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Cesar de la Fuente, Ph.D.
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Presidential Associate Professor
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Department: Psychiatry
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Graduate Group Affiliations
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Contact information
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Robert Wood Johnson Pavilion / 3610 Hamilton Walk
16 Lab: Room 302C
34 Office: Room 303C
Philadelphia, PA 19104
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16 Lab: Room 302C
34 Office: Room 303C
Philadelphia, PA 19104
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Office: 2157466083
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Publications
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Education:
21 a B.Sc. 1a (Biotechnology) c
2b University of Leon, 2009.
21 a Ph.D. 26 (Microbiology & Immunology) c
37 University of British Columbia, 2014.
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Permanent link21 a B.Sc. 1a (Biotechnology) c
2b University of Leon, 2009.
21 a Ph.D. 26 (Microbiology & Immunology) c
37 University of British Columbia, 2014.
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12a Torres M.D.T., Chen T., Wan F., Chatterjee P., de la Fuente-Nunez C. : Generative latent diffusion language modeling yields anti-infective synthetic peptides. Cell Biomaterials 2025 Notes: doi: 10.1016/j.celbio.2025.100183.
130 Guan C., Torres M.D.T., Li S., de la Fuente-Nunez C. : Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence. Nature Communications 2025 Notes: doi: 10.1038/s41467-025-60051-6.
151 Torres M.D.T., Brooks E.F., Cesaro A., Sberro H., Gill M.O., Nicolaou C., Bhatt A.S., de la Fuente-Nunez C.: Mining human microbiomes reveals an untapped source of peptide antibiotics. Cell 187(19): 5453-5467, September 2024 Notes: doi: 10.1016/j.cell.2024.07.027.
1d2 Santos-Júnior C.D., Torres M.D.T., Duan Y., Rodríguez Del Río Á., Schmidt T.S.B., Chong H., Fullam A., Kuhn M., Zhu C., Houseman A., Somborski J., Vines A., Zhao X.M., Bork P., Huerta-Cepas J., de la Fuente-Nunez C., Coelho L.P.: Discovery of antimicrobial peptides in the global microbiome with machine learning. Cell 187(14): 3761-3778, July 2024 Notes: doi: 10.1016/j.cell.2024.05.013.
11f Maasch J.R.M.A., Torres M.D.T., Melo M.C.R., de la Fuente-Nunez C.: Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning. Cell Host Microbe. Cell Press, 31(8): 1260-74, August 2023.
147 Torres M.D.T., Melo M.C.R., Flowers L., Crescenzi O., Notomista E., de la Fuente-Nunez C. : Mining for encrypted peptide antibiotics in the human proteome. Nature Biomedical Engineering 6(1): 67–75, January 2022 Notes: doi: 10.1038/s41551-021-00801-1.
18b Cesaro A., Torres M.D.T., Gaglione R., Dell'Olmo E., Di Girolamo R., Bosso A., Pizzo E., Haagsman H.P., Veldhuizen E.J.A., de la Fuente-Nunez C., Arciello A.: Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma. ACS Nano 16(2): 1880-1895, February 2022 Notes: doi: 10.1021/acsnano.1c04496.
1b8 Silva O.N., Torres M.D.T., Cao J., Alves E.S.F., Rodrigues L.V., Resende J.M., Lião L.M., Porto W.F., Fensterseifer I.C.M., Lu T.K., Franco O.L., de la Fuente-Nunez C.: Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties. PNAS 117(43): 26936-26945, October 2020 Notes: doi: 10.1073/pnas.2012379117.
16d Boaro A., Ageitos L., Torres M.D.T., Broset E.B., Oztekin S., and de la Fuente-Nunez C. : Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom. Cell Reports Physical Science 4(7): 101459, July 2023 Notes: doi: 10.1016/j.xcrp.2023.101459.
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Selected Publications
100 Torres M.D.T., Wan F., de la Fuente-Nunez C. : Deep learning reveals antibiotics in the archaeal proteome. Nature Microbiology. August 2025 Notes: doi: 10.1038/s41564-025-02061-0.12a Torres M.D.T., Chen T., Wan F., Chatterjee P., de la Fuente-Nunez C. : Generative latent diffusion language modeling yields anti-infective synthetic peptides. Cell Biomaterials 2025 Notes: doi: 10.1016/j.celbio.2025.100183.
130 Guan C., Torres M.D.T., Li S., de la Fuente-Nunez C. : Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence. Nature Communications 2025 Notes: doi: 10.1038/s41467-025-60051-6.
151 Torres M.D.T., Brooks E.F., Cesaro A., Sberro H., Gill M.O., Nicolaou C., Bhatt A.S., de la Fuente-Nunez C.: Mining human microbiomes reveals an untapped source of peptide antibiotics. Cell 187(19): 5453-5467, September 2024 Notes: doi: 10.1016/j.cell.2024.07.027.
1d2 Santos-Júnior C.D., Torres M.D.T., Duan Y., Rodríguez Del Río Á., Schmidt T.S.B., Chong H., Fullam A., Kuhn M., Zhu C., Houseman A., Somborski J., Vines A., Zhao X.M., Bork P., Huerta-Cepas J., de la Fuente-Nunez C., Coelho L.P.: Discovery of antimicrobial peptides in the global microbiome with machine learning. Cell 187(14): 3761-3778, July 2024 Notes: doi: 10.1016/j.cell.2024.05.013.
11f Maasch J.R.M.A., Torres M.D.T., Melo M.C.R., de la Fuente-Nunez C.: Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning. Cell Host Microbe. Cell Press, 31(8): 1260-74, August 2023.
147 Torres M.D.T., Melo M.C.R., Flowers L., Crescenzi O., Notomista E., de la Fuente-Nunez C. : Mining for encrypted peptide antibiotics in the human proteome. Nature Biomedical Engineering 6(1): 67–75, January 2022 Notes: doi: 10.1038/s41551-021-00801-1.
18b Cesaro A., Torres M.D.T., Gaglione R., Dell'Olmo E., Di Girolamo R., Bosso A., Pizzo E., Haagsman H.P., Veldhuizen E.J.A., de la Fuente-Nunez C., Arciello A.: Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma. ACS Nano 16(2): 1880-1895, February 2022 Notes: doi: 10.1021/acsnano.1c04496.
1b8 Silva O.N., Torres M.D.T., Cao J., Alves E.S.F., Rodrigues L.V., Resende J.M., Lião L.M., Porto W.F., Fensterseifer I.C.M., Lu T.K., Franco O.L., de la Fuente-Nunez C.: Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties. PNAS 117(43): 26936-26945, October 2020 Notes: doi: 10.1073/pnas.2012379117.
16d Boaro A., Ageitos L., Torres M.D.T., Broset E.B., Oztekin S., and de la Fuente-Nunez C. : Structure-function-guided design of synthetic peptides with anti-infective activity derived from wasp venom. Cell Reports Physical Science 4(7): 101459, July 2023 Notes: doi: 10.1016/j.xcrp.2023.101459.
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