Daniel P Kelly, MD

faculty photo
Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Director, Cardiovascular Institute
Department: Medicine
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd.
Smilow Center for Translational Research
Philadelphia, PA 19104
Office: 215-898-0768
Lab: 215-898-2374
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Hahn V, Petucci C, Kim MS, Bedi K, Wang H, Mishra S, Koleini N, Yoo E, Margulies K, Arany Z, Kelly DP, Kass D, and Sharma K: Myocardial Metabolomics of Human Heart Failure with Preserved Ejection Fraction. Circulation 11;147(15): 1147-1161, April 2023.

Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoi DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP: RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. J Clin Invest 16;e162309 (Online ahead of print): Online ahead of print, March 2023.

Bailey LRJ, Bugg D, Reichardt IM, Ortac CD, Gunaje J, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis JM: MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states. bioRxiv 16;2023.03.16.532974, March 2023.

Cao Y, Zhang X, Akerberg B, Yuan H, Sakamoto T, Xiao F, VanDusen N, Zhou P, Sweat M, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu W: In vivo dissection of chamber selective enhancers reveals estrogen-related receptor as a regulator of ventricular cardiomyocyte identity. Circulation 14;147(11): 881-896, March 2023.

Vidula M, Kelly DP, Arany Z, Margulies KB, Shah SH, Cappola TP, Bavo PE, Selvaraj S: Metabolomic signatures of myocardial glucose uptake on FDG-PET. JACC BTS In Press October 2022.

Previs MJ, O’Leary TS, MP Morley, Palmer BM, LeWinter M, Yob JM, Pagani FD, Petucci C, Kim MS, Margulies KB, Arany Z, Kelly DP, Day SM: Defects in the proteome and metabolome in human hypertrophic cardiomyopathy. Circ Heart Failure 15(6): e009521, June 2022.

Selvaraj S, Margulies K, Dugyala S, Schubert E, Tierney A, Arany Z, Pryma DA, Shah SH, Rame E, Kelly DP, Bravo PE: Comparison of exogenous ketone administration versus dietary carbohydrate restriction on myocardial glucose suppression: A randomized clinical trial. Journal of Nuclear Medicine 63(5): 770-776, May 2022.

Dierickx P, Carpenter B, Celwyn I, Kelly DP, Baur JA, Lazar MA: Nicotinamide riboside improves cardiac function and prolongs survival after disruption of the cardiomyocyte clock. Frontiers in Molecular Medicine 2, May 2022.

Gibb AA, Murray EK, Huynh AT, Gasper RB, Ploesch TL, Bedi K Lombardi AA,, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW: Glutaminolysis is essential for myofibroblast persistence and in vivo targeting reverses fibrosis and cardiac dysfunction in heart failure. Circulation 24;145(21): 1625-1628, May 2022.

Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP: The nuclear receptor ERRgamma cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte differentiation. Nat Commun 13(1): 1991, April 2022.

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Last updated: 04/19/2023
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