Cassie Kline, MD, MAS
Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Director, Neuro-Oncology Clinical Research, Children’s Hospital of Philadelphia
Pediatric Neuro-Oncology Consortium Site PI, Children’s Hospital of Philadelphia
Department: Pediatrics
Contact information
Children’s Hospital of Philadelphia
The Hub for Clinical Collaboration
3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
The Hub for Clinical Collaboration
3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
Office: 267-426-6559
Email:
klinec@chop.edu
klinec@chop.edu
Education:
BA (Biology, Cum Laude)
University of Virginia, 2004.
Post-Bacc (Post-baccalaureate)
University of California, San Diego, 2006.
MD (Medicine)
University of California, San Diego, 2011.
MAS (Clinical Research )
University of California, San Francisco, 2017.
Permanent linkBA (Biology, Cum Laude)
University of Virginia, 2004.
Post-Bacc (Post-baccalaureate)
University of California, San Diego, 2006.
MD (Medicine)
University of California, San Diego, 2011.
MAS (Clinical Research )
University of California, San Francisco, 2017.
Selected Publications
Cassie Kline, Darren Hargrave, Dong-Anh Khong-Quang, Daniel Landi, Sarah Leary, Jasper van der Lugt, Sabine Mueller, Karsten Nysom, Sébastien Perreault, Angela Waanders, Olaf Witt, David Ziegler, Peter Manley, Jingyang Zhang , Elly Barry , Lindsay Kilburn: Clinical stability following tovorafenib treatment in relapsed/refractory pediatric low-grade glioma: updated results from the phase 2 FIREFLY-1 trial WFSNO/SNO 2025 (Honolulu, HI) Neuro-Oncology, 27(5): v149, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0589.Aashim Bhatia, Em Triolo, Luke Bloy, Jeffrey Berman, Akinbanji Afolabi, Apoorva Kotha, Cassie Kline, Michael LaRiviere, Peter Madsen, Chelsea Kotch, Jessica Foster, Michael Fisher, Mohammad Harris, Blake Benyard, Neil Wilson, Ravinder Reddy, Fernando Boada, Timothy Roberts: BIOM-87. SODIUM (23NA) MRI AND CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING IN TYPICALLY DEVELOPING CHILDREN AND IN PEDIATRIC BRAIN TUMORS. Neuro-Oncology 27(5): v44–v45, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0175.
Eric Montgomery, Siddhartha Mitra, Cassie Kline, Todd C. Hankinson: Advances in Cancer Research. Elsevier-Chapter Seven - Craniopharyngioma 167: 243-277, Nov 2025 Notes: ISBN: 978-0-443-43055-8.
Rachel Moor, Frances Weidert, Christina von Roemeling, Nagheme Thomas, Mahya Aghaee, Dingpeng Zhang, Cassie Kline, Michael Prados, Sabine Mueller, Maryam Rahman, Paul Castillo, Ashley Ghiaseddin, Sheila Carrera-Justiz, Duane Mitchell, Hector Mendez-Gomez, John Ligon, Elias Sayour: CTIM-34. PARAPROGRESSION DEFINES A DAMAGE RESPONSE FROM SYSTEMIC MRNA IMMUNOTHERAPY IN MALIGNANT GLIOMA. Neuro-Oncology 27: v122, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0491.
Clara Savary, Mika L Persson, Evangeline Jackson, Ryan J. Duchatel, Tuan Vo, Izac J. Findlay, Alicia M Douglas, Liesl Bramberger, Daniel de la Nava, Bryce C. Thomas, Holly P McEwen, Tyrone S Beitaki, Laura Rodriguez de la Fuente, Yolanda Colino Sanguino, Fatima Valdes Mora, Martin R Larsen, Pouya Faridi, Jeff Holst, Jemma Mayall, Cassie N Kline, Andrea T. Franson, Sriram Venneti, Hubert Hondermarck, ay Horvat, Brett Nixon, Rodrigo Cartaxo, Javad Nazarian, Esther Hulleman, Sabine Mueller, Nicholas A Vitanza, Carl Koschmann, Marta M Alonso, Tiago Ferreira Carvalheiro, Jasper van der Lugt, Matt D. Dun : DDDR-38. Leveraging the immunomodulatory effects of dordaviprone (ONC201) to induce long-term survival response in diffuse midline glioma patients and models. Neuro-Oncology 27 (Supplement_5):v171-v171 November 2025 Notes: DOI:10.1093/neuonc/noaf201.0675.
Nicholas Whipple , Annette Molinaro , Alyssa Reddy , Marie Jaeger-Krause , Michael Iv , Javier Villanueva-Meyer , Janine Lupo , Tabitha Cooney , Shannon Raber , Carly Hoffman , Jessica Jensen , Michael Prados , Robyn Gartrell , Cassie Kline , Samuel Cheshier , Sabine Mueller , Howard Colman: CTP-18. PNOC025: A phase 1 study assessing the safety and tolerability of magrolimab in children and adults with recurrent or progressive malignant brain tumors. Neuro-Oncology 27(5): v149–v150, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0590.
Eric Montgomery, Siddhartha Mitra, Cassie Kline, Todd C Hankinson: Craniopharyngioma. Adv Cancer Res . October 2025 Notes: DOI: 10.1016/bs.acr.2025.09.005.
Nicole Edwards, Lauren W. Yowelunh McLester-Davis, Cassie Kline, Alex Brown, Nadine R. Caron & Louise C. Parr-Brownlie: Towards the implementation of Indigenous data governance in neurogenomics research. Nature Neuroscience Sept 2025 Notes: https://doi.org/10.1038/s41593-025-02070-6.
Bhatia A, Kline C, Madsen PJ, Fisher MJ, Boada FE, Roberts TPL.: Sodium MRI in Pediatric Brain Tumors. Am J Neuroradiol 46(7): 1309-1317, July 2025 Notes: doi: 10.3174/ajnr.A8642.
Karsten Nysom, Lindsay B Kilburn, Sarah E S Leary, Daniel B Landi, Evelien de Vos-Kerkhof, Sébastien Perreault, Olaf Witt, David S Ziegler, Pablo Hernáiz Driever, Andrea T Franson, Patricia A Baxter, Nicholas S Whipple, Cassie Kline, Devorah Segal, Nada Jabado, Simon Bailey, Geoffrey McCowage, Jordan R Hansford, Dong-Anh Khuong-Quang, Nicholas G Gottardo, Timothy Hassall, Jung Woo Han, Michal Yalon Oren, Susan N Chi, Jiaheng Qiu, Daniel Da Costa, Sandya Govinda Raju, Peter Manley, Darren Hargrave: Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial. Neuro Oncol 27(5): 1341-1355, June 2025 Notes: https://doi.org/10.1093/neuonc/noae274.