Saman Nazarian, MD, PhD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Cardiac Electrophysiology, 9 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5220
Fax: 215-615-5235
BS (Biology and Chemistry, Summa Cum Laude)
University of California, Davis, California, 1995.
MD (Medicine)
Stanford University School of Medicine, Stanford, California, 1999.
PhD (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
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Description of Clinical Expertise

Dr. Nazarian is an Associate Professor in the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:

• Atrial and ventricular arrhythmia substrate identification and ablation
• Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
• Prevention of sudden cardiac death
• Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
• Arrhythmia risk management in patients with neurologic disease
• Management of arrhythmias in cardiac sarcoidosis
• Management of arrhythmias in hypertrophic cardiomyopathy

Description of Other Expertise

Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.

Description of Research Expertise

Dr. Nazarian is an active investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. Dr. Nazarian has been and continues to serve as the principal investigator for several grants from the National Institutes of Health to characterize the substrate for malignant arrhythmia.

Selected Publications

Markman Timothy M, Hyman Matthew C, Kumareswaran Ramanan, Arkles Jeffrey S, Santangeli Pasquale, Schaller Robert D, Supple Gregory E, Frankel David S, Riley Michael P, Lin David, Garcia Fermin, Dixit Sanjay, Callans David J, Marchlinski Francis E, Nazarian Saman: Durability of posterior wall isolation after catheter ablation among patients with recurrent atrial fibrillation. Heart rhythm May 2020.

Markman Timothy M, Hamilton Roy H, Marchlinski Francis E, Nazarian Saman: Case Series of Transcutaneous Magnetic Stimulation for Ventricular Tachycardia Storm. JAMA May 5 2020 Notes: [Epub ahead of print] doi: 10.1001/jama.2020.3833.

Siripanthong Bhurint, Nazarian Saman, Muser Daniele, Deo Rajat, Santangeli Pasquale, Khanji Mohammed Y, Cooper Leslie T, Chahal C Anwar A: Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management. Heart rhythm S1547-5271(20): 30422-7, May 5 2020.

Markman Timothy M, Nazarian Saman: Moving Toward Improved Risk Stratification in Patients With Dilated Cardiomyopathy. Circulation. Cardiovascular imaging 13(4): e010629, Apr 2020.

Liang Jackson J, Frankel David S, Pieretti Janice, Deshpande Charuhas, Nazarian Saman: Diagnosis of cardiac amyloidosis in patients undergoing catheter ablation for atrial arrhythmias. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 57(3): 489-490, Apr 2020.

Rahsepar Amir Ali, Zimmerman Stefan L, Hansford Rozann, Guttman Michael A, Castro Valeria, McVeigh Diana, Kirsch John E, Halperin Henry R, Nazarian Saman: The Relationship between MRI Radiofrequency Energy and Function of Nonconditional Implanted Cardiac Devices: A Prospective Evaluation. Radiology 295(2): 191132, Mar 2020.

Tanawuttiwat Tanyanan, Lande Jeff, Smeets Pascal, Gerritse Bart, Nazarian Saman, Guallar Eliseo, Cheng Alan: Atrial fibrillation burden and subsequent heart failure events in patients with cardiac resynchronization therapy devices. Journal of cardiovascular electrophysiology Mar 12 2020 Notes: [Epub ahead of print] doi: 10.1111/jce.14444.

Markman Timothy M, Geng Zhi, Epstein Andrew E, Nazarian Saman, Deo Rajat, Marchlinski Francis E, Groeneveld Peter W, Frankel David S: Trends in Antiarrhythmic Drug Use Among Patients in the United States Between 2004 and 2016. Circulation 141(11): 937-939, Mar 2020.

Ustunkaya Tuna, Liang Jackson J, Lin Aung N, Shirai Yasuhiro, Molina Maria, Owens Anjali T, Acker Michael A, Bermudez Christian A, Santangeli Pasquale, Nazarian Saman, Dixit Sanjay, Marchlinski Francis E, Callans David J: Clinical and Procedural Characteristics Predicting Need for Chronotropic Support and Permanent Pacing Post-Heart Transplantation. Heart rhythm S1547-5271(20): 30172-7, Feb 27 2020.

McNally Elizabeth M, Mann Douglas L, Pinto Yigal, Bhakta Deepak, Tomaselli Gordon, Nazarian Saman, Groh William J, Tamura Takuhisa, Duboc Denis, Itoh Hideki, Hellerstein Leah, Mammen Pradeep P A: Clinical Care Recommendations for Cardiologists Treating Adults With Myotonic Dystrophy. Journal of the American Heart Association 9(4): e014006, Feb 2020.

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Last updated: 01/20/2021
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