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Gary D. Wu, MD
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Ferdinand G. Weisbrod Professor in Gastroenterology
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Associate Director NIH Training Grant in Gastrointestinal Sciences, Perelman School of Medicine, University of Pennsylvania (T32-DK07066)
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Director, Human-Microbial Analytic and Repository Core Facility, NIH Center for Molecular Studies in Digestive and Liver Diseases (P30 DK50306), Perelman School of Medicine, University of Pennsylvania
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Ferdinand G. Weisbrod Professor in Gastroenterology, University of Pennsylvania School of Medicine
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Co-Director, Penn-CHOP Microbiome Program , Perelman School of Medicine, University of Pennsylvania and the Children's Hospital of Philadelphia
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Director, Microbial Culture and Metabolomics Core for the PennCHOP Microbiome Program, Perelman School of Medicine, University of Pennsylvania and the Children's Hospital of Philadelphia
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Director, Penn Center for Nutritional Science and Medicine, Pereleman School of Medicine, University of Pennsylvania
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Co-Vice Chief for Research, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania
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Co-Associate Director, UPENN Digestive and Liver Center
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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421 Curie Boulevard
4a 915 Biomedical Research Building II/III
Philadelphia, PA 19104
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4a 915 Biomedical Research Building II/III
Philadelphia, PA 19104
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Office: 215-898-0158
32 Fax: 215-573-2024
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32 Fax: 215-573-2024
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Publications
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Links
c8 Search PubMed for articles
c3 University of Pennsylvania Perelman School of Medicine Center for Molecular Studies in Digestive and Liver Diseases
74 PennCHOP Microbiome Program
ce University of Pennsylvania Perelman School of Medicine Host-Microbial Analytic and Repository Core (H-MARC)
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c8 Search PubMed for articles
c3 University of Pennsylvania Perelman School of Medicine Center for Molecular Studies in Digestive and Liver Diseases
74 PennCHOP Microbiome Program
ce University of Pennsylvania Perelman School of Medicine Host-Microbial Analytic and Repository Core (H-MARC)
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Education:
21 9 A.B. 16 (Chemistry) c
2b Cornell University, 1980.
21 9 M.D. c
3f Northwestern University Medical School, 1986.
21 9 M.A. 15 (Honorary) c
33 University of Pennsylvania, 2002.
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Permanent link21 9 A.B. 16 (Chemistry) c
2b Cornell University, 1980.
21 9 M.D. c
3f Northwestern University Medical School, 1986.
21 9 M.A. 15 (Honorary) c
33 University of Pennsylvania, 2002.
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36 Diet, the Gut Microbiome, and Host Metabolism
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1f Program Summary
4cf Gary D. Wu, MD is the Ferdinand G. Weisbrod Professor in Gastroenterology at the University of Pennsylvania’s Perelman School of Medicine. He is the Vice Chief for Research in the Division of Gastroenterology and Hepatology, Director of the Penn Center for Nutritional Science and Medicine, Co-Director of both the PennCHOP Microbiome Program and Associate Director of the NIH Center for Molecular Studies in Digestive and Liver Disease. He was the inaugural Director and Chair of the Scientific Advisory Board for the American Gastroenterological Association’s Center for Gut Microbiome Research and Education and is an elected member of both the American Society for Clinical Investigation and the Association of American Physicians. As a physician-scientist with knowledge of human physiology and biochemistry who has a particular interest in the impact of diet on the gut microbiome and its metabolome, Dr. Wu has a significant level of administrative experience in multidisciplinary team research projects involving biomedical informatics, computational biology, and biostatistics. He has published numerous manuscripts in high impact journals such as Science, Nature, Nature Microbiology, and Cell Host & Microbe.
