Selected Publications

Gorgodze N, Matsuura TR, Nisini N, Berretta R, Recchia A, Werlen A, Wang T, Houser S, Kelly DP, Recchia FA: The Medium Chain Fatty Acid Octanoate is a Beneficial Fuel for the Failing Heart. Am J Phsiol Heart Circ Physiol 330(6): H1785-1790, June 2026.

Uchida K, Scarborough EA, Pruzinsky E, Stone KR, Hartman H, Kelly DP, Edwards JJ, Kehat I, Prosser BL: mTORC1 and nucler ERK spatially control translation in cardiomyocytes through 4EBP1 phosphorylation. Science Signaling 19(934), April 2026.

Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. Scientific Reports 15(1), Jan 2025.

Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sakamoto T, Leone TC, Khurana T, Kelly DP: A Role for the Transcriptional Coregulator RIP140 in the Control of Muscle Endurance Fitness. JCI Insight 2025.

Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP: Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice. CircRes August 2024.

Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoi DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP: RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. J Clin Invest 133(9): e162309, May 2023.

Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP: The nuclear receptor ERRgamma cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte differentiation. Nat Commun 13(1): 1991, April 2022.

Tomoya Sakamoto , Timothy R Matsuura , Shibiao Wan , David M Ryba , Junil Kim , Kyoung-Jae Won , Ling Lai , Christopher Petucci , Nataliya Petrenko , Kiran Musunuru , Rick B Vega , and Daniel P Kelly: A Critical Role for Estrogen-related Receptor Signaling in Cardiac Maturation. Circulation Research Jun 2020.

Aubert Gregory, Martin Ola J, Horton Julie L, Lai Ling, Vega Rick B, Leone Teresa C, Koves Timothy, Gardell Stephen J, Krüger Marcus, Hoppel Charles L, Lewandowski E Douglas, Crawford Peter A, Muoio Deborah M, Kelly Daniel P: The Failing Heart Relies on Ketone Bodies as a Fuel. Circulation 133(8): 698-705, Feb 2016.

Gan Zhenji, Rumsey John, Hazen Bethany C, Lai Ling, Leone Teresa C, Vega Rick B, Xie Hui, Conley Kevin E, Auwerx Johan, Smith Steven R, Olson Eric N, Kralli Anastasia, Kelly Daniel P: Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. The Journal of clinical investigation 123(6): 2564-75, Jun 2013.

Lai Ling, Leone Teresa C, Zechner Christoph, Schaeffer Paul J, Kelly Sean M, Flanagan Daniel P, Medeiros Denis M, Kovacs Attila, Kelly Daniel P: Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes & development 22(14): 1948-61, Jul 2008.

Huss Janice M, Imahashi Ken-ichi, Dufour Catherine R, Weinheimer Carla J, Courtois Michael, Kovacs Atilla, Giguère Vincent, Murphy Elizabeth, Kelly Daniel P: The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell metabolism 6(1): 25-37, Jul 2007.

Finck Brian N, Bernal-Mizrachi Carlos, Han Dong Ho, Coleman Trey, Sambandam Nandakumar, LaRiviere Lori L, Holloszy John O, Semenkovich Clay F, Kelly Daniel P: A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell metabolism 1(2): 133-44, Feb 2005.

Finck Brian N, Han Xianlin, Courtois Michael, Aimond Franck, Nerbonne Jeanne M, Kovacs Attila, Gross Richard W, Kelly Daniel P: A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proceedings of the National Academy of Sciences of the United States of America 100(3): 1226-31, Feb 2003.

Finck Brian N, Lehman John J, Leone Teresa C, Welch Michael J, Bennett Michael J, Kovacs Attila, Han Xianlin, Gross Richard W, Kozak Ray, Lopaschuk Gary D, Kelly Daniel P: The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. The Journal of clinical investigation 109(1): 121-30, Jan 2002.

Lehman J J, Barger P M, Kovacs A, Saffitz J E, Medeiros D M, Kelly D P: Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. The Journal of clinical investigation 106(7): 847-56, Oct 2000.

Sack M N, Rader T A, Park S, Bastin J, McCune S A, Kelly D P: Fatty acid oxidation enzyme gene expression is down regulated in the failing heart. Circulation 94(11): 2837-42, Dec 1996.