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Daniel P Kelly, MD
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Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
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Director, Cardiovascular Institute
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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3400 Civic Center Blvd.
31 Smilow Center for Translational Research
29 11-122
Philadelphia, PA 19104
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31 Smilow Center for Translational Research
29 11-122
Philadelphia, PA 19104
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Office: 215-898-0768
3e Lab: 215-898-2374
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3e Lab: 215-898-2374
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Education:
21 a B.S. 14 (Biology) c
2f University of Illinois, 1978.
21 a M.D. 16 (Medicine ) c
56 University of Illinois College of Medicine, Chicago, Illinois, 1982.
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Permanent link21 a B.S. 14 (Biology) c
2f University of Illinois, 1978.
21 a M.D. 16 (Medicine ) c
56 University of Illinois College of Medicine, Chicago, Illinois, 1982.
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1e2 Selvaraj S, He M, Thompson EJ, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Kwee LC, Taylor L, Milosovic S, Hurdle M, Cade WT, Ilkayeva O, Muehlbauer MJ, Newgard CB, Kelly DP, Zamani P, Margulies KB; Shah SH: Metabolic and pharmacokinetic profiling of an exogenous ketone ester by background SGLT2 inhibitor therapy in heart failure with reduced ejection: A Phase I clinical trial. JACC: BTS March 2025.
1e2 164. Selvaraj S, Karaj A, Chirinos J, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner S, Cohen J, Ischiropoulos H, Rickels M, Poole D, Church D, Wolfe R, Kelly DP, Putt M, Margulies K, Zamani P: Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail March 2025.
1ae Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. Scientific Reports 15(1), Jan 2025.
113 Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sakamoto T, Leone TC, Khurana T, Kelly DP: A Role for the Transcriptional Coregulator RIP140 in the Control of Muscle Endurance Fitness. JCI Insight 2025.
1ab Doan KV, Gaspar RB, Lee WD, Oschmann AM, Ts’olo TT, Frederick DW, Velِázquez Aponte RA, Adzika GK, McGaunn JP, Bye N, Mukherjee S, Davis JG, Holman CD, Chu Q, Garcia A, Ranamurthy R, Cheng L, Migaud ME, Rabinowitz JD, Kelly DP, Baur JA: Low cardiac NAD+ causes hypertrophy through a ketone-sensitive beta-adrenergic signaling pathway. Submitted 2025.
116 Gorgodze N, Matsuura TR, Nisini N, Berretta R, Recchia A, Werlen A, Wang T, Houser S, Kelly DP, Recchia FA: The Medium Chain Fatty Acid Octanoate is a Beneficial Fuel for the Failing Heart. Submitted 2025.
1b5 Doan K, Luongo TS, Ts’olo T, Lee WD, Frederick D, Mukherjee S, Adzika G, Perry C, Gaspar R, Walker N, Blair MC, Bye N, Davis J, Holman C, Chu Q, Wang L, Rabinowitz J, Kelly DP, Cappola TP, Margulies KB, Baur JA: Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nat Cardiovasc Res October 2024.
15d Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP: Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice. CircRes August 2024.
154 Bailey LRJ, Bugg D, Reichardt IM, Ortac CD, Nagle A, Gunaje J, Martinson A, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis JM: MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states. Circulation June 2024.
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Selected Publications
1a8 166. Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow-Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Roth Flach RJ, Rader DJ, and Kelly DP: Targeted Quantitative Plasma Metabolomics Identifies Metabolite Signatures that Distinguish Heart Failure with Reduced and Preserved Ejection Fraction. ESC Hear Failure August 2025.1e2 Selvaraj S, He M, Thompson EJ, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Kwee LC, Taylor L, Milosovic S, Hurdle M, Cade WT, Ilkayeva O, Muehlbauer MJ, Newgard CB, Kelly DP, Zamani P, Margulies KB; Shah SH: Metabolic and pharmacokinetic profiling of an exogenous ketone ester by background SGLT2 inhibitor therapy in heart failure with reduced ejection: A Phase I clinical trial. JACC: BTS March 2025.
1e2 164. Selvaraj S, Karaj A, Chirinos J, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner S, Cohen J, Ischiropoulos H, Rickels M, Poole D, Church D, Wolfe R, Kelly DP, Putt M, Margulies K, Zamani P: Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail March 2025.
1ae Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. Scientific Reports 15(1), Jan 2025.
113 Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sakamoto T, Leone TC, Khurana T, Kelly DP: A Role for the Transcriptional Coregulator RIP140 in the Control of Muscle Endurance Fitness. JCI Insight 2025.
1ab Doan KV, Gaspar RB, Lee WD, Oschmann AM, Ts’olo TT, Frederick DW, Velِázquez Aponte RA, Adzika GK, McGaunn JP, Bye N, Mukherjee S, Davis JG, Holman CD, Chu Q, Garcia A, Ranamurthy R, Cheng L, Migaud ME, Rabinowitz JD, Kelly DP, Baur JA: Low cardiac NAD+ causes hypertrophy through a ketone-sensitive beta-adrenergic signaling pathway. Submitted 2025.
116 Gorgodze N, Matsuura TR, Nisini N, Berretta R, Recchia A, Werlen A, Wang T, Houser S, Kelly DP, Recchia FA: The Medium Chain Fatty Acid Octanoate is a Beneficial Fuel for the Failing Heart. Submitted 2025.
1b5 Doan K, Luongo TS, Ts’olo T, Lee WD, Frederick D, Mukherjee S, Adzika G, Perry C, Gaspar R, Walker N, Blair MC, Bye N, Davis J, Holman C, Chu Q, Wang L, Rabinowitz J, Kelly DP, Cappola TP, Margulies KB, Baur JA: Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nat Cardiovasc Res October 2024.
15d Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP: Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice. CircRes August 2024.
154 Bailey LRJ, Bugg D, Reichardt IM, Ortac CD, Nagle A, Gunaje J, Martinson A, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis JM: MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states. Circulation June 2024.
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