Yanqing Anna Gong, MS, PhD
Research Associate Professor of Medicine (Translational Medicine and Human Genetics)
Department: Medicine
Contact information
Perelman School of Medicine at The University of Pennsylvania
Division of Translational Medicine and Human Genetics
Smilow Center for Translational Research, Room 11-143
3400 Civic Center Blvd.
Philadelphia, PA 19104
Pennsylvania, PA 19104
Division of Translational Medicine and Human Genetics
Smilow Center for Translational Research, Room 11-143
3400 Civic Center Blvd.
Philadelphia, PA 19104
Pennsylvania, PA 19104
Office: 215-746-3510
Fax: 215-573-8606
Fax: 215-573-8606
Education:
M.S. (Medicinal Chemistry)
China Pharmaceutical University, 2000.
PhD (Pharmacology)
China Pharmaceutical University, 2003.
Permanent linkM.S. (Medicinal Chemistry)
China Pharmaceutical University, 2000.
PhD (Pharmacology)
China Pharmaceutical University, 2003.
Description of Research Expertise
My research has focused on vascular function, inflammation, and tissue repair in the hypoxic microenvironment. My lab uses a multidisciplinary approach combining cell and molecular biology, genetics, and animal models to investigate the regulatory mechanisms underlying: 1) endothelial plasticity-driven aberrant vascularity and cardiac repair after myocardial infarction, and 2) vascular regulation of macrophage polarization, T cell infiltration, fibroblast activation, and stem cell function after cardiac injury. Rewiring vascular niche may offer promising opportunities for normalization of aberrant vasculature, stimulation of reparative immunity, and resolution of excessive inflammation in the ischemic microenvironment, eventually promoting cardiac repair after myocardial infarction.Selected Publications
Xinye Ashley Zhao, Thomas Williamson, Yanqing Gong,*, Jonathan A. Epstein,* & Yi Fan*: Immunomodulatory therapy for ischemic heart diseases. Circulation 150 (13), September 2024 Notes: * Corresponding author.Yang F, Akhtar N, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y*, & Fan Y*: An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Science Advances 10(9):eadj4678, March 2024 Notes: * Corresponding author.
Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y*, Fan Y*: Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Nature Protocols 19, pages1053–1082, Jan 2024 Notes: * Corresponding author.
Huang M., Yang F., Zhang D., Lin M., Duan H. EI-Mayta R., Zhang L., Qin L., Shewale S., Pei L., Mitchell M., Rader D., Fan Y*., Gong Y*.: Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Nature Cardiovasc. Res. Apr 2022 Notes: * Corresponding author.
Wang L. Yao L. Duan H. Yang F. Lin M. Zhang R. He, Z. Ahn J. Fan Y. Qin L*. Gong Y*. : Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors. Journal of Bone and Mineral Research 36(11), November 2021 Notes: * Corresponding author.
Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH*, Gong Y*, & Fan Y*.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nat. Commun. 12(1), June 2021 Notes: *Corresponding author.
Ma W., Wang Y., Zhang R., Yang F., Zhang D., Huang, M., Zhang L., Dorsey J., Binder Z., O'Rourke D., Fraietta J., Gong Y*., Fan Y*., : Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Nature Cancer Nov 2020 Notes: *Corresponding author.
Duan H, He Z, Lin M, Wang Y, Yang F, Mitteer, R, Kim H, Yeo E, Han H, Qin L, Fan Y, and Gong Y.: Plasminogen regulates mesenchymal stem cellmediated tissue repair after ischemia through cyr61 activation. JCI insight 5(15), Aug 2020.
Gong Y*, Zhao Y, Li Y, Fan Y, Hoover-Plow J : Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart. J Am Coll Cardiol 63(25): 2862-2872, Jul 2014 Notes: *Corresponding author.
Gong Y, Hart E, Shchurin A, Hoover-Plow J: Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice. J Clin Invest 118(9): 3012-24, September 2008.