8
1e Lab personnel:
19 Lillian Chau, MS
22 Elliot Friedman, PhD
17 Dylan Curry, MS
1a Lindsey Herman, BS
22 Margaret Pichardo, MD, PhD
11 Jacob Cao
10 Arthur Li
26 29
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Description of Research Expertise
28 Research Program36 Diet, the Gut Microbiome, and Host Metabolism
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1f Program Summary
4cf Gary D. Wu, MD is the Ferdinand G. Weisbrod Professor in Gastroenterology at the University of Pennsylvania’s Perelman School of Medicine. He is the Vice Chief for Research in the Division of Gastroenterology and Hepatology, Director of the Penn Center for Nutritional Science and Medicine, Co-Director of both the PennCHOP Microbiome Program and Associate Director of the NIH Center for Molecular Studies in Digestive and Liver Disease. He was the inaugural Director and Chair of the Scientific Advisory Board for the American Gastroenterological Association’s Center for Gut Microbiome Research and Education and is an elected member of both the American Society for Clinical Investigation and the Association of American Physicians. As a physician-scientist with knowledge of human physiology and biochemistry who has a particular interest in the impact of diet on the gut microbiome and its metabolome, Dr. Wu has a significant level of administrative experience in multidisciplinary team research projects involving biomedical informatics, computational biology, and biostatistics. He has published numerous manuscripts in high impact journals such as Science, Nature, Nature Microbiology, and Cell Host & Microbe.
8
1e Lab personnel:
19 Lillian Chau, MS
22 Elliot Friedman, PhD
17 Dylan Curry, MS
1a Lindsey Herman, BS
22 Margaret Pichardo, MD, PhD
11 Jacob Cao
10 Arthur Li
26 29
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221 Bloom PP, Garrett WS, Penniston KL, Winkler MH, Hazen SL, Agudelo J, Suryavanshi M, Babiker A, Dodd D, Fischbach MA, Huang KC, Huttenhower C, Joe B, Kalantar-Zadeh K, Knight R, Miller AW, Rabb H, Srivastava A, Tang WHW, Turnbaugh PJ, Walker AW, Wilck N, Xu J, Yang T, Himmelfarb J, Redinbo MR, Wu GD, Woodworth MH, Ackerman AL, Winter S, Rinschen MM, Hassan HA, Biruete A, Anderson AH, Pluznick JL.: Microbiota and kidney disease: the road ahead. Nat Rev Nephrol Jul 2025.
15e Ren X, Clark RM, Bansah DA, Varner EN, Tiffany CR, Jaswal K, Geary JH, Todd OA, Winkelman JD, Friedman ES, Jarrett RN, Zemel BS, Wu GD, Zackular JP, DePas WH, Behnsen J, Palmer LD.: Amino acid competition shapes Acinetobacter baumannii gut carriage. Cell Host Microbe Jul 2025.
15a Hewlett KK, PeBenito A, Hecht AL, Tiffany C, Tanes C, Glover RC, Fawad JA, Friedman ES, Reynolds JC, Bittinger K, Lewis JD, Wu GD, Ahuja NK, Zackular JP.: Dietary Fiber Modulates the Window of Susceptibility to Clostridioides difficile Infection. Gastroenterology May 2025.
194 Barekat K, Ghosh S, Herrmann C, Keat K, Assenmacher CA, Tanes C, Wilson N, Sengupta A, Das US, Joshi R, Ritchie MD, Bittinger K, Weljie A, Cadwell K, Bushman FD, Wu GD, FitzGerald GA, Ricciotti E.: Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use. bioRxiv May 2025.
157 Damani R, Vasisht S, Luks V, Vargas G, Compher C, Titchenell PM, Tasian G, Li H, Wu GD, Witschey WR, Gershuni VM.: Sex-based differences in imaging-derived body composition and their association with clinical malnutrition in abdominal surgery patients. medRxiv Apr 2025.
1b6 Hecht AL, Mahmud N, Chaudhry S, Cao JY, Branigan GP, Lee J, Theiller E, Roggiani M, Friedman ES, Herman L, Galis BE, Jones SM, Planet PJ, Zackular JP, Kaplan DE, Serper M, Rajender Reddy K, Moustafa AM, Goulian M, Wu GD.: Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection. bioRxiv Mar 2025.
16b Yan J, Ren R, Chang R, Dan W, Zhang X, Pan F, Yan B, Lee H, Josie N, Sun G, Peng L, Wu GD, Yang Y.: Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics. Chronic Dis Transl Med 11: 130-139, Feb 2025.
151 Benitez AJ, Tanes C, Friedman ES, Zackular JP, Ford E, Gerber JS, DeRusso PA, Kelly A, Li H, Elovitz MA, Wu GD, Zemel B, Bittinger K.: Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants. Microbiome 13: 21, Jan 2025.
