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Melina Elpi Marmarelis, MD, MSCE
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Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
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Attending Physician , Hospital of the University of Pennsylvania
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Attending Physician , Penn Presbyterian Medical Center
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Medical Director of Penn Medicine Mesothelioma and Pleural Program, University of Pennsylvania
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PC3I Faculty, Penn Center for Cancer Care Innovation, University of Pennsylvania
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Physician Lead -Airways Research Program, University of Pennsylvania
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Department: Medicine
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Contact information
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Perelman Center for Advanced Medicine
1e 3400 Civic Center Blvd
2d 10th Floor
Philadelphia, PA 19104
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1e 3400 Civic Center Blvd
2d 10th Floor
Philadelphia, PA 19104
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Education:
21 7 BA 3d (Bachelors in Biochemistry and Molecular Biology ) c
2a Dartmouth College, 2007.
21 7 MD 15 (Medicine) c
30 Harvard Medical School , 2013.
21 9 MSCE 23 (Clinical Epidemiology ) c
34 University of Pennsylvania , 2019.
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Permanent link21 7 BA 3d (Bachelors in Biochemistry and Molecular Biology ) c
2a Dartmouth College, 2007.
21 7 MD 15 (Medicine) c
30 Harvard Medical School , 2013.
21 9 MSCE 23 (Clinical Epidemiology ) c
34 University of Pennsylvania , 2019.
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Description of Clinical Expertise
2d Lung cancer and mesothelioma.71
Description of Research Expertise
3f Clinical trials in lung cancer in mesothelioma.e 29
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157 Benjamin A. Bleiberg, Lauren Reed-Guy, Roger B. Cohen, Charu Aggarwal, Corey J. Langer, Aditi P. Singh, Melina E. Marmarelis: Carboplatin plus Pemetrexed versus Pemetrexed alone in Advanced Thymoma and Thymic Carcinoma: A Retrospective Cohort Study. Frontiers June 2026.
24d Cole Friedes, Michelle Iocolano, Nikhil Yegya-Raman, John C Kucharczuk, Taine T V Pechet, Roger B Cohen, Charu Aggarwal, Melina E Marmarelis, William P Levin, Keith A Cengel, Christine A Ciunci, Christopher D'Avella, Aditi P Singh, Christiana W Davis, Corey J Langer, Jeffrey Bradley, Steven J Feigenberg: Real World Radiographic Response Rates and Preoperative Attrition in Patients With Non-Small Cell Lung Cancer (NSCLC) Treated With Neoadjuvant Chemoimmunotherapy. American Journal of Clinical Oncology May 2026.
126 Teja Voruganti, Christiana Davis, Melina E. Marmarelis, Charu Aggarwal: Illusion of Comprehensive Testing in Non–Small Cell Lung Cancer: Why Coverage, Sensitivity, and Reporting Matter. JCO Oncology Practice April 2026.
1df Melina E. Marmarelis, Adrienne M. Gilligan, Tomoko Sugihara, Shen Zheng, Tyler Marquart, Samuel Whipple, Naleen Raj Bhandari, Charu Aggarwal: Evaluation of Guideline-Recommended Care in First-Line Treatment for Advanced/Metastatic Non-Small Cell Lung Cancer Patients who underwent Next-Generation Sequencing Testing: Results from a Real-World Study. Cancer Treatment and Research Communications April 2026.
23d Benjamin T. Cooper, Jeffrey D. Bradley, Sushma Patel, Michael A. Pritchett, Steven J. Feigenberg, Kevin C. Ma, Isaac Laniado, Melina E. Marmarelis, Matthew Scarlotta, Joshua K. Sabari, Yi-Wen Ma, Yina Kuang, Kiran Devisetty, Balaji Laxmanan, David M. DiBardino: Novel Intratumoral Radioenhancer (JNJ -1900) with Chemoradiation and Consolidative Immunotherapy for Stage III Unresectable Non -Small Cell Lung Cancer (NSCLC): Early Outcomes from the Phase II CONVERGE Study. ELCC 2026 Poster March 2026.
1ab Adam Barsouk, Alec Heidlauf, Keshav Goel, Lynn Rushkin, Anna Anran Huang, Omar Elghawy, Connie Yu, Lucy Wang, David Yang, Martin Kurian, Lauren Reed-Guy, Lova Sun, Aditi Singh, Charu Aggarwal, Roger B. Cohen, Corey Langer, Melina E. Marmarelis: Osimertinib Dose-Reduction and Survival in First-Line EGFR-Mutated mNSCLC. Lung Cancer 213: 108936, Mar 2026.
