Cassie Kline, MD, MAS

faculty photo
Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Director, Neuro-Oncology Clinical Research, Children’s Hospital of Philadelphia
Pediatric Neuro-Oncology Consortium Site PI, Children’s Hospital of Philadelphia
Department: Pediatrics

Contact information
Children’s Hospital of Philadelphia
The Hub for Clinical Collaboration
3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
Office: 267-426-6559
Education:
BA (Biology, Cum Laude)
University of Virginia, 2004.
Post-Bacc (Post-baccalaureate)
University of California, San Diego, 2006.
MD (Medicine)
University of California, San Diego, 2011.
MAS (Clinical Research )
University of California, San Francisco, 2017.
Permanent link
 
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Selected Publications

Karsten Nysom, Lindsay B Kilburn, Sarah E S Leary, Daniel B Landi, Evelien de Vos-Kerkhof, Sébastien Perreault, Olaf Witt, David S Ziegler, Pablo Hernáiz Driever, Andrea T Franson, Patricia A Baxter, Nicholas S Whipple, Cassie Kline, Devorah Segal, Nada Jabado, Simon Bailey, Geoffrey McCowage, Jordan R Hansford, Dong-Anh Khuong-Quang, Nicholas G Gottardo, Timothy Hassall, Jung Woo Han, Michal Yalon Oren, Susan N Chi, Jiaheng Qiu, Daniel Da Costa, Sandya Govinda Raju, Peter Manley, Darren Hargrave: Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial. Neuro Oncol February 2025 Notes: https://doi.org/10.1093/neuonc/noae274.

Ryan J Corbett, Cricket C Gullickson, Zhuangzhuang Geng, Miguel A Brown, Bo Zhang, Chuwei Zhong, Nicholas Van Kuren, Antonia Chroni, Christopher Blackden, Ammar S Naqvi, Alexa Plisiewicz, Sean McHugh, Emmett Drake, Kaitlin Lehmann, Tom B Davidson, Michael Prados, Phillip B Storm, Adam C Resnick, Angela J Waanders, Sebastian M Waszak, Sabine Mueller, Jo Lynne Rokita, Cassie Kline: Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the PBTA and PNOC. Neuro Oncol Jan 2025 Notes: Ref.: Ms. No. N-O-D-24-00560R3 doi: 10.1093/neuonc/noaf017.

Wright K, Kline C, Abdelbaki MS, Sayour E, Crotty E, Raabe E, Elster J, Prados M, Haas-Kogan D, Mueller S: Decreased growth velocity in a phase 1 trial (PNOC014) of Tovorafenib in patients with recurrent or progressive MAPK-altered tumors. Neuro Oncol 26(8), November 2024.

Apps JR, Gonzalez-Meljem JM, Guiho R, Pickles JC, Prince E, Schwalbe E, Joshi N, Stone TJ, Ogunbiyi O, Chalker J, Bassey A, Otto G, Davies R, Hughes D, Brandner S, Tan E, Lee V, Hayhurst C, Kline C, Castellano S, Hankinson T, Deutschbein T, Jacques TS, Martinez-Barbera JP. : Recurrent adamantinomatous craniopharyngioma show MAPK pathway activation, clonal evolution and rare TP53-loss-mediated malignant progression. Acta Neuropathol Commun August 2024.

Beauchemin MP, Ortega M, Santacroce SJ, Robles JM, Ruiz J, Hall AG, Kahn JM, Fu C, Orjuela-Grimm M, Hillyer GC, Solomon S, Pelletier W, Montiel-Esparza R, Blazin LJ, Kline C, Seif AE, Aristizabal P, Winestone LE, Velez MC. : Clinical trial recruitment of people who speak languages other than English: a Children’s Oncology Group report. JNCI Cancer Spectr July 2024.

Hanson D, Chi S, Braunstein S, Elhalawani H, Kool M, Filbin M, Gojo Johannes, Plasschaert S, Von Hoff K, Margol A, Kline C, Molinaro A, Prados M, Mueller S.: PNOC031 - International trial for embryonal tumor with multilayered rosettes. Neuro Oncol 26(4), June 2024.

Raber S, Hoffman C, Kline C, Mueller S, Prados M, Meyer A. : Implementing a nursing led working group within the Pediatric Neuro-Oncology Consortium (PNOC), a two-year experience and evaluation. Podium presentation at: 21st International Symposium on Pediatric Neuro-Oncology; Philadelphia, Pennsylvania. June 29-July 2, 2024. June 2024.

Franson A, Kilburn L, Cooney T, Stoller S, Reddy A, Banerjee A, Packer R, Bendel A, Skrypek M, Minturn J, ABdelbaki M, Whipple N, Chan P, Crawford J, Leary S, Waanders A, Elster J, Cohen K, George E, Pinto S, Vossough A, Kraya A, Prados M, Kline C, Nazarian J, Solomon D, Long-Boyle J, Molinaro A, Waszak S, Mueller S.: PNOC008: a pilot trial testing the Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan in Children and Young Adults with High-Grade Glioma (Excluding Diffuse Intrinsic Pontine Glioma). Poster presentation at: 21st International Symposium on Pediatric Neuro-Oncology; Philadelphia, Pennsylvania. June 29-July 2, 2024. June 2024.

Kline C, Franson A, Banerjee A, Reddy AT, Raber S, Hoffman C, Minturn J, van der Lugt J, de Vos-Kerkhof E, van Vuurden D, Gerber N, Guerreiro Stuecklin A, Kilburn LB, Elster J, Whipple N, Cohen KJ, Yalon Oren M, Gardner SL, Cluster A, Chi SN, Landi DB, McCowage G, Vo J, Resnick A, Phillips J, Bhatia A, George E, Vossough A, Nabavizadeh A, Braunstein SE, Gupta N, Prados M, Waszak SM, Boyle-Lang J, Molinaro AM, Dun MD, Koschmann CJ, Nazarian J, Mueller S: PNOC022 report: a combination therapy trial using an adaptive platform design for patients with diffuse midline glioma at initial diagnosis, post-radiation therapy, or progression. Podium presentation at: 21st International Symposium on Pediatric Neuro-Oncology June 2024.

Seidl K, Briamonte C, Higgins M, Hoffman C, Holtzlaw S, McHugh M, Meyer A, Rangan K, Schmus C, Strachan M, Waters K, Yeh-Nayre L, Kline C, Prados M, Mueller S, Raber S. : Exploration of correlative studies in early phase trials for pediatric central nervous system (CNS) tumors and the potential translation to clinical care. Podium presentation at: 21st International Symposium on Pediatric Neuro-Oncology; Philadelphia, Pennsylvania. June 29-July 2, 2024. June 2024.

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Last updated: 02/27/2025
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