Jan-Karl Burkhardt, MD
Assistant Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Director, Neurovascular Tissue Bank and Translational Lab, Burkardt Lab, Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania
Director, Center of Excellence - Cavernous Malformation, Hospital of the University of Pennsylvania, Penn Medicine
Educational Site Director, Department of Neurosurgery, The Hospital of the University of Pennsylvania
Interim Director, Neurosurgery Comprehensive Stroke Center, Department of Neurosurgery, University of Pennsylvania
Director, Cerebral Revascularization Program, Hospital of the University of Pennsylvania, Department of Neurosurgery
Director, Neurointerventional Fellowship Program, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania
Division Head, Cerebrovascular Surgery , Hospital Of the University of Pennsylvania, Penn Medicine
Department: Neurosurgery
Contact information
Department of Neurosurgery
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
Publications
Education:
MD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
Permanent linkMD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
Description of Clinical Expertise
Primary Area of Expertise / Neurosurgical Interests:Aneurysms, Arteriovenous Malformations (AVMs), Arteriovenous Fistulas (AVFs) and Cerebral Cavernous Malformations. Cerebral Revascularization and Extracranial-Intracranial (EC-IC) and IC-IC Bypass Procedures. Moyamoya Disease, Subarachnoid Hemorrhage, Intracranial Hemorrhage, Acute Ischemic Stroke and Chronic Vessel Stenosis or Occlusion.
Interested in both open microsurgical vascular and endovascular neurosurgery/neuroradiology.
Description of Research Expertise
Revascularization, Moyamoya diseaseSelected Publications
Dicpinigaitis AJ, Kazim SF, Al-Mufti F, Hall DE, Reitz KE, Rumalla K, McIntyre MK, Arthur AS, Srinivasan VM, Burkhardt J-K, Schmidt MH, Gandhi CD, Bowers CA : Frailty in aneurysmal subarachnoid hemorrhage: the risk analysis index. J Neurol 270(10): 4820-4826, Oct 2023.Salem MM, Khalife J, Desai S, Sharashidze V, Badger C, Kuhn AL, Monteiro A, Salahuddin H, Siddiqui AH, Singh J, Levy EI, Lang M, Grandhi R, Thomas AJ, Lin LM, Tanweer O, Burkhardt, J.-K., Puri AS, Gross BA, Nossek E, Hassan AE, Shaikh HA, Jankowitz BT. : COManeci MechANical dilation for vasospasm (COMMAND): multicenter experience J Neurointerv Surg 15(9): 864-870, Sep 2023.
Lun Li, Aileen A Ren, Siqi Gao, Yourong S Su, Jisheng Yang, Jenna Bockman, Patricia Mericko-Ishizuka, Joanna Griffin, Robert Shenkar, Roberto Alcazar, Thomas Moore, Rhonda Lightle, Dorothy DeBiasse, Issam A Awad, Douglas A Marchuk, Mark L Kahn, Jan-Karl Burkhardt: mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice. Stroke 54(11): 2906-2917, Sep 2023.
Vivanco-Suarez J, Sioutas GS, Matache IM, Muhammad N, Salem MM, Kandregula S, Jankowitz BT, Burkhardt J-K, Srinivasan VM. : Intraoperative angiography during neurosurgical procedures on patients in prone, three-quarters prone, and park-bench positions: tertiary single-center experience with systematic review and meta-analysis. J Neurointerv Surg 15(8): 793-800, Aug 2023.
Muhammad N, Sioutas GS, Gajjar A, Salem MM, Kandregula S, Srinivasan VM, Jankowitz BT, Burkhardt J-K. : Intraoperative angiography via popliteal artery access for spinal neurovascular lesions: an institutional experience and systematic review. J Neurointerv Surg 15(8): 787-792, Aug 2023.
Sioutas GS, Mannam SS, Corral Tarbay A, Nia AM, Salem MM, Vivanco-Suarez J, Burkhardt JK, Jankowitz BT, Srinivasan VM. : Dexamethasone and Statins in Patients Undergoing Primary Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Propensity-Matched Study in the TriNetX Research Network. World Neurosurg 176: e83-e90, Aug 2023.
Galea I, Bandyopadhyay S, Bulters D, Humar R, Hugelshofer M, Schaer DJ; SAH Delphi Group : Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation. Stroke 54(7): 1930-1942, Jul 2023.
Graffeo CS, Srinivasan VM, Frisoli F, Lang MJ, Mascitelli JR, Burkhardt JK, Walcott BP, Owen CM, Rodriguez-Hernandez A, Abla AA. : Twenty Years, 10 Fellows, 1 Article: Reflections on Cerebrovascular Training and the Evolution of Basilar Apex Aneurysm Treatments. Neurosurgery 93: e7-9, Jul 2023.
Salem MM, Ravindran K, Hoang AN, Doron O, Esparza R, Raper D, Jankowitz BT, Tanweer O, Lopes D, Langer D, Nossek E, Burkhardt J.-K. : Sonolucent Cranioplasty in Extracranial to Intracranial Bypass Surgery: Early Multicenter Experience of 44 Cases. Oper Neurosurg (Hagerstown) 25(1): 20-27, Jul 2023.
Siddiq F, Nunna RS, Beall JM, Khan I, Khan M, Tekle WG, Ezzeldin M, Tanweer O, Burkhardt JK, Jabbour PM, Tjoumakaris SI, Herial NA, Siddiqui AH, Grandhi R, Martin RL, Qureshi AI, Hassan AE.: 30-Day Outcomes of Resolute Onyx Stent for Symptomatic Intracranial Stenosis: A Multicenter Propensity Score-Matched Comparison With Stenting Versus Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial. Neurosurgery 92(6): 1155-1162, Jun 2023.