Naomi E Butler Tjaden, MD, PhD
Instructor A of Pediatrics
Attending Physician, Division of GI, Hepatology, and Nutrition, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
3615 Civic Center Blvd
Philadelphia, PA 19104
3615 Civic Center Blvd
Philadelphia, PA 19104
Publications
Education:
BA (Quantitative Biology)
Boston University, 2009.
PhD (Anatomy and Cell Biology)
University of Kansas Medical Center, Stowers Institute for Medical Research, 2015.
MD
University of Kansas Medical Center, 2017.
Permanent linkBA (Quantitative Biology)
Boston University, 2009.
PhD (Anatomy and Cell Biology)
University of Kansas Medical Center, Stowers Institute for Medical Research, 2015.
MD
University of Kansas Medical Center, 2017.
Description of Clinical Expertise
Motility, Constipation, Hirschsprung disease, Hirschsprung associated enterocolitis, Irritable Bowel SyndromeDescription of Research Expertise
Enteric Nervous System, Hirschsprung associated enterocolitis, dysbiosis, microbiome, metabolome, dietSelected Publications
Naomi E Butler Tjaden, Stephen R Shannon, Thoa Truong, Christopher W Seidel, Melissa Childers, Kazushi Aoto, Lisa L Sandell, Paul A Trainor: Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS Formation. Human Molecular Genetics Page: doi.org/10.1093/hmg/ddaf197, Feb 2026.Sharon Wolfson; Myra Butrviengpunt; Naomi Tjaden; Alain J. Benitez; Archana S Kota; Jennifer Webster; Prasanna Kapavarapu; Hayat Mousa; Robert O. Heuckeroth: Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo-obstruction: a case series. JPGN Page: doi: 10.1002, February 2026.
Tjaden, Allukian, Kapavarapu: Intestinal Neuronal Dysplasia. Nelson's Pediatrics, 23rd Edition. Robert Kliegman & Joseph W. St. Geme III (eds.). Elsevier, 2026 Notes: Chapter.
Tjaden, Allukian, Kapavarapu: Congenital Megacolon (Hirschsprung Disease). Nelson's Pediatrics, 23rd Edition. Robert Kliegman & Joseph W. St. Geme III (eds.). Elsevier, 2026 Notes: Chapter.
Chinn V, Sax S, Beigel K, Wilkens B, Raab J, Eisenberg J, Heuckeroth R, Hamilton K, Tjaden N: Epithelial Stem Cell Defects Precede the Development of Hirschsprung Associated Enterocolitis in the Piebald Lethal Model of Hirschsprung Disease. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, Chicago, IL, Poster Nov 2025.
NEB Tjaden, M Liou, S Sax, K Beigel, M Lou, N Lassoued, L Litichevskiy, S Anderson, N Pilon, C Thaiss, RO Heuckeroth: Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease. NeuroGASTRO, London, UK, Podium Sep 2025.
NEB Tjaden, C Tanes, K Graham, S Wolfson, AJ Benitez, N Wilson, A Degunia, K Bittinger, RO Heuckeroth: Microbiome Alterations in Hirschsprung Disease and Enterocolitis: Insights into Pathogenesis and Potential Therapeutic Strategies. NeuroGASTRO, London, UK, Podium Sep 2025.
NEB Tjaden, M Liou, S Sax, K Beigel, M Lou, N Lassoued, L Litichevskiy, S Anderson, N Pilon, C Thaiss, RO Heuckeroth: Diet, Microbes and Immunity Converge in the Pathogenesis of Hirschsprung Associated Enterocolitis in Mice. American Neurogastroenterology and Motility Society, Minneapolis, MN, Plenary Podium Aug 2025.
Chinn, V, Sax, S, Beigal, K, Wilkens B, Raab J, Eisenberg J, Thompson Z, Rubenstein R, Heuckeroth RO, Hamilton KE, Tjaden NEB.: Colonic Epithelial Stem Cell Defects Precede the Development of Hirschsprung Associated Enterocolitis in Mice. North American Society For Pediatric Gastroenterology, Hepatology & Nutrition, Chicago, IL, Podium August 2025.
NEB Tjaden, C Tanes, K Graham, S Wolfson, AJ Benitez, N Wilson, A Degunia, K Bittinger, RO Heuckeroth: Microbiome Alterations in Hirschsprung Disease and Enterocolitis: Insights into Pathogenesis and Potential Therapeutic Strategies. American Neurogastroenterology and Motility Society, Minneapolis, MN, Poster Aug 2025.