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Cassie Kline, MD, MAS
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Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
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Director, Neuro-Oncology Clinical Research, Children’s Hospital of Philadelphia
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Pediatric Neuro-Oncology Consortium Site PI, Children’s Hospital of Philadelphia
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Department: Pediatrics
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Contact information
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Children’s Hospital of Philadelphia
2a The Hub for Clinical Collaboration
44 3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
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2a The Hub for Clinical Collaboration
44 3500 Civic Center Blvd, Room 3591
Philadelphia, PA 19104
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Office: 267-426-6559
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Email:
klinec@chop.edu
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klinec@chop.edu
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Education:
21 7 BA 1f (Biology, Cum Laude) c
2f University of Virginia, 2004.
21 e Post-Bacc 1f (Post-baccalaureate) c
3c University of California, San Diego, 2006.
21 7 MD 15 (Medicine) c
3c University of California, San Diego, 2011.
21 8 MAS 1f (Clinical Research ) c
40 University of California, San Francisco, 2017.
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Permanent link21 7 BA 1f (Biology, Cum Laude) c
2f University of Virginia, 2004.
21 e Post-Bacc 1f (Post-baccalaureate) c
3c University of California, San Diego, 2006.
21 7 MD 15 (Medicine) c
3c University of California, San Diego, 2011.
21 8 MAS 1f (Clinical Research ) c
40 University of California, San Francisco, 2017.
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1cc Cassie Kline, Darren Hargrave, Dong-Anh Khong-Quang, Daniel Landi, Sarah Leary, Jasper van der Lugt, Sabine Mueller, Karsten Nysom, Sébastien Perreault, Angela Waanders, Olaf Witt, David Ziegler, Peter Manley, Jingyang Zhang , Elly Barry , Lindsay Kilburn: Clinical stability following tovorafenib treatment in relapsed/refractory pediatric low-grade glioma: updated results from the phase 2 FIREFLY-1 trial 24 WFSNO/SNO 2025 (Honolulu, HI) 2 74 Neuro-Oncology, 27(5): v149, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0589.
252 Aashim Bhatia, Em Triolo, Luke Bloy, Jeffrey Berman, Akinbanji Afolabi, Apoorva Kotha, Cassie Kline, Michael LaRiviere, Peter Madsen, Chelsea Kotch, Jessica Foster, Michael Fisher, Mohammad Harris, Blake Benyard, Neil Wilson, Ravinder Reddy, Fernando Boada, Timothy Roberts: BIOM-87. SODIUM (23NA) MRI AND CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING IN TYPICALLY DEVELOPING CHILDREN AND IN PEDIATRIC BRAIN TUMORS. Neuro-Oncology 27(5): v44–v45, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0175.
10b Eric Montgomery, Siddhartha Mitra, Cassie Kline, Todd C. Hankinson: Advances in Cancer Research. Elsevier-Chapter Seven - Craniopharyngioma 167: 243-277, Nov 2025 Notes: ISBN: 978-0-443-43055-8.
227 Rachel Moor, Frances Weidert, Christina von Roemeling, Nagheme Thomas, Mahya Aghaee, Dingpeng Zhang, Cassie Kline, Michael Prados, Sabine Mueller, Maryam Rahman, Paul Castillo, Ashley Ghiaseddin, Sheila Carrera-Justiz, Duane Mitchell, Hector Mendez-Gomez, John Ligon, Elias Sayour: CTIM-34. PARAPROGRESSION DEFINES A DAMAGE RESPONSE FROM SYSTEMIC MRNA IMMUNOTHERAPY IN MALIGNANT GLIOMA. Neuro-Oncology 27: v122, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0491.
