Jan-Karl Burkhardt, MD
The James and Agnes Kim Associate Professor of Neurosurgery
Director, Neurovascular Tissue Bank and Translational Lab, Burkardt Lab, Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania
Director, Center of Excellence - Cavernous Malformation, Hospital of the University of Pennsylvania, Penn Medicine
Educational Site Director, Department of Neurosurgery, The Hospital of the University of Pennsylvania
Director, Cerebral Revascularization Program, Hospital of the University of Pennsylvania, Department of Neurosurgery
Director, Neurointerventional Fellowship Program, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania
Neurosurgical Director, Comprehensive Stroke Center, Department of Neurosurgery, University of Pennsylvania
Division Head, Cerebrovascular Surgery , Hospital Of the University of Pennsylvania, Penn Medicine
Department: Neurosurgery
Contact information
Department of Neurosurgery
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
Publications
Education:
MD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
MBA (Physician Executive MBA)
University of Tennessee, 2024.
Permanent linkMD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
MBA (Physician Executive MBA)
University of Tennessee, 2024.
Description of Clinical Expertise
Primary Area of Expertise / Neurosurgical Interests:Aneurysms, Arteriovenous Malformations (AVMs), Arteriovenous Fistulas (AVFs) and Cerebral Cavernous Malformations. Cerebral Revascularization and Extracranial-Intracranial (EC-IC) and IC-IC Bypass Procedures. Moyamoya Disease, Subarachnoid Hemorrhage, Intracranial Hemorrhage, Acute Ischemic Stroke and Chronic Vessel Stenosis or Occlusion.
Interested in both open microsurgical vascular and endovascular neurosurgery/neuroradiology.
Description of Research Expertise
Revascularization, Moyamoya diseaseSelected Publications
Ezzeldin R, Mir O, Delora A, Boo S, Ortega-Gutierrez S, Dolia J, Haussen DC, Schirmer CM, Alsaiegh F, Mascitelli J, Hassan AE, Khan MW, Burkhardt JK, Malik O, Diehl D, Zanaty M, Aljuboori A, Miller S, Srinivasan VM, Scott K, Ali Z, Ezzeldin M.: Broadway 8 system: a multicenter early evaluation of safety, performance, and clinical outcomes in mechanical thrombectomy. J Neurointerv Surg Oct 2025.Gomez-Paz S, Salem MM, Richter KR, McGrath M, Breton JM, Aljuboori A, Hendrix P, Weiner GM, McNulty AM, Khalife J, Kuybu O, Lang MJ, Tanweer O, Tonetti DA, Ogilvy CS, Spiotta AM, Thomas AJ, Gross BA, Duckworth EAM, Burkhardt JK, Srinivasan VM, Snyder T, Jankowitz BT, Levitt MR, Armonda RA, Felbaum DR, Paul AR, Ares WJ, Grandhi R.: Single-session versus staged approaches for chronic subdural hematoma treatment with middle meningeal artery embolization and evacuation surgery: a propensity score-matched analysis. Neurosurg Focus 59: E7, Oct 2025.
Roy JM, Musmar B, Patil S, Sizdahkhani S, Atallah E, Momin A, Paul A, Field NC, Zhang Y, Burkhardt JK, Kühn AL, Puri A, Levy E, Gooch MR, Jabbour P, Rosenwasser RH, Tjoumakaris SI.: Predictors of In-Stent Stenosis After Flow Diversion of Intracranial Aneurysms Using the FRED-X Device: A Multicenter Analysis of 6-month and 12-Month Outcomes. Oper Neurosurg Sep 2025.
Musmar B, Abdalrazeq H, Roy JM, Adeeb N, Atallah E, El Naamani K, Chen CJ, Jabre R, Saad H, Grossberg JA, Dmytriw AA, Patel AB, Khorasanizadeh M, Ogilvy CS, Thomas AJ, Monteiro A, Siddiqui A, Cortez GM, Hanel RA, Porto G, Spiotta AM, Piscopo AJ, Hasan DM, Ghorbani M, Weinberg J, Nimjee SM, Bekelis K, Salem MM, Burkhardt JK, Zetchi A, Matouk C, Howard BM, Lai R, Du R, Abbas R, Amllay A, Munoz A, Herial NA, Tjoumakaris SI, Gooch MR, Notarianni C, Guthikonda B, Rosenwasser RH, Jabbour P.: Outcomes of bypass surgery in asymptomatic moyamoya angiopathy: A multicenter study with propensity-score weighting. Eur Stroke J Aug 2025.
