Melina Elpi Marmarelis, MD, MSCE
Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Attending Physician , Hospital of the University of Pennsylvania
Attending Physician , Penn Presbyterian Medical Center
Medical Director of Penn Medicine Mesothelioma and Pleural Program, University of Pennsylvania
PC3I Faculty, Penn Center for Cancer Care Innovation, University of Pennsylvania
Physician Lead -Airways Research Program, University of Pennsylvania
Department: Medicine
Contact information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
10th Floor
Philadelphia, PA 19104
3400 Civic Center Blvd
10th Floor
Philadelphia, PA 19104
Education:
BA (Bachelors in Biochemistry and Molecular Biology )
Dartmouth College, 2007.
MD (Medicine)
Harvard Medical School , 2013.
MSCE (Clinical Epidemiology )
University of Pennsylvania , 2019.
Permanent linkBA (Bachelors in Biochemistry and Molecular Biology )
Dartmouth College, 2007.
MD (Medicine)
Harvard Medical School , 2013.
MSCE (Clinical Epidemiology )
University of Pennsylvania , 2019.
Description of Clinical Expertise
Lung cancer and mesothelioma.Description of Research Expertise
Clinical trials in lung cancer in mesothelioma.Selected Publications
Pascale Tomasini, MD, MSc Yongsheng Wang, MD Yongsheng Li, MD, PhD Enriqueta Felip, MD, PhD Lin Wu, MD Jiuwei Cui, MD, PhD Benjamin Besse, MD, PhD Alexander I. Spira, MD, PhD Joel W. Neal, MD, PhD Koichi Goto, MD, PhD Christina S. Baik, MD, MPH Melina E. Marmarelis, MD Eiki Ichihara, MD, PhD Yiping Zhang, MD Jong-Seok Lee, MD, PhD Se-Hoon Lee, MD, PhD James Chih-Hsin Yang, MD, PhD Sebastian Michels, MD Zacharias Anastasiou, MS Joshua C. Curtin, PhD Xuesong Lyu, PhD Janine Mahoney, BSN, RN Levon Demirdjian, PhD Craig S. Meyer, MS, PhD, MPH Youyi Zhang, PhD Isabelle Leconte, PhD Patricia Lorenzini, MS Roland E. Knoblauch, MD, PhD Leonardo Trani, MD Mahadi Baig, MD Joshua M. Bauml, MD Byoung Chul Cho, MD, PhD: Amivantamab Plus Lazertinib in Atypical EGFR-Mutated Advanced Non–Small Cell Lung Cancer: Results From CHRYSALIS-2. Journal of Clinical Oncology December 2025.Mariam Alexander, Ying Cheng, Se-Hoon Lee, Antonio Passaro, Alexander I. Spira, Byoung Chul Cho, Sun Min Lim, Yuichiro Ohe, Adnan Nagrial, Jiunn Liang Tan, Vanina Wainsztein, Elisa Ramos, Maria del Rosario Garcia Campelo , Hiroaki Akamatsu, Danny Nguyen, Alexis B. Cortot, Alona Zer, Dilek Erdem , Rachel E. Sanborn, Till-Oliver Emde, Anna R. Minchom, Bogdan Zurawski, Maria Lurdes Ferreira, James Chih-Hsin Yang, Melina E. Marmarelis, Julia Schuchard, Jefferson Alves, Debopriya Ghosh, Gregor Balaburski, Remy B. Verheijen, Liliana Ribeiro, Mohamed Gamil, Joshua M. Bauml, Mahadi Baig, Natasha B. Leighl : Subcutaneous Versus Intravenous Amivantamab, Both in Combination With Lazertinib, in Refractory EGFR-mutated Non-small Cell Lung Cancer: Patient Satisfaction and Resource Utilization Results from the PALOMA-3 Study. European Journal of Cancer July 2025.
Lauren Reed-Guy, Melina E. Mamarelis: Immunotherapy for Resectable Non-Small Cell Lung Cancer - Not If, But When. JAMA Network Open 8(6), June 2025.
