Susan E McClory, MD, PhD

Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Attending Physician, Division of Oncology, Children's Hospital of Philadelphia
Full Member (Research), Abramson Cancer Center Immunobiology Research Program
Medical Director of the Program for Integrated Immunodeficiency and Cellular Therapy, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Oncology
4010 Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Division of Oncology
4010 Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-303-4638
Email:
mcclorys@chop.edu
mcclorys@chop.edu
Education:
B.S. (Molecular Genetics)
Ohio State University, 2005.
PhD (Integrated Biomedical Sciences)
Ohio State University, 2012.
MD (Medicine)
Ohio State University , 2014.
Permanent linkB.S. (Molecular Genetics)
Ohio State University, 2005.
PhD (Integrated Biomedical Sciences)
Ohio State University, 2012.
MD (Medicine)
Ohio State University , 2014.
Selected Publications
McClory SE, Oved JH. : Transplantation for immune dysregulatory disorders: current themes and future expectations. Curr Opin Pediatr December 2024.Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R.: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature Sep 2024.
Alsaati N, Grier A, Ochfeld E, McClory S, Heimall J.: Hematopoietic stem cell transplantation for primary immunodeficiency. Allergy Asthma Proc 45: 371-383, Sep 2024.
Doan AE, Mueller KP, Chen AY, Rouin GT, Chen Y, Daniel B, Lattin J, Markovska M, Mozarsky B, Arias-Umana J, Hapke R, Jung IY, Wang A, Xu P, Klysz D, Zuern G, Bashti M, Quinn PJ, Miao Z, Sandor K, Zhang W, Chen GM, Ryu F, Logun M, Hall J, Tan K, Grupp SA, McClory SE, Lareau CA, Fraietta JA, Sotillo E, Satpathy AT, Mackall CL, Weber EW: FOXO1 is a master regulator of memory programming in CAR T cells. Nature 629(8010): 211-218, May 2024.
Susan E McClory, Caitlin W. Elgarten, Kaitlyn N Quijano, Anne Wohlschlaeger, Patricia Hankins, Lei Wang, Yongping Wang, Stephan Kadauke, Dimitri Monos, Timothy S. Olson, Stephan A. Grupp, Elisa Ochfeld, Jennifer R. Heimall, and Nancy J. Bunin: Unrelated and Haploidentical Peripheral Stem Cell Transplant with Tcrαβ/CD19 Depletion for the Treatment of Pediatric Patients with Inborn Errors of Immunity. American Society of Transplantation and Cell Therapy February 2024.
McClory SE, Maude SL.: The Current State of Chimeric Antigen Receptor T Cell Therapy for B Lymphoblastic Leukemia. Hematol Oncol Clin North Am Jul 2023.
McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS.: The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR(+) CD8(+) effector state, and its deletion improves checkpoint blockade. Cell Rep 42: 112905, Jul 2023.
Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Lanwei Xu, Phyllis A. Gimotty, Martha S. Jordan, and Warren S. Pear: Trib1 Inhibition Promotes the KLR Effector State and Augments Checkpoint Blockade to Enhance T Cell Function during T Cell Exhaustion. American Society of Hematology Annual Meeting 2022 Notes: Poster.
Susan McClory, MD, PhD; Oishi Bardhan; Kelly Rome, PhD; Warren Pear, MD, PhD; and Martha Jordan, PhD: Trib1 Inhibits Viral-specific T Cell Responses during Chronic Infection by Promoting Terminal Exhaustion. Keystone Symposium on Advances in Checkpoints Immunology from Autoimmunity to Oncology to Infectious Diseases, Virtual 2022 Notes: Poster.
Rome, K. S., Stein, S. J., Kurachi, M., Petrovic, J., Schwartz, G. W., Mack, E. A., Uljon, S., Wu, W. W., DeHart, A. G., McClory, S. E., Xu, L., Gimotty, P. A., Blacklow, S. C., Faryabi, R. B., Wherry, E. J., Jordan, M. S., Pear, W. S.: Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. J Exp Med 217(5): e20190888, May 2020.