Amanda DiNofia, MD, MSCE
Assistant Professor of Clinical Pediatrics (Oncology)
Associate Chief Clinical Research Officer (ACCRO), Research Institute, Children's Hospital of Philadelphia
Associate Director, Cellular Immunotherapy Clinical Research, Cell Therapy and Transplant Section, Division of Oncology, Children’s Hospital of Philadelphia
Full Member, Abramson Cancer Center, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Colket Translational Research Building
3501 Civic Center Boulevard, Room 3004
Philadelphia, PA 19104
Colket Translational Research Building
3501 Civic Center Boulevard, Room 3004
Philadelphia, PA 19104
Education:
B.S. (Biology)
Ursinus College, 2004.
M.D.
Drexel University, 2009.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2016.
Permanent linkB.S. (Biology)
Ursinus College, 2004.
M.D.
Drexel University, 2009.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2016.
Selected Publications
L Cain, Y Li, H Liu, S Christensen, R Myers, A Barz Leahy, C Diorio, N Shapiro, E McBride, C Callahan, D Baniewicz, A DiNofia, S Rheingold, L Wray, S Hunger, R Aplenc, S McClory, M Stewart, G Wertheim, A Fesnak, S Maude: Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia. Oral presentation at American Society of Hematology Annual Meeting. Orlando, FL Dec 2025.L Cain, Y Li, A Bhagwat, D Baniewicz, A Barz Leahy, C Callahan, S Christensen, A Cosey, A DiNofia, C Diorio, J Fraietta, V Gonzalez, E Hexner, S Hunger, A Marshall, S Maude, S McClory, R Myers, G Plesa, S Rheingold, R Aplenc: CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia. Poster Presentation at the American Society of Hematology Annual Meeting. Orlando, FL Dec 2025.
A DiNofia, R Myers, Y Li, H Liu, R Aplenc, D Baniewicz, A Barz Leahy, L Cain, C Callahan, C Diorio, J Fraietta, E Hexner, C Hopkins, S Hunger, V Gonzalez, J Jadlowsky, M Kerolos, R Khan, S McClory, S Maude, S Grupp: CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric B ALL. Oral presentation at American Society of Hematology Annual Meeting. Orlando, FL Dec 2025.
DJ Zheng, L Wang, K Getz, R Aplenc, KQ Coughlin, AM DiNofia, SL Maude, RM Myers, H Newman, TJ Orsini, D Paris, S Grupp, A Barz Leahy: Financial toxicity and association with treatment outcomes during pediatric CAR T therapy. Poster presentation at the American Society of Clinical Oncology. Chicago, IL Jun 2025.
Regina M Myers, Amanda M DiNofia, Yimei Li, Caroline Diorio, Hongyan Liu, Gerald Wertheim, Joseph A Fraietta, Vanessa Gonzalez, Gabriela Plesa, Donald L Siegel, Emma Iannone, Laura Shinehouse, Jennifer L Brogdon, Clare Taylor, Julie K Jadlowsky, Elizabeth O Hexner, Boris Engels, Diane Baniewicz, Colleen Callahan, Marco Ruella, Richard Aplenc, Allison Barz Leahy, Susan E McClory, Susan R Rheingold, Lisa Wray, Carl H June, Shannon L Maude, Noelle V Frey, Stephan A Grupp: CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy. Journal for Immunotherapy of Cancer 13(4), Apr 2025.
J.K. Jadlowsky, E.O. Hexner, A. Marshall, S.A. Grupp, N.V. Frey, J.L. Riley, E. Veloso, H. McConville, W. Rogal, C. Czuczman, W-T. Hwang, Y. Li, R.M. Leskowitz, O. Farrelly, J. Karar, S. Christensen, J. Barber-Rotenberg, A. Gaymon, N. Aronson, W. Bernstein, J.J. Melenhorst, A.M. Roche, J.K. Everett, S.A. Zolnoski, A.G. McFarland, S. Reddy, A. Petrichenko, E.J. Cook, C. Lee, V.E. Gonzalez, K. Alexander, I. Kulikovskaya, A. Ramirez-Fernandez, J.C. Minehart, M. Ruella, S.I. Gill, S.J. Schuster, A.D. Cohen, A.L. Garfall, P.D. Shah, D.L. Porter, S.L. Maude, B.L. Levin, D.L. Siegel, A. Chew, S. McKenna, L. Lledo, M.M. Davis, G. Plesa, F. Herbst, E.A. Stadtmauer, P. Tebas, A. DiNofia, A. Haas, N.B. Haas, R. Myers, D.M. O’Rourke, J. Svoboda, J.L. Tanyi, R. Aplenc, J.M. Jacobson, A.H. Ko, R.B. Cohen, C.H. June, F.D. Bushman, J.A. Fraietta: Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies. Nature Medicine 31(4): 1134-1144, Apr 2025.
R.M. Myers, Y. Li, A. Lamble, E.M. Hsieh, S. John, G. Dolan, H. Liu, L. Chen, J. Sheppard, A.M. DiNofia, C. Annesley, S.A. Grupp, D. Bhojwani, R.A. Gardner, L. Gore, S.R. Rheingold, N.N. Shah, M.A. Pulsipher: Clinical factors associated with prolonged cytopenias after CD19 chimeric antigen receptor T-cell therapy for pediatric B-cell acute lymphoblastic leukemia. Oral presentation at American Society for Transplantation and Cellular Therapy Meeting. Honolulu, HI Feb 2025.
B.D. Friedes, A.M. DiNofia, E. Iannone, Y. Li, S.R. Rheingold, A. Barz Leahy, L. Wray, C. Callahan, D. Baniewicz, L. Vernau, K.D. Getz, R. Aplenc, S.L. Maude, S.A. Grupp, R.M. Myers: Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy. Blood Advances 9(2): 354-359, Jan 2025.
C. Diorio, R.M. Myers, Y. Li, A.M. DiNofia, H. Liu, A.B. Leahy, H. Newman, J. Dolan, Z. Martinez, A. Elhachimi, C. Mullen, A. Li, J. Kim, D.T. Teachey, S.L. Maude, J. McGuire, S.A. Grupp: Preinfusion risk factors for the development of severe immune effector cell associated neurotoxicity syndrome following chimeric antigen receptor T-cell infusion in pediatric patients. Poster presentation at American Society of Hematology Meeting and Exposition. San Diego, CA Dec 2024.
C.R. Hopkins, A.M. DiNofia, S.L. Maude, G.M. Chen, K.A. Boateng-Antwi, J. Perazzelli, A.F. Mendez Corea, A. Shestov, M. Gohil, Y. Li, W-T. Hwang, B. Valentic, S. Christensen, J. Jadlowsky, R.M. Myers, C. Diorio, M.M. Davis, T. Colligon, G. Plesa, D.L. Siegel, J.A. Fraietta: In vivo persistence and function of CAR19 T-cell products for pediatric B-cell acute lymphoblastic leukemia are impacted by media, cytokine supplementation, and metabolite bioavailability during ex vivo manufacturing. Poster presentation at American Society of Hematology Meeting and Exposition. San Diego, CA Dec 2024.