Benjamin Besse, MD, PhD, Koichi Goto, MD, PhD, Yongsheng Wang, MD, Se-Hoon Lee, MD, PhD, Melina E. Marmarelis, MD, Yuichiro Ohe, MD, PhD, Reyes Bernabe Caro, MD, Dong-Wan Kim, MD, PhD, Jong-Seok Lee, MD, PhD, Sophie Cousin, MD, MSc, Eiki Ichihara, MD, PhD, Yongsheng Li, MD, PhD, Paz-Ares Luis, MD, PhD, Akira Ono, MD, PhD, Rachel E. Sanborn, MD, Naohiro Watanabe, MD, Maria Jose de Miguel, MD, PhD, Carole Helissey, MD, Catherine A. Shu, MD, Alexander Spira, MD, PhD, Pascale Tomasini, MD, MSc, James Chih-Hsin Yang, MD, PhD, Yiping Zhang, MD, Enriqueta Felip, MD, PhD, Frank Griesinger, MD, PhD, Saima N. Waqar, MD, Antonio Calles, MD, Joel Neal, MD, PhD, Christina S. Baik, MD, Pasi A. Jänne, MD, PhD, S. Martin Shreeve, MD, PhD, Joshua C. Curtin, PhD, Bharvin Patel, PhD, Michael Gormley, PhD, Xuesong Lyu, PhD, Jun Chen, MD, MSc, Pei-Ling Chu, PhD, Janine Mahoney, BSN, RN, Leonardo Trani, MD, Joshua M. Bauml, MD, Meena Thayu, MD, MSCE, Roland E. Knoblauch, MD, PhD, Byoung Chul Cho, MD, PhD: Amivantamab Plus Lazertinib in Patients With EGFR-mutant Non-small Cell Lung Cancer (NSCLC) After Progression on Osimertinib and Platinum-based Chemotherapy: Results From CHRYSALIS-2 Cohort A. J Thorac Oncol 20(5): 651-664, May 2025.
Adam Barsouk, Omar Elghawy, Alex Watts, Lauren Reed-Guy, William Tompkins, Krishna Chandrasekhara, Connor B. Grady, Wade Iams, Fangdi Sun, Geoffrey Liu, Devalben Patel, Jorge J. Nieva, Kristen A. Marrone, Vamsidhar Velcheti , Stephen V. Liu, Tejas Patil, Jared Weiss, William Schwartzman, Liza C Villaruz, Amanda Hermann, Melina E. Marmarelis: Osimertinib vs. Afatinib in 1L therapy of atypical EGFR-mutated metastatic non-small cell lung cancer (mNSCLC): A multi-institution, real-world survival analysis. Lung Cancer 203: 108551, May 2025.
Omar Elghawy MD , Adam Barsouk MD , Jonathan H. Sussman BS , Benjamin A. Bleiberg MD , Lauren Reed-Guy MD , Christopher D’Avella MD , Aditi Singh MD, Christine Ciunci MD, MSCE , Kyle Robinson MD , John Kosteva MD , Corey Langer MD , Roger B. Cohen MD , Charu Aggarwal MD, MPH , Melina Marmarelis MD, MSCE, Lova Sun MD, MSCE : Brief Report: Late Immune-Related Adverse Events (IRAEs) After ≥2 Years of Immune Checkpoint Inhibitor (ICI) Therapy: Incidence and Association with Survival in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC). JTO Clinical and Research Reports May 2025.
Elghawy O, Barsouk A, Reed-Guy L, Stalker M, Sussman J, Robinson K, Kosteva J, Singh A, Cohen RB, Langer C, Ciunci C, D'Avella C, Sun L, Marmarelis ME, Aggarwal C: Brief Report: Osimertinib Plus Capmatinib for Patients With MET-Altered EGFR-Mutant NSCLC Following Progression on Front Line Therapy. Clin Lung Cancer 26(2): 158-163.e2, Mar 2025.
Margaret Stalker, Suzanne L. Walker, Emily Lebow, Emily Ling-Lin Pai, Alex Watts, Wei-Ting Hwang, Amir Banihashemi, Evan Anderson, Leonid Roshkovan, Sharyn I. Katz, Leslie Litzky, Andrew R. Haas, Sunil Singhal, Corey J. Langer, Keith Cengel, Melina E. Marmarelis: Incidence and outcomes of brain metastasis in pleural mesothelioma in the era of immunotherapy. JTO Clin Res Rep 6(5): 100823, March 2025.
Lova Sun, Melina E. Marmarelis, Charu Aggarwal: Oncology Grand Rounds: Management of Patients With EGFR Exon 20-Mutant Advanced Non-Small Cell Lung Cancer. J Clin Oncol 43(13): 1527-1533, March 2025.
Tejas Patila ∙ Dexiang Gaob ∙ Alexander Watsona ∙ Mandy Sakamotoa ∙ Yunan Niec ∙ Amanda Gibsond ∙ Michelle L Deand ∙ Benjamin A. Yodera ∙ Eliza Millera ∙ Margaret Stalkere ∙ Dara L. Aisnerf ∙ Paul A. Bunna ∙ Erin L. Schenka ∙ Melina E. Marmarelise ∙ Chiara Bennatig ∙ Vishal Navanid ∙ Yongchang Zhangh ∙ D. Ross Camidge: The efficacy of continuing osimertinib with platinum pemetrexed chemotherapy upon progression in patients with metastatic non-small cell lung cancer harboring sensitizing EGFR mutations. Lung Cancer 199(108040), January 2025.