Jan-Karl Burkhardt, MD
The James and Agnes Kim Associate Professor of Neurosurgery
Director, Neurovascular Tissue Bank and Translational Lab, Burkardt Lab, Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania
Director, Center of Excellence - Cavernous Malformation, Hospital of the University of Pennsylvania, Penn Medicine
Educational Site Director, Department of Neurosurgery, The Hospital of the University of Pennsylvania
Director, Cerebral Revascularization Program, Hospital of the University of Pennsylvania, Department of Neurosurgery
Director, Neurointerventional Fellowship Program, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania
Neurosurgical Director, Comprehensive Stroke Center, Department of Neurosurgery, University of Pennsylvania
Division Head, Cerebrovascular Surgery , Hospital Of the University of Pennsylvania, Penn Medicine
Department: Neurosurgery
Contact information
Department of Neurosurgery
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
Publications
Education:
MD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
MBA (Physician Executive MBA)
University of Tennessee, 2024.
Permanent linkMD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
MBA (Physician Executive MBA)
University of Tennessee, 2024.
Description of Clinical Expertise
Primary Area of Expertise / Neurosurgical Interests:Aneurysms, Arteriovenous Malformations (AVMs), Arteriovenous Fistulas (AVFs) and Cerebral Cavernous Malformations. Cerebral Revascularization and Extracranial-Intracranial (EC-IC) and IC-IC Bypass Procedures. Moyamoya Disease, Subarachnoid Hemorrhage, Intracranial Hemorrhage, Acute Ischemic Stroke and Chronic Vessel Stenosis or Occlusion.
Interested in both open microsurgical vascular and endovascular neurosurgery/neuroradiology.
Description of Research Expertise
Revascularization, Moyamoya diseaseSelected Publications
Salem MM, Sioutas GS, Gajjar A, Khalife J, Kuybu O, Carroll KT, Hoang AN, Baig AA, Salih M, Baker C, Cortez GM, Abecassis Z, Ruiz Rodriguez JF, Davies JM, Cawley CM, Riina H, Spiotta AM, Khalessi A, Howard BM, Hanel RA, Tanweer O, Tonetti D, Siddiqui AH, Lang M, Levy EI, Ogilvy CS, Srinivasan VM, Kan P, Gross BA, Jankowitz B, Levitt MR, Thomas AJ, Grandhi R, Burkhardt JK.: Femoral versus radial access for middle meningeal artery embolization for chronic subdural hematomas: multicenter propensity score matched study. J Neurointerv Surg 17: 890-897, Jul 2025.Salim H, Hamdan D, Adeeb N, Kandregula S, Aslan A, Musmar B, Ogilvy CS, Dmytriw AA, Abdelsalam A, Ataoglu C, Erginoglu U, Kondziolka D, El Naamani K, Sheehan J, Ironside N, Kumbhare D, Gummadi S, Essibayi MA, Tos SM, Keles A, Muram S, Sconzo D, Rezai A, Alwakaa O, Pöppe J, Sen RD, Baskaya MK, Griessenauer CJ, Jabbour P, Tjoumakaris SI, Atallah E, Riina H, Abushehab A, Swaid C, Burkhardt JK, Starke RM, Sekhar LN, Levitt MR, Altschul DJ, Haranhalli N, McAvoy M, Abla A, Stapleton C, Koch MJ, Srinivasan VM, Chen PR, Blackburn S, Cochran J, Choudhri O, Pukenas B, Orbach DB, Smith ER, Moehlenbruch M, Mosimann PJ, Alaraj A, Aziz-Sultan MA, Patel AB, Yedavalli V, Wintermark M, Savardekar A, Cuellar HH, Lawton MT, Morcos JJ, Guthikonda B.: Efficacy and safety of preoperative embolization in surgical treatment of brain arteriovenous malformations: a multicentre study with propensity score matching. J Neurol Neurosurg Psychiatry 96: 766-774, Jul 2025.
Alawieh AM, Dimisko L, Zohdy YM, Koo AB, Saad H, El Baba B, Newman S, Grossberg JA, Matouk C, Cawley CM, Pradilla G, Reisner A, Fox WC, Perez-Vega C, Burkhardt JK, Salem MM, Jabbour P, El Naamani K, Schmidt RF, Gooch MR, Starke RM, Abdelsalam A, Lu VM, Levitt M, Chalhoub RM, Kobeissy F, Spiotta AM, Barrow D, Howard BM.: Outcomes of medical and surgical management in infectious intracranial aneurysms: a multicenter cohort analysis. J Neurointerv Surg Jul 2025.
Davis P, Napole A, Reddy C, Palepu SK, Wu AQ, Mannam SS, Gajjar AA, Jabarkheel R, Ajmera S, Ahmad H, Scott KW, Sioutas G, Shekhtman O, Kandregula S, Rahmani R, Catapano JS, Burkhardt JK, Srinivasan VM.: Systematic evaluation of AI-based text-to-image models for generating medical illustrations in neurosurgery: a multi-stage comparative study. Clin Neurol Neurosurg 257: 109039, Jul 2025.
Jabarkheel R, Gajjar AA, Muhammad N, Tang OY, Tomlinson SB, Golubovsky J, Corral Tarbay A, Sioutas GS, Mannam S, Vaz A, Ajmera S, Kandregula S, Pukenas B, Choudhri O, Jankowitz BT, Burkhardt JK, Srinivasan VM.: The role of Area Deprivation Index in treatment selection for anterior communicating artery aneurysms. J Neurosurg Jul 2025.
