Daniel B Goodman, Ph.D.
Assistant Professor of Cancer Biology
Investigator, Center for Cellular Immunotherapies
Department: Cancer Biology
Education:
B.S. (Bioengineering w/ specialization in Bioinformatics)
University of California at San Diego, San Diego, CA, 2008.
Ph.D. (Bioinformatics and Integrative Genomics)
Massachusetts Institute of Technology, Cambridge, MA, 2016.
Permanent linkB.S. (Bioengineering w/ specialization in Bioinformatics)
University of California at San Diego, San Diego, CA, 2008.
Ph.D. (Bioinformatics and Integrative Genomics)
Massachusetts Institute of Technology, Cambridge, MA, 2016.
Description of Research Expertise
The Goodman Lab develops high-throughput and computational approaches to understand and engineer immune cell function, with the goal of creating safer and more effective cellular therapies for cancer and other diseases. We combine synthetic biology, protein engineering, and genome editing with clonal tracking, single-cell genomics, and machine-learning-guided design to map how genetic sequences shape immune signaling and cell fate. Our work aims to overcome key barriers in cellular immunotherapies — efficacy, persistence, and control — and to establish engineered immune cells as a central pillar of medicine.Selected Publications
Chang CR, Vykunta VS, Goodman DB, Muldoon JJ, Nyberg WA, Liu C, Allain V, Rothrock A, Wang CH, Marson A, Shy BR, Eyquem J: Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection. bioRxiv [Preprint] Feb 2024.Garcia J, Daniels J, Lee Y, Zhu I, Cheng K, Liu Q, Goodman D, Burnett C, Law C, Thienpont C, Alavi J, Azimi C, Montgomery G, Roybal KT, Choi J: Naturally occurring T cell mutations enhance engineered T cell therapies. Nature 626(7999): 626-634, Feb 2024.
Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A: Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell 186(19): 4216-4234, Sep 2023.
Christmas MJ, Kaplow IM, Genereux DP, Dong MX, Hughes GM, Li X, Sullivan PF, Hindle AG, Andrews G, Armstrong JC, Bianchi M, Breit AM, Diekhans M, Fanter C, Foley NM, Goodman DB, Goodman L, Keough KC, Kirilenko B, Kowalczyk A, Lawless C, Lind AL, Meadows JRS, Moreira LR, Redlich RW, Ryan L, Swofford R, Valenzuela A, Wagner F, Wallerman O, Brown AR, Damas J, Fan K, Gatesy J, Grimshaw J, Johnson J, Kozyrev SV, Lawler AJ, Marinescu VD, Morrill KM, Osmanski A, Paulat NS, Phan BN, Reilly SK, Schäffer DE, Steiner C, Supple MA, Wilder AP, Wirthlin ME, Xue JR; Zoonomia Consortium§; Birren BW, Gazal S, Hubley RM, Koepfli KP, Marques-Bonet T, Meyer WK, Nweeia M, Sabeti PC, Shapiro B, Smit AFA, Springer MS, Teeling EC, Weng Z, Hiller M, Levesque DL, Lewin HA, Murphy WJ, Navarro A, Paten B, Pollard KS, Ray DA, Ruf I, Ryder OA, Pfenning AR, Lindblad-Toh K, Karlsson EK: Evolutionary constraint and innovation across hundreds of placental mammals. Science 380(6643), Apr 2023.
Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, Bluestone JA, Roybal KT: Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Science Translational Medicine 14(670), Nov 2022.
Bucktrout SL, Banovich NE, Butterfield LH, Cimen-Bozkus C, Giles JR, Good Z, Goodman DB, Jonsson VD, Lareau C, Marson A, Maurer DM, Munson PV, Stubbington M, Taylor S, Cutchin A: Advancing T cell-based cancer therapy with single-cell technologies. Nature Medicine 28: 1761– 1764, Sep 2022.
Schubert MG, Goodman DB, Wannier TM, Kaur D, Farzadfard F, Lu TK, Shipman SL, Church GM: High-throughput functional variant screens via in vivo production of single-stranded DNA. Proceedings of the National Academy of Sciences 118(18), May 2021.
Ferreira L, Muller YD, Kaul AM, Shaikh H, Guerrero-Moreno R, Yao LE, Goodman DB, Bluestone JA, Tang Q: Chimeric antigen receptor signaling confers antitumor activity to human regulatory T cells. American Association of Immunologists May 2020.
Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ: Genomically recoded organisms expand biological functions. Science 342(6156): 357-60, Oct 2013.
Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A: Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nature Biotechnology 38(1): 44-49, Jan 2020.
Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A: Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell 181(3): 728-744, Apr 2020.
Kuznetsov G, Goodman DB, Filsinger GT, Landon M, Rohland N, Aach J, Lajoie MJ, Church GM: Optimizing complex phenotypes through model-guided multiplex genome engineering. Genome Biology 18(1): 1-12, May 2017.
Goodman DB, Church GM, Kosuri S: Causes and effects of N-terminal codon bias in bacterial genes. Science 342(6157): 475-9, Oct 2013.