Emily Anne Partridge, MHS, MD, PhD

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Assistant Professor of Surgery
Active Surgeon, Children's Hospital of Philadelphia, Philadelphia, PA
Department: Surgery

Contact information
Department of Surgery
Children's Hospital of Philadelphia
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-2730
Fax: 215-590-3265
Education:
BS (Molecular Biology and Molecular Genetics)
University of Toronto, Faculty of Arts and Sciences, Toronto, Ontario, Canada , 1999.
MHS (Health Sciences)
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada , 2001.
PhD (Philosophy)
University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada, 2005.
MD (Medicine)
University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada, 2009.
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Description of Research Expertise

• Development of an artificial placenta
• Pumpless extracorporeal membrane oxygenation in congenital diaphragmatic hernia
• Glycosylation defects in cancer
• Signal transduction pathways regulating glycosylation
• Immunomodulatory activities of GnT-V
• Expression of fetuin, a serum glycoprotein, in human and murine colon cancers
• Role of fetuin as a competitive inhibitor of TGF- signalling through SMAD proteins
• Immunomodulatory activities of TGF-1 and fetuin in a mouse model of septic shock
• Study of mammalian Core 2 GlcNAc-transferase enzyme homologues in C. elegans
• By RT-PCR, sub cloning and sequencing, identified transcripts, conserved residues and splice junctions for all six genes
• Carried out expression cloning of one homologue and subsequent enzyme activity assays
• Regulation of biosynthesis of juvenile hormone (JH) by the neuropeptide allatostatin
• Regulation of development and metamorphosis of Diploptera punctata by allatostatin

Selected Publications

Partridge EA: Giant omphalocele. Fundamentals of Pediatric Surgery, 3rd Edition. Mattei P (eds.). New York: Springer, 2023 (in press).

Larson AC, Hedrick HL, Partridge EA: Extracorporeal membrane oxygenation. Fundamentals of Pediatric Surgery, 3rd Edition. Mattei P (eds.). New York: Springer, 2023 (in press).

De Bie FR, Kim SD, Bose SK, Nathanson P, Partridge EA, Flake AW, Feudtner C: Ethics considerations regarding artificial womb technology for the fetonate. American Journal of Bioethics Apr. 1 2022 (Epub) Notes: doi: 10.1080/15265161.2022.2048738.

De Bie FR, Didier RA, Halline C, Sridharan A, Russo FM, Deprest J, Hedrick HL, Partridge EA: Lung stiffness measured with shear wave elastography is increased in the nitrofen model of congenital diaphragmatic hernia. Podium presentation at the 40th International Fetal Medicine and Surgery Society Meeting, Los Cabos, Mexico Nov. 2022.

Larson AC, Didier R, Hodgson EC, Sridharan A, Agarwal D, Chang J, De Bie FR, Partridge EA: Abnormal alveolar morphometry and increased lung stiffness in the fetal ovine model of congenital diaphragmatic hernia. Podium presentation at the 40th International Fetal Medicine and Surgery Society Meeting, Los Cabos, Mexico Nov. 2022.

Eubanks AL, Hodgson EC, Dicker J, Tilden SA, Kotzur T, Kwechin ME, Daszewska-Smith G, Hedrick HL, Rintoul NE, Fox WW, Partridge EA: Acute effects of partial liquid ventilation as an adjunct to Pumpless Extracorporeal Membrane Oxygenation (P-ECMO) in the lamb model of CDH. Podium presentation at the 40th International Fetal Medicine and Surgery Society Meeting, Los Cabos, Mexico Nov. 2022.

Daszewska-Smith G, Larson AC, Assenmacher C, Radaelli E, Partridge EA: Neurohistologic analysis of abnormalities in fetal brain development in the ovine model of congenital diaphragmatic hernia. Podium presentation at the 40th International Fetal Medicine and Surgery Society Meeting, Los Cabos, Mexico Nov. 2022.

De Bie FR, Kim SD, Bose SK, Nathanson P, Partridge EA, Flake AW, Feudtner C: Ethics considerations regarding artificial womb technology for the fetonate. Podium presentation at the 40th International Fetal Medicine and Surgery Society Meeting, Los Cabos, Mexico Nov. 2022.

Hodgson EC, Eubanks AL, Dicker J, Tilden SA, Kotzur T, Kwechin ME, Daszewska-Smith G, Hedrick HL, Rintoul NE, Fox WW, Partridge EA: Acute effects of partial liquid ventilation as an adjunct to Pumpless Extracorporeal Membrane Oxygenation (P-ECMO) in the lamb model of CDH. Podium presentation at the American Academy of Pediatrics National Conference & Exhibition, Anaheim, CA Oct. 2022.

Russo FM, De Bie FR, Partridge EA, Allegaert K, Deprest J: The antenatal sildenafil STRIDER trial for severe fetal growth restriction, are post hoc reflections ad rem? European Journal of Pediatrics 181(10): 3775-3776, Oct. 2022 Notes: Letter; Epub July 26, 2022.

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Last updated: 01/04/2023
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