Lauren M Hook, PhD

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Research Assistant Professor of Medicine (Infectious Diseases)
Department: Medicine

Contact information
4020 1 uCity
Philadelphia, PA 19104
Education:
BS (Biology)
Bates College, Lewiston, Maine, 1998.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 2006.
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Selected Publications

Egan KP, Awasthi S, Tebaldi G, Hook LM, Naughton AM, Fowler BT, Beattie M, Alameh MG, Weissman D, Cohen GH, Friedman HM: A trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-LNP vaccine provides outstanding protection in mice against genital and non-genital HSV-1 infection, comparable to the same antigens derived from HSV-1. Viruses 15(1): 1483, Jun 2023.

Awasthi S, Onishi M, Lubinski JM, Fowler BT, Naughton AM, Hook LM, Egan KP, Hagiwara M, Shirai S, Sakai A, Nakagawa T, Goto K, Yoshida O, Stephens AJ, Choi G, Cohen GH, Katayama K, Friedman HM: Novel adjuvant S-540956 targets lymph nodes and reduces genital recurrences and vaginal shedding of HSV-2 DNA when administered with HSV-2 glycoprotein D as a therapeutic vaccine in guinea pigs. Viruses 15(1): 1148, May 2023.

Hook LM, Awasthi S, Cairns TM, Alameh MG, Fowler BT, Egan KP, Sung MMH, Weissman D, Cohen GH, Friedman HM: Antibodies to crucial epitopes on HSV-2 glycoprotein D as a guide to dosing an mRNA genital herpes vaccine. Viruses 14(1): 540, Mar 2022.

Awasthi S, Knox JJ, Desmond A, Alameh MG, Gaudette BT, Lubinski JM, Naughton A, Hook LM, Egan KP, Tam YK, Pardi N, Allman D, Luning Prak ET, Cancro MP, Weissman D, Cohen GH, and Friedman HM: Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models. The Journal of Clinical Investigation 131(1): e152310, Nov 2021.

Egan K, Hook LM, Naughton A, Friedman HM, Awasthi S.: Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection. Hum Vaccin Immunother 16(1): 2109-2113, Sep 2020.

Egan KP, Hook LM, Naughton A, Pardi N, Awasthi S, Cohen GH, Weissman D, Friedman HM: An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection. PLoS Pathog 16(1): e1008795, July 2020.

Awasthi S, Hook LM, Pardi N, Wang F, Myles A, Cancro MP, Cohen GH, Weissman D, Friedman HM: Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes. Sci Immunol 4(39): pii: eaaw7083, Sep 2019.

Awasthi S, Hook LM, Swaminathan G, Cairns TM, Brooks B, Smith JS, Ditto NT, Gindy ME, Bett AJ, Espeseth AS, Cohen GH, Friedman HM: Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants. Vaccine 37(29): 3770-3778, Jun 2019.

Hook LM, Awasthi S, Dubin J, Flechtner J, Long D, Friedman HM: A trivalent gC2/gD2/gE2 vaccine for herpes simplex virus generates antibody responses that block immune evasion domains on gC2 better than natural infection. Vaccine 37(4): 664-669, Jan 2019.

Hook LM, Cairns TM, Awasthi S, Brooks BD, Ditto NT, Eisenberg RJ, Cohen GH, Friedman HM: Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs. PLoS Pathog 14(5): e1007095, May 2018.

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Last updated: 02/05/2024
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