Cassie Kline, MD, MAS

Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Director, Neuro-Oncology Clinical Research, Children’s Hospital of Philadelphia
Pediatric Neuro-Oncology Consortium Site PI, Children’s Hospital of Philadelphia
Department: Pediatrics
Contact information
Children’s Hospital of Philadelphia
The Hub for Clinical Collaboration
3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
The Hub for Clinical Collaboration
3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
Office: 267-426-6559
Email:
klinec@chop.edu
klinec@chop.edu
Education:
BA (Biology, Cum Laude)
University of Virginia, 2004.
Post-Bacc (Post-baccalaureate)
University of California, San Diego, 2006.
MD (Medicine)
University of California, San Diego, 2011.
MAS (Clinical Research )
University of California, San Francisco, 2017.
Permanent linkBA (Biology, Cum Laude)
University of Virginia, 2004.
Post-Bacc (Post-baccalaureate)
University of California, San Diego, 2006.
MD (Medicine)
University of California, San Diego, 2011.
MAS (Clinical Research )
University of California, San Francisco, 2017.
Selected Publications
Bhatia A, Kline C, Madsen PJ, Fisher MJ, Boada FE, Roberts TPL.: Sodium MRI in Pediatric Brain Tumors. Am J Neuroradiol 46(7): 1309-1317, July 2025 Notes: doi: 10.3174/ajnr.A8642.Karsten Nysom, Lindsay B Kilburn, Sarah E S Leary, Daniel B Landi, Evelien de Vos-Kerkhof, Sébastien Perreault, Olaf Witt, David S Ziegler, Pablo Hernáiz Driever, Andrea T Franson, Patricia A Baxter, Nicholas S Whipple, Cassie Kline, Devorah Segal, Nada Jabado, Simon Bailey, Geoffrey McCowage, Jordan R Hansford, Dong-Anh Khuong-Quang, Nicholas G Gottardo, Timothy Hassall, Jung Woo Han, Michal Yalon Oren, Susan N Chi, Jiaheng Qiu, Daniel Da Costa, Sandya Govinda Raju, Peter Manley, Darren Hargrave: Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial. Neuro Oncol 27(5): 1341-1355, June 2025 Notes: https://doi.org/10.1093/neuonc/noae274.
Yu B, Kline C, Hoare O, Jung J, Knowles T, Ranavaya A, Minturn J, Banerjee A, Leary S, Crotty E, Abdelbaki M, Whipple N, Goldman S, Margol A, Bhatia A, Dababo N, George E, Nabavizadeh A, Pampaloni MH, Inagaki A, Collins S, Chuntova P, Barcova M, Patel TS, Phillips J, Prados M, Molinaro A, Gupta N, Raffel C, Cole K, Kasahara N, Diaz AA, Mueller S.: Measles oncolytic virus as an immunotherapy for recurrent/refractory pediatric medulloblastoma and atypical teratoid rhabdoid tumor: results from PNOC005. Clin Cancer Res. [Epub ahead of print] June 2025 Notes: doi: 10.1158/1078-0432.CCR-24-3721.
Craig Erker, Lorena Baroni, Kline Cassie, Martin Mynarek, Darren Klawinski, Eric Sandler, Giles Robinson, Amar Gajjar, Anna Hoppmann, Girish Dhall, Sylvia Cheng, Juliette Hukin, Ralph Salloum, Maura Massimino, Sebastien Perreault, Vicente Santa Maria Lopez, Andres Morales, Sabine Muller, Stefan Rutkowski, Steven Clifford, Kenneth Cohen, Simon Bailey, Eric Bouffet, Lucie Lafay-Cousin: Pattern of relapse and outcome of early childhood medulloblastoma treated with upfront adjuvant focal radiotherapy. Podium presentations – 8th Biennial Pediatric Neuro-Oncology Conference; San Diego, CA May 2025.
