Daniel P Kelly, MD

faculty photo
Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Department: Medicine
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd.
Smilow Center for Translational Research
11-122
Philadelphia, PA 19104
Office: 215-898-0768
Lab: 215-898-2374
Education:
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.
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Selected Publications

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD: Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency. Cardiovasc Res Sep 2019.

Ahn B, Wan S, Jaiswal N, Vega RB, Titchenell PM, Han X, Won KJ, Kelly DP: MondoA drives muscle lipid accumulation and insulin resistance. JCI Insight, in press Jul 2019.

Lui X Zhang S-M, McGeary MK, Krykbaeva I, Lai L, Jasen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q : KDM5B promotes drug resistance by regulating melanoma-propagating cell subpopulations. Molecular Cancer Therapeutics 18(3): 706-717, Mar 2019.

Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thomspon JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM: Respiratory phenomics across multiple models of protein hyperacetylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Reports Feb 2019.

Horton JL, Davidson M, Kurishima C, Vega RB, Powers JC, Matsuura T, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP: The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. JCI Insight Jan 2019.

Kumar A, Kelly DP, Chirinos J: Mitochondrial dysfunction in heart failure with preserved ejection fraction. Circulation Jan 2019.

Trevino MB, Zhang X, Standley RA, Wang M, Han X, Reis FCG, Periasamy M, Yu G, Kelly DP, Goodpaster BH, Vega RB, Coen PM: Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Meta, in press 2019.

Lombardi A, Gibb A, Arif E, Kolmetzky D, Tomar D, Luongo T, Jadiya P, Murray E, Lorkiewicz P, Hajnoczky G, Murphy E, Arany Z, Kelly DP, Margulies K, Hill B, Elrod J: Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nature Communications, in press 2019.

Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M: Single-nucleotide polymorphism of the MLX gene is associated with Takayasu arteritis. Circ Genom Precis Med 11(10): e002296, Oct 2018.

Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM: Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J of Gerontol A Biol Sci Med Sci 73(10): 1313-1322, Sep 2018.

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Last updated: 09/06/2019
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