Melina Elpi Marmarelis, MD, MSCE
Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Attending Physician , Hospital of the University of Pennsylvania
Attending Physician , Penn Presbyterian Medical Center
Medical Director of Penn Medicine Mesothelioma and Pleural Program, University of Pennsylvania
PC3I Faculty, Penn Center for Cancer Care Innovation, University of Pennsylvania
Physician Lead -Airways Research Program, University of Pennsyvlania
Department: Medicine
Contact information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
10th Floor
Philadelphia, PA 19104
3400 Civic Center Blvd
10th Floor
Philadelphia, PA 19104
Education:
BA (Bachelors in Biochemistry and Molecular Biology )
Dartmouth College, 2007.
MD (Medicine)
Harvard Medical School , 2013.
MSCE (Clinical Epidemiology )
University of Pennsylvania , 2019.
Permanent linkBA (Bachelors in Biochemistry and Molecular Biology )
Dartmouth College, 2007.
MD (Medicine)
Harvard Medical School , 2013.
MSCE (Clinical Epidemiology )
University of Pennsylvania , 2019.
Description of Clinical Expertise
Lung cancer and mesothelioma.Description of Research Expertise
Clinical trials in lung cancer in mesothelioma.Selected Publications
Benjamin Besse, MD, PhD, Koichi Goto, MD, PhD, Yongsheng Wang, MD, Se-Hoon Lee, MD, PhD, Melina E. Marmarelis, MD, Yuichiro Ohe, MD, PhD, Reyes Bernabe Caro, MD, Dong-Wan Kim, MD, PhD, Jong-Seok Lee, MD, PhD, Sophie Cousin, MD, MSc, Eiki Ichihara, MD, PhD, Yongsheng Li, MD, PhD, Paz-Ares Luis, MD, PhD, Akira Ono, MD, PhD, Rachel E. Sanborn, MD, Naohiro Watanabe, MD, Maria Jose de Miguel, MD, PhD, Carole Helissey, MD, Catherine A. Shu, MD, Alexander Spira, MD, PhD, Pascale Tomasini, MD, MSc, James Chih-Hsin Yang, MD, PhD, Yiping Zhang, MD, Enriqueta Felip, MD, PhD, Frank Griesinger, MD, PhD, Saima N. Waqar, MD, Antonio Calles, MD, Joel Neal, MD, PhD, Christina S. Baik, MD, Pasi A. Jänne, MD, PhD, S. Martin Shreeve, MD, PhD, Joshua C. Curtin, PhD, Bharvin Patel, PhD, Michael Gormley, PhD, Xuesong Lyu, PhD, Jun Chen, MD, MSc, Pei-Ling Chu, PhD, Janine Mahoney, BSN, RN, Leonardo Trani, MD, Joshua M. Bauml, MD, Meena Thayu, MD, MSCE, Roland E. Knoblauch, MD, PhD, Byoung Chul Cho, MD, PhD: Amivantamab Plus Lazertinib in Patients With EGFR-mutant Non-small Cell Lung Cancer (NSCLC) After Progression on Osimertinib and Platinum-based Chemotherapy: Results From CHRYSALIS-2 Cohort A. Journal of Thoracic Oncology December 2024 Notes: Accepted November 2024.Connor B. Grady, Wei-Ting Hwang, Joshua E. Reuss, Wade Iams, Amanda Cass, Geoffrey Liu, Devalben Patel, Stephen V. Liu, Gabriela Liliana Bravo Montenegro, Tejas Patil, Jorge J. Nieva, Amanda Herrmann, Kristen A. Marrone, Vincent K. Lam, William Schwartzman, Jonathan Dowell, Liza C Villaruz, Kelsey Leigh Miller, Jared Weiss, Fangdi Sun, Vamsidhar Velcheti, D. Ross Camidge, Charu Aggarwal, Lova Sun, Melina E. Marmarelis: Determining Line of Therapy from Real-World Data in Non-Small Cell Lung Cancer. Pharmacoepidemiology and Drug Safety 33(12): e70049. Dec 2024.
Ferdinandos Skoulidis, Haniel Araujo, Minh Truong Do, Ana Galan-Cobo, Yu Qian , Meagan Montesion, Rachael Palmer, Nadine Jahchan, Joseph Juan, Chengyin Min, Yi Yu, Xuewen Pan, Kathryn Arbour, Natalie Vokes, David Molkentine, Dwight Owen, Regan Memmott, Pradnya Patil, Melina Marmarelis, Mark Awad, Joseph Murray, Jessica Hellyer, Justin Gainor, Anastasios Dimou, Christine Bestvina, Catherine Shu, Jonathan Riess, Collin Blakely, Chad Pecot, Laura Mezquita, Fabrizio Tabbo, Matthias Scheffler, Subba Digumarthy, Meghan Mooradian, Adrian Sacher, Sally Lau, Andreas Saltos, Julia Rotow, Rocio Perez Johnson, Corrine Liu, Tyler Stewart, Sarah Goldberg, Jonathan Killam, Zenta Walther, Kurt Schalper, Kurtis Davies, Mark Woodcock, Valsamo Anagnostou, Kristen Marrone, Patrick Forde, Biagio Ricciuti, Deepti Venkatraman, Eliezer Van Allen, Amy Cummings, Jonathan Goldman, Hiram Shaish, Melanie Kier, Sharyn Katz, Charu Aggarwal, Ying Ni, Joseph Azok, Jeremy Segal, Lauren Ritterhouse, Joel Neal, LUDOVIC LACROIX, Yasir Elamin, Marcelo Negrao, Xiuning Le, Vincent Lam, Whitney Lewis, Haley Kemp, Brett Carter, Jack Roth, Stephen Swisher, Richard Lee, Teng Zhou, Tina Cascone, Jianjun Zhang, George Blumenschein, Carl Gay, Lauren Averett Byers, Don Gibbons, Anne Tsao, Jack Lee, Trever Bivona, D. Ross Camidge, Jhanelle Gray, Natasha Leighl, Benjamin Levy, Julie Brahmer, Marina Garassino, David Gandara, Edward Garon, Naiyer Rizvi, Giorgio Scagliotti, Jürgen Wolf, David Planchard, Benjamin Besse, Roy Herbst, Heather Wakelee, Nathan Pennell, Alice Shaw, Pasi Jänne, David Carbone, Matthew Hellmann, Charles Rudin, Lee Albacker, Helen Mann, Zhou Zhu, Zhongwu Lai, Ross Stewart, Solange Peters, Melissa Johnson, Kwok-Kin Wong, Alan Huang, Monte Winslow, Michael Rosen, Ian Winters, Vassiliki Papadimitrakopoulou, Philip Jewsbury, Xin Sun, John Le, Stephanie Schmidt, Alissa Poteete, Yifan Kong, Tomohiro Takehara, Alvaro Guimaraes Paula, Edwin Parra, Carmen Behrens, Ignacio Wistuba: CTLA-4 blockade abrogates KEAP1/STK11-related PD-(L)1-inhibitor resistance. Nature 635(8038): 462-471, Nov 2024.
