Noam A. Cohen, M.D., PhD

faculty photo
Ralph Butler Endowed Professor for Medical Research
Director, Rhinology Research, University of Pennsylvania, Department of Otorhinolaryngology
Chair of the Otorhinolaryngology Resident Research Committee, University of Pennsylvania Department of Otorhinolaryngology
Department: Otorhinolaryngology: Head and Neck Surgery
Graduate Group Affiliations

Contact information
UPHS, Department of ORL:HNS
3400 Spruce Street, 5 Ravdin
Philadelphia, PA 19104-4283
B.A. (Biology)
Johns Hopkins University , 1990.
M.D. (Medicine)
Johns Hopkins University , 1998.
Ph.D. (Neuroscience)
Johns Hopkins University , 1998.
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Description of Research Expertise

Upper airway mucosal innate immunity
Airway taste receptors
Respiratory cilia function
respiratory mucosal biofilms
Chronic Rhinosinusitis

Description of Clinical Expertise

Chronic Rhinosinusitis
Paranasal sinus disorders
Endoscopic Sinus and Skull Base Surgery

Selected Publications

Lee, R.J., Cohen, N.A.: Bitter Taste Bodyguards. Scientific American 314(2): 38-43, February 2016.

Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, Abraham V, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Beauchamp GK, Paschalis-Thomas D, Ischriopoulos H, Kriendler JL, Reed DR, Cohen NA: T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 122(11): 4145-59, Nov 2012.

Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L, Xiong G, Adappa ND, Palmer JN, Kennedy DW, Kreindler JL, Margolskee RF, Cohen NA: Bitter and sweet taste receptor regulation of human upper respiratory innate immunity. J Clin Invest 124(3): 1393-405, Mar 2014.

Lee RJ, Workman AD, Carey RM, Chen B, Rosen PL, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Cohen NA: Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function. Nat Sci Rep 14(6): 33221, Sep 2016.

Adappa ND, Farquhar D, Palmer JN, Kennedy DW, Doghramji L, Morris SA, Owens D, Mansfield C, Lysenko A, Lee RJ, Cowart BJ, Reed DR, Cohen NA: TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6(1): 25-33, Jan 2016.

Stevens WW, Lee RJ, Schleimer RP, Cohen NA: Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol 136(6): 1442-53, Dec 2015.

Adappa AD, Howland TJ, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Lee RJ, Cohen NA: Genetics of the Taste Receptor T2R38 Correlates with Chronic Rhinosinusitis Necessitating Surgical Intervention. Int Forum Allergy Rhinol 3(3): 184-7, Mar 2013.

Adappa AD, Zhang Z, Palmer JN, Kennedy DW, Doghramji L, Lysenko A, Reed DR, Scott T, Zhao NW, Owens D, Lee RJ, Cohen NA: The Bitter Taste Receptor T2R38 is an Independent Risk Factor for Chronic Rhinosinusitis Requiring Sinus Surgery. Int Forum Allergy Rhinol 4(1): 3-7, Jan 2014.

Adappa ND, Truesdale CM, Workman AD, Doghramji L, Mansfield C, Kennedy DW, Palmer JN, Cowart BJ, Cohen NA: Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients. Int Forum Allergy Rhinol 6(8): 783-91, Aug 2016.

Douglas JE, Saunders CJ, Reed DR, Cohen NA : A role for airway taste receptor modulation in the treatment of upper respiratory infections. Expert Rev Respir Med 10(2): 157-70, Feb 2016.

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Last updated: 02/22/2024
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