Bender MT, Schartz D, Burkhardt JK, Grandhi R, Jankowitz B, Ezzeldin M, Yaghi S, Moldovan K, Al Jehani H, Psychogios M, Inoa V, Grossberg JA, Alawieh A, Mascitelli J, Samaniego E, Fragata I, Almallouhi E, Jumaa M, Capasso F, Nahhas M, Starke RM, Maier I, Jabbour P, Abdalkader M, Hassan A, Altschul D, Goyal N, Mattingly TK, Bhalla T, Ellens N, Regenhardt RW, Wolfe S, Limaye K, Niazi H, Anadani M, Zaidat O, Derdeyn C, Nguyen T, de Havenon A, Al Kasab S.: Predictors of Futile Recanalization After Endovascular Therapy for Acute Large Vessel Occlusive Intracranial Atherosclerosis: A Secondary Analysis of RESCUE-ICAS. Neurosurgery Aug 2025.
Gomez-Paz S, Andreão FF, Kendall N, Richter KR, McGrath M, Breton JM, Aljuboori A, Hendrix P, Weiner GM, Duckworth EAM, McNulty AM, Burkhardt JK, Srinivasan VM, Snyder T, Jankowitz BT, Levitt MR, Armonda RA, Felbaum DR, Paul AR, Salem MM, Grandhi R.: Single-Session Middle Meningeal Artery Embolization With Concomitant Evacuation Surgery for Chronic Subdural Hematoma: Impact of Surgical Approach. Oper Neurosurg Aug 2025.
Napole A, Sioutas G, Davis P, Reddy C, Patel S, Kandregula S, Mannam SS, Jabarkheel R, Scott KW, Shekhtman O, Burkhardt JK, Srinivasan VM.: Comprehensive Assessment of the Vecta46 Intermediate Catheter for Neurovascular Interventions. Cureus 17: e90577, Aug 2025.
Musmar B, Adeeb N, Abdalrazeq H, Salim HA, Roy J, Tjoumakaris SI, Kandregula S, Ogilvy CS, Kondziolka D, Sheehan JP, Dmytriw AA, Aslan A, Patel P, Lan M, Baldassari MP, Koduri S, Atallah E, Zeineddine H, Pontarelli MK, Abou-Al-Shaar H, El Naamani K, Abdelsalam A, Ironside N, Kumbhare D, Gummadi S, Baskaya M, Ataoglu C, Mccarthy F, Sanchez-Forteza A, Essibayi MA, Keles A, Muram S, Sconzo D, Riina H, Rezai A, Alwakaa O, Tos SM, Mantziaris G, Park MS, Hanalioglu S, Erginoglu U, Pöppe J, Sen RD, Griessenauer CJ, Ocampo-Navia MI, Devia DA, Perez-Mendez W, Puentes JC, Abo Kasem R, Spiotta AM, Puri AS, Singh J, Kuhn AL, Burkhardt JK, Starke RM, Sekhar LN, Levitt M, Altschul D, Haranhalli N, McAvoy M, Eltiti M, Abushehab A, Foreman P, Shakir HJ, Zaidat OO, AlMajali M, Ruppert-Gomez M, See AP, Abla AA, Stapleton CJ, Patel A, Nguyen A, Koch MJ, Srinivasan VM, Chen PR, Blackburn S, Alshahrani R, Gooch MR, Rosenwasser RH, Bulsara KR, Kan P, Kim LJ, Choudhri O, Pukenas B, Simonato D, Li YL, Alaraj A, Fuschi M, Patel AB, Savardekar A, Notarianni C, Cuellar HH, Lawton MT, Guthikonda B, Morcos J, Jabbour P.: Safety and efficacy of preoperative embolization in the treatment of brain arteriovenous malformations with perinidal aneurysms and single draining vein: a multicenter study with propensity score-weighting. J Neurointerv Surg Aug 2025.
Psychogios M, Brehm A, Goyal N, Boulouis G, Burkhardt JK, Chowdhry SA, Frei D, Gralla J, Kaesmacher J, Kellogg RT, Kellner CP, Lopes DK, Raz E, Strbian D, Mannismäki L, Tomasello A, Tsogkas I, von Hessling A, Karwacki GM, Guzman R, Rommers N, Liebeskind DS, Arthur AS; SPINNERS investigators.: ProSPective evaluation of the dIagnostic accuracy of siNe spiN non-contrast flatdEtectoR CT (FDCT) for the detection of intracranial hemorrhage in stroke patients - Protocol of a non-inferiority comparison to multi detector CT. PLoS One 20: e0330608, Aug 2025.
Salem MM, Sioutas GS, Gajjar A, Khalife J, Kuybu O, Carroll KT, Hoang AN, Baig AA, Salih M, Baker C, Cortez GM, Abecassis Z, Ruiz Rodriguez JF, Davies JM, Cawley CM, Riina H, Spiotta AM, Khalessi A, Howard BM, Hanel RA, Tanweer O, Tonetti D, Siddiqui AH, Lang M, Levy EI, Ogilvy CS, Srinivasan VM, Kan P, Gross BA, Jankowitz B, Levitt MR, Thomas AJ, Grandhi R, Burkhardt JK.: Femoral versus radial access for middle meningeal artery embolization for chronic subdural hematomas: multicenter propensity score matched study. J Neurointerv Surg 17: 890-897, Jul 2025.