboration
3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
The Hub for Clinical Collaboration
3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
Office: 267-426-6559
Email:
klinec@chop.edu
klinec@chop.edu
Education:
BA (Biology, Cum Laude)
University of Virginia, 2004.
Post-Bacc (Post-baccalaureate)
University of California, San Diego, 2006.
MD (Medicine)
University of California, San Diego, 2011.
MAS (Clinical Research )
University of California, San Francisco, 2017.
Permanent linkBA (Biology, Cum Laude)
University of Virginia, 2004.
Post-Bacc (Post-baccalaureate)
University of California, San Diego, 2006.
MD (Medicine)
University of California, San Diego, 2011.
MAS (Clinical Research )
University of California, San Francisco, 2017.
Selected Publications
Bhatia A, Kline C, Madsen PJ, Fisher MJ, Boada FE, Roberts TPL.: Sodium MRI in Pediatric Brain Tumors. AJNR Am J Neuroradiol. 1(46(7):): 1309-1317. July 2025 Notes: doi: 10.3174/ajnr.A8642.Karsten Nysom, Lindsay B Kilburn, Sarah E S Leary, Daniel B Landi, Evelien de Vos-Kerkhof, Sébastien Perreault, Olaf Witt, David S Ziegler, Pablo Hernáiz Driever, Andrea T Franson, Patricia A Baxter, Nicholas S Whipple, Cassie Kline, Devorah Segal, Nada Jabado, Simon Bailey, Geoffrey McCowage, Jordan R Hansford, Dong-Anh Khuong-Quang, Nicholas G Gottardo, Timothy Hassall, Jung Woo Han, Michal Yalon Oren, Susan N Chi, Jiaheng Qiu, Daniel Da Costa, Sandya Govinda Raju, Peter Manley, Darren Hargrave: Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial. Neuro Oncol 21(27): (5):1341-1355, June 2025 Notes: https://doi.org/10.1093/neuonc/noae274.
Yu B, Kline C, Hoare O, Jung J, Knowles T, Ranavaya A, Minturn J, Banerjee A, Leary S, Crotty E, Abdelbaki M, Whipple N, Goldman S, Margol A, Bhatia A, Dababo N, George E, Nabavizadeh A, Pampaloni MH, Inagaki A, Collins S, Chuntova P, Barcova M, Patel TS, Phillips J, Prados M, Molinaro A, Gupta N, Raffel C, Cole K, Kasahara N, Diaz AA, Mueller S.: Measles oncolytic virus as an immunotherapy for recurrent/refractory pediatric medulloblastoma and atypical teratoid rhabdoid tumor: results from PNOC005. Clin Cancer Res. [Epub ahead of print] (20), June 2025 Notes: doi: 10.1158/1078-0432.CCR-24-3721.
Cassie Kline, Karen Wright, Lindsay Baker Kilburn, Susan N. Chi, Daniel B. Landi, Jasper van der Lugt, Sarah Leary, Mohamed Abdelbaki, Simon Bailey, Karsten Nysom, Dong-Anh Khuong-Quang, Elias Joseph Sayour, Olaf Witt, Pablo Hernáiz Driever, Valérie Larouche, Ashley Bailey-Torres, Lindsey Ott, Jiaheng Qiu, Lisa McLeod, and Sabine Mueller : Growth recovery in patients with BRAF altered pediatric low-grade gliomas (LGG) after discontinuation of tovorafenib. Journal of Clinical Oncology 43(16), May 2025 Notes: https://doi.org/10.1200/JCO.2025.43.16_suppl.1002.
Joshi N, Mueller S, Kline C. : Current clinical trials for craniopharyngiomas: what's on the horizon? J Neurooncol. Apr 2025 Notes: doi: 10.1007/s11060-024-04899-6
Erker C, Mynarek M, Simbozel M, Craig BT, Harrod VL, Cappellano AM, Cohen KJ, Lopez VS, Morales-La Madrid A, Cacciotti C, Baroni L, Salloum R, Margol AS, Michaiel G, Aguilera D, Mazewski CM, Kline CN, Finlay JL, Abdelbaki MS, Murray JC, Dorris K, Crooks B, Ginn KF, Amayiri N, Tippelt S, Fleischhack G, Tonn S, Gerber NU, Lassaletta A, Hansford JR, Khan S, Gilheeney SW, Hoffman LM, Zapotocky M, Larouche V, Shah S, Ramaswamy V, Gajjar A, Perreault S, Mueller S, Hukin J, Cheng S, Wang ZJ, Matheson K, Bailey S, Bouffet E, Clifford SC, Robinson G, Dufour C, Rutkowski S, Lafay-Cousin L. : Salvage therapies for first relapse of SHH medulloblastoma in early childhood. Neuro Oncol. Apr 2025 Notes: doi: 10.1093/neuonc/noaf092.
Roberts HJ, Ravi K, Marini BL, Schepers A, Kline C, Kilburn L, Prados M, Byron SA, Sturza J, Mueller S, Koschmann C, Franson AT.: Retrospective Comparison of Targeted Anticancer Drugs Predicted by the CNS-TAP Tool Versus Those Selected by a Molecularly Driven Tumor Board in Children With DIPG. J Pediatr Hematol Oncol. Jan 2025 Notes: doi: 10.1097/MPH.0000000000002964.
Ryan J Corbett, Cricket C Gullickson, Zhuangzhuang Geng, Miguel A Brown, Bo Zhang, Chuwei Zhong, Nicholas Van Kuren, Antonia Chroni, Christopher Blackden, Ammar S Naqvi, Alexa Plisiewicz, Sean McHugh, Emmett Drake, Kaitlin Lehmann, Tom B Davidson, Michael Prados, Phillip B Storm, Adam C Resnick, Angela J Waanders, Sebastian M Waszak, Sabine Mueller, Jo Lynne Rokita, Cassie Kline: Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the PBTA and PNOC. Neuro Oncol Jan 2025 Notes: Ref.: Ms. No. N-O-D-24-00560R3 doi: 10.1093/neuonc/noaf017.
Mueller S, Kline C, Lu AY, Hoogendijk R, Wembacher-Schroeder E, Banerjee A, Reddy AT, Raber S, Hoffman C, Stoller S, Prados M, Molinaro A, Gupta N.: PNOC009: Convection-enhanced delivery of liposomal irinotecan in patients with newly diagnosed diffuse intrinsic pontine glioma. Neurooncol Adv. (1):vdaf093.(7), Jan-Dec 2025 Notes: doi: 10.1093/noajnl/vdaf093.
Hoogendijk R, van den Broek TJM, Lee H, Mueller S, Kline C, Bianco J, Top J, de Zoete MR, Kester L, Calkoen F, van der Lugt J.: Omnigene-Gut(tm) ensures fecal microbiome stability in the pediatric population. AMB Express Dec 2024 Notes: doi: 10.1186/s13568-024-01798-x.