Saman Nazarian, MD, PhD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Cardiac Electrophysiology, 9 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5220
Fax: 215-615-5235
BS (Biology and Chemistry, Summa Cum Laude)
University of California, Davis, California, 1995.
MD (Medicine)
Stanford University School of Medicine, Stanford, California, 1999.
PhD (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
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Description of Clinical Expertise

Dr. Nazarian is an Associate Professor in the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:

• Atrial and ventricular arrhythmia substrate identification and ablation
• Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
• Prevention of sudden cardiac death
• Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
• Arrhythmia risk management in patients with neurologic disease
• Management of arrhythmias in cardiac sarcoidosis
• Management of arrhythmias in hypertrophic cardiomyopathy

Description of Other Expertise

Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.

Description of Research Expertise

Dr. Nazarian is an active investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. In 2013, he was awarded a $1 million grant from the National Institutes of Health to characterize the substrate for malignant arrhythmia.

Selected Publications

Markman Timothy M, Ruble Kathryn, Loeb David, Chen Allen, Zhang Yiyi, Beasley Gary S, Thompson W Reid, Nazarian Saman: Electrophysiological effects of anthracyclines in adult survivors of pediatric malignancy. Pediatric blood & cancer 64(11), Nov 2017.

Enriquez Andres, Pathak Rajeev K, Santangeli Pasquale, Liang Jackson J, Al Rawahi Mohammed, Hayashi Tatsuya, Muser Daniele, Frankel David S, Supple Gregory, Schaller Robert, Lin David, Nazarian Saman, Zado Erica, Marchlinski Francis E, Garcia Fermin C: Inferior lead discordance in ventricular arrhythmias: A specific marker for certain arrhythmia locations. Journal of cardiovascular electrophysiology 28(10): 1179-1186, Oct 2017.

Nazarian Saman, Zghaib Tarek: Is Atrial Fibrillation a Necessary Component of the Thrombogenic Atrium? Journal of the American College of Cardiology 70(11): 1322-1324, Sep 2017.

O'Neal Wesley T, Nazarian Saman, Alonso Alvaro, Heckbert Susan R, Vaccarino Viola, Soliman Elsayed Z: Sex hormones and the risk of atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA). Endocrine Aug 2017.

Indik Julia H, Gimbel J Rod, Abe Haruhiko, Alkmim-Teixeira Ricardo, Birgersdotter-Green Ulrika, Clarke Geoffrey D, Dickfeld Timm-Michael L, Froelich Jerry W, Grant Jonathan, Hayes David L, Heidbuchel Hein, Idriss Salim F, Kanal Emanuel, Lampert Rachel, Machado Christian E, Mandrola John M, Nazarian Saman, Patton Kristen K, Rozner Marc A, Russo Robert J, Shen Win-Kuang, Shinbane Jerold S, Teo Wee Siong, Uribe William, Verma Atul, Wilkoff Bruce L, Woodard Pamela K: 2017 HRS expert consensus statement on magnetic resonance imaging and radiation exposure in patients with cardiovascular implantable electronic devices. Heart rhythm 14(7): e97-e153, Jul 2017.

Gleason Kelly T, Nazarian Saman, Dennison Himmelfarb Cheryl R: Atrial Fibrillation Symptoms and Sex, Race, and Psychological Distress: A Literature Review. The Journal of cardiovascular nursing Jun 2017.

Balouch Muhammad, Gucuk Ipek Esra, Chrispin Jonathan, Bajwa Rizma J, Zghaib Tarek, Berger Ronald D, Ashikaga Hiroshi, Nazarian Saman, Marine Joseph E, Calkins Hugh, Spragg David D: Impact of rotor temperospatial stability on acute and one-year atrial fibrillation ablation outcomes. Clinical cardiology 40(6): 383-389, Jun 2017.

Markman Timothy M, Nazarian Saman: Risk Stratification for Sudden Cardiac Death: Is It Too Late to Establish a Role for Cardiac MRI? Circulation 135(22): 2116-2118, May 2017.

Markman Timothy M, Nazarian Saman: Anticoagulation for atrial fibrillation in dialysis patients: What is known and what does the future hold? Heart rhythm 14(5): 652-653, May 2017.

O'Neal Wesley T, Efird Jimmy T, Nazarian Saman, Alonso Alvaro, Michos Erin D, Szklo Moses, Heckbert Susan R, Soliman Elsayed Z: Mitral annular calcification progression and the risk of atrial fibrillation: results from MESA. European heart journal cardiovascular Imaging Apr 2017.

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Last updated: 11/05/2018
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