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Jane Elizabeth Minturn, M.D., Ph.D.

Jane Elizabeth Minturn, M.D., Ph.D.

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Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Oncology, 4028 CTRB
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-426-5026
Fax: 215-590-9956
Education:
B.S. (Psychobiology)
University of Southern California, 1986.
M.Phil. (Neurobiology)
Yale University, 1993.
M.D. (Medicine)
Yale University School of Medicine, 1996.
Ph.D. (Neurobiology)
Yale University, 1996.
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Description of Research Expertise

Early phase clinical trial development in pediatric central nervous system tumors. Targeting oncogenic signal transduction pathways and resistance mechanisms for therapeutic intervention.

Description of Clinical Expertise

Pediatric Neuro-Oncology and Early Phase Clinic Trials/Developmental Therapeutics in Pediatric Brain Tumors. Particular interest in intratumoral hypoxia as a therapeutic target, a marker of treatment resistance, and a biomarker exploitable for non-invasive tumor imaging.

Selected Publications

Shah AC, Minturn JE, Li Y, Belasco JB, Phillips PC, Kang TI, Cole KA, Waanders AJ, Pollack R, Didomenico C, Wildes C, Fisher MJ: Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Pediatric Blood & Cancer Submitted 2015.

Frick M, Minturn JE, Li Y, Hill-Kayser C: Radiotherapy-related outcomes in pediatric patients with atypical teratoid rhabdoid tumor of the central nervous system. Journal of Pediatric Hematology/Oncology Submitted 2015.

Iyer Radhika, Varela Carly R, Minturn Jane E, Ho Ruth, Simpson Anisha M, Light Jennifer E, Evans Audrey E, Zhao Huaqing, Thress Kenneth, Brown Jeffrey L, Brodeur Garrett M: AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts. Cancer chemotherapy and pharmacology 70(3): 477-86, Sep 2012.

Light Jennifer E, Koyama Hiroshi, Minturn Jane E, Ho Ruth, Simpson Anisha M, Iyer Radhika, Mangino Jennifer L, Kolla Venkatadri, London Wendy B, Brodeur Garrett M: Clinical significance of NTRK family gene expression in neuroblastomas. Pediatric blood & cancer 59(2): 226-32, Aug 2012.

Warren Katherine E, Gururangan Sri, Geyer J Russell, McLendon Roger E, Poussaint Tina Young, Wallace Dana, Balis Frank M, Berg Stacey L, Packer Roger J, Goldman Stewart, Minturn Jane E, Pollack Ian F, Boyett James M, Kun Larry E: A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study. Journal of neuro-oncology 106(3): 643-9, Feb 2012.

Norris Robin E, Minturn Jane E, Brodeur Garrett M, Maris John M, Adamson Peter C: Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma. Cancer chemotherapy and pharmacology 68(6): 1469-75, Dec 2011.

Minturn Jane E, Evans Audrey E, Villablanca Judith G, Yanik Gregory A, Park Julie R, Shusterman Suzanne, Groshen Susan, Hellriegel Edward T, Bensen-Kennedy Debra, Matthay Katherine K, Brodeur Garrett M, Maris John M: Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study. Cancer chemotherapy and pharmacology 68(4): 1057-65, Oct 2011.

Long Patrick M, Stradecki Holly M, Minturn Jane E, Wesley Umadevi V, Jaworski Diane M: Differential aminoacylase expression in neuroblastoma. International journal of cancer. Journal international du cancer 129(6): 1322-30, Sep 2011.

Ho Ruth, Minturn Jane E, Simpson Anisha M, Iyer Radhika, Light Jennifer E, Evans Audrey E, Brodeur Garrett M: The effect of P75 on Trk receptors in neuroblastomas. Cancer letters 305(1): 76-85, Jun 2011.

Haas-Kogan Daphne A, Banerjee Anuradha, Poussaint Tina Young, Kocak Mehmet, Prados Michael D, Geyer J Russell, Fouladi Maryam, Broniscer Alberto, Minturn Jane E, Pollack Ian F, Packer Roger J, Boyett James M, Kun Larry E: Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas. Neuro-oncology 13(3): 298-306, Mar 2011.

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Last updated: 06/09/2015
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