Gomez-Paz S, Richter K, McGrath M, Breton JM, Wakelin SH, Christie I, Pasko KBD, Aljuboori A, Hendrix P, Weiner GM, Slee B, Duckworth EAM, Burkhardt JK, Srinivasan VM, Jankowitz BT, Snyder T, Levitt MR, Armonda R, Felbaum DR, Ares WJ, Salem MM, Grandhi R.: Single-Session Middle Meningeal Artery Embolization With Concomitant Evacuation Surgery for Chronic Subdural Hematomas: A Multicenter Assessment of Feasibility, Safety, and Efficacy. Oper Neurosurg Jul 2025.
Musmar B, Abdalrazeq H, Adeeb N, Roy JM, Aslan A, Tjoumakaris SI, Salim HA, Ogilvy CS, Baskaya MK, Kondziolka D, Sheehan J, Riina H, Kandregula S, Dmytriw AA, Abushehab A, El Naamani K, Abdelsalam A, Ironside N, Kumbhare D, Gummadi S, Ataoglu C, Essibayi MA, Keles A, Muram S, Sconzo D, Rezai A, Alwakaa O, Tos SM, Mantziaris G, Park MS, Erginoglu U, Pöppe J, Sen RD, Griessenauer CJ, Burkhardt JK, Starke RM, Sekhar LN, Levitt MR, Altschul DJ, Haranhalli N, McAvoy M, Zeineddine HA, Abla AA, Sizdahkhani S, Koduri S, Atallah E, Karadimas S, Gooch MR, Rosenwasser RH, Stapleton C, Koch M, Srinivasan VM, Chen PR, Blackburn S, Bulsara K, Kim LJ, Choudhri O, Pukenas B, Orbach D, Smith E, Mosimann PJ, Alaraj A, Aziz-Sultan MA, Patel AB, Savardekar A, Notarianni C, Cuellar HH, Lawton M, Guthikonda B, Morcos J, Jabbour P; MISTA consortium.: Outcomes of arteriovenous malformations with single versus multiple draining veins: A multicenter study. J Neurol Sci 473: 123503, Jun 2025.
Abdelsalam A, Ramsay IA, Luther EM, Burks JD, Wu EM, Silva MA, Thompson JW, Bandes M, Fountain HB, Eatz T, Sanikommu S, Abla AA, Salem MM, Burkhardt JK, Srinivasan VM, Brunozzi D, Alaraj A, Atwal G, Al-Mufti F, Kellner CP, Rai AT, Starke RM.: Middle Meningeal Artery Embolization for Chronic Subdural Hematoma Using N-Butyl Cyanoacrylate With a D5W Push Technique: A Multicentric North American Study of 269 Patients. Oper Neurosurg 28: 817-823, Jun 2025.
Sconzo D, Ramirez-Velandia F, Muram S, Enriquez-Marulanda A, Riordan CP, Adeeb N, Musmar B, Salim HA, Kandregula S, Dmywtriw AA, Abdelsalam A, Ataoglu C, Erginoglu U, Kondziolka D, Aslan A, Naamani KE, Sheehan J, Park MS, Zeineddine HA, Ironside N, Kumbhare D, Gummadi S, Essibayi MA, Tos SM, Keles A, Rezai A, Pöppe J, Sen RD, Baskaya MK, Griessenauer CJ, Jabbour P, Tjoumakaris SI, Atallah E, Riina H, Abushehab A, Burkhardt JK, Starke RM, Sekhar LN, Levitt MR, Altschul DJ, Haranhalli N, McAvoy M, Abla A, Stapleton C, Koch M, Srinivasan VM, Chen PR, Blackburn S, Kim LJ, Choudhri O, Pukenas B, Mantziaris G, O'Leary S, Kan P, Li YL, Simonato D, Bulsara K, Fuschi M, Alaraj A, Hanalioglu S, Patel A, Savardekar A, Cuellar H, Lawton M, Morcos J, Guthikonda B, Taussky P, Ogilvy CS; MISTA Consortiumn.: Impact of smoking on occlusion rates following stereotactic radiosurgery for Spetzler Martin grade I-III brain arteriovenous malformations - A propensity score matched analysis of the MISTA consortium. J Clin Neurosci 139: 111411, Jun 2025.
Musmar B, Roy JM, Abdalrazeq H, Kaul A, Atallah E, El Naamani K, Chen CJ, Jabre R, Saad H, Grossberg JA, Dmytriw AA, Patel AB, Khorasanizadeh M, Ogilvy CS, Thomas AJ, Monteiro A, Siddiqui A, Cortez GM, Hanel RA, Porto G, Spiotta AM, Piscopo AJ, Hasan DM, Ghorbani M, Weinberg J, Nimjee SM, Bekelis K, Salem MM, Burkhardt JK, Zetchi A, Matouk C, Howard BM, Lai R, Du R, Abbas R, Sioutas GS, Amllay A, Munoz A, Herial NA, Tjoumakaris SI, Gooch MR, Rosenwasser RH, Jabbour P.: Comparative Outcomes of Unilateral vs Bilateral Revascularization in Moyamoya Disease: A Multicenter Retrospective Study. Neurosurgery 96: 1364-1373, Jun 2025.