Daniel P Kelly, MD

faculty photo
Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Department: Medicine
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd.
Smilow Center for Translational Research
Philadelphia, PA 19104
Office: 215-898-0768
Lab: 215-898-2374
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Lui X Zhang S-M, McGeary MK, Krykbaeva I, Lai L, Jasen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q: : KDM5B promotes drug resistance by regulating melanoma-propagating cell subpopulations. Molecular Cancer Therapeutics 18(3): 706-717, Mar 2019.

Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thomspon JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM: Respiratory phenomics across multiple models of protein hyperacetylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Reports, In press Feb 2019.

Horton JL, Davidson M, Kurishima C, Vega RB, Powers JC, Matsuura T, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP: The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. JCI Insight, Jan 2019.

Kumar A, Kelly DP, Chirinos J: Mitochondrial dysfunction in heart failure with preserved ejection fraction. Circulation, In press Jan 2019.

Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M: Single-nucleotide polymorphism of the MLX gene is associated with Takayasu arteritis. Circ Genom Precis Med 11(10): e002296, Oct 2018.

Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM: Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J of Gerontol A Biol Sci Med Sci 73(10): 1313-1322, Sep 2018.

Maurya SK, Reis FCG, Vega RB, Kelly DP, Periasamy M: Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle. Cell Reports 24(11): 2919-2931, Sep 2018.

Gan Z, Fu T, Kelly DP, Vega RB: Skeletal Muscle Mitochondrial Remodeling in Exercise and Diseases. Cell Research 2018.

Mann DL, Kelly DP: Empagliflozin and the prevention of heart failure: Will reverse translation lead to new paradigms for the treatment of heart failure? JACC Basic Transl Sci 2(4): 355-357, Aug 2017.

Lee Samuel, Leone Teresa C, Rogosa Lisa, Rumsey John, Ayala Julio, Coen Paul M, Fitts Robert H, Vega Rick B, Kelly Daniel P: Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice. American journal of physiology. Endocrinology and metabolism 312(5): E394-E406, May 2017.

back to top
Last updated: 03/05/2019
The Trustees of the University of Pennsylvania