Amanda DiNofia, MD, MSCE
Assistant Professor of Clinical Pediatrics (Oncology)
Associate Chief Clinical Research Officer (ACCRO), Research Institute, Children's Hospital of Philadelphia
Member, Abramson Cancer Center, University of Pennsylvania
Associate Director, Cellular Immunotherapy Clinical Research, Cell Therapy and Transplant Section, Division of Oncology, The Children’s Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Colket Translational Research Building
3501 Civic Center Boulevard, Room 3004
Philadelphia, PA 19104
Colket Translational Research Building
3501 Civic Center Boulevard, Room 3004
Philadelphia, PA 19104
Education:
B.S. (Biology)
Ursinus College, 2004.
M.D. (Medicine)
Drexel University, 2009.
M.S.C.E. (Epidemiology)
University of Pennsylvania, 2016.
Permanent linkB.S. (Biology)
Ursinus College, 2004.
M.D. (Medicine)
Drexel University, 2009.
M.S.C.E. (Epidemiology)
University of Pennsylvania, 2016.
Selected Publications
J.K. Jadlowsky, E.O. Hexner, A. Marshall, S.A. Grupp, N.V. Frey, J.L. Riley, E. Veloso, H. McConville, W. Rogal, C. Czuczman, W-T. Hwang, Y. Li, R.M. Leskowitz, O. Farrelly, J. Karar, S. Christensen, J. Barber-Rotenberg, A. Gaymon, N. Aronson, W. Bernstein, J.J. Melenhorst, A.M. Roche, J.K. Everett, S.A. Zolnoski, A.G. McFarland, S. Reddy, A. Petrichenko, E.J. Cook, C. Lee, V.E. Gonzalez, K. Alexander, I. Kulikovskaya, A. Ramirez-Fernandez, J.C. Minehart, M. Ruella, S.I. Gill, S.J. Schuster, A.D. Cohen, A.L. Garfall, P.D. Shah, D.L. Porter, S.L. Maude, B.L. Levin, D.L. Siegel, A. Chew, S. McKenna, L. Lledo, M.M. Davis, G. Plesa, F. Herbst, E.A. Stadtmauer, P. Tebas, A. DiNofia, A. Haas, N.B. Haas, R. Myers, D.M. O’Rourke, J. Svoboda, J.L. Tanyi, R. Aplenc, J.M. Jacobson, A.H. Ko, R.B. Cohen, C.H. June, F.D. Bushman, J.A. Fraietta: Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies. Nature Medicine Jan 20 2025.R.M. Myers, Y. Li, A. Lamble, E.M. Hsieh, S. John, G. Dolan, H. Liu, L. Chen, J. Sheppard, A.M. DiNofia, C. Annesley, S.A. Grupp, D. Bhojwani, R.A. Gardner, L. Gore, S.R. Rheingold, N.N. Shah, M.A. Pulsipher: Clinical factors associated with prolonged cytopenias after CD19 chimeric antigen receptor T-cell therapy for pediatric B-cell acute lymphoblastic leukemia. Oral presentation at American Society for Transplantation and Cellular Therapy Meeting. Honolulu, HI 2025.
B.D. Friedes, A.M. DiNofia, E. Iannone, Y. Li, S.R. Rheingold, A. Barz Leahy, L. Wray, C. Callahan, D. Baniewicz, L. Vernau, K.D. Getz, R. Aplenc, S.L. Maude, S.A. Grupp, R.M. Myers: Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy. Blood Advances Nov 20 2024.
Diorio C, Hernandez-Miyares L, Espinoza DA, Banwell BL, Bar-Or A, DiNofia AM, Barz Leahy A, Martinez Z, Myers RM, Hopkins SE, Rheingold SR, Teachey DT, Viaene AN, Wray LM, Maude SL, Grupp SA, McGuire JL.: Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents. Blood 144(13): 1387-1398, Sept 26 2024.
R.M. Myers, K. Devine, Y. Li, S. Lawrence, A.B. Leahy, H. Liu, L. Vernau, C. Callahan, D. Baniewicz, S. Kadauke, R. McGuire, G.B. Wertheim, I. Kulikovskaya, V.E. Gonzalez, J.A. Fraietta, A.M. DiNofia, S.P. Hunger, S.R. Rheingold, R. Aplenc, C.H. June, S.A. Grupp, L. Wray, S.L. Maude: Reinfusion of CD19 CAR T cells for relapse prevention and treatment in children with acute lymphoblastic leukemia. Blood Advances 8(9): 2182-2192, May 14 2024.
C. Diorio, R.M. Myers, Y. Li, A.M. DiNofia, H. Liu, A.B. Leahy, H. Newman, J. Dolan, Z. Martinez, A. Elhachimi, C. Mullen, A. Li, J. Kim, D.T. Teachey, S.L. Maude, J. McGuire, S.A. Grupp: Preinfusion risk factors for the development of severe immune effector cell associated neurotoxicity syndrome following chimeric antigen receptor T-cell infusion in pediatric patients. Poster presentation at American Society of Hematology Meeting and Exposition. San Diego, CA 2024.
A.B. Leahy, J. Brogdon, L. Cain, A.M. DiNofia, J.A. Fraietta, R. Hanna, S. Kadauke, R. Khan, Y. Li, S.L. Maude, R.M. Myers, L. Shinehouse, A. Sparrow, M. Varghese, L. Wang, Y. Wang, S.A. Grupp: Cost-effective manufacture and promising initial efficacy of huCART19 cells manufactured using the Clinimacs Prodigy platform. Poster presentation at American Society of Hematology Meeting and Exposition. San Diego, CA 2024.
R.M. Myers, Y. Li, A. Lamble, E.M. Hsieh, S. John, G. Dolan, H. Liu, L. Chen, J. Sheppard, A.M. DiNofia, C. Annesley, S.A. Grupp, D. Bhojwani, R.A. Gardner, L. Gore, S.R. Rheingold, N.N. Shah, M.A. Pulsipher: Clinical factors associated with prolonged cytopenias after CD19 chimeric antigen receptor T-cell therapy for pediatric B-cell acute lymphoblastic leukemia. Poster presentation at American Society of Hematology Meeting and Exposition. San Diego, CA 2024.
C. Diorio, L. Uppuluri, A. Thadi, R.M. Myers, R. Schraim, A.M. DiNofia, Z. Martinez, A. Elhachimi, J. Fraietta, V. Gonzalez, V. Yi, H. Newman, A. Hughes, K. Tan, S.A. Grupp, D.T. Teachey: Marrow and peripheral blood cytokine architecture differences between pediatric patients receiving CD19- and CD22-directed CART. Poster presentation at American Association for Cancer Research Special Conference on Advances in Pediatric Cancer Research, Toronto, Ontario 2024.
C.R. Hopkins, A.M. DiNofia, S.L. Maude, G.M. Chen, K.A. Boateng-Antwi, J. Perazzelli, A.F. Mendez Corea, A. Shestov, M. Gohil, Y. Li, W-T. Hwang, B. Valentic, S. Christensen, J. Jadlowsky, R.M. Myers, C. Diorio, M.M. Davis, T. Colligon, G. Plesa, D.L. Siegel, J.A. Fraietta: In vivo persistence and function of CAR19 T-cell products for pediatric B-cell acute lymphoblastic leukemia are impacted by media, cytokine supplementation, and metabolite bioavailability during ex vivo manufacturing. Poster presentation at American Society of Hematology Meeting and Exposition. San Diego, CA 2024.