19d Michael Offin...Melina E. Marmarelis: eVOLVE-02 SS5 Meso TiP Abstract entitled: Volrustomig, a novel bispecific PD-1/CTLA-4 monoclonal antibody, as single-agent first-line therapy for unresectable pleural mesothelioma (PM): Substudy 5 of the eVOLVE-02 phase 2 study. ELCC March 2026 March 2026 Notes: Poster Presentation. Trial in Progress.
ab Pascale Tomasini, MD, MSc, Yongsheng Wang, MD, Yongsheng Li, MD, PhD, Enriqueta Felip, MD, PhD, Lin Wu, MD, Jiuwei Cui, MD, PhD 98 Benjamin Besse, MD, PhD, Alexander I. Spira, MD, PhD, Joel W. Neal, MD, Ph, Koichi Goto, MD, PhD, Christina S. Baik, MD, MPH, Melina E. Marmarelis, MD 29b Eiki Ichihara, MD, PhD, Yiping Zhang, MD, Jong-Seok Lee, MD, PhD, Se-Hoon Lee, MD, PhD, James Chih-Hsin Yang, MD, PhD, Sebastian Michels, MD, Zacharias Anastasiou, MS, Joshua C. Curtin, PhD, Xuesong Lyu, PhD, Janine Mahoney, BSN, RN, Levon Demirdjian, PhD, Craig S. Meyer, MS, PhD, MPH, Youyi Zhang, PhD, Isabelle Leconte, PhD, Patricia Lorenzini, MS, Roland E. Knoblauch, MD, PhD, Leonardo Trani, MD, Mahadi Baig, MD, Joshua M. Bauml, MD, Byoung Chul Cho, MD, PhD: Amivantamab Plus Lazertinib in Atypical EGFR-Mutated Advanced Non–Small Cell Lung Cancer: Results From CHRYSALIS-2. Journal of Clinical Oncology 44(1): 54-65. Jan 2026.
1c5 Melina E. Marmarelis, Meijia Zhou, Sajjad Raza, Qing Huang, Kiran Devisetty, Balaji Laxmanan, Rachael L. DiSantostefano, Iftekhar Kalsekar, Daniel Goomez: Real-world Utilization and Outcomes with Pacific Regimen in Stage III Unresectable Non-small Cell Lung Cancer Patients: Results from a Multicenter US Database. ESMO Annual Meeting 2025 October 2025 Notes: Poster Presentation.
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Selected Publications
1c3 Benjamin A. Bleiberg, Dylan G. Scholes, Lauren Reed-Guy, Devaki Dravid, Lova L. Sun, Aditi P. Singh, Roger B. Cohen, Corey J. Langer, Melina E. Marmarelis, Charu Aggarwal: The incremental value of liquid biopsy in the initial evaluation of patients with metastatic non-small cell lung cancer undergoing tissue-based molecular testing. The Journal of Liquid Biopsy 12, June 2026.157 Benjamin A. Bleiberg, Lauren Reed-Guy, Roger B. Cohen, Charu Aggarwal, Corey J. Langer, Aditi P. Singh, Melina E. Marmarelis: Carboplatin plus Pemetrexed versus Pemetrexed alone in Advanced Thymoma and Thymic Carcinoma: A Retrospective Cohort Study. Frontiers June 2026.
24d Cole Friedes, Michelle Iocolano, Nikhil Yegya-Raman, John C Kucharczuk, Taine T V Pechet, Roger B Cohen, Charu Aggarwal, Melina E Marmarelis, William P Levin, Keith A Cengel, Christine A Ciunci, Christopher D'Avella, Aditi P Singh, Christiana W Davis, Corey J Langer, Jeffrey Bradley, Steven J Feigenberg: Real World Radiographic Response Rates and Preoperative Attrition in Patients With Non-Small Cell Lung Cancer (NSCLC) Treated With Neoadjuvant Chemoimmunotherapy. American Journal of Clinical Oncology May 2026.
