Daniel P Kelly, MD

faculty photo
Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Department: Medicine
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd.
Smilow Center for Translational Research
Philadelphia, PA 19104
Office: 215-898-0768
Lab: 215-898-2374
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.
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> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Tomoya Sakamoto , Timothy R Matsuura , Shibiao Wan , David M Ryba , Junil Kim , Kyoung-Jae Won , Ling Lai , Christopher Petucci , Nataliya Petrenko , Kiran Musunuru , Rick B Vega , and Daniel P Kelly: A Critical Role for Estrogen-related Receptor Signaling in Cardiac Maturation. Circulation Research Mar 2020.

Timothy R. Matsuura, Teresa C. Leone, Daniel P. Kelly: Fueling Cardiac Hypertrophy. Circulation Research 126(2): 197 - 199, Jan 2020.

Lombardi A, Gibb A, Arif E, Kolmetzky D, Tomar D, Luongo T, Jadiya P, Murray E, Lorkiewicz P, Hajnoczky G, Murphy E, Arany Z, Kelly DP, Margulies K, Hill B, Elrod J: Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nature Communications 10(1): 4509, Oct 2019.

Trevino MB, Zhang X, Standley RA, Wang M, Han X, Reis FCG, Periasamy M, Yu G, Kelly DP, Goodpaster BH, Vega RB, Coen PM: Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Meta 317(5): E899-E910, Sept 2019.

Tian R, Wilson SC, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn II GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O’Brien KD, O’Rourke B, Park JY, Ping P, Sack MN, Sheu S-S, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Longacre LS: Unlocking the secrets of mitochondria in the cardiovascular system: Path to a cure in heart failure; A Report from the 2018 National Heart, Lung, and Blood Institute Workshop. Circulation 140(14): 1205-1216, Sept 2019.

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD: Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency. Cardiovasc Res 115(11): 1606-1616, Sep 2019.

Ahn B, Wan S, Jaiswal N, Vega RB, Titchenell PM, Han X, Won KJ, Kelly DP: MondoA drives muscle lipid accumulation and insulin resistance. JCI Insight 5, Jul 2019.

Lui X Zhang S-M, McGeary MK, Krykbaeva I, Lai L, Jasen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q : KDM5B promotes drug resistance by regulating melanoma-propagating cell subpopulations. Molecular Cancer Therapeutics 18(3): 706-717, Mar 2019.

Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thomspon JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM: Respiratory phenomics across multiple models of protein hyperacetylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Reports 26(6): 1557-1572, Feb 2019.

Horton JL, Davidson M, Kurishima C, Vega RB, Powers JC, Matsuura T, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP: The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. JCI Insight Jan 2019.

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Last updated: 04/03/2020
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