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Lin Z. Li, Ph.D.
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Research Associate Professor of Radiology
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Member, The Institute of Translational Medicine and Therapeutics of the University of Pennsylvania
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Member, Radiation Biology and Imaging Research Program, Abramson Cancer Center at the University of Pennsylvania
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Member, The Institute of Regenerative Medicine of the University of Pennsylvania
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Director, Britton Chance Laboratory of Redox Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania
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Department: Radiology
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Contact information
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B6 Blockley Hall, 423 Guardian Drive
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Email:
linli@pennmedicine.upenn.edu
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linli@pennmedicine.upenn.edu
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Publications
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Links
ac Search PubMed for articles
103 Britton Chance Laboratory of Redox Imaging
9f PUBMED URL for an incomplete list of my published work
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ac Search PubMed for articles
103 Britton Chance Laboratory of Redox Imaging
9f PUBMED URL for an incomplete list of my published work
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Education:
21 7 BS 14 (Physics) c
2a Peking University, 1991.
21 7 MS 14 (Physics) c
38 Northeastern University, Boston, 1994.
21 8 PhD 32 (Biochemistry and Molecular Biophysics) c
33 University of Pennsylvania, 2000.
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Permanent link21 7 BS 14 (Physics) c
2a Peking University, 1991.
21 7 MS 14 (Physics) c
38 Northeastern University, Boston, 1994.
21 8 PhD 32 (Biochemistry and Molecular Biophysics) c
33 University of Pennsylvania, 2000.
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Description of Research Expertise
60 Optical and NMR imaging of redox metabolism in cancer, aging and other diseases.65
Description of Clinical Expertise
98 Translation of optical/NMR imaging/spectroscopy indices to clinic for disease diagnosis and predicting and monitoring treatment response1a 29
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156 Lin Z.J. Li, Rong Zhou, Tuoxiu Zhong, Lily Moon, Eun Ju. Kim, Hui Qiao, M. J. Hendrix, Britton Chance, Jerry D. Glickson: Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Advances in Experimental Medicine and Biology 599: 67-78, 2007.
115 He N. Xu, Shoko Nioka, Jerry D. Glickson, Britton Chance, Lin Z. Li: Quantitative mitochondrial redox imaging of breast cancer metastatic potential. Journal of Biomedical Optics 15(3): 036010(1-10), 2010.
10f He N. Xu, Julia Tchou, Min Feng, Huaqing Zhao, Lin Z. Li. : Optical redox imaging indices discriminate human breast cancer from normal tissues. Journal of Biomedical Optics 21(11): 114003-1-8, 2016.
f3 Sun, N., Xu, H.N., Luo, Q., Li, L.Z.: Potential indexing of the invasiveness of breast cancer cells by mitochondrial redox ratios. Adv Exp Med Biol 923: 121-127, 2016.
e4 He N. Xu, Julia Tchou, Lin Z. Li: Redox imaging of human breast cancer core biopsies: a preliminary investigation. Academic Radiology 20(4): 764-768, 2013.
11f He N. Xu, Gang Zheng, Julia Tchou, Shoko Nioka, Lin Z. Li: Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging. SpringerPlus 2(1): 73 (1-9), 2013.
11d He N. Xu, Shoko Nioka, Lin Z. Li: Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model. Biomarker Research 1(1): 6(1-11), 2013.
ee Lin Z. Li: Imaging mitochondrial redox potential and its possible link to tumor metastatic potential. J Bioenerg Biomembr 44(6): 645-653, 2012 Notes: invited review.
e1 Lily Moon, David W. Frederick, Joseph A. Baur, and Lin Z. Li: Imaging redox state in mouse muscles of different ages. Adv Exp Med Biol 977: 51-57, 2017.
147 Lin Z. Li, Nannan Sun: Autofluorescence perspective of cancer diagnostics. Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications. Vladimir Ghukasyan, Ahmed A. Heikal (eds.). CRC Press, Page: 273-297, 2014 Notes: invited paper.
17b Xiaohong Ma, Shengfu Piao, Dan Wang, Quentin Mcafee, Katherine L. Nathanson, Julian J. Lum, *Lin Z. Li, *Ravi Amaravadi (*Equal contribution) : Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clinical Cancer Research 17(10): 3478-3489, 2011.
126 Nathan G. Dolloff, Xiahong Ma, David T. Dicker, Robin C. Humphreys, Lin Z. Li and Wafik S. El-Deiry: Spectral imaging-based methods for quantifying autophagy and apoptosis. Cancer Biology and Therapy 12(4): 349-356, 2011.