289 Clara Savary, Mika L Persson, Evangeline Jackson, Ryan J. Duchatel, Tuan Vo, Izac J. Findlay, Alicia M Douglas, Liesl Bramberger, Daniel de la Nava, Bryce C. Thomas, Holly P McEwen, Tyrone S Beitaki, Laura Rodriguez de la Fuente, Yolanda Colino Sanguino, Fatima Valdes Mora, Martin R Larsen, Pouya Faridi, Jeff Holst, Jemma Mayall, Cassie N Kline, Andrea T. Franson, Sriram Venneti, Hubert Hondermarck, ay Horvat, Brett Nixon, Rodrigo Cartaxo, Javad Nazarian, Esther Hulleman, Sabine Mueller, Nicholas A Vitanza, Carl Koschmann, Marta M Alonso, Tiago Ferreira Carvalheiro, Jasper van der Lugt, Matt D. Dun 120 : DDDR-38. Leveraging the immunomodulatory effects of dordaviprone (ONC201) to induce long-term survival response in diffuse midline glioma patients and models. Neuro-Oncology 27 (Supplement_5):v171-v171 November 2025 Notes: DOI:10.1093/neuonc/noaf201.0675.
275 Nicholas Whipple , Annette Molinaro , Alyssa Reddy , Marie Jaeger-Krause , Michael Iv , Javier Villanueva-Meyer , Janine Lupo , Tabitha Cooney , Shannon Raber , Carly Hoffman , Jessica Jensen , Michael Prados , Robyn Gartrell , Cassie Kline , Samuel Cheshier , Sabine Mueller , Howard Colman: CTP-18. PNOC025: A phase 1 study assessing the safety and tolerability of magrolimab in children and adults with recurrent or progressive malignant brain tumors. Neuro-Oncology 27(5): v149–v150, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0590.
9b Eric Montgomery, Siddhartha Mitra, Cassie Kline, Todd C Hankinson: Craniopharyngioma. Adv Cancer Res 4a . October 2025 Notes: DOI: 10.1016/bs.acr.2025.09.005.
78 Nicole Edwards, Lauren W. Yowelunh McLester-Davis, Cassie Kline, Alex Brown, ee Nadine R. Caron & Louise C. Parr-Brownlie: Towards the implementation of Indigenous data governance in neurogenomics research. Nature Neuroscience Sept 2025 Notes: https://doi.org/10.1038/s41593-025-02070-6.
af Bhatia A, Kline C, Madsen PJ, Fisher MJ, Boada FE, Roberts TPL.: Sodium MRI in Pediatric Brain Tumors. Am J Neuroradiol 52 46(7): 1309-1317, July 2025 Notes: doi: 10.3174/ajnr.A8642.
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Selected Publications
27c Dimosthenis Chrysochoou, Deep B. Gandhi, Sahand Adib, Ariana M. Familiar, Bhavyasri Vunnava, Sanaz Varshochi, Neda Khalili, Nastaran Khalili, Jeffrey B. Ware, Wenxin Tu, Paarth Jain, Hannah Anderson, Shuvanjan Haldar, Phillip B. Storm, Andrea Franson, Michael Prados, Cassie Kline, Sabine Mueller, Adam Resnick, Arastoo Vossough, Christos Davatzikos, Ali Nabavizadeh, Anahita Fathi Kazerooni: AI-Powered Segmentation and Prognosis with Missing MRI in Pediatric Brain Tumors. npj Precision Oncology Dec 2025 Notes: doi: https://doi.org/10.1101/2025.07.14.25331187.1cc Cassie Kline, Darren Hargrave, Dong-Anh Khong-Quang, Daniel Landi, Sarah Leary, Jasper van der Lugt, Sabine Mueller, Karsten Nysom, Sébastien Perreault, Angela Waanders, Olaf Witt, David Ziegler, Peter Manley, Jingyang Zhang , Elly Barry , Lindsay Kilburn: Clinical stability following tovorafenib treatment in relapsed/refractory pediatric low-grade glioma: updated results from the phase 2 FIREFLY-1 trial 24 WFSNO/SNO 2025 (Honolulu, HI) 2 74 Neuro-Oncology, 27(5): v149, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0589.