Zhou Yan, Prince Eric, Staulcup Susan, Medlin Stephen, Knox Aaron, Montgomery Eric, Chen Vincent, Guttipatti Pavan, Tran Callista, Feldstein Neil, Johnston James, Dewan Michael, Niazi Toba, Thompson Eric, Prolo Laura, Jackson Eric, Ginn Kevin, Wright Avery, Dudley Roy, Kilburn Lindsay, Chern Joshua, Leonard Jeffrey, Lam Sandi, Hersh David, Anderson Richard, Mangum Ross, Kline Cassie, Mitra Siddhartha, Hankinson Todd : Sex-associated differences in disease progression and functional outcomes of adamantinomatous craniopharyngioma in prepubescent patients. Podium presentations – 8th Biennial Pediatric Neuro-Oncology Conference; San Diego, CA(15-17), May 2025.
Dimosthenis Chrysochoou, Deep Gandhi, Ariana Familiar, Neda Khalili, Nastaran Khalili, Arastoo Vossough, Cassie Kline, Jeffrey Ware, Paarth Jain, Hannah Anderson, Wenxin Tu, Shuvanjan Haldar, Phillip Storm, Michael Prados, Sabine Mueller, Adam Resnick, Christos Davatzikos, Ali Nabavizadeh, Anahita Fathi Kazerooni: Enhancing Longitudinal Tumor Volume Assessment in Pediatric Brain Tumors with Synthetic MRI Generation. Podium presentations – 8th Biennial Pediatric Neuro-Oncology Conference; San Diego, CA(15-17), May 2025.
Gandhi Deep, Khalili Neda, Khalili Nastaran , Vossough Arastoo, Kline Cassie, Franson Andrea, Familiar Ariana, Ware Jeffrey, Jain Paarth, Anderson Hannah, Tu Wenxin, Haldar Shuvanjan, Storm Phillip, Prados Michael, Mueller Sabine, Resnick Adam, Nabavizadeh Ali, Kazerooni Anahita Fathi: Longitudinal clinicoradiomic modeling of overall survival in diffuse midline glioma patients using serial MRI scans. Podium presentations – 8th Biennial Pediatric Neuro-Oncology Conference; San Diego, CA(15-17), May 2025.
Cassie Kline, Karen Wright, Lindsay Baker Kilburn, Susan N. Chi, Daniel B. Landi, Jasper van der Lugt, Sarah Leary, Mohamed Abdelbaki, Simon Bailey, Karsten Nysom, Dong-Anh Khuong-Quang, Elias Joseph Sayour, Olaf Witt, Pablo Hernáiz Driever, Valérie Larouche, Ashley Bailey-Torres, Lindsey Ott, Jiaheng Qiu, Lisa McLeod, and Sabine Mueller : Growth recovery in patients with BRAF altered pediatric low-grade gliomas (LGG) after discontinuation of tovorafenib. J Clin Oncol 43(16), May 2025 Notes: https://doi.org/10.1200/JCO.2025.43.16_suppl.1002.
Cassie Kline1, Jonathan Schoenfeld2, Dimple Modi3, Nathalie Fiaschi3, Jingxiao Chen3, Anne Bendel, Mary Skrypek, Amar Gajjar, Christopher Tinkle, Ashley Margol, Tom Davidson, Lindsay Kilburn, Roger Packer, Alyssa Reddy, Mohamed Abdelbaki, Josh Rubin, Elias Sayour, Duane Mitchell, Susan Chi, Angela Waanders, Jennifer Elster, Patricia Baxter, Erin Crotty, Kenneth Cohen, Christopher Moertel, Andrea Franson, Nicholas Whipple, Shikha Bansal, Tamara Schmidt, Kevin Liu, Lauren Gunasti, Denise Morinigo, Shefali Singh, Schuyler Stoller, Joanna Phillips, Mariella Filbin, Sebastian Waszak, Javad Nazarian, Paul Catalano, Michael Prados, Daphne Haas-Kogan, Heather Magnan, Sabine Mueller: Tumor and systemic molecular / immune correlates and patient reported QOL in pediatric CNS and solid tumors treated with PD1 inhibition and conventional versus hypofractionated radiation on PNOC013. Podium presentations – 8th Biennial Pediatric Neuro-Oncology Conference; San Diego, CA(15-17), May 2025.
Joshi N, Mueller S, Kline C. : Current clinical trials for craniopharyngiomas: what's on the horizon? J Neurooncol 172(2): 281-288, Apr 2025 Notes: doi: 10.1007/s11060-024-04899-6