Jan-Karl Burkhardt, MD
The James and Agnes Kim Associate Professor of Neurosurgery
Associate Professor Neurosurgery, Lady of Lourdes, Virtua
Associate Professor Neurosurgery/Radiology, CHOP
Director, Neurovascular Tissue Bank and Translational Lab, Burkardt Lab, Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania
Director, Center of Excellence - Cavernous Malformation, Hospital of the University of Pennsylvania, Penn Medicine
Co-Director, Neurointerventional Fellowship Program, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania
Director, Cerebral Revascularization Program, Hospital of the University of Pennsylvania, Department of Neurosurgery
Neurosurgical Director, Comprehensive Stroke Center, Department of Neurosurgery, University of Pennsylvania
Division Head, Cerebrovascular Surgery , Hospital Of the University of Pennsylvania, Penn Medicine
Department: Neurosurgery
Contact information
Department of Neurosurgery
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
3400 Civic Center Blvd
15th Floor, South Tower
Philadelphia, PA 19104
Publications
Education:
MD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
MBA (Physician Executive MBA)
University of Tennessee, 2024.
Permanent linkMD
University of Leipzig, Germany, 2007.
MD Thesis
University of Leipzig, Germany, 2009.
PhD (Venia Legendi, Habilitation)
University of Zurich, Switzerland, 2016.
MBA (Physician Executive MBA)
University of Tennessee, 2024.
Description of Clinical Expertise
Primary Area of Expertise / Neurosurgical Interests:Aneurysms, Arteriovenous Malformations (AVMs), Arteriovenous Fistulas (AVFs) and Cerebral Cavernous Malformations. Cerebral Revascularization and Extracranial-Intracranial (EC-IC) and IC-IC Bypass Procedures. Moyamoya Disease, Subarachnoid Hemorrhage, Intracranial Hemorrhage, Acute Ischemic Stroke and Chronic Vessel Stenosis or Occlusion.
Interested in both open microsurgical vascular and endovascular neurosurgery/neuroradiology.
Description of Research Expertise
Revascularization, Moyamoya diseaseSelected Publications
Wu AQ, Gitlevich R, Palepu C, Hoglund ZT, Sollenberger CH, Kahlon AS, Scott KW, Ehtiati T, Burkhardt JK, Catapano JS, Kandregula S, Favilla CG, Srinivasan VM.: Mapping real-time hemodynamic changes in venous sinus stenting using intraoperative transcranial Doppler ultrasonography and quantitative angiography. Neurosurg Focus 60: E10, Jan 2026.Kayir I, Italia T, Gajjar AA, Mehta A, Patel S, Patel S, Ciobanu-Caraus O, Jabarkheel R, Shekhtman O, Wu AQ, Scott K, Ajmera S, Kandregula S, Rahmani R, Burkhardt JK, Srinivasan VM, Catapano JS.: Efficacy of carotid devices for resistant hypertension: a systematic review. J Neurointerv Surg Jan 2026.
Diana F, Siddiqui AH, Jaikumar V, Baig AA, Tomasello A, Hernandez D, Requena M, de Dios Lascuevas M, Arikan F, Xu B, Liao Y, Raz E, Chung C, Nossek E, Stroh-Holly N, Gmeiner M, Civelli V, Arpaia F, Khattar NK, Hoffman HA, Nickele CM, Arthur AS, Charbel FT, Vajkoczy P, Sanchin A, Jabbour P, Lanzino G, Ransom RC, Raabe A, Petutschnigg T, Velinov N, Burkhardt JK, Hassan AE, Saei H, Salcuni A, Manfrini E, Eusebi P, Bonura A, Romoli M, Peschillo S.: Associated Risks to the Treatment of Unruptured Intracranial Aneurysms (MARTA) Score: Development and External Validation. Neurosurgery Jan 2026.
Musmar B, Roy JM, Abdalrazeq H, Yacoub C, Adeeb N, Fuleihan AA, Koduri S, Baldassari M, Lan M, Patel P, Momin AA, Atallah E, Alshahrani R, Karadimas S, Sizdahkhani S, Garg A, Naamani KE, Chen CJ, Jabre R, Saad H, Grossberg JA, Dmytriw AA, Patel AB, Khorasanizadeh M, Ogilvy CS, Thomas AJ, Monteiro A, Siddiqui A, Cortez GM, Hanel RA, Kasem RA, Porto G, Spiotta AM, Piscopo AJ, Hasan DM, Ghorbani M, Weinberg J, Nimjee SM, Bekelis K, Salem MM, Burkhardt JK, Zetchi A, Matouk C, Howard BM, Lai R, Du R, Abbas R, Amllay A, Munoz A, Herial NA, Tjoumakaris SI, Gooch MR, Notarianni C, Guthikonda B, Morcos J, Rosenwasser RH, Jabbour P.: Outcomes of Bypass Surgery in Patients with Moyamoya Syndrome Secondary To Sickle Cell Disease: a Multicenter Study. Transl Stroke Res 17: 18, Jan 2026.
