Yanqing Anna Gong, MS, PhD

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
Perelman School of Medicine at The University of Pennsylvania
Division of Translational Medicine and Human Genetics
Smilow Center for Translational Research, Room 11-142
3400 Civic Center Blvd.
Philadelphia, PA 19104
Pennsylvania, PA 19104
Office: 215-746-3510
Fax: 215-573-8606
M.S. (Medicinal Chemistry)
China Pharmaceutical University, 2000.
PhD (Pharmacology)
China Pharmaceutical University, 2003.
Department of Anatomy, Case Western Reserve University, 2005.
Department of Molecular Cardiology, Cleveland Clinic, 2008.
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Description of Research Expertise

My research focuses on deciphering the key molecular mechanism that regulates vessel formation and cardiac repair. My lab uses a multidisciplinary approach combining cell and molecular biology, genetics, and animal models to investigate: 1. The molecular mechanisms by which proteases regulate stem cell function during cardiac repair and regeneration; 2. The regulatory mechanism underlying new vessel formation in normal development and ischemic heart disease; 3 Endothelial plasticity in ischemic microenvironment that leads to the abnormal neovascularization in ischemic heart disease.

Selected Publications

Ma W., Wang Y., Zhang R., Yang F., Zhang D., Huang, M., Zhang L., Dorsey J., Binder Z., O'Rourke D., Fraietta J., Gong Y*., Fan Y*., : Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Nature Cancer Nov 2020 *co-senior author.

Duo H, He Z, Lin M, Wang Y, Yang F, Mitteer, R, Kim H, Yeo E, Han H, Qin L, Fan Y, and Gong Y*.: Plasminogen regulates mesenchymal stem cellmediated tissue repair after ischemia through cyr61 activation. JCI insight 5(15), Aug 2020.

Huang M, Zhang D, Wu JY, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder ZA, O’Rourke DM, Brem S, Koumenis C, Gong Y, and Fan Y.: Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Science Transl Medicine 15(532), Feb 2020.

Wang Q, He Z, Huang M, Liu T, Xu H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O’Rourke DM, Dahmane N, Brem S, Gong Y, & Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α Nature Comm. 9(559), February 2018.

Tao L., Yang J., Cao F., Xie H., Zhang M., Gong Y.*, Zhang C.* : Mogroside IIIE, A novel anti-fibrotic compound, reduces pulmonary fibrosis through Toll like receptor 4 pathways. J Pharmacol. Exp. Ther. 361(2), 268-279 2017 *co-senior author Notes: Epub 2017 Mar 9. doi: 10.1124/jpet.116.239137.

Gong Y*, Zhao Y, Li Y, Fan Y, Hoover-Plow J : Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart. J Am Coll Cardiol 63(25): 2862-2872, Jul 2014 *Corresponding author.

Huang M., Liu T., Ma P., Mitteer A., Cai, P., Li C., Zhang L., Zhao B., Gong Y. Koumenis, C., Fan Y: c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J. Clin. Invest. 126 (5): 1801-14, 2016.

Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL. : Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol 14(10): 1046-56, October 2012.

Gong Y*, Fan Y, Hoover-Plow J: Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9. Arterioscler Thromb Vasc Biol 31(9): 2035-43, September 2011 *Corresponding author.

Gong Y, Hart E, Shchurin A, Hoover-Plow J: Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice. J Clin Invest 118(9): 3012-24, September 2008.

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Last updated: 12/11/2020
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