1a1 Lin Z. Li, He N. Xu, S. Kadlececk, Kavindra Nath, Kejia Cai, Hari Hariharan, Jerry D. Glickson, Rahim Rizi: Non-invasive quantification of intracellular redox state in tissue by hyperpolarized 13C-NMR. Proceedings of the Annual Meeting of the International Society of Magnetic Resonance in Medicine, Melbourne, Australia May 2012 Notes: poster.
18c Lin Z. Li, Stephen Kadlececk, He N. Xu, Dania Daye, Benjamin Pullinger, Harrilla Profka, Lewis Chodosh, Rahim Rizi: Ratiometric analysis in hyperpolarized NMR (I): Test of the two-site exchange model and the quantification of reaction rate constants. NMR in Biomedicine 26(10): 1308-20, 2013 Notes: E-pub on April 29, 2013.
137 He N. Xu, Stephen Kadlececk, Harrilla Profka, Jerry D. Glickson, Rahim Rizi, Lin Z. Li: Is higher lactate an indicator of tumor metastatic risk?-A pilot MRS study using hyperpolarized 13C-pyruvate. Academic Radiology 21(2): 223-231, 2014.
f8 Lin Z. Li: A pre-tracer approach for improving the accuracy of metabolic measurements by hyperpolarized nuclear magnetic resonance. Quant Imaging Med Surg 6(5): 612-614, 2016.
198 He N. Xu, Stephen Kadlececk, Hoora Shaghaghi, Huaqing Zhao, Harilla Profka, Mehrdad Pourfathi, Rahim Rizi, Lin Z. Li: Differentiating inflamed and normal lungs by the apparent reaction rate constants of lactate dehydrogenase probed by hyperpolarized 13C labeled pyruvate. Quantitative Imaging in Medicine and Surgery 6(1): 57-66, 2016.
70 Kejia Cai, He N. Xu, Anup Singh, Lily Moon, Mohammad Haris, Ravinder c6 Reddy, Lin Z. Li: Breast cancer redox heterogeneity detectable with chemical exchange saturation transfer (CEST) MRI. Molecular Imaging and Biology 16(5): 670-9, 2014.
e7 Lin Z. Li: Magnetic susceptibility quantification for arbitrarily shaped objects in inhomogeneous fields. Magnetic Resonance in Medicine 46(5): 907-916, 2001.
d8 Lin Z. Li, Z.Y.J. Wang: Magnetic susceptibility quantitation with MRI by solving boundary value problems. Medical Physics 30(3): 449-453, 2003.
f9 Lin Z. Li, John S. Leigh: High-precision mapping of the magnetic field utilizing the harmonic function mean value property. Journal of Magnetic Resonance 148(2): 442-448, 2001.
de Lin Z. Li: Averaging of harmonic physical fields over an annular region enclosing field sources. American Journal of Physics 70(10): 1029-1033, 2002.
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Selected Publications
161 *Lin Z. Li, *Rong Zhou, He N. Xu, Lily Moon, Tuoxiu Zhong, Eun Ju Kim, Hui Qiao, Dennis Leeper, Britton Chance, Jerry D. Glickson (*Equal contribution): Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. PNAS 106(16): 6608-6613, 2009.156 Lin Z.J. Li, Rong Zhou, Tuoxiu Zhong, Lily Moon, Eun Ju. Kim, Hui Qiao, M. J. Hendrix, Britton Chance, Jerry D. Glickson: Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Advances in Experimental Medicine and Biology 599: 67-78, 2007.
115 He N. Xu, Shoko Nioka, Jerry D. Glickson, Britton Chance, Lin Z. Li: Quantitative mitochondrial redox imaging of breast cancer metastatic potential. Journal of Biomedical Optics 15(3): 036010(1-10), 2010.
10f He N. Xu, Julia Tchou, Min Feng, Huaqing Zhao, Lin Z. Li. : Optical redox imaging indices discriminate human breast cancer from normal tissues. Journal of Biomedical Optics 21(11): 114003-1-8, 2016.
f3 Sun, N., Xu, H.N., Luo, Q., Li, L.Z.: Potential indexing of the invasiveness of breast cancer cells by mitochondrial redox ratios. Adv Exp Med Biol 923: 121-127, 2016.
e4 He N. Xu, Julia Tchou, Lin Z. Li: Redox imaging of human breast cancer core biopsies: a preliminary investigation. Academic Radiology 20(4): 764-768, 2013.
