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Saman Nazarian, MD, PhD
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Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
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Attending Physician, Hospital of the University of Pennsylvania
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Director of EP Cardiovascular Imaging, University of Pennsylvania Perelman School of Medicine
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Department: Medicine
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Contact information
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Hospital of the University of Pennsylvania
36 Cardiac Electrophysiology, 9 Founders Pavilion
35 3400 Spruce Street
Philadelphia, PA 19104
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36 Cardiac Electrophysiology, 9 Founders Pavilion
35 3400 Spruce Street
Philadelphia, PA 19104
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Office: 215-615-5220
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32 Fax: 215-615-5235
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Links
a6 Search PubMed for articles
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Education:
21 7 BS 33 (Biology and Chemistry, Summa Cum Laude) c
44 University of California, Davis, California, 1995.
21 7 MD 15 (Medicine) c
55 Stanford University School of Medicine, Stanford, California, 1999.
21 8 PhD 22 (Clinical Epidemiology) c
5d Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
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Permanent link21 7 BS 33 (Biology and Chemistry, Summa Cum Laude) c
44 University of California, Davis, California, 1995.
21 7 MD 15 (Medicine) c
55 Stanford University School of Medicine, Stanford, California, 1999.
21 8 PhD 22 (Clinical Epidemiology) c
5d Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
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53 • Atrial and ventricular arrhythmia substrate identification and ablation
60 • Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
2e • Prevention of sudden cardiac death
76 • Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
4a • Arrhythmia risk management in patients with neurologic disease
3c • Management of arrhythmias in cardiac sarcoidosis
43 • Management of arrhythmias in hypertrophic cardiomyopathy
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Description of Clinical Expertise
486 Dr. Nazarian is Professor of Medicine at the Hospital of the University of Pennsylvania and the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:8
53 • Atrial and ventricular arrhythmia substrate identification and ablation
60 • Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
2e • Prevention of sudden cardiac death
76 • Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
4a • Arrhythmia risk management in patients with neurologic disease
3c • Management of arrhythmias in cardiac sarcoidosis
43 • Management of arrhythmias in hypertrophic cardiomyopathy
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Description of Other Expertise
214 Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.65
Description of Research Expertise
3ac Dr. Nazarian is a clinical and translational investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. Dr. Nazarian has been and continues to serve as the principal investigator for several grants from the National Institutes of Health to characterize the substrate for malignant arrhythmia.e 29
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168 Gurin M, Litt M, Zghaib T, Peters C, Markman TM, Luebbert JJ, Riley MP, Shivamurthy P, Hyman MC, Deo R, Guandalini GS, Nazarian S, Supple GE, Frankel DS, Marchlinski FE, Schaller RD.: Left Bundle Branch Area Pacing in Patients With Cardiac Sarcoidosis. JACC Clin Electrophysiol Nov 2025.
191 Gudmundsson S, Singer-Berk M, Stenton SL, Goodrich JK, Wilson MW, Einson J, Watts NA; Genome Aggregation Database Consortium; Lappalainen T, Rehm HL, MacArthur DG, O'Donnell-Luria A.: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database. Nat Commun 16: 9623, Oct 2025.
d5 Markman TM, Marchlinski F, Nazarian S.: Direct Stellate Ganglion or Vertebral Vein Stimulation?-Reply. JAMA Cardiol 10: 1075-1076, Oct 2025.
134 Xu L, Hrybouski S, Liao TE, Dong J, Khoshknab M, Callans D, Marchlinski FE, Witschey WR, Desjardins B, Nazarian S.: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. Circulation Oct 2025.
18b Rekapalli P, Oraii A, Heintz J, Dixit S, Epstein AE, Frankel DS, Hyman M, Lin D, Markman T, Messé SR, Nazarian S, Cucchiara B, Schaller RD, See VY, Yang W, Kasner SE, Marchlinski FE, Deo R.: Detection and Significance of Nonsustained Ventricular Tachycardia in a Post-Stroke Population. JACC Clin Electrophysiol Sep 2025.
180 Tan JL, Chirinos J, Patel D, Jagasia D, Hyman MC, Guandalini GS, Nazarian S, Lin D, Supple G, Frankel DS, Callans DJ, Marchlinski FE, Ren JF, Markman TM.: Intracardiac echocardiography for left ventricular diastolic function assessment during atrial fibrillation ablation. J Interv Card Electrophysiol Aug 2025.
1eb Chaumont C, Oraii A, Rodriguez-Queralto O, Petzl A, Zado E, Hanumanthu BKJ, Markman TM, Hyman MC, Tschabrunn CM, Enriquez A, Shivamurthy P, Kumareswaran R, Riley MP, Lin D, Schaller RD, Nazarian S, Callans DJ, Supple GE, Garcia FC, Frankel DS, Dixit S, Anselme F, Marchlinski FE.: Sex-Related Differences in Non-Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation. JAMA Netw Open 8: e2529527, Aug 2025.