Shekhtman O, Matache IM, Sioutas GS, Kandregula S, Muhammad N, Kayir I, Covell M, Capone S, Piavchenko G, Catapano JS, Burkhardt JK, Srinivasan VM.: Epigenetic mechanisms in aneurysm formation, growth, and rupture: A systematic review. Interv Neuroradiol Dec 2025.
Essibayi MA, Jabal MS, Jamil H, Salim HA, Musmar B, Adeeb N, Dibas M, Cancelliere NM, Diestro JDB, Algin O, Ghozy S, Lay SV, Guenego A, Renieri L, Carnevale J, Saliou G, Mastorakos P, Naamani KE, Momin AA, Shotar E, Möhlenbruch M, Kral M, Chung C, Salem MM, Lylyk I, Foreman PM, Shaikh H, Župančić V, Hafeez MU, Catapano J, Waqas M, Besler MS, Gunes YC, Rabinov JD, Maingard J, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Starke RM, Hassan A, Ogilvie M, Nguyen A, Jones J, Brinjikji W, Nawka MT, Psychogios M, Ulfert C, Pukenas B, Burkhardt JK, Huynh T, Martinez-Gutierrez JC, Sheth SA, Slawski D, Tawk R, Pulli B, Lubicz B, Panni P, Puri AS, Pero G, Raz E, Griessenauer CJ, Asadi H, Siddiqui A, Levy EI, Khatri D, Haranhalli N, Ducruet AF, Albuquerque FC, Regenhardt RW, Stapleton CJ, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Tjoumakaris SI, Cuellar-Saenz HH, Jabbour PM, Clarençon F, Limbucci N, Pereira VM, Patel AB, Altschul DJ, Dmytriw AA; WorldWideWEB Consortium Collaborators.: Factors influencing immediate post-angiographic occlusion outcomes in intracranial aneurysms treated with the woven endobridge device: a multi-center analysis and predictive model from the WorldWideWEB consortium. Neurosurg Rev 49: 36, Dec 2025.
Italia T, Kayir I, Chilukuri G, Patel S, Patel SA, Gajjar AA, Jabarkheel R, Eberle A, Marcos-Contreras OA, Scott KW, Kasner SE, Jha RM, Pukenas B, Burkhardt JK, Srinivasan VM, Catapano JS.: Blood Biomarkers for Large Vessel Occlusions: A Systematic Review. Stroke Vasc Interv Neurol 5: e001863, Nov 2025.
Goyal AD, Gajjar AA, Muhammad N, Wu AQ, Polavarapu H, Tang O, Salem MM, Paliwoda ED, Gupta N, Doad J, Jankowitz BT, Srinivasan VM, Burkhardt JK.: A Three-Decade Analysis of Ischemic Stroke in India: Mortality, Morbidity, and Risk Factors Using the Global Burden of Diseases Study from 1990 to 2019. J Clin Med 14: 7807, Nov 2025.
Karamchandani RR, Wolman DN, Bielinski TM, Goyal N, Rhoten JB, Jayaraman MV, Sidebottom CT, Gross BA, Al-Bayati AR, Doheim MF, Tobin MK, Chinthala A, Gajjar A, Mascitelli J, Webb MR, Burkhardt JK, Scott KW, Srinivasan V, Tonetti D, Koneru M, Altschul DJ, Vaishnav D, Multani S, Theofanis T, Ares WJ, Sone JY, Zand R, Bahrami S, Li J, Defilipp G, Strong D, Torabi R, Moldovan K, Kline KE, Schirmer CM, Nogueira RG, Paul AR, Bohnstedt BN, Hendrix P.: Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment (BAO-TNK). Ann Clin Transl Neurol Nov 2025.
Wolman DN, Karamchandani RR, Hemmer S, Bielinski TM, Goyal N, Rhoten JB, Jayaraman MV, Sidebottom CT, Gross BA, Al-Bayati AR, Doheim MF, Tobin MK, Chinthala A, Gajjar A, Mascitelli J, Webb MR, Burkhardt JK, Scott KW, Srinivasan V, Tonetti D, Koneru M, Altschul DJ, Vaishnav D, Multani S, Theofanis T, Ares WJ, Sone JY, Zand R, Bahrami S, Li J, Defilipp G, Strong D, Torabi R, Moldovan K, Schirmer CM, Paul AR, Bohnstedt BN, Nogueira RG, Hendrix P.: Tenecteplase Versus Alteplase for First-Pass Reperfusion in Basilar Artery Occlusion Stroke Thrombectomy. Ann Neurol Nov 2025.