11f He N. Xu, Gang Zheng, Julia Tchou, Shoko Nioka, Lin Z. Li: Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging. SpringerPlus 2(1): 73 (1-9), 2013.
11d He N. Xu, Shoko Nioka, Lin Z. Li: Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model. Biomarker Research 1(1): 6(1-11), 2013.
ee Lin Z. Li: Imaging mitochondrial redox potential and its possible link to tumor metastatic potential. J Bioenerg Biomembr 44(6): 645-653, 2012 Notes: invited review.
e1 Lily Moon, David W. Frederick, Joseph A. Baur, and Lin Z. Li: Imaging redox state in mouse muscles of different ages. Adv Exp Med Biol 977: 51-57, 2017.
147 Lin Z. Li, Nannan Sun: Autofluorescence perspective of cancer diagnostics. Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications. Vladimir Ghukasyan, Ahmed A. Heikal (eds.). CRC Press, Page: 273-297, 2014 Notes: invited paper.
17b Xiaohong Ma, Shengfu Piao, Dan Wang, Quentin Mcafee, Katherine L. Nathanson, Julian J. Lum, *Lin Z. Li, *Ravi Amaravadi (*Equal contribution) : Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clinical Cancer Research 17(10): 3478-3489, 2011.
126 Nathan G. Dolloff, Xiahong Ma, David T. Dicker, Robin C. Humphreys, Lin Z. Li and Wafik S. El-Deiry: Spectral imaging-based methods for quantifying autophagy and apoptosis. Cancer Biology and Therapy 12(4): 349-356, 2011.
1a1 Lin Z. Li, He N. Xu, S. Kadlececk, Kavindra Nath, Kejia Cai, Hari Hariharan, Jerry D. Glickson, Rahim Rizi: Non-invasive quantification of intracellular redox state in tissue by hyperpolarized 13C-NMR. Proceedings of the Annual Meeting of the International Society of Magnetic Resonance in Medicine, Melbourne, Australia May 2012 Notes: poster.
18c Lin Z. Li, Stephen Kadlececk, He N. Xu, Dania Daye, Benjamin Pullinger, Harrilla Profka, Lewis Chodosh, Rahim Rizi: Ratiometric analysis in hyperpolarized NMR (I): Test of the two-site exchange model and the quantification of reaction rate constants. NMR in Biomedicine 26(10): 1308-20, 2013 Notes: E-pub on April 29, 2013.
137 He N. Xu, Stephen Kadlececk, Harrilla Profka, Jerry D. Glickson, Rahim Rizi, Lin Z. Li: Is higher lactate an indicator of tumor metastatic risk?-A pilot MRS study using hyperpolarized 13C-pyruvate. Academic Radiology 21(2): 223-231, 2014.
f8 Lin Z. Li: A pre-tracer approach for improving the accuracy of metabolic measurements by hyperpolarized nuclear magnetic resonance. Quant Imaging Med Surg 6(5): 612-614, 2016.
198 He N. Xu, Stephen Kadlececk, Hoora Shaghaghi, Huaqing Zhao, Harilla Profka, Mehrdad Pourfathi, Rahim Rizi, Lin Z. Li: Differentiating inflamed and normal lungs by the apparent reaction rate constants of lactate dehydrogenase probed by hyperpolarized 13C labeled pyruvate. Quantitative Imaging in Medicine and Surgery 6(1): 57-66, 2016.
70 Kejia Cai, He N. Xu, Anup Singh, Lily Moon, Mohammad Haris, Ravinder c6 Reddy, Lin Z. Li: Breast cancer redox heterogeneity detectable with chemical exchange saturation transfer (CEST) MRI. Molecular Imaging and Biology 16(5): 670-9, 2014.
e7 Lin Z. Li: Magnetic susceptibility quantification for arbitrarily shaped objects in inhomogeneous fields. Magnetic Resonance in Medicine 46(5): 907-916, 2001.
d8 Lin Z. Li, Z.Y.J. Wang: Magnetic susceptibility quantitation with MRI by solving boundary value problems. Medical Physics 30(3): 449-453, 2003.
f9 Lin Z. Li, John S. Leigh: High-precision mapping of the magnetic field utilizing the harmonic function mean value property. Journal of Magnetic Resonance 148(2): 442-448, 2001.
de Lin Z. Li: Averaging of harmonic physical fields over an annular region enclosing field sources. American Journal of Physics 70(10): 1029-1033, 2002.
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