1f4 Enriquez A, Yogasundaram H, Neira V, Guandalini G, Markman T, Shivamurthy P, Hyman M, Hanumanthu B, Lin D, Schaller R, Supple G, Dixit S, Deo R, Nazarian S, Kumareswaran R, Riley M, Epstein AE, See V, Zado E, Callans D, Frankel D, Marchlinski F, Garcia F.: Stepwise Anatomical Approach to Ablation of Intramural Outflow Tract Ventricular Arrhythmias Guided by Septal Coronary Venous Mapping. Circulation 152: 163-171, Jul 2025.
22f Oraii A, Hanumanthu BKJ, Petzl A, Liao TW, Afzalian A, Rodriguez-Queralto O, Chaumont C, Spears J, Markman TM, Hyman MC, Tschabrunn CM, Guandalini G, Enriquez A, Shivamurthy P, Kumareswaran R, Deo R, Ferrari VA, Riley MP, Lin D, Callans DJ, Supple GE, Schaller RD, Frankel DS, Garcia FC, Nazarian S, Dixit S, Marchlinski FE.: Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes. Europace 27: euaf100, Jun 2025.
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Selected Publications
131 Feng JY, Frankel DS, Supple G, Garcia FC, Arkles JS, Nazarian S, See VY, Tung R, Zado ES, Marchlinski FE, Saenz LC, Schaller RD.: Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex. Heart Rhythm Nov 2025.168 Gurin M, Litt M, Zghaib T, Peters C, Markman TM, Luebbert JJ, Riley MP, Shivamurthy P, Hyman MC, Deo R, Guandalini GS, Nazarian S, Supple GE, Frankel DS, Marchlinski FE, Schaller RD.: Left Bundle Branch Area Pacing in Patients With Cardiac Sarcoidosis. JACC Clin Electrophysiol Nov 2025.
191 Gudmundsson S, Singer-Berk M, Stenton SL, Goodrich JK, Wilson MW, Einson J, Watts NA; Genome Aggregation Database Consortium; Lappalainen T, Rehm HL, MacArthur DG, O'Donnell-Luria A.: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database. Nat Commun 16: 9623, Oct 2025.
d5 Markman TM, Marchlinski F, Nazarian S.: Direct Stellate Ganglion or Vertebral Vein Stimulation?-Reply. JAMA Cardiol 10: 1075-1076, Oct 2025.
134 Xu L, Hrybouski S, Liao TE, Dong J, Khoshknab M, Callans D, Marchlinski FE, Witschey WR, Desjardins B, Nazarian S.: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. Circulation Oct 2025.
18b Rekapalli P, Oraii A, Heintz J, Dixit S, Epstein AE, Frankel DS, Hyman M, Lin D, Markman T, Messé SR, Nazarian S, Cucchiara B, Schaller RD, See VY, Yang W, Kasner SE, Marchlinski FE, Deo R.: Detection and Significance of Nonsustained Ventricular Tachycardia in a Post-Stroke Population. JACC Clin Electrophysiol Sep 2025.
180 Tan JL, Chirinos J, Patel D, Jagasia D, Hyman MC, Guandalini GS, Nazarian S, Lin D, Supple G, Frankel DS, Callans DJ, Marchlinski FE, Ren JF, Markman TM.: Intracardiac echocardiography for left ventricular diastolic function assessment during atrial fibrillation ablation. J Interv Card Electrophysiol Aug 2025.
1eb Chaumont C, Oraii A, Rodriguez-Queralto O, Petzl A, Zado E, Hanumanthu BKJ, Markman TM, Hyman MC, Tschabrunn CM, Enriquez A, Shivamurthy P, Kumareswaran R, Riley MP, Lin D, Schaller RD, Nazarian S, Callans DJ, Supple GE, Garcia FC, Frankel DS, Dixit S, Anselme F, Marchlinski FE.: Sex-Related Differences in Non-Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation. JAMA Netw Open 8: e2529527, Aug 2025.
1f4 Enriquez A, Yogasundaram H, Neira V, Guandalini G, Markman T, Shivamurthy P, Hyman M, Hanumanthu B, Lin D, Schaller R, Supple G, Dixit S, Deo R, Nazarian S, Kumareswaran R, Riley M, Epstein AE, See V, Zado E, Callans D, Frankel D, Marchlinski F, Garcia F.: Stepwise Anatomical Approach to Ablation of Intramural Outflow Tract Ventricular Arrhythmias Guided by Septal Coronary Venous Mapping. Circulation 152: 163-171, Jul 2025.
22f Oraii A, Hanumanthu BKJ, Petzl A, Liao TW, Afzalian A, Rodriguez-Queralto O, Chaumont C, Spears J, Markman TM, Hyman MC, Tschabrunn CM, Guandalini G, Enriquez A, Shivamurthy P, Kumareswaran R, Deo R, Ferrari VA, Riley MP, Lin D, Callans DJ, Supple GE, Schaller RD, Frankel DS, Garcia FC, Nazarian S, Dixit S, Marchlinski FE.: Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes. Europace 27: euaf100, Jun 2025.
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