Naomi E Butler Tjaden, MD, PhD
Instructor A of Pediatrics
Attending Physician, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
3401 Civic Center Blvd.
Philadelphia, PA 19104
Philadelphia, PA 19104
Publications
Education:
BA (Quanitative Biology)
Boston University, 2009.
PhD (Anatomy and Cell Biology)
University of Kansas Medical Center, Stowers Institute for Medical Research, 2015.
MD
University of Kansas Medical Center, 2017.
Permanent linkBA (Quanitative Biology)
Boston University, 2009.
PhD (Anatomy and Cell Biology)
University of Kansas Medical Center, Stowers Institute for Medical Research, 2015.
MD
University of Kansas Medical Center, 2017.
Description of Clinical Expertise
Motility, Constipation, Hirschsprung disease, Hirschsprung associated enterocolitis, Irritable Bowel SyndromeDescription of Research Expertise
Enteric Nervous System, Hirschsprung associated enterocolitis, dysbiosis, microbiome, metabolome, dietSelected Publications
NEB Tjaden, M Liou, S Sax, K Beigel, M Lou, N Lassoued, L Litichevskiy, S Anderson, N Pilon, C Thaiss, RO Heuckeroth: Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease. NeuroGASTRO Sept 2025.NEB Tjaden, C Tanes, K Graham, S Wolfson, AJ Benitez, N Wilson, A Degunia, K Bittinger, RO Heuckeroth: Microbiome Alterations in Hirschsprung Disease and Enterocolitis: Insights into Pathogenesis and Potential Therapeutic Strategies. NeuroGASTRO Sept 2025.
NEB Tjaden, M Liou, S Sax, K Beigel, M Lou, N Lassoued, L Litichevskiy, S Anderson, N Pilon, C Thaiss, RO Heuckeroth: DIET, MICROBES AND IMMUNITY CONVERGE IN THE PATHOGENESIS OF HIRSCHSPRUNG ASSOCIATED ENTEROCOLITIS IN MICE. ANMS Plenary Podium Aug 2025.
NEB Tjaden, C Tanes, K Graham, S Wolfson, AJ Benitez, N Wilson, A Degunia, K Bittinger, RO Heuckeroth: Microbiome Alterations in Hirschsprung Disease and Enterocolitis: Insights into Pathogenesis and Potential Therapeutic Strategies. ANMS Poster Aug 2025.
Naomi E Butler Tjaden, Megan Liou, Sophie Sax, Meng Lou, Nejia Lassoued, Lev Litichevskiy, Sierra Anderson, Nicolas Pilon, Christoph Thaiss, Robert O Heuckeroth: DIET MANIPULATION AND SELECTIVE MICROBE EDITING AMELIORATES LETHAL ENTEROCOLITIS IN HIRSCHSPRUNG DISEASE. DDW, Podium Presentation May 2025.
Naomi Tjaden: Getting to the Guts of Enteric Nervous System Formation and Function. AAA Anatomy Connected, Invited Podium Presentation March 2025.
Naomi E Butler Tjaden, Megan Liou, Sophie Sax, Katherine Beigel, Meng Lou, Nejia Lassoued, Lev Litichevskiy, Sierra Anderson, Nicolas Pilon, Christoph Thaiss, Robert O Heuckeroth: DIET MANIPULATION AND SELECTIVE MICROBE EDITING AMELIORATES LETHAL ENTEROCOLITIS IN HIRSCHSPRUNG DISEASE PennCHOP Research Retreat, Podium Presentation March 2025.
Naomi E Butler Tjaden, Megan J Liou, Sophie E Sax, Nejia Lassoued, Meng Lou, Sabine Schneider, Katherine Beigel, Joshua D Eisenberg, Emma Loeffler, Sierra E Anderson, Guang Yan, Lev Litichevskiy, Lenka Dohnalová, Yixuan Zhu, Daniela Min Jing Che Jin, Jessica Raab, Emma E Furth, Zachary Thompson, Ronald C Rubenstein, Nicolas Pilon, Christoph A Thaiss, Robert O Heuckeroth: Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease. bioRxiv Feb 2025 Notes: doi: 10.1101/2025.02.10.637436.
Naomi E Butler Tjaden, Stephen R Shannon, Christopher W Seidel, Melissa Childers, Kazushi Aoto, Lisa L Sandell, Paul A Trainor: Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS Formation. bioRxiv Jan 2025 Notes: doi: 10.1101/2025.01.23.634504.
Sharon Wolfson; Myra Butrviengpunt; Naomi Tjaden; Alain J. Benitez; Archana S Kota; Jennifer Webster; Prasanna Kapavarapu; Hayat Mousa; Robert O. Heuckeroth: Clinical, manometric, genetic, and histologic associations in pediatric intestinal pseudo-obstruction: a case series. Submitted to JPGN 7/9/25 2025.