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Carina A Dehner
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Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
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Department: Pathology and Laboratory Medicine
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Contact information
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Hospital of the University of Pennsylvania
37 Department of Pathology and Laboratory Medicine
41 3400 Spruce Street, 6 Founders
Philadelphia, PA 19104
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37 Department of Pathology and Laboratory Medicine
41 3400 Spruce Street, 6 Founders
Philadelphia, PA 19104
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Education:
21 b MD PhD c
34 Technical University Munich, 2016.
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Permanent link21 b MD PhD c
34 Technical University Munich, 2016.
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23 Areas of Expertise include:
18 Rhabdomyosarcoma
53 NF1-associated neoplasms including malignant peripheral nerve sheath tumors
2b Fusion-driven mesenchymal neoplasms
1a Pemphigus Vulgaris
23 Cutaneous mesenchymal tumors
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Description of Clinical Expertise
45 I practice Bone & Soft Tissue and Dermatopathology.23 Areas of Expertise include:
18 Rhabdomyosarcoma
53 NF1-associated neoplasms including malignant peripheral nerve sheath tumors
2b Fusion-driven mesenchymal neoplasms
1a Pemphigus Vulgaris
23 Cutaneous mesenchymal tumors
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Description of Research Expertise
44b I am an Assistant Professor in the Department of Pathology at the University of Pennsylvania, with subspecialty board certification in Dermatopathology and fellowship training in Bone & Soft Tissue Pathology. My research interests are focused on molecular drivers of neurofibromatous neoplasms including malignant peripheral nerve sheath tumors (MPNST) and adult-type rhabdomyosarcomas (RMS). While my PhD work focused on the cutaneous autoimmune disease Pemphigus Vulgaris, I subsequently performed an MD fellowship and postdoctoral fellowship at Yale University where I studied the role of commensal bacteria in autoimmune diseases and cutaneous T-cell lymphoma. During my time at Washington University, I joined the laboratory of Dr. Angela Hirbe where I embarked on various projects focusing on MPNST. Specifically, I showed that chr8 gain is associated with malignant transformation in MPNST. At Indiana University, I worked closely with Dr. Steven Rhodes studying NF1 and MPNST pathogenesis and I am hoping to continue this and other interesting sarcoma projects here at UPenn.e 29
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121 Dehner C, Pissaloux D, Thamphya B, Tirode F, Von Deimling A, Guo RR, Wieland C, de la Fouchardière A, Kervarrec T.: ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case. Virchows Arch 486(4): 871-875, April 2025.
1d9 Lucas CG, Gross AM, Romo CG, Dehner CA, Lazar AJ, Miettinen M, Pekmezci M, Quezado M, Rodriguez FJ, Stemmer-Rachamimov A, Viskochil D, Perry A; Symposium on Atypical Neurofibroma: State of the Science Members.: Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis Type 1. Neuro Oncol 27(3): 616-624, March 2025.
f0 Arnold PJ, Spio M, Youssef R, Dehner C, Rice K.: Perivascular epithelioid cell neoplasm of the bladder with peritoneal metastasis. Can J Urol 32(1): 47-53, March 2025.
16e Li A, Umphress B, Dehner C, Jones R, Toral K, Warren S, Alomari AK.: Genomic and Transcriptomic Characterization of Protein Kinase C Fusion Melanocytic Neoplasms With Distinctive Hypopigmented Histomorphology: A Single-Institution Study. J Cutan Pathol March 2025 Notes: Online ahead of print.
26b Legrand M, Louveau B, Osio A, Tallet A, Calonje E, Scoazec JY, de la Fouchardiere A, Tirode F, Von Deimling A, Busam K, Shah A, Flaman A, Jouenne F, Mourah S, Pissaloux D, Lantuejoul S, French CA, Goto K, Cribier B, Dehner CA, Alomari AK, Fletcher CD, Hanna J, Macagno N, Battistella M, Kervarrec T.: Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1-rearranged porocarcinoma. Histopathology March 2025 Notes: online ahead of print.
1bd Dehner CA, Jour G, Gassenmaier M, Michal M, de Saint Aubain N, Papke DJ Jr, Umphress B, Li A, Tanner MM, Calonje E, Brenn T, Fletcher CDM, Mentzel T, Busam K, Linos K.: Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions: A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma? Am J Surg Pathol March 2025 Notes: Online ahead of print.
116 Toklu A, Panse G, Jour G, Linos K, Cloutier JM, Dehner CA.: Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations. Virchows Arch March 2025 Notes: Online ahead of print.
