Saman Nazarian, MD, PhD

faculty photo
Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania
Director of EP Cardiovascular Imaging, University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Cardiac Electrophysiology, 9 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5220
Fax: 215-615-5235
BS (Biology and Chemistry, Summa Cum Laude)
University of California, Davis, California, 1995.
MD (Medicine)
Stanford University School of Medicine, Stanford, California, 1999.
PhD (Clinical Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 2012.
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Description of Clinical Expertise

Dr. Nazarian is Professor of Medicine at the Hospital of the University of Pennsylvania and the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian earned his M.D. degree from the Stanford University School of Medicine. He completed his internship and residency training in Internal Medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiovascular Medicine and Clinical Cardiac Electrophysiology at the Johns Hopkins University School of Medicine. Following completion of his training he joined the Electrophysiology Faculty at the Johns Hopkins Hospital. At Johns Hopkins he developed a busy clinical practice as well as an active portfolio of National Institutes of Health funded research. He was promoted to Associate Professor of Medicine and Director of the Ventricular Arrhythmia Ablation service by 2014. In 2016, Dr. Nazarian joined the Electrophysiology Faculty at the Hospital of the University of Pennsylvania where he will continue to focus on his clinical interests including:

• Atrial and ventricular arrhythmia substrate identification and ablation
• Optimal catheter ablation strategies for longstanding persistent atrial fibrillation
• Prevention of sudden cardiac death
• Implantation and management of permanent pacemakers, defibrillators, and cardiac resynchronization systems
• Arrhythmia risk management in patients with neurologic disease
• Management of arrhythmias in cardiac sarcoidosis
• Management of arrhythmias in hypertrophic cardiomyopathy

Description of Other Expertise

Dr. Nazarian served as a mentor to medical students, residents, and post-doctoral fellows at the Johns Hopkins University School of Medicine during the first 9 years of his career and will replicate this interaction at the University of Pennsylvania Perelman School of Medicine. He is an appointed member of the Heart Rhythm Journal Editorial Board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.

Description of Research Expertise

Dr. Nazarian is an active investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. In addition to his medical expertise, Dr. Nazarian has a Ph.D. degree in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health. He has published extensively on the anatomy of the ventricular arrhythmia substrate. In his arrhythmia imaging laboratory, he oversees a team of individuals dedicated to facilitating atrial and ventricular arrhythmia research and clinical care within an academic medical center environment. Dr. Nazarian has been and continues to serve as the principal investigator for several grants from the National Institutes of Health to characterize the substrate for malignant arrhythmia.

Selected Publications

Markman TM, Khoshknab M, Santangeli P, Marchlinski FE, Nazarian S.: Feasibility of Computed Tomography-Guided Cardioneuroablation for Atrial Fibrillation. JACC Clin Electrophysiol Jul 2022.

Turkbey EB, Backlund JC, Gai N, Nacif M, van der Geest RJ, Lachin JM, Armstrong A, Volpe GJ, Nazarian S, Lima JAC, Bluemke DA; DCCT/EDIC Research Group.: Left Ventricular Structure, Tissue Composition, and Aortic Distensibility in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications. Am J Cardiol 174: 158-165, Jul 2022.

Amankwah NA, Pothineni NVK, Guandalini G, Santangeli P, Schaller R, Supple GE, Deo R, Nazarian S, Lin D, Epstein AE, Dixit S, Callans DJ, Marchlinski FE, Frankel DS.: Impact of atrial fibrillation recurrences during the blanking period following catheter ablation on long-term arrhythmia-free survival: a prospective study with continuous monitoring. J Interv Card Electrophysiol Jul 2022.

Khoshknab M, Zghaib T, Xu L, Arkles J, Santangeli P, Marchlinski FE, Han Y, Desjardins B, Nazarian S.: Esophageal image segmentation for guidance of posterior wall lesions during atrial fibrillation ablation. J Interv Card Electrophysiol Jul 2022.

Marrouche NF, Wazni O, McGann C, Greene T, Dean JM, Dagher L, Kholmovski E, Mansour M, Marchlinski F, Wilber D, Hindricks G, Mahnkopf C, Wells D, Jais P, Sanders P, Brachmann J, Bax JJ, Morrison-de Boer L, Deneke T, Calkins H, Sohns C, Akoum N; DECAAF II Investigators.: Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial. JAMA 327: 2296-2305, Jun 2022.

Groh WJ, Bhakta D, Tomaselli GF, Aleong RG, Teixeira RA, Amato A, Asirvatham SJ, Cha YM, Corrado D, Duboc D, Goldberger ZD, Horie M, Hornyak JE, Jefferies JL, Kääb S, Kalman JM, Kertesz NJ, Lakdawala NK, Lambiase PD, Lubitz SA, McMillan HJ, McNally EM, Milone M, Namboodiri N, Nazarian S, Patton KK, Russo V, Sacher F, Santangeli P, Shen WK, Sobral Filho DC, Stambler BS, Stöllberger C, Wahbi K, Wehrens XHT, Weiner MM, Wheeler MT, Zeppenfeld K.: 2022 HRS expert consensus statement on evaluation and management of arrhythmic risk in neuromuscular disorders. Heart Rhythm Apr 2022.

Markman TM, Pothineni NVK, Zghaib T, Smietana J, McBride D, Amankwah NA, Linn KA, Kumareswaran R, Hyman M, Arkles J, Santangeli P, Schaller RD, Supple GE, Frankel DS, Deo R, Lin D, Riley MP, Epstein AE, Callans DJ, Marchlinski FE, Hamilton R, Nazarian S.: Effect of Transcutaneous Magnetic Stimulation in Patients With Ventricular Tachycardia Storm: A Randomized Clinical Trial. JAMA Cardiol 7: 445-449, Apr 2022.

Walsh KA, Daw JM, Lin A, Guandalini G, Hyman MC, Kumareswaran R, Arkles JS, Schaller RD, Supple GE, Frankel DS, Nazarian S, Riley MP, Garcia F, Lin D, Tschabrunn C, Dixit S, Epstein AE, Callans DJ, Marchlinski FE, Santangeli P.: Characterization of the right ventricular substrate participating in postinfarction ventricular tachycardia. Heart Rhythm Mar 2022.

Daw JM, Chahal CAA, Arkles JS, Callans DJ, Dixit S, Epstein AE, Frankel DS, Garcia FC, Hyman MC, Kumareswaran R, Lin D, Nazarian S, Riley MP, Santangeli P, Schaller RD, Supple GE, Tschabrunn C, Marchlinski FE, Deo R.: Longitudinal electrocardiographic assessment in Brugada syndrome. Heart Rhythm O2 3: 233-240, Feb 2022.

Zghaib T, Markman TM, Nazarian S.: All That Glitters Is Not Scar. Circ Arrhythm Electrophysiol 2022.

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Last updated: 09/18/2022
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