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Laurence U Buxbaum, MD, Ph.D.
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Clinical Associate Professor of Medicine (Infectious Diseases)
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Department: Medicine
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Contact information
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A316
19 VA Medical Center
3e 3900 Woodland Ave., Res 151
Philadelphia, PA 19104
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19 VA Medical Center
3e 3900 Woodland Ave., Res 151
Philadelphia, PA 19104
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Office: 215-284-1674
32 Fax: 662-200-5984
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32 Fax: 662-200-5984
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Education:
21 9 S.B. 18 (Mathematics) c
3e Massachusetts Institute of Technology, 1987.
21 9 S.B. 14 (Biology) c
3e Massachusetts Institute of Technology, 1987.
21 a Ph.D. 19 (Biochemistry) c
39 Johns Hopkins School of Medicine, 1995.
21 9 M.D. c
39 Johns Hopkins School of Medicine, 1995.
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Permanent link21 9 S.B. 18 (Mathematics) c
3e Massachusetts Institute of Technology, 1987.
21 9 S.B. 14 (Biology) c
3e Massachusetts Institute of Technology, 1987.
21 a Ph.D. 19 (Biochemistry) c
39 Johns Hopkins School of Medicine, 1995.
21 9 M.D. c
39 Johns Hopkins School of Medicine, 1995.
c
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33 Immunology of Chronic Leishmania Infection
25 IgG and FcgammaR interactions
17 IL-10 responses
1b Parasite Immunology
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75 Key words: immunology, immunoparasitology, Leishmania, parasite, IL-10, Fcgamma R, cysteine proteinase
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1f Research Details
261 Worldwide there are 12 million people infected with the single-celled parasite Leishmania, with 2 million new infections a year. Spread by sandfly bites, this parasite causes fatal disease of the internal organs as well as non-healing and potentially disfiguring diseases of the skin and mucous membranes. Thirteen Gulf War veterans contracted an unusual version of leishmaniasis that affected the internal organs, even though this strain exclusively causes skin disease in local populations. Over 1200 cases of cutaneous leishmaniasis have occurred in the US troops stationed in Iraq and Afghanistan.
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38d We have been studying infection of mice by Leishmania mexicana, attempting to understand why this parasite causes non-healing disease, whereas a related parasite, L. major, causes lesions that heal. We have found that the cytokine IL-10 suppresses a protective T cell-mediated IFN-gamma response and that IL-10 is therefore required for chronic infection. IL-10 production is triggered by antibodies on the surface of parasites. FcgammaR, likely on macrophages, are also required for chronic disease to occur. We are trying to determine the IgG isotypes and FcγR types involved in this IL-10 process as well as the cellular source of IL-10 (macrophages, T cells, B cells, other?) in order to better understand the mechanism of this suppressive response and to help guide vaccine development. More recently we began new investigations into the role of glycolipids as parasite surface targets of IgG.
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10d A better understanding of the immune mechanisms of Leishmania infection may give insights into many other diseases that involve cell-mediated immunity, especially those caused by pathogens that live inside host cells such as tuberculosis, toxoplasmosis, and HIV.
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21 General Internal Medicine
30 Hospital in Home- acute care in the home
22 Home IV Antibiotic Therapy
1b Geriatrics Home Care
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Description of Research Expertise
2b Research Interests33 Immunology of Chronic Leishmania Infection
25 IgG and FcgammaR interactions
17 IL-10 responses
1b Parasite Immunology
8
75 Key words: immunology, immunoparasitology, Leishmania, parasite, IL-10, Fcgamma R, cysteine proteinase
8
1f Research Details
261 Worldwide there are 12 million people infected with the single-celled parasite Leishmania, with 2 million new infections a year. Spread by sandfly bites, this parasite causes fatal disease of the internal organs as well as non-healing and potentially disfiguring diseases of the skin and mucous membranes. Thirteen Gulf War veterans contracted an unusual version of leishmaniasis that affected the internal organs, even though this strain exclusively causes skin disease in local populations. Over 1200 cases of cutaneous leishmaniasis have occurred in the US troops stationed in Iraq and Afghanistan.
8
38d We have been studying infection of mice by Leishmania mexicana, attempting to understand why this parasite causes non-healing disease, whereas a related parasite, L. major, causes lesions that heal. We have found that the cytokine IL-10 suppresses a protective T cell-mediated IFN-gamma response and that IL-10 is therefore required for chronic infection. IL-10 production is triggered by antibodies on the surface of parasites. FcgammaR, likely on macrophages, are also required for chronic disease to occur. We are trying to determine the IgG isotypes and FcγR types involved in this IL-10 process as well as the cellular source of IL-10 (macrophages, T cells, B cells, other?) in order to better understand the mechanism of this suppressive response and to help guide vaccine development. More recently we began new investigations into the role of glycolipids as parasite surface targets of IgG.
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10d A better understanding of the immune mechanisms of Leishmania infection may give insights into many other diseases that involve cell-mediated immunity, especially those caused by pathogens that live inside host cells such as tuberculosis, toxoplasmosis, and HIV.
