Selected Publications

Indeglia, A., Leung, J.C., Miller, S.A., Leu, J.I., Dougherty, J.F., Clarke, N.L., Kirven, N.A., Shao, C., Ke, L., Lovell, S., Barnoud, T., Lu, D.Y., Lin, C., Kannan, T., Battaile, K.P., Yang, T.H.L., Batista Oliva, I., Claiborne, D.T., Vogel, P., Liu, L., Liu, Q., Nefedova, Y., Cassel, J., Auslander, N., Kossenkov, A.V., Karanicolas, J., Murphy, M.E.: An African-specific variant of TP53 reveals PADI4 as a regulator of p53-mediated tumor suppression. Cancer Discovery 13(7): 1696-1719, 2023.

Leung, J.C., Leu, J.I., Indeglia, A., Kannan, T., Clarke, N.L., Kirven, N.A., Dweep, H., Garlick, D., Barnoud, T., Kossenkov, A.V., George, D.L., Murphy, M.E.: Common activities and predictive gene signature identified for genetic hypomorphs of TP53. Proc. Natl. Acad. Sci. USA. 120(7): e2212940120, 2023.

Leu, J.I., Murphy, M.E., George, D.L.: Targeting ErbB3 and Cellular NADPH/NADP+ Abundance Sensitizes Cutaneous Melanomas to Ferroptosis Inducers. ACS Chemical Biology 17(5): 1038-1044, 2022.

Leu, J.I., Murphy, M.E., George, D.L.: P53 regulates cellular redox state, ferroptosis and metabolism. Molecular & Cellular Oncology 8(2): 1877076, 2021.

Parris, J.L.D., Barnoud, T., Leu, J.I., Leung, J.C., Ma, W., Kirven, N.A., Poli, A.N.R., Kossenkov, A.V., Liu, Q., Salvino, J.M., George, D.L., Weeraratna, A.T., Chen, Q., Murphy, M.E.: HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS mutant melanoma. Cancer Research Communications. 1: 17-29, 2021.

Singh, K.S., Leu*, J.I., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J.C., Kossenkov, A.V., George, D.L., Murphy, M.E., Dotiwala, F.: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nature Communications 11(1): 473, 2020. Notes: *Co-first author.

Gnanapradeepan, K., Leu, J.I., Basu, S., Barnoud, T., Good, M., Lee, J.V., Quinn, W.J., Kung, C.P., Ahima, R., Baur, J.A., Wellen, K.E., Liu, Q., Schug, Z.T., George, D.L., Murphy, M.E.: Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser. Elife 9: e55994, 2020.

Barnoud, T., Leung*, J.C., Leu*, J.I., Basu*, S., Poli*, A.N.R., Parris, J.L.D., Indeglia, A., Martynyuk, T., Good, M., Gnanapradeepan, K., Sanseviero, E., Moeller, R., Tang, H.Y., Cassel, J., Kossenkov, A.V., Liu, Q., Speicher, D.W., Gabrilovich, D.I., Salvino, J.M., George, D.L., Murphy, M.E.: A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors. Cancer Research. 80(23): 5270-5281, 2020. Notes: *Equal contribution.

Leu, J.I., Murphy, M.E., George, D.L.: Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53. Proc. Natl. Acad. Sci. USA. 117(43): 26804-26811, 2020.

Leu, J.I., Murphy, M.E., George, D.L.: Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53. Proc. Natl. Acad. Sci. USA. 116(17): 8390-8396, 2019.

Barnoud, T., Budina-Kolomets, A., Basu, S., Leu, J.I., Good, M., Kung, C.P., Liu, J., Liu, Q., Villanueva, J., Zhang, R., George, D.L., Murphy, M.E.: Tailoring Chemotherapy for the African-Centric S47 Variant of TP53. Cancer Research 78(19): 5694-5705, 2018.

Leu, J.I., Barnoud, T., Zhang, G., Tian, T., Wei, Z., Herlyn, M., Murphy, M.E., George, D.L.: Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function. Oncotarget 8(28): 45656-45669, 2017.

Kung, C.P., Leu, J.I., Basu, S., Khaku, S., Anokye-Danso, F., Liu, Q., George, D.L., Ahima, R.S., Murphy, M.E.: The P72R polymorphism of p53 predisposes to obesity and metabolic dysfunction. Cell Reports 14(10): 2413-2425, 2016.

Budina-Kolomets, A., Webster, M.R., Leu, J.I., Jennis, M., Krepler, C., Guerrini, A., Kossenkov, A.V., Xu, W., Karakousis, G.C., Schuchter, L.M., Amaravadi, R.K., Wu, H., Yin, X., Liu, Q., Lu, Y., Mills, G.B., Xu, X., George, D.L., Weeraratna, A.T., Murphy, M.E.: HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors. Cancer Research 76(9): 2720-2730, 2016.

Jennis, M., Kung, C.P., Basu, S., Budina-Kolomets, A., Leu, J.I., Khaku, S., Scott, J.P., Cai, K.Q., Campbell, M.R., Porter, D.K., Wang, X., Bell, D.A., Li, X., Garlick, D.S., Liu, Q., Hollstein, M., George, D.L., Murphy, M.E.: An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model. Genes & Development 30(8): 918-930, 2016.