Emily Anne Partridge, MHS, MD, PhD
Assistant Professor of Surgery
Active Surgeon, Children's Hospital of Philadelphia, Philadelphia, PA
Department: Surgery
Contact information
Department of Surgery
Children's Hospital of Philadelphia
3401 Civic Center Boulevard
Philadelphia, PA 19104
Children's Hospital of Philadelphia
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-2730
Fax: 215-590-3265
Fax: 215-590-3265
Email:
partridgee@chop.edu
partridgee@chop.edu
Education:
BS (Molecular Biology and Molecular Genetics)
University of Toronto, Faculty of Arts and Sciences, Toronto, Ontario, Canada , 1999.
MHS (Health Sciences)
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada , 2001.
PhD (Philosophy)
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada, 2005.
MD (Medicine)
University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada, 2009.
Permanent linkBS (Molecular Biology and Molecular Genetics)
University of Toronto, Faculty of Arts and Sciences, Toronto, Ontario, Canada , 1999.
MHS (Health Sciences)
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada , 2001.
PhD (Philosophy)
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada, 2005.
MD (Medicine)
University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada, 2009.
Description of Research Expertise
• Development of an artificial placenta• Pumpless extracorporeal membrane oxygenation in congenital diaphragmatic hernia
• Glycosylation defects in cancer
• Signal transduction pathways regulating glycosylation
• Immunomodulatory activities of GnT-V
• Expression of fetuin, a serum glycoprotein, in human and murine colon cancers
• Role of fetuin as a competitive inhibitor of TGF- signalling through SMAD proteins
• Immunomodulatory activities of TGF-1 and fetuin in a mouse model of septic shock
• Study of mammalian Core 2 GlcNAc-transferase enzyme homologues in C. elegans
• By RT-PCR, sub cloning and sequencing, identified transcripts, conserved residues and splice junctions for all six genes
• Carried out expression cloning of one homologue and subsequent enzyme activity assays
• Regulation of biosynthesis of juvenile hormone (JH) by the neuropeptide allatostatin
• Regulation of development and metamorphosis of Diploptera punctata by allatostatin
Selected Publications
Wild KT, Hedrick HL, Ades AM, Fraga MV, Avitabile CM, Gebb JS, Oliver ER, Coletti K, Kesler EM, Van Hoose KT, Panitch HB, Johng S, Ebbert RP, Herkert LM, Hoffman C, Ruble D, Flohr S, Reynolds T, Duran M, Foster A, Isserman RS, Partridge EA, Rintoul NE: Update on management and outcomes of congenital diaphragmatic hernia. Journal of Intensive Care Medicine 39(12): 1175-1193, Dec. 2024 Notes: epub Nov. 6, 2023.Sachs RA, Daszewska-Smith G, Larson A, Kwechin M, Conan R, Partridge EA: Hypoxia-inducible factor 1-alpha in the fetal lamb model of congenital diaphragmatic hernia's hippocampus. Journal of the American College of Surgeons 239(5 Suppl 1): S350, Nov. 2024 Notes: Presented at the Owen H. Wangensteen Scientific Forum at the 2024 American College of Surgeons Clinical Congress, San Francisco, CA, Oct. 2024.
Burrill N, Crane H, Khalek N, Soni S, Wild KT, Skraban C, McManus M, Szigety K, Oliver ER, Partridge E, Agarwal S, Fisher A, Wang J, Moldenhauer JS: Expansion of the prenatal phenotype of Baraitser-Winter syndrome: Presentation of two cases of multiple congenital anomaly syndrome. American Journal of Medical Genetics A 194(10): e63719, Oct. 2024 Notes: Epub May 24, 2024.
Wild KT, Conlin L, Blair J, Manfredi M, Hamilton TE, Muir A, Zackai EH, Nace G, Partridge EA, Devine M, Reynolds T, Rintoul NE, Hedrick HL, Spinner N, Krantz ID: Genomic contributors to esophageal atresia and tracheoesophageal fistula: A 12 year retrospective review. Journal of Pediatrics 271: 114060, Aug. 2024 Notes: Epub Apr. 18, 2024.
Wild KT, Rintoul NE, Ades AM, Gebb JS, Moldenhauer JS, Mathew L, Flohr S, Bostwick A, Reynolds T, Ruiz RL, Javia LR, Nelson O, Peranteau WH, Partridge EA, Adzick NS, Hedrick HL: The delivery room resuscitation of infants with congenital diaphragmatic hernia treated with fetoscopic endoluminal tracheal occlusion: Beyond the balloon. Fetal Diagnosis & Therapy 51(2): 184-190, Feb. 2024 Notes: Epub Jan. 10, 2024.
De Bie FR, Regin Y, Dubois A, Scuglia M, Arai T, Muylle E, Basurto D, Regin M, Croubels S, Cherlet M, Partridge EA, Allegaert K, Russo FM, Deprest JA: Prenatal treprostinil improves pulmonary arteriolar hypermuscularization in the rabbit model of congenital diaphragmatic hernia. Biomedical Pharmacotherapy 170: 115996, Jan. 2024 Notes: Epub Dec. 12, 2023.
Bose SK, Stratigis JD, Ahn N, Pogoriler J, Hedrick HL, Rintoul NE, Partridge EA, Flake AW, Khalek N, Gebb J, Teefey CP, Soni S, Hamaguchi R, Moldenhauer J, Adzick NS, Peranteau WH: Prenatally diagnosed large lung lesions: Timing of resection and perinatal outcomes. Journal of Pediatric Surgery 58(12): 2384-2390, Dec. 2023 Notes: Epub Sept. 9, 2023.
Eubanks A, Hodgson E, Larson A, Chang J, Tilden SA, Kotzur T, Dicker J, Kwechin M, Daszewska-Smith G, Partridge EA: Pumpless extracorporeal membrane oxygenation provides stable respiratory support for 3 weeks in the lamb model of congenital diaphragmatic hernia. Journal of the American College of Surgeons 237(5 Suppl 1): S361-S362, Nov. 2023 Notes: Presented at the 9th Owen H Wangensteen Scientific Forum of the American College of Surgeons Clinical Congress, Boston, MA, Oct. 2023.
De Bie FR, Kim SD, Bose SK, Nathanson P, Partridge EA, Flake AW, Feudtner C: Ethics considerations regarding artificial womb technology for the fetonate. American Journal of Bioethics 23(5): 67-78, May 2023 Notes: Epub Apr. 1, 2022.
Partridge EA: Omphalocele. Fundamentals of Pediatric Surgery, 3rd Edition. Mattei P (eds.). New York: Springer, Page: 757-764, 2023 Notes: Part IX, Chap. 78.