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Description of Clinical Expertise
24 Infectious Diseases21 General Internal Medicine
30 Hospital in Home- acute care in the home
22 Home IV Antibiotic Therapy
1b Geriatrics Home Care
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104 Agyingi, E.O., Wiandt, T.I., Buxbaum, L.U., and Thomas, B.N. : Modeling the immune system response: an application to leishmaniasis. Math Biosciences Eng 17(2): 1253-1271, November 2019.
110 Buxbaum, L.U.: Interleukin-10 from T cells but not macrophages and granulocytes, is required for chronic disease in Leishmania Mexicana infection. Infection and Immunity 83(4): 1366-1371, March 2015.
134 Brennick, M.J., Delikatny, J., Pack, A.I., Pickup, S., Shinde, S., Zhu, J-X, Roscoe, I., Kim, D.Y., Buxbaum, L.U., Cater, J.R., and Schwab, R.J.: Tongue Fat Infiltration in Obese vs. Lean Zucker Rats. Sleep 37(6): 1095-1102, June 2014.
10f Buxbaum LU: Leishmania mexicana Infection Induces IgG to Parasite Surface Glycoinositol Phospholipids That Can Induce IL-10 in Mice and Humans PLoS Neglected Tropical Diseases 7(5): 2224, May 2013.
13a Buxbaum LU: IL-10 from T cells, but not macrophages is required for chronic disease in Leishmania mexicana infection American Association of Immunologists, Immunology 2013, Honolulu, HI 83(4): 1366-71, April 2013 Notes: Poster Presentation.
1bd Jackson-Malik, P., McLaughlin, M., O’Hara, K.T., and Buxbaum, L. : Rapid Oral Fluid Testing for HIC in Veterans with Mental Health Diagnoses and Residing in Community Assisted Living Facilities. Practice Based on Evidence: The Future of Nursing. University of Maryland, School of Nursing and VA Maryland Health Care System, Baltimore, MD 2012 Notes: Poster presentation.
117 Buxbaum LU*, DeRitis P, Chu N, and Conti PA.* corresponding author: Eliminating mouse norovirus by cross-fostering. Journal of the American Association for Laboratory Animal Science 50(4): 495-9, July 2011.
11f Buxbaum LU: IL-10 From Macrophages and Granulocytes Is Not Required For Chronic Disease In Leishmania mexicana Infection. Woods Hole Immunoparasitology Meeting, Woods Hole, MA April 2011 Notes: Poster presentation.
cf Chu N, Thomas BN, Patel SR, Buxbaum LU: IgG1 is pathogenic in Leishmania mexicana infection. J Immunol 185(1): 6939-46, December 2010.
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Selected Publications
125 Cai, S., Intrator, O., Chan, C., Buxbaum, L., Haggerty, M.A., Phibbs, C.S., Schwab, E., and Kinosian, B. : Association of Costs and Days at Home With Transfer Hospital in Home. JAMA Network Open 4(3): 2114920, June 2021.104 Agyingi, E.O., Wiandt, T.I., Buxbaum, L.U., and Thomas, B.N. : Modeling the immune system response: an application to leishmaniasis. Math Biosciences Eng 17(2): 1253-1271, November 2019.
110 Buxbaum, L.U.: Interleukin-10 from T cells but not macrophages and granulocytes, is required for chronic disease in Leishmania Mexicana infection. Infection and Immunity 83(4): 1366-1371, March 2015.
134 Brennick, M.J., Delikatny, J., Pack, A.I., Pickup, S., Shinde, S., Zhu, J-X, Roscoe, I., Kim, D.Y., Buxbaum, L.U., Cater, J.R., and Schwab, R.J.: Tongue Fat Infiltration in Obese vs. Lean Zucker Rats. Sleep 37(6): 1095-1102, June 2014.
10f Buxbaum LU: Leishmania mexicana Infection Induces IgG to Parasite Surface Glycoinositol Phospholipids That Can Induce IL-10 in Mice and Humans PLoS Neglected Tropical Diseases 7(5): 2224, May 2013.
13a Buxbaum LU: IL-10 from T cells, but not macrophages is required for chronic disease in Leishmania mexicana infection American Association of Immunologists, Immunology 2013, Honolulu, HI 83(4): 1366-71, April 2013 Notes: Poster Presentation.
1bd Jackson-Malik, P., McLaughlin, M., O’Hara, K.T., and Buxbaum, L. : Rapid Oral Fluid Testing for HIC in Veterans with Mental Health Diagnoses and Residing in Community Assisted Living Facilities. Practice Based on Evidence: The Future of Nursing. University of Maryland, School of Nursing and VA Maryland Health Care System, Baltimore, MD 2012 Notes: Poster presentation.
117 Buxbaum LU*, DeRitis P, Chu N, and Conti PA.* corresponding author: Eliminating mouse norovirus by cross-fostering. Journal of the American Association for Laboratory Animal Science 50(4): 495-9, July 2011.
11f Buxbaum LU: IL-10 From Macrophages and Granulocytes Is Not Required For Chronic Disease In Leishmania mexicana Infection. Woods Hole Immunoparasitology Meeting, Woods Hole, MA April 2011 Notes: Poster presentation.
cf Chu N, Thomas BN, Patel SR, Buxbaum LU: IgG1 is pathogenic in Leishmania mexicana infection. J Immunol 185(1): 6939-46, December 2010.
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