Amanda DiNofia, MD, MSCE

faculty photo
Assistant Professor of Clinical Pediatrics
Associate Chief Clinical Research Officer (ACCRO), Research Institute, Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
Colket Translational Research Building
3501 Civic Center Boulevard, Room 3016
Philadelphia, PA 19104
B.S. (Biology)
Ursinus College, 2004.
M.D. (Medicine)
Drexel University, 2009.
M.S.C.E. (Epidemiology)
University of Pennsylvania, 2016.
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Selected Publications

A Barz Leahy, KJ Devine, Y Li, H Liu, RM Myers, AM DiNofia, L Wray, SR Rheingold, C Callahan, D Baniewicz, M Patino, H Newman, SP Hunger, SA Grupp, DM Barrett, SL Maude: Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy. Blood April 2022.

RM Myers, A Taraseviciute, SM Steinberg, AJ Lamble, J Sheppard, B Yates, AE Kovach, B Wood, MJ Borowitz, M Stetler-Stevenson, CM Yuan, V Pillai, T Foley, P Chung, L Chen, DW Lee, C Annesley, AM DiNofia, SA Grupp, S John, D Bhojwani, PA Brown, TW Laetsch, L Gore, RA Gardner, SR Rheingold, MA Pulsipher, NN Shah: Blinatumomab nonresponse and high-disease burden are associated with inferior outcomes after CD19-CAR for B-ALL. Journal of Clinical Oncology March 2022.

KO McNerney, AM DiNofia, DT Teachey, SA Grupp, SL Maude: Potential Role of IFN inhibition in refractory cytokine release syndrome associated with CAR T-cell therapy. Blood Cancer Discovery March 2022.

BJ Lerman, Y Li, H Liu, RM Myers, K Devine, C Callahan, D Baniewicz, S Kaduake, AM DiNofia, SR Rheingold, L Wray, R Aplenc, SA Grupp, SL Maude, A Barz Leahy: Completed versus incomplete hematologic recovery after CAR T cell therapy: implications for relapse free survival and overall survival in pediatric and young adult patients with relapse/refractory B-ALL. Poster Presentation at American Society of Hematology Meeting and Exposition. Atlanta, GA Dec 2021.

AB Leahy, H Newman, Y Li, H Liu, R Myers, AM DiNofia, JG Dolan, C Callahan, D Baniewicz, K Devine, L Wray, R Aplenc, CH June, SA Grupp, SR Rheingold, SL Maude: CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukemia; a post-hoc analysis of pool data from five clinical trials. The Lancet Haematology October 2021.

RM Myers, Y Li, AB Leahy, DM Barrett, DT Teachey, C Callahan, CC Fasano, SR Rheingold, AM DiNofia, L Wray, R Aplenc, D Baniewicz, H Liu, PA Shaw, E Pequignot, KD Getz, JL Brogdon, AD Fesnak, DL Siegel, MM Davis, C Bartoszek, SF Lacey, EO Hexner, A Chew, GB Wertheim, BL Levine, CH June, SA Grupp, SL Maude: Humanized CD19-targeted chimeric antigen receptor (CAR) T cells in CAR-naïve and CAR-exposed children and young adults with relapsed or refractory acute lymphoblastic leukemia. Journal of Clinical Onclolgy September 2021.

SJ Si Lim, SA Grupp, AM DiNofia: Tisagenlecleucel for treatment of children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia. Pediatric Blood and Cancer June 2021 Notes: doi: 10.1002/pbc.29123. Online ahead of print.

AM DiNofia, SA Grupp: Will allogeneic CAR T cells for CD19 + malignancies take autologous CAR T cells 'off the shelf'? Nature Reviews Clinical Oncology 18(4): 195-196, Apr 2021.

S Kadauke, RM Myers, Y Li, R Aplenc, D Baniewicz, DM Barrett, A Barz Leahy, C Callahan, JG Dolan, JC Fitzgerald, W Gladney, SF Lacey, H Liu, SL Maude, R McGuire, LS Motley, DT Teachey, GB Wertheim, L Wray, AM DiNofia, SA Grupp: Risk-adapted preemptive tocilizumab to prevent severe cytokine release syndrome after CTL019 for pediatric B-cell acute lymphoblastic leukemia: a prospective clinical trial. Journal of Clinical Oncology 39(8): 920-930, Mar 2021.

C Diorio, PA Shaw, E Pequignot, A Orlenko, F Chen, R Aplenc, DM Barrett, H Bassiri, E Behrens, AM DiNofia, V Gonzalez, N Koterba, BL Levine, SL Maude, NJ Meyer, JH Moore, M Paessler, DL Porter, JL Bush, DL Siegel, MM Davis, D Zhang, CH June, SA Grupp, JJ Melenhorst, SF Lacey, SL Weiss, DT Teachey: Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children. Blood Advances 4(20): 5174-5183, Oct 2020.

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Last updated: 04/11/2022
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