126 Teja Voruganti, Christiana Davis, Melina E. Marmarelis, Charu Aggarwal: Illusion of Comprehensive Testing in Non–Small Cell Lung Cancer: Why Coverage, Sensitivity, and Reporting Matter. JCO Oncology Practice April 2026.
1df Melina E. Marmarelis, Adrienne M. Gilligan, Tomoko Sugihara, Shen Zheng, Tyler Marquart, Samuel Whipple, Naleen Raj Bhandari, Charu Aggarwal: Evaluation of Guideline-Recommended Care in First-Line Treatment for Advanced/Metastatic Non-Small Cell Lung Cancer Patients who underwent Next-Generation Sequencing Testing: Results from a Real-World Study. Cancer Treatment and Research Communications April 2026.
23d Benjamin T. Cooper, Jeffrey D. Bradley, Sushma Patel, Michael A. Pritchett, Steven J. Feigenberg, Kevin C. Ma, Isaac Laniado, Melina E. Marmarelis, Matthew Scarlotta, Joshua K. Sabari, Yi-Wen Ma, Yina Kuang, Kiran Devisetty, Balaji Laxmanan, David M. DiBardino: Novel Intratumoral Radioenhancer (JNJ -1900) with Chemoradiation and Consolidative Immunotherapy for Stage III Unresectable Non -Small Cell Lung Cancer (NSCLC): Early Outcomes from the Phase II CONVERGE Study. ELCC 2026 Poster March 2026.
1ab Adam Barsouk, Alec Heidlauf, Keshav Goel, Lynn Rushkin, Anna Anran Huang, Omar Elghawy, Connie Yu, Lucy Wang, David Yang, Martin Kurian, Lauren Reed-Guy, Lova Sun, Aditi Singh, Charu Aggarwal, Roger B. Cohen, Corey Langer, Melina E. Marmarelis: Osimertinib Dose-Reduction and Survival in First-Line EGFR-Mutated mNSCLC. Lung Cancer 213: 108936, Mar 2026.
19d Michael Offin...Melina E. Marmarelis: eVOLVE-02 SS5 Meso TiP Abstract entitled: Volrustomig, a novel bispecific PD-1/CTLA-4 monoclonal antibody, as single-agent first-line therapy for unresectable pleural mesothelioma (PM): Substudy 5 of the eVOLVE-02 phase 2 study. ELCC March 2026 March 2026 Notes: Poster Presentation. Trial in Progress.
ab Pascale Tomasini, MD, MSc, Yongsheng Wang, MD, Yongsheng Li, MD, PhD, Enriqueta Felip, MD, PhD, Lin Wu, MD, Jiuwei Cui, MD, PhD 98 Benjamin Besse, MD, PhD, Alexander I. Spira, MD, PhD, Joel W. Neal, MD, Ph, Koichi Goto, MD, PhD, Christina S. Baik, MD, MPH, Melina E. Marmarelis, MD 29b Eiki Ichihara, MD, PhD, Yiping Zhang, MD, Jong-Seok Lee, MD, PhD, Se-Hoon Lee, MD, PhD, James Chih-Hsin Yang, MD, PhD, Sebastian Michels, MD, Zacharias Anastasiou, MS, Joshua C. Curtin, PhD, Xuesong Lyu, PhD, Janine Mahoney, BSN, RN, Levon Demirdjian, PhD, Craig S. Meyer, MS, PhD, MPH, Youyi Zhang, PhD, Isabelle Leconte, PhD, Patricia Lorenzini, MS, Roland E. Knoblauch, MD, PhD, Leonardo Trani, MD, Mahadi Baig, MD, Joshua M. Bauml, MD, Byoung Chul Cho, MD, PhD: Amivantamab Plus Lazertinib in Atypical EGFR-Mutated Advanced Non–Small Cell Lung Cancer: Results From CHRYSALIS-2. Journal of Clinical Oncology 44(1): 54-65. Jan 2026.
1c5 Melina E. Marmarelis, Meijia Zhou, Sajjad Raza, Qing Huang, Kiran Devisetty, Balaji Laxmanan, Rachael L. DiSantostefano, Iftekhar Kalsekar, Daniel Goomez: Real-world Utilization and Outcomes with Pacific Regimen in Stage III Unresectable Non-small Cell Lung Cancer Patients: Results from a Multicenter US Database. ESMO Annual Meeting 2025 October 2025 Notes: Poster Presentation.
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