Selected Publications

Alexandra U Zezulin, Darwin Ye, Elizabeth Howell, Daniel Yen, Erica Bresciani, Jamie Diemer, Jian-gang Ren, Mohd Hafiz Ahmad, Lucio H Castilla, Ivo P Touw, Andy J Minn, Wei Tong, P Paul Liu, Kai Tan, Wenbao Yu*, Nancy A Speck*: RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes & Development Page: doi: 10.1101, Jan 2023 Notes: Co-corresponding author. Online pub.

Changya Chen*, Wenbao Yu*, Fatemeh Alikarami*, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P Hunger, Carolyn A Felix, Hao Wu, Patrick A Brown, Erin M Guest, David M Barrett, Kathrin M Bernt, Kai Tan: Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia. Blood 139(14): 2198-2211, Apr 2022 Notes: Co-first author.

Yu, W., Uzun, Y., Zhu, Q., Chen, C., & Tan, K.: scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data. Genome Biology 21(94): doi: 10.1186, Apr 2020 Notes: online pub.

Yu, W., He, B., & Tan, K.: Identifying topologically associating domains and subdomains by Gaussian mixture model and proportion test. Nature communications 8(535): 535, Sep 2017.

Changya Chen*, Wenbao Yu*, Joanna Tober, Peng Gao, Bing He, Kiwon Lee, Tuan Trieu, Gerd A Blobel, Nancy A Speck, Kai Tan: Spatial genome re-organization between fetal and adult hematopoietic stem cells. Cell Reports 29(12): 4200-4211, 2019 Notes: Co-first author.

Yu, W., Lee, S., & Park, T.: A unified model based multifactor dimensionality reduction framework for detecting gene–gene interactions. Bioinformatics 32(17): i605-i610, 2016.

Chen, G. M., Chen, C., Das, R. K., Gao, P., Yu, W., & Tan, K. : Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy. Cancer Discovery 11(9): 2186-2199, Sep 2021.

Yu, W., & Park, T.: Two simple algorithms on linear combination of multiple biomarkers to maximize partial area under the ROC curve. Computational Statistics & Data Analysis 88: 15-27, 2015.

Yu, W., Kwon, M.S., & Park. T.: Multivariate quantitative multifactor dimensionality reduction for detecting gene-gene interactions. Human heredity 79(3-4): 168-181, 2015.

Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A Speck, Kai Tan : Developmental trajectory of prehematopoietic stem cell formation from endothelium. Blood 136(7): 845-856, Aug 2020.

Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E Rood, Orr Ashenberg, Ethan Cerami, Robert J Coffey, Emek Demir, Li Ding, Edward D Esplin, James M Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W Gray, Justin Guinney, Sean E Hanlon, Shannon K Hughes, E Shelley Hwang, Christine A Iacobuzio-Donahue, Judit Jané-Valbuena, Bruce E Johnson, Ken S Lau, Tracy Lively, Sarah A Mazzilli, Dana Pe'er, Sandro Santagata, Alex K Shalek, Denis Schapiro, Michael P Snyder, Peter K Sorger, Avrum E Spira, Sudhir Srivastava, Kai Tan, Robert B West, Elizabeth H Williams, Human Tumor Atlas Network: The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell 181(2): 236-249, Apr 2020 Notes: Participating Investigator.

Yu, W., Kim, J. K., & Park, T. : Estimation of Area Under the ROC Curve under nonignorable verification bias. Statistica Sinica 28(4): 2149–2166, 2018.

Yu, W., & Park, T.: AucPR: An AUC-based approach using penalized regression for disease prediction with high-dimensional omics data. BMC genomics 15(S1): doi: 10.1186, 2014 Notes: online pub.

Yu, W., Ivan Chang, Y. C., & Park, E.: A modified area under the ROC curve and its application to marker selection and classification. Journal of the Korean Statistical Society 43(2): 161-175, 2014.