Carina A Dehner
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
3400 Spruce Street, 6 Founders
Philadelphia, PA 19104
Department of Pathology and Laboratory Medicine
3400 Spruce Street, 6 Founders
Philadelphia, PA 19104
Education:
MD PhD
Technical University Munich, 2016.
Permanent linkMD PhD
Technical University Munich, 2016.
Description of Clinical Expertise
I practice Bone & Soft Tissue and Dermatopathology.Areas of Expertise include:
Rhabdomyosarcoma
NF1-associated neoplasms including malignant peripheral nerve sheath tumors
Fusion-driven mesenchymal neoplasms
Pemphigus Vulgaris
Cutaneous mesenchymal tumors
Description of Research Expertise
I am an Assistant Professor in the Department of Pathology at Indiana University School of Medicine, with subspecialty board certification in Dermatopathology and fellowship training in Bone & Soft Tissue Pathology. My research interests are focused on molecular drivers of neurofibromatous neoplasms including malignant peripheral nerve sheath tumors (MPNST) and adult-type rhabdomyosarcomas (RMS). While my PhD work focused on the cutaneous autoimmune disease Pemphigus Vulgaris, I subsequently performed an MD fellowship and postdoctoral fellowship at Yale University where I studied the role of commensal bacteria in autoimmune diseases and cutaneous T-cell lymphoma. During my time at Washington University, I joined the laboratory of Dr. Angela Hirbe where I embarked on various projects focusing on MPNST. Specifically, I showed that chr8 gain is associated with malignant transformation in MPNST. Since joining the Pathology department at Indiana University, I have joined Dr. Steven Rhodes laboratory where I am enthusiastic about studying genetic and immunologic signatures that may delineate plexiform neurofibromas (PN)s that are at high risk of undergoing malignant transformation to MPNST. I am looking forward to continuing this work at the University of Pennsylvania.Selected Publications
Prechtel TJ, Brashear E, Dehner CA, Alomari AK.: A Case of Hybrid Cellular Neurothekeoma and Perineurioma With a Folliculin Gene Mutation. J Cutan Pathol 52(5): 374-378, May 2025.Dehner C, Pissaloux D, Thamphya B, Tirode F, Von Deimling A, Guo RR, Wieland C, de la Fouchardière A, Kervarrec T.: ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case. Virchows Arch 486(4): 871-875, April 2025.
Lucas CG, Gross AM, Romo CG, Dehner CA, Lazar AJ, Miettinen M, Pekmezci M, Quezado M, Rodriguez FJ, Stemmer-Rachamimov A, Viskochil D, Perry A; Symposium on Atypical Neurofibroma: State of the Science Members.: Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis Type 1. Neuro Oncol 27(3): 616-624, March 2025.
Arnold PJ, Spio M, Youssef R, Dehner C, Rice K.: Perivascular epithelioid cell neoplasm of the bladder with peritoneal metastasis. Can J Urol 32(1): 47-53, March 2025.
Li A, Umphress B, Dehner C, Jones R, Toral K, Warren S, Alomari AK.: Genomic and Transcriptomic Characterization of Protein Kinase C Fusion Melanocytic Neoplasms With Distinctive Hypopigmented Histomorphology: A Single-Institution Study. J Cutan Pathol March 2025 Notes: Online ahead of print.
Legrand M, Louveau B, Osio A, Tallet A, Calonje E, Scoazec JY, de la Fouchardiere A, Tirode F, Von Deimling A, Busam K, Shah A, Flaman A, Jouenne F, Mourah S, Pissaloux D, Lantuejoul S, French CA, Goto K, Cribier B, Dehner CA, Alomari AK, Fletcher CD, Hanna J, Macagno N, Battistella M, Kervarrec T.: Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1-rearranged porocarcinoma. Histopathology March 2025 Notes: online ahead of print.
Dehner CA, Jour G, Gassenmaier M, Michal M, de Saint Aubain N, Papke DJ Jr, Umphress B, Li A, Tanner MM, Calonje E, Brenn T, Fletcher CDM, Mentzel T, Busam K, Linos K.: Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions: A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma? Am J Surg Pathol March 2025 Notes: Online ahead of print.
Toklu A, Panse G, Jour G, Linos K, Cloutier JM, Dehner CA.: Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations. Virchows Arch March 2025 Notes: Online ahead of print.
Warmke LM, Ameline B, Fritchie KJ, Dehner CA, Agaimy A, Din NU, Miettinen MM, Dermawan JK, Gross JM, Thangaiah JJ, Chrisinger JSA, Suster DI, Perret R, Le Loarer F, Charville GW, Buehler D, Yeung MCF, Smith BF, Baumhoer D, Davis JL.: YAP1::KMT2A-rearranged sarcomas harbor a unique methylation profile and are distinct from sclerosing epithelioid fibrosarcoma and low-grade fibromyxoid sarcoma. Virchows Arch 486(3): 457-477, March 2025.
Dehner CA, Warmke LM, Umphress B, Malik F, Cloutier JM, Dermawan JK, Fritz M, Que SKT, Ameline B, Fritchie KJ, Kerr DA, Linos K, Baumhoer D, Billings SD, Folpe AL.: Superficial Neurocristic FET::ETS Fusion Tumor: Expanding the Clinicopathological and Molecular Genetic Spectrum of a Recently Described Entity. Mod Pathol 38(2): 100656, February 2025.