Saman Nazarian, MD, PhD

faculty photo
Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania
Director of EP Cardiovascular Imaging, University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Cardiac Electrophysiology, 9 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5220
Fax: 215-615-5235
Education:
BS (Biology and Chemistry, Summa Cum Laude)
University of California, Davis, California, 1995.
MD (Medicine)
Stanford University School of Medicine, Stanford, California, 1999.
PhD (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
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Description of Clinical Expertise

Dr. Nazarian is Professor of Medicine at the Hospital of the University of Pennsylvania and the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:

• Atrial and ventricular arrhythmia substrate identification and ablation
• Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
• Prevention of sudden cardiac death
• Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
• Arrhythmia risk management in patients with neurologic disease
• Management of arrhythmias in cardiac sarcoidosis
• Management of arrhythmias in hypertrophic cardiomyopathy

Description of Other Expertise

Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.

Description of Research Expertise

Dr. Nazarian is a clinical and translational investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. Dr. Nazarian has been and continues to serve as the principal investigator for several grants from the National Institutes of Health to characterize the substrate for malignant arrhythmia.

Selected Publications

Toloubidokhti M, Gharbia OA, Parkosa A, Trayanova N, Hadjis A, Tung R, Nazarian S, Sapp JL, Wang L.: Understanding the Utility of Endocardial Electrocardiographic Imaging in Epi-Endocardial Mapping of 3D Reentrant Circuits. medRxiv Nov 2024.

Liao TE, Xu L, Khoshknab MP, Peters CJ, Callans DJ, Marchlinski FE, Schaller RD, Frankel DS, Luebbert JJ, Guandalini GS, Nazarian S.: Techniques and outcomes of atrial fibrillation ablation in patients with persistent left superior vena cava. J Cardiovasc Electrophysiol Nov 2024.

Yogasundaram H, Petzl AM, Raad M, Chaumont C, Guandalini GS, Kumareswaran R, Hyman MC, Schaller RD, Supple GE, Garcia FC, Nazarian S, Lin D, Riley MP, Dixit S, Callans DJ, Marchlinski FE, Frankel DS.: Combined catheter ablation of atrial fibrillation and premature ventricular complexes. Heart Rhythm Oct 2024.

Khoshknab M, Zghaib T, Xu L, Markman T, Mavroudis C, Desjardins B, Nazarian S.: Noninvasive Visualization of the Atrioventricular Conduction System Using Cardiac Computed Tomography. JAMA Cardiol 9: 909-913, Oct 2024.

Markman TM, Xu L, Zahid S, Patel D, Marchlinski FE, Callans D, Nazarian S.: Augmentation of Atrial Conduction Velocity With Pharmacological and Direct Electrical Sympathetic Stimulation. JACC Clin Electrophysiol Sep 2024.

Yogasundaram H, Papireddy MR, Nazarian S, Guandalini GS, Markman TM, Schaller RD, Riley MP, Lin D, Dixit S, D'Souza B, Kumareswaran R, Callans DJ, Frankel DS, Garcia FC, Zado E, Deo R, Epstein AE, Supple GE, Marchlinski FE, Hyman MC.: Long-term risk of right coronary artery injury after catheter ablation of cavotricuspid isthmus-dependent flutter. Heart Rhythm Sep 2024.

Markman TM, Lin D, Nazarian S, van Niekerk CJ, Mirwais M, Garg L, Bode W, Smietana J, Sugrue A, Patel NA, Patel D, Ha B, Hyman MC, Riley M, Callans DJ, Deo R, Yang R, Schaller RD, Kumareswaran R, Guandalini GS, Epstein AE, Marchlinski FE, Frankel DS.: Intraoperative pectoral nerve blocks during cardiac implantable electronic device procedures. Heart Rhythm Aug 2024.

Wasiak M, DePietro D, Chaumont C, Oraii A, Schaller R, Supple G, Nazarian S, Garcia F, Trerotola S, Soulen MC, Marchlinski FE, Frankel DS.: Transhepatic approach for catheter ablation of atrial fibrillation in patients with interrupted inferior vena cava. Heart Rhythm Aug 2024.

Alderete J, Fernández-Armenta J, Zucchelli G, Sommer P, Nazarian S, Falasconi G, Soto-Iglesias D, Silva E, Mazzocchetti L, Bergau L, Khoshknab M, Penela D, Berruezo A.: The Ablate-by-LAWT multicentre prospective study: Personalized paroxysmal atrial fibrillation ablation with ablation index adapted to local left atrial wall thickness. J Interv Card Electrophysiol Jul 2024.

Keane S, Patel D, Otto B, Englander L, Kumareswaran R, Lin D, Riley MP, Nazarian S, Marchlinski FE, Markman TM.: Incidental ablation of ganglionated plexus during atrial fibrillation ablation. J Interv Card Electrophysiol Jul 2024.

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Last updated: 12/18/2024
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