Saman Nazarian, MD, PhD

faculty photo
Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania
Director of EP Cardiovascular Imaging, University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Cardiac Electrophysiology, 9 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5220
Fax: 215-615-5235
Education:
BS (Biology and Chemistry, Summa Cum Laude)
University of California, Davis, California, 1995.
MD (Medicine)
Stanford University School of Medicine, Stanford, California, 1999.
PhD (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Dr. Nazarian is Professor of Medicine at the Hospital of the University of Pennsylvania and the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:

• Atrial and ventricular arrhythmia substrate identification and ablation
• Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
• Prevention of sudden cardiac death
• Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
• Arrhythmia risk management in patients with neurologic disease
• Management of arrhythmias in cardiac sarcoidosis
• Management of arrhythmias in hypertrophic cardiomyopathy

Description of Other Expertise

Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.

Description of Research Expertise

Dr. Nazarian is a clinical and translational investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. Dr. Nazarian has been and continues to serve as the principal investigator for several grants from the National Institutes of Health to characterize the substrate for malignant arrhythmia.

Selected Publications

Kim D, Collins JD, White JA, Hanneman K, Lee DC, Patel AR, Hu P, Litt H, Weinsaft JW, Davids R, Mukai K, Ng MY, Luetkens JA, Roguin A, Rochitte CE, Woodard PK, Manisty C, Zareba KM, Mont L, Bogun F, Ennis DB, Nazarian S, Webster G, Stojanovska J.: SCMR expert consensus statement for cardiovascular magnetic resonance of patients with a cardiac implantable electronic device. J Cardiovasc Magn Reson 26: 100995, Jan 2024.

Zghaib T, Nazarian S.: Synopsis of JBS recommendations for magnetic resonance imaging in patients with cardiac implantable electronic devices. Heart 110: 225-227, Jan 2024.

Thind M, Oraii A, Chaumont C, Arceluz MR, Sekigawa M, Yogasundaram H, Sugrue A, Mirwais M, AlSalem AB, Zado ES, Guandalini GS, Markman TM, Deo R, Schaller RD, Dixit S, Epstein AE, Supple GE, Tschabrunn CM, Santangeli P, Callans DJ, Hyman MC, Nazarian S, Frankel DS, Marchlinski FE.: Predictors of Non-Pulmonary Vein Triggers for Atrial Fibrillation: A Clinical Risk Score. Heart Rhythm Jan 2024.

Chen S, Francioli LC, Goodrich JK, Collins RL, Kanai M, Wang Q, Alföldi J, Watts NA, Vittal C, Gauthier LD, Poterba T, Wilson MW, Tarasova Y, Phu W, Grant R, Yohannes MT, Koenig Z, Farjoun Y, Banks E, Donnelly S, Gabriel S, Gupta N, Ferriera S, Tolonen C, Novod S, Bergelson L, Roazen D, Ruano-Rubio V, Covarrubias M, Llanwarne C, Petrillo N, Wade G, Jeandet T, Munshi R, Tibbetts K; Genome Aggregation Database Consortium; O'Donnell-Luria A, Solomonson M, Seed C, Martin AR, Talkowski ME, Rehm HL, Daly MJ, Tiao G, Neale BM, MacArthur DG, Karczewski KJ.: Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes. Nature 2024.

Schaller RD, Hyman M, Supple GE, Santangeli P, Riley MP, Nazarian S, Arkles J, Garcia F, Lin D, Guandalini G, Kumareswaran R, Deo R, Bode W, Markman T, Epstein A, Callans DJ, Dixit S, Brozoski J, Marchlinski FE, Frankel DS.: Defibrillation testing of the subcutaneous implantable cardioverter-defibrillator at the time of generator replacement. Heart Rhythm 2024.

Guo MH, Francioli LC, Stenton SL, Goodrich JK, Watts NA, Singer-Berk M, Groopman E, Darnowsky PW, Solomonson M, Baxter S; gnomAD Project Consortium; Tiao G, Neale BM, Hirschhorn JN, Rehm HL, Daly MJ, O'Donnell-Luria A, Karczewski KJ, MacArthur DG, Samocha KE.: Inferring compound heterozygosity from large-scale exome sequencing data. Nat Genet 2024.

Chen S, Francioli LC, Goodrich JK, Collins RL, Kanai M, Wang Q, Alföldi J, Watts NA, Vittal C, Gauthier LD, Poterba T, Wilson MW, Tarasova Y, Phu W, Grant R, Yohannes MT, Koenig Z, Farjoun Y, Banks E, Donnelly S, Gabriel S, Gupta N, Ferriera S, Tolonen C, Novod S, Bergelson L, Roazen D, Ruano-Rubio V, Covarrubias M, Llanwarne C, Petrillo N, Wade G, Jeandet T, Munshi R, Tibbetts K; Genome Aggregation Database Consortium; O'Donnell-Luria A, Solomonson M, Seed C, Martin AR, Talkowski ME, Rehm HL, Daly MJ, Tiao G, Neale BM, MacArthur DG, Karczewski KJ.: A genomic mutational constraint map using variation in 76,156 human genomes. Nature 2024.

Arkles J, Markman T, Trevillian R, Yegya-Raman N, Garg L, Nazarian S, Santangeli P, Garcia F, Callans D, Frankel DS, Supple G, Lin D, Riley M, Kumaraeswaran R, Marchlinski F, Schaller R, Desjardins B, Chen H, Apinorasethkul O, Alonso-Basanta M, Diffenderfer E, Kim MM, Feigenberg S, Zou W, Marcel J, Cengel KA.: One-year outcomes after stereotactic body radiotherapy for refractory ventricular tachycardia. Heart Rhythm 2024.

Pothineni NVK, Batnyam U, Schwennesen H, Tierney A, Messé SR, Cucchiara B, Mendelson TB, Luebbert JJ, Yang W, Kumareswaran R, Hyman MC, Lin D, Dixit S, Epstein AE, Arkles JS, Nazarian S, Schaller RD, Supple GE, Callans D, Yaeger A, Frankel DS, Santangeli P, Kasner SE, Marchlinski FE, Deo R.: Evaluation of organized atrial arrhythmias after cryptogenic stroke. Heart Rhythm O2 5: 34-40, Dec 2023.

Patel NA, Lin D, Ha B, Hyman MC, Nazarian S, Frankel DS, Epstein AE, Marchlinski FE, Markman TM.: Intraoperative ultrasound-guided pectoral nerve blocks for cardiac implantable device procedures. J Interv Card Electrophysiol Dec 2023.

back to top
Last updated: 02/22/2024
The Trustees of the University of Pennsylvania