Saman Nazarian, MD, PhD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Cardiac Electrophysiology, 9 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5220
Fax: 215-615-5235
BS (Biology and Chemistry, Summa Cum Laude)
University of California, Davis, California, 1995.
MD (Medicine)
Stanford University School of Medicine, Stanford, California, 1999.
PhD (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
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Description of Clinical Expertise

Dr. Nazarian is an Associate Professor in the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:

• Atrial and ventricular arrhythmia substrate identification and ablation
• Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
• Prevention of sudden cardiac death
• Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
• Arrhythmia risk management in patients with neurologic disease
• Management of arrhythmias in cardiac sarcoidosis
• Management of arrhythmias in hypertrophic cardiomyopathy

Description of Other Expertise

Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.

Description of Research Expertise

Dr. Nazarian is an active investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. Dr. Nazarian has been and continues to serve as the principal investigator for several grants from the National Institutes of Health to characterize the substrate for malignant arrhythmia.

Selected Publications

Habibi M, Lima JAC, Gucuk Ipek E, Spragg D, Ashikaga H, Marine JE, Berger RD, Calkins H, Nazarian S.: Short- and long-term associations of atrial fibrillation catheter ablation with left atrial structure and function: A cardiac magnetic resonance study. J Cardiovasc Electrophysiol 32: 316-324, Feb 2021.

Kuo L, Muser D, Shirai Y, Lin A, Liang J, Schaller RD, Hyman M, Kumareswaran R, Arkles J, Supple GE, Frankel DS, Garcia F, Tschabrunn C, Nazarian S, Dixit S, Lin D, Riley MP, Callans DJ, Deo R, Epstein A, Zado ES, Marchlinski FE, Santangeli P.: Periprocedural Acute Kidney Injury in Patients With Structural Heart Disease Undergoing Catheter Ablation of VT. JACC Clin Electrophysiol 7: 174-186, Feb 2021.

Pothineni NVK, Amankwah N, Santangeli P, Schaller RD, Supple GE, Deo R, Nazarian S, Garcia FC, Dixit S, Callans DJ, Marchlinski FE, Frankel DS.: Continuous rhythm monitoring-guided anticoagulation after atrial fibrillation ablation. J Cardiovasc Electrophysiol 32: 345-353, Feb 2021.

Siripanthong B, Hanff TC, Levin MG, Vidula MK, Khanji MY, Nazarian S, Chahal CAA.: Coronavirus disease 2019 is delaying the diagnosis and management of chest pain, acute coronary syndromes, myocarditis and heart failure. Future Cardiol 17: 3-6, Jan 2021.

Johansen MC, Doria de Vasconcellos H, Nazarian S, Lima JAC, Gottesman RF.: The Investigation of Left Atrial Structure and Stroke Etiology: The I-LASER Study. J Am Heart Assoc 10: e018766, Jan 2021.

Kuo L, Frankel DS, Lin A, Arkles J, Hyman M, Santangeli P, Marchlinski FE, Nazarian S.: PRECAF Randomized Controlled Trial. Circ Arrhythm Electrophysiol 14: e008993, Jan 2021.

Mariani MV, Pothineni NVK, Arkles J, Deo R, Frankel D, Supple G, Garcia F, Lin D, Hyman MC, Kumareswaran R, Riley M, Nazarian S, Schaller RD, Epstein AE, Bermudez C, Dixit S, Callans D, Marchlinski FE, Santangeli P.: Catheter ablation of atrial arrhythmias following lung transplant: Electrophysiological findings and outcomes. J Cardiovasc Electrophysiol 32: 49-57, Jan 2021.

Muser D, Nucifora G, Castro SA, Enriquez A, Chahal CAA, Magnani S, Kumareswaran R, Arkles J, Supple G, Schaller R, Hyman M, Dixit S, Lin D, Zado ES, Tschabrunn C, Callans DJ, Nazarian S, Frankel DS, Marchlinski FE, Santangeli P.: Myocardial Substrate Characterization by CMR T(1) Mapping in Patients With NICM and No LGE Undergoing Catheter Ablation of VT. JACC Clin Electrophysiol ACC Clin Electrophysiol, 2021.

Schaller RD, Brunker T, Riley MP, Marchlinski FE, Nazarian S, Litt H.: Magnetic Resonance Imaging in Patients With Cardiac Implantable Electronic Devices With Abandoned Leads. JAMA Cardiol AMA Cardiol, 2021.

Bhatla A, Borovskiy Y, Katz R, Hyman MC, Patel PJ, Arkles J, Callans DJ, Chokshi N, Dixit S, Epstein AE, Frankel DS, Garcia FC, Kumareswaran R, Liang JJ, Lin D, Messé SR, Nazarian S, Riley MP, Santangeli P, Schaller RD, Supple GE, Kasner SE, Marchlinski F, Deo R.: Stroke, Timing of Atrial Fibrillation Diagnosis, and Risk of Death. Neurology eurology, 2021.

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Last updated: 04/16/2021
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