Yanqing Anna Gong, MS, PhD

faculty photo
Research Associate Professor of Medicine (Translational Medicine and Human Genetics)
Department: Medicine

Contact information
Perelman School of Medicine at The University of Pennsylvania
Division of Translational Medicine and Human Genetics
Smilow Center for Translational Research, Room 8-155
3400 Civic Center Blvd.
Philadelphia, PA 19104
Pennsylvania, PA 19104
Office: 215-746-3510
Fax: 215-573-8606
M.S. (Medicinal Chemistry)
China Pharmaceutical University, 2000.
PhD (Pharmacology)
China Pharmaceutical University, 2003.
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Description of Research Expertise

My research has focused on deciphering the key molecular mechanism that regulates vessel formation and tissue repair. My lab uses a multidisciplinary approach combining cell and molecular biology, genetics, and animal models to investigate: 1. The molecular mechanisms by which protease regulate stem cell function during tissue repair and regeneration; 2. The regulatory mechanism underlying new vessel formation in development and disease; 3 Endothelial plasticity in tumor and ischemia microenvironment leads to aberrant vascularity in tumor and heart disease.

Selected Publications

Huang M., Yang F., Zhang D., Lin M., Duan H. EI-Mayta R., Zhang L., Qin L., Shewale S., Pei L., Mitchell M., Rader D., Fan Y*., Gong Y*.: Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Nature Cardiovasc. Res. Apr 2022 Notes: * Corresponding author.

Wang L. Yao L. Duan H. Yang F. Lin M. Zhang R. He, Z. Ahn J. Fan Y. Qin L*. Gong Y*. : Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors. Journal of Bone and Mineral Research 36(11), November 2021 Notes: * Corresponding author.

Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH*, Gong Y*, & Fan Y*.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nat. Commun. 12(1), June 2021 Notes: *Corresponding author.

Ma W., Wang Y., Zhang R., Yang F., Zhang D., Huang, M., Zhang L., Dorsey J., Binder Z., O'Rourke D., Fraietta J., Gong Y*., Fan Y*., : Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Nature Cancer Nov 2020 Notes: *Corresponding author.

Duan H, He Z, Lin M, Wang Y, Yang F, Mitteer, R, Kim H, Yeo E, Han H, Qin L, Fan Y, and Gong Y.: Plasminogen regulates mesenchymal stem cellmediated tissue repair after ischemia through cyr61 activation. JCI insight 5(15), Aug 2020.

Tao L., Yang J., Cao F., Xie H., Zhang M., Gong Y.*, Zhang C.* : Mogroside IIIE, A novel anti-fibrotic compound, reduces pulmonary fibrosis through Toll like receptor 4 pathways. J Pharmacol. Exp. Ther. 361(2), 268-279 2017 Notes: *Corresponding author.

Huang M., Liu T., Ma P., Mitteer A., Cai, P., Li C., Zhang L., Zhao B., Gong Y. Koumenis, C., Fan Y: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J. Clin. Invest. 126 (5): 1801-14, 2016.

Gong Y*, Zhao Y, Li Y, Fan Y, Hoover-Plow J : Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart. J Am Coll Cardiol 63(25): 2862-2872, Jul 2014 Notes: *Corresponding author.

Gong Y*, Fan Y, Hoover-Plow J: Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9. Arterioscler Thromb Vasc Biol 31(9): 2035-43, September 2011 Notes: *Corresponding author.

Gong Y, Hart E, Shchurin A, Hoover-Plow J: Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice. J Clin Invest 118(9): 3012-24, September 2008.

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Last updated: 01/18/2024
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