Amanda DiNofia, MD, MSCE
Assistant Professor of Clinical Pediatrics (Oncology)
Associate Chief Clinical Research Officer (ACCRO), Research Institute, Children's Hospital of Philadelphia
Associate Director, Cellular Immunotherapy Clinical Operations, Cell Therapy and Transplant Section, Division of Oncology, Children’s Hospital of Philadelphia
Full Member, Abramson Cancer Center, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Colket Translational Research Building
3501 Civic Center Boulevard, Room 3004
Philadelphia, PA 19104
Colket Translational Research Building
3501 Civic Center Boulevard, Room 3004
Philadelphia, PA 19104
Education:
B.S. (Biology)
Ursinus College, 2004.
M.D.
Drexel University, 2009.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2016.
Permanent linkB.S. (Biology)
Ursinus College, 2004.
M.D.
Drexel University, 2009.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2016.
Selected Publications
J. Xu, M. McCoy, Z. Martinez, J.H. Sussman, D. Gao, T. Vincent, H. Wang, C. Ma, O. Elghawy, G.M. Chen, A.G. Yang, P. Pölönen, K. Natan, R. Shraim, H. Newman, T.J. Hofmann, S. Scoma, A.M. DiNofia, S.P. Hunger, J.J. Yang, C.G. Mullighan, K.M. Bernt, E.O. Hexner, S.A. Grupp, K. Watanabe, C.H. June, K. Tan, D.T. Teachey, C. Diorio: CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia. Blood Advances 10(8): 2676-2686, April 2026.C. Diorio, R.M. Myers, Y. Li, H. Liu, S. Belfer, A. DiNofia, A.B. Leahy, H. Newman, J. Dolan, Z. Martinez, A. Elhachimi, R.B. Lindell, C. Mullen, A. Li, J. Kim, D.T. Teachey, S.L. Maude, S.A. Grupp, J.L. McGuire: Preinfusion risk factors for the development of severe neurotoxicity following CART therapy in pediatric patients. Hemasphere 10(4): e70337, April 2026.
S.E. McClory, D. Zheng, Y. Li, H. Liu, A. Grier, E.E. Keenan, B.E. Henry, C.W. Elgarten, A. DiNofia, L. Wang, D. Baniewicz, C.A. Callahan, M. Stewart, L.E. Cain, C. Diorio, S.P. Hunger, A.B. Leahy, S.R. Rheingold, S.K. Tasian, L. Wray, J.R. Heimall, B.T. Fisher, S.L. Maude, S.A. Grupp, R.M. Myers.: High Rates of Clinically Significant Late Infections and Recurrent Sinopulmonary Disease in Long-Term Survivors after CD19 CAR T-cell Therapy for Pediatric B-ALL. Poster presentation at American Society for Transplantation and Cellular Therapy Meeting. Salt Lake City Feb 2026.
A.W. Rankin, R.M. Myers, A.J. Lamble, E.M. Hsieh, H. Sankaran, L. Chen, C. Annesley, A.M. DiNofia, S.A. Grupp, M.A. Pulsipher, J.G. Dolan, D. Bhojwani, R.A. Gardner, N.N. Shah, S.R. Rheingold: CD19 CAR T-cell outcomes in relapsed/refractory extramedullary B-ALL: a multi-site, retrospective cohort review. Blood Advances Online ahead of print, February 2026.
K.Utley Lyons, L.E. Cain, Y. Li, D. Baniewicz, C.A. Callahan, M. Stewart, A. DiNofia, A.B. Leahy, C. Diorio, S.R. Rheingold, L.E. Brodersen, S.L. Maude, S.A. Grupp, K.M. Bernt, R.M. Myers.: CD19 CAR T-cell Therapy in Infant B-ALL: Durable Remissions, Relapse Patterns, and Molecular Correlates. Oral presentation at American Society for Transplantation and Cellular Therapy Meeting. Salt Lake City Feb 2026.
L Cain, Y Li, H Liu, S Christensen, R Myers, A Barz Leahy, C Diorio, N Shapiro, E McBride, C Callahan, D Baniewicz, A DiNofia, S Rheingold, L Wray, S Hunger, R Aplenc, S McClory, M Stewart, G Wertheim, A Fesnak, S Maude: Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia. Oral presentation at American Society of Hematology Annual Meeting. Orlando, FL Dec 2025.
L Cain, Y Li, A Bhagwat, D Baniewicz, A Barz Leahy, C Callahan, S Christensen, A Cosey, A DiNofia, C Diorio, J Fraietta, V Gonzalez, E Hexner, S Hunger, A Marshall, S Maude, S McClory, R Myers, G Plesa, S Rheingold, R Aplenc: CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia. Poster Presentation at the American Society of Hematology Annual Meeting. Orlando, FL Dec 2025.
A DiNofia, R Myers, Y Li, H Liu, R Aplenc, D Baniewicz, A Barz Leahy, L Cain, C Callahan, C Diorio, J Fraietta, E Hexner, C Hopkins, S Hunger, V Gonzalez, J Jadlowsky, M Kerolos, R Khan, S McClory, S Maude, S Grupp: CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric B ALL. Oral presentation at American Society of Hematology Annual Meeting. Orlando, FL Dec 2025.
R.M. Myers, Y. Li, H. Liu, S. Mumanachit, L. Wang, A.B. Leahy, L.E. Cain, A.M. DiNofia, C. Diorio, J.L. Freedman, S.P. Hunger, S.L. Maude, S.E. McClory, S.R. Rheingold, S.K. Tasian, L. Wray, T.S. Olson, S.A. Grupp, N.J. Bunin, A.E. Seif, C.W. Elgarten: Hematopoietic cell transplantation after CD19-directed CAR T-cell therapy for remission consolidation or relapse treatment in pediatric acute lymphoblastic leukemia. Haematologica Page: Online ahead of print, November 2025.
DJ Zheng, L Wang, K Getz, R Aplenc, KQ Coughlin, AM DiNofia, SL Maude, RM Myers, H Newman, TJ Orsini, D Paris, S Grupp, A Barz Leahy: Financial toxicity and association with treatment outcomes during pediatric CAR T therapy. Poster presentation at the American Society of Clinical Oncology. Chicago, IL Jun 2025.