146 Soto Ocaña J, Friedman ES, Keenan O, Bayard NU, Ford E, Tanes C, Munneke MJ, Beavers WN, Skaar EP, Bittinger K, Zemel BS, Wu GD, Zackular JP.: Metal availability shapes early life microbial ecology and community succession. mBio 15: e0153424, Oct 2024.
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Selected Publications
135 Harling LC, Hecht AL, Meyer F, Wu GD.: Revisiting nitrogen assimilation strategies in the mammalian gut: lessons from Enterobacteriaceae as pathobiont models and a challenge to the limitation paradigm. Arch Microbiol 207: 203, Jul 2025.221 Bloom PP, Garrett WS, Penniston KL, Winkler MH, Hazen SL, Agudelo J, Suryavanshi M, Babiker A, Dodd D, Fischbach MA, Huang KC, Huttenhower C, Joe B, Kalantar-Zadeh K, Knight R, Miller AW, Rabb H, Srivastava A, Tang WHW, Turnbaugh PJ, Walker AW, Wilck N, Xu J, Yang T, Himmelfarb J, Redinbo MR, Wu GD, Woodworth MH, Ackerman AL, Winter S, Rinschen MM, Hassan HA, Biruete A, Anderson AH, Pluznick JL.: Microbiota and kidney disease: the road ahead. Nat Rev Nephrol Jul 2025.
15e Ren X, Clark RM, Bansah DA, Varner EN, Tiffany CR, Jaswal K, Geary JH, Todd OA, Winkelman JD, Friedman ES, Jarrett RN, Zemel BS, Wu GD, Zackular JP, DePas WH, Behnsen J, Palmer LD.: Amino acid competition shapes Acinetobacter baumannii gut carriage. Cell Host Microbe Jul 2025.
15a Hewlett KK, PeBenito A, Hecht AL, Tiffany C, Tanes C, Glover RC, Fawad JA, Friedman ES, Reynolds JC, Bittinger K, Lewis JD, Wu GD, Ahuja NK, Zackular JP.: Dietary Fiber Modulates the Window of Susceptibility to Clostridioides difficile Infection. Gastroenterology May 2025.
194 Barekat K, Ghosh S, Herrmann C, Keat K, Assenmacher CA, Tanes C, Wilson N, Sengupta A, Das US, Joshi R, Ritchie MD, Bittinger K, Weljie A, Cadwell K, Bushman FD, Wu GD, FitzGerald GA, Ricciotti E.: Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use. bioRxiv May 2025.
157 Damani R, Vasisht S, Luks V, Vargas G, Compher C, Titchenell PM, Tasian G, Li H, Wu GD, Witschey WR, Gershuni VM.: Sex-based differences in imaging-derived body composition and their association with clinical malnutrition in abdominal surgery patients. medRxiv Apr 2025.
1b6 Hecht AL, Mahmud N, Chaudhry S, Cao JY, Branigan GP, Lee J, Theiller E, Roggiani M, Friedman ES, Herman L, Galis BE, Jones SM, Planet PJ, Zackular JP, Kaplan DE, Serper M, Rajender Reddy K, Moustafa AM, Goulian M, Wu GD.: Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection. bioRxiv Mar 2025.
16b Yan J, Ren R, Chang R, Dan W, Zhang X, Pan F, Yan B, Lee H, Josie N, Sun G, Peng L, Wu GD, Yang Y.: Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics. Chronic Dis Transl Med 11: 130-139, Feb 2025.
151 Benitez AJ, Tanes C, Friedman ES, Zackular JP, Ford E, Gerber JS, DeRusso PA, Kelly A, Li H, Elovitz MA, Wu GD, Zemel B, Bittinger K.: Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants. Microbiome 13: 21, Jan 2025.
146 Soto Ocaña J, Friedman ES, Keenan O, Bayard NU, Ford E, Tanes C, Munneke MJ, Beavers WN, Skaar EP, Bittinger K, Zemel BS, Wu GD, Zackular JP.: Metal availability shapes early life microbial ecology and community succession. mBio 15: e0153424, Oct 2024.
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