Wenbao Yu, PhD
Research Assistant Professor of Pediatrics (Oncology)
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
3501 Civic Center Blvd.
Philadelphia, PA 19104
3501 Civic Center Blvd.
Philadelphia, PA 19104
Education:
B.S (Mathematics)
Chongqing University, China, 2006.
M.S. (Computational Mathematics)
University of Science and Technology of China, China, 2009.
Ph.D. (Statistics)
Chonnam National University, South Korea, 2013.
Permanent linkB.S (Mathematics)
Chongqing University, China, 2006.
M.S. (Computational Mathematics)
University of Science and Technology of China, China, 2009.
Ph.D. (Statistics)
Chonnam National University, South Korea, 2013.
Description of Research Expertise
Computational BiologySingle-cell Multi-omics
Cancer Genomics
3D Genome Organization
Selected Publications
Wenbao Yu, Rumeysa Biyik-Sit, Yasin Uzun, Chia-Hui Chen, Anusha Thadi, Jonathan H. Sussman, Minxing Pang, Chi-Yun Wu, Liron D. Grossmann, Peng Gao, David W. Wu, Aliza Yousey, Mei Zhang, Christina S. Turn, Zhan Zhang, Shovik Bandyopadhyay, Jeffrey Huang, Tasleema Patel, Changya Chen, Daniel Martinez, Lea F. Surrey, Michael D. Hogarty, Kathrin Bernt, Nancy R. Zhang, John M. Maris, and Kai Tan: Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring. Nature Genetics 2025.Alexandra U Zezulin, Darwin Ye, Elizabeth Howell, Daniel Yen, Erica Bresciani, Jamie Diemer, Jian-gang Ren, Mohd Hafiz Ahmad, Lucio H Castilla, Ivo P Touw, Andy J Minn, Wei Tong, P Paul Liu, Kai Tan, Wenbao Yu*, Nancy A Speck*: RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes & Development 37: doi: 10.1101, Jan 2023 Notes: Co-corresponding author. Online pub.
Changya Chen*, Wenbao Yu*, Fatemeh Alikarami*, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P Hunger, Carolyn A Felix, Hao Wu, Patrick A Brown, Erin M Guest, David M Barrett, Kathrin M Bernt, Kai Tan: Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia. Blood 139(14): 2198-2211, Apr 2022 Notes: Co-first author.
Yu, W., Uzun, Y., Zhu, Q., Chen, C., & Tan, K.: scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data. Genome Biology 21(94): doi: 10.1186, Apr 2020 Notes: online pub.
Chen, G. M., Chen, C., Das, R. K., Gao, P., Yu, W., & Tan, K. : Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy. Cancer Discovery 11(9): 2186-2199, Sep 2021.
Yu, W., Kim, J. K., & Park, T. : Estimation of Area Under the ROC Curve under nonignorable verification bias. Statistica Sinica 28(4): 2149–2166, 2018.
Yu, W., & Park, T.: Two simple algorithms on linear combination of multiple biomarkers to maximize partial area under the ROC curve. Computational Statistics & Data Analysis 88: 15-27, 2015.
Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A Speck, Kai Tan : Developmental trajectory of prehematopoietic stem cell formation from endothelium. Blood 136(7): 845-856, Aug 2020.