Susan E McClory, MD, PhD
Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Attending Physician, Division of Oncology, Children's Hospital of Philadelphia
Full Member (Research), Abramson Cancer Center Immunobiology Research Program
Medical Director of the Program for Integrated Immunodeficiency and Cellular Therapy, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Oncology
4010 Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Division of Oncology
4010 Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-303-4638
Email:
mcclorys@chop.edu
mcclorys@chop.edu
Education:
B.S. (Molecular Genetics)
Ohio State University, 2005.
PhD (Integrated Biomedical Sciences)
Ohio State University, 2012.
MD (Medicine)
Ohio State University , 2014.
Permanent linkB.S. (Molecular Genetics)
Ohio State University, 2005.
PhD (Integrated Biomedical Sciences)
Ohio State University, 2012.
MD (Medicine)
Ohio State University , 2014.
Selected Publications
McClory SE, Zheng D, Li Y, Liu H, Grier A, Keenan EE, Henry BE, Elgarten CW, Dinofia A, Wang L, Baniwicz D, Callahan CA, Stewart M, Cain LE, Diorio C, Hunger SP, Leahy AB, Rheingold SR, Tasian SK, Wray L, Heimall JR, Fisher BT, Maude SL, Grupp SA, Myers RM: High Rates of Clinically Significant Late Infections and Recurrent Sinopulmonary Disease in Long-Term Survivors after CD19 CAR T-cell Therapy for Pediatric B-ALL. American Society of Transplantation and Cell Therapy Annual Meeting 2026.Grier AE, Bosticardo M, Pala F, Delmonte OM, Amini K, Anaya E, Romberg N, McClory SE, Bunin NJ, Abdalgani M, Notarangelo LD, Heimal J: Unmanipulated bone marrow infusion without conditioning can rescue RECQL4-/- severe combined immunodeficiency. J Hum Immun 2026.
Myers RM, Li Y, Liu H, Mumanachit S, Wang L, Leahy AB, Cain LE, DiNofia AM, Diorio C, Freedman JL, Hunger SP, Maude SL, McClory SE, Rheingold SR, Tasian SK, Wray L, Olson TS, Grupp SA, Bunin NJ, Seif AE, Elgarten CW: Hematopoietic cell transplantation after CD19-directed CAR T-cell therapy for remission consolidation or relapse treatment in pediatric acute lymphoblastic leukemia. Haematologica November 2025.
Myers RM, DiNofia AM, Li Y, Diorio C, Liu H, Wertheim G, Fraietta JA, Gonzalez V, Plesa G, Siegel DL, Iannone E, Shinehouse L, Brogdon JL, Taylor C, Jadlowsky JK, Hexner EO, Engels B, Baniewicz D, Callahan C, Ruella M, Aplenc R, Barz Leahy A, McClory SE, Rheingold SR, Wray L, June CH, Maude SL, Frey NV, Grupp SA: CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy. J Immunother Cancer 2025.
McClory SE, Oved JH. : Transplantation for immune dysregulatory disorders: current themes and future expectations. Curr Opin Pediatr December 2024.
Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R.: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature Sep 2024.
Alsaati N, Grier A, Ochfeld E, McClory S, Heimall J.: Hematopoietic stem cell transplantation for primary immunodeficiency. Allergy Asthma Proc 45: 371-383, Sep 2024.
Doan AE, Mueller KP, Chen AY, Rouin GT, Chen Y, Daniel B, Lattin J, Markovska M, Mozarsky B, Arias-Umana J, Hapke R, Jung IY, Wang A, Xu P, Klysz D, Zuern G, Bashti M, Quinn PJ, Miao Z, Sandor K, Zhang W, Chen GM, Ryu F, Logun M, Hall J, Tan K, Grupp SA, McClory SE, Lareau CA, Fraietta JA, Sotillo E, Satpathy AT, Mackall CL, Weber EW: FOXO1 is a master regulator of memory programming in CAR T cells. Nature 629(8010): 211-218, May 2024.
McClory SE, Elgarten CW, Quijano KN, Wohlschlaeger A, Hankins P, Wang L, Wang Y, Kadauke S, Monos D, Olson TS, Grupp SA, Ochfeld E, Heimall JR, and Bunin NJ: Unrelated and Haploidentical Peripheral Stem Cell Transplant with Tcrαβ/CD19 Depletion for the Treatment of Pediatric Patients with Inborn Errors of Immunity. American Society of Transplantation and Cell Therapy February 2024.
McClory SE, Maude SL.: The Current State of Chimeric Antigen Receptor T Cell Therapy for B Lymphoblastic Leukemia. Hematol Oncol Clin North Am Jul 2023.