1fe Warmke LM, Ameline B, Fritchie KJ, Dehner CA, Agaimy A, Din NU, Miettinen MM, Dermawan JK, Gross JM, Thangaiah JJ, Chrisinger JSA, Suster DI, Perret R, Le Loarer F, Charville GW, Buehler D, Yeung MCF, Smith BF, Baumhoer D, Davis JL.: YAP1::KMT2A-rearranged sarcomas harbor a unique methylation profile and are distinct from sclerosing epithelioid fibrosarcoma and low-grade fibromyxoid sarcoma. Virchows Arch 486(3): 457-477, March 2025.
1a7 Dehner CA, Warmke LM, Umphress B, Malik F, Cloutier JM, Dermawan JK, Fritz M, Que SKT, Ameline B, Fritchie KJ, Kerr DA, Linos K, Baumhoer D, Billings SD, Folpe AL.: Superficial Neurocristic FET::ETS Fusion Tumor: Expanding the Clinicopathological and Molecular Genetic Spectrum of a Recently Described Entity. Mod Pathol 38(2): 100656, February 2025.
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Selected Publications
fc Prechtel TJ, Brashear E, Dehner CA, Alomari AK.: A Case of Hybrid Cellular Neurothekeoma and Perineurioma With a Folliculin Gene Mutation. J Cutan Pathol 52(5): 374-378, May 2025.121 Dehner C, Pissaloux D, Thamphya B, Tirode F, Von Deimling A, Guo RR, Wieland C, de la Fouchardière A, Kervarrec T.: ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case. Virchows Arch 486(4): 871-875, April 2025.
1d9 Lucas CG, Gross AM, Romo CG, Dehner CA, Lazar AJ, Miettinen M, Pekmezci M, Quezado M, Rodriguez FJ, Stemmer-Rachamimov A, Viskochil D, Perry A; Symposium on Atypical Neurofibroma: State of the Science Members.: Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis Type 1. Neuro Oncol 27(3): 616-624, March 2025.
f0 Arnold PJ, Spio M, Youssef R, Dehner C, Rice K.: Perivascular epithelioid cell neoplasm of the bladder with peritoneal metastasis. Can J Urol 32(1): 47-53, March 2025.
16e Li A, Umphress B, Dehner C, Jones R, Toral K, Warren S, Alomari AK.: Genomic and Transcriptomic Characterization of Protein Kinase C Fusion Melanocytic Neoplasms With Distinctive Hypopigmented Histomorphology: A Single-Institution Study. J Cutan Pathol March 2025 Notes: Online ahead of print.
26b Legrand M, Louveau B, Osio A, Tallet A, Calonje E, Scoazec JY, de la Fouchardiere A, Tirode F, Von Deimling A, Busam K, Shah A, Flaman A, Jouenne F, Mourah S, Pissaloux D, Lantuejoul S, French CA, Goto K, Cribier B, Dehner CA, Alomari AK, Fletcher CD, Hanna J, Macagno N, Battistella M, Kervarrec T.: Primary cutaneous NUT adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous NUT carcinoma and NUTM1-rearranged porocarcinoma. Histopathology March 2025 Notes: online ahead of print.
1bd Dehner CA, Jour G, Gassenmaier M, Michal M, de Saint Aubain N, Papke DJ Jr, Umphress B, Li A, Tanner MM, Calonje E, Brenn T, Fletcher CDM, Mentzel T, Busam K, Linos K.: Cutaneous Hemangioma With Epithelioid Features Harboring TPM3/4::ALK Fusions: A Distinct Entity or a Molecular Variant of Epithelioid Hemangioma? Am J Surg Pathol March 2025 Notes: Online ahead of print.
116 Toklu A, Panse G, Jour G, Linos K, Cloutier JM, Dehner CA.: Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations. Virchows Arch March 2025 Notes: Online ahead of print.
1fe Warmke LM, Ameline B, Fritchie KJ, Dehner CA, Agaimy A, Din NU, Miettinen MM, Dermawan JK, Gross JM, Thangaiah JJ, Chrisinger JSA, Suster DI, Perret R, Le Loarer F, Charville GW, Buehler D, Yeung MCF, Smith BF, Baumhoer D, Davis JL.: YAP1::KMT2A-rearranged sarcomas harbor a unique methylation profile and are distinct from sclerosing epithelioid fibrosarcoma and low-grade fibromyxoid sarcoma. Virchows Arch 486(3): 457-477, March 2025.
1a7 Dehner CA, Warmke LM, Umphress B, Malik F, Cloutier JM, Dermawan JK, Fritz M, Que SKT, Ameline B, Fritchie KJ, Kerr DA, Linos K, Baumhoer D, Billings SD, Folpe AL.: Superficial Neurocristic FET::ETS Fusion Tumor: Expanding the Clinicopathological and Molecular Genetic Spectrum of a Recently Described Entity. Mod Pathol 38(2): 100656, February 2025.
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