252 Aashim Bhatia, Em Triolo, Luke Bloy, Jeffrey Berman, Akinbanji Afolabi, Apoorva Kotha, Cassie Kline, Michael LaRiviere, Peter Madsen, Chelsea Kotch, Jessica Foster, Michael Fisher, Mohammad Harris, Blake Benyard, Neil Wilson, Ravinder Reddy, Fernando Boada, Timothy Roberts: BIOM-87. SODIUM (23NA) MRI AND CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING IN TYPICALLY DEVELOPING CHILDREN AND IN PEDIATRIC BRAIN TUMORS. Neuro-Oncology 27(5): v44–v45, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0175.
10b Eric Montgomery, Siddhartha Mitra, Cassie Kline, Todd C. Hankinson: Advances in Cancer Research. Elsevier-Chapter Seven - Craniopharyngioma 167: 243-277, Nov 2025 Notes: ISBN: 978-0-443-43055-8.
227 Rachel Moor, Frances Weidert, Christina von Roemeling, Nagheme Thomas, Mahya Aghaee, Dingpeng Zhang, Cassie Kline, Michael Prados, Sabine Mueller, Maryam Rahman, Paul Castillo, Ashley Ghiaseddin, Sheila Carrera-Justiz, Duane Mitchell, Hector Mendez-Gomez, John Ligon, Elias Sayour: CTIM-34. PARAPROGRESSION DEFINES A DAMAGE RESPONSE FROM SYSTEMIC MRNA IMMUNOTHERAPY IN MALIGNANT GLIOMA. Neuro-Oncology 27: v122, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0491.
289 Clara Savary, Mika L Persson, Evangeline Jackson, Ryan J. Duchatel, Tuan Vo, Izac J. Findlay, Alicia M Douglas, Liesl Bramberger, Daniel de la Nava, Bryce C. Thomas, Holly P McEwen, Tyrone S Beitaki, Laura Rodriguez de la Fuente, Yolanda Colino Sanguino, Fatima Valdes Mora, Martin R Larsen, Pouya Faridi, Jeff Holst, Jemma Mayall, Cassie N Kline, Andrea T. Franson, Sriram Venneti, Hubert Hondermarck, ay Horvat, Brett Nixon, Rodrigo Cartaxo, Javad Nazarian, Esther Hulleman, Sabine Mueller, Nicholas A Vitanza, Carl Koschmann, Marta M Alonso, Tiago Ferreira Carvalheiro, Jasper van der Lugt, Matt D. Dun 120 : DDDR-38. Leveraging the immunomodulatory effects of dordaviprone (ONC201) to induce long-term survival response in diffuse midline glioma patients and models. Neuro-Oncology 27 (Supplement_5):v171-v171 November 2025 Notes: DOI:10.1093/neuonc/noaf201.0675.
275 Nicholas Whipple , Annette Molinaro , Alyssa Reddy , Marie Jaeger-Krause , Michael Iv , Javier Villanueva-Meyer , Janine Lupo , Tabitha Cooney , Shannon Raber , Carly Hoffman , Jessica Jensen , Michael Prados , Robyn Gartrell , Cassie Kline , Samuel Cheshier , Sabine Mueller , Howard Colman: CTP-18. PNOC025: A phase 1 study assessing the safety and tolerability of magrolimab in children and adults with recurrent or progressive malignant brain tumors. Neuro-Oncology 27(5): v149–v150, November 2025 Notes: https://doi.org/10.1093/neuonc/noaf201.0590.
9b Eric Montgomery, Siddhartha Mitra, Cassie Kline, Todd C Hankinson: Craniopharyngioma. Adv Cancer Res 4a . October 2025 Notes: DOI: 10.1016/bs.acr.2025.09.005.
78 Nicole Edwards, Lauren W. Yowelunh McLester-Davis, Cassie Kline, Alex Brown, ee Nadine R. Caron & Louise C. Parr-Brownlie: Towards the implementation of Indigenous data governance in neurogenomics research. Nature Neuroscience Sept 2025 Notes: https://doi.org/10.1038/s41593-025-02070-6.
af Bhatia A, Kline C, Madsen PJ, Fisher MJ, Boada FE, Roberts TPL.: Sodium MRI in Pediatric Brain Tumors. Am J Neuroradiol 52 46(7): 1309-1317, July 2025 Notes: doi: 10.3174/ajnr.A8642.
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