Jennifer A. Mark, Nishant Gandhi, Balazs Halmos, Melina E. Marmarelis, So Yeon Kim, Lyudmila Bazhenova, Suresh S. Ramalingam, Joanne Xiu, Phillip Walker, Matthew J. Oberley, Patrick C. Ma, Stephen V. Liu: Molecular profiling METex14+ non-small cell lung cancer (NSCLC): Impact of histology. Lung Cancer 196: 107935. doi: 10.1016/j.lungcan.2024.107935. Oct 2024.
Leighl NB, Akamutsu H, Lim SM, Cheng Y, Minchom AR, Marmarelis ME, Sanborn RE… Bauml JM, Baig M, Passaro A.: Subcutaneous versus Intravenous Amivantamab, both in Combination with Lazertinib, in Refractory EGFR-mutated NSCLC: Primary Results from the Phase 3 PALOMA-3 Study. Journal of Clinical Oncology 42(30): 3593-3605. Oct 2024.
Libre M, Barsouk A, Lu M, Lessans S, Elghawy O, Yu C, Goel K, Wu J, Bhatia S, Cass A, Marmarelis ME, Iams W: Lurbinectedin vs Platinum Rechallenge in Extensive Stage Small Cell Lung Cancer after Platinum Double, A Multicenter Retrospective Study. IASLC World Conference on Lung Cancer, San Diego, CA September 2024 Notes: "Poster Presentation"
M. Alexander, Y. Cheng, S-H. Lee, A. Passaro, A.I. Spira, B.C. Cho, S.M. Lim, Y. Ohe, A. Nagrial, J.L. Tan, V. Wainsztein, E. Ramos, M. del Rosario Garcia Campelo, H. Akamatsu, D. Nguyen, A.B. Cortot, A. Zer, D. Erdem, R.E. Sanborn, T-O. Emde, A.R. Minchom, B. Zurawski, M.L. Ferreira, J.C-H. Yang, M.E. Marmarelis, J. Schuchard, J. Alves, D. Ghosh, R.B. Verheijen, M. Gamil, J.M. Bauml, M. Baig, N.B. Leighl: Subcutaneous vs Intravenous Amivantamab: Patient Satisfaction and Resource Utilization Results from the PALOMA-3 Study. IASLC World Conference on Lung Cancer, San Diego, CA. September 2024 Notes: "Oral Presentation"
M. Alexander1, Y. Cheng, S-H. Lee, A. Passaro, A.I. Spira, B.C. Cho, S.M. Lim, Y. Ohe, A. Nagrial, J.L. Tan, V. Wainsztein, E. Ramos, M. del Rosario Garcia Campelo1, H. Akamatsu, D. Nguyen, A.B. Cortot, A. Zer, D. Erdem, R.E. Sanborn, T-O. Emde, A.R. Minchom, B. Zurawski, M.L. Ferreira, J.C-H. Yang, M.E. Marmarelis, J. Schuchard, J. Alves, D. Ghosh, R.B. Verheijen, M. Gamil, J.M. Bauml, M. Baig, N.B. Leighl: eVOLVE-Meso: A Global Phase 3 Study of First-Line Volrustomig Plus Chemotherapy in Unresectable Pleural Mesothelioma. IASLC World Conference on Lung Cancer, San Diego, CA. September 2024 Notes: "Poster Presentation"
Barsouk A, Elghawy O, Yang G, Heidlauf A, Yu C, Wang L, Goel K, Rushkin L, Huang A, Sun L, Singh A, Cohen RB, Aggarwal C, Marmarelis ME, Langer CJ. : Race may affect survival in 1L patients with metastatic non-small cell lung cancer on egfr-targeted therapy. IASLC World Conference on Lung Cancer, San Diego, CA. September 2024 Notes: "E-Poster Presentation"
Stalker M, Marmarelis ME, Langer CJ, Cohen RB, Singh A, Aggarwal C, Sun L: Survival after Salvage Treatment Following Durvalumab Consolidation in Locally Advanced Non-Small Cell Lung Cancer. IASLC World Lung Cancer Conference, San Diego, CA. September 2024 Notes: "Poster Presentation"