Angela M DeMichele, MD, MSCE, FASCO

faculty photo
Mariann T. and Robert J. MacDonald Professor in Breast Cancer Care Excellence
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
Co-Leader, Breast Cancer Program, Abramson Cancer Center, University of Pennsylvania
Co-Director, 2-PREVENT Breast Cancer Translational Center of Excellence, Abramson Cancer Center, University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-153
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-349-5730
Fax: 215-615-3349
B.A. (Biochemistry)
Brown University, 1988.
M.D. (Medicine)
Washington University School of Medicine, 1991.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, School of Medicine, 2001.
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Description of Research Expertise

breast cancer, biomarkers, clinical trials, pharmacogenetics, cytokines, host immunogenetics, cancer survivorship, molecular epidemiology

Description of Clinical Expertise

breast cancer, neoadjuvant therapy, menopausal symptoms related to cancer, cancer survivorship

Selected Publications

Magbanua MJM., Ahmed Z., Sayaman RW., Swigart LB., Hirst GL., Yau C., Wolf DM., Li W., Delson AL., Perlmutter J., Pohlmann P., Symmans WF., Yee D., Hylton NM., Esserman LJ., DeMichele A., Rugo HS., van 't Veer LJ. : Cell-free DNA concentration as a biomarker of response and recurrence in HER2-negative breast cancer receiving neoadjuvant chemotherapy Clin Cancer Res Apr 2024.

Mayer EL., Ren Y., Wagle N., Mahtani R., Ma C., DeMichele A., Cristofanilli M., Meise J., Kathy D Miller KD., Abdou Y., Riley EC., Qamar R., Sharma P., Reid S., Sinclair N., Faggen M., Block CC., Ko N., Partridge AH., Chen WY., DeMeo M., Attaya V., Amanda Okpoebo A., Alberti J., Liu Y., Gauthier E., Burstein HJ., Regan MM., Tolaney SM: PACE: A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab After Progression on Cyclin-Dependent Kinase 4/6 Inhibitor and Aromatase Inhibitor for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-Negative Metastatic Breast Cancer. J Clin Oncol Mar 2024.

Lawrence-Paul MR, Pan T, Pant DK, Chen Y, Belka GK, Feldman M, DeMichele A, Chodosh LA: Rare subclonal sequencing of breast cancers indicates putative metastatic driver mutations are predominately acquired after dissemination. Genome Medicine Feb 2024.

Albain KS., Yau C., Petricoin EF., Wolf DM., Lang JE., Chien AJ., Haddad T., Forero-Torres A., Wallace AM., Kaplan H., Pusztai L., Euhus D., Nanda R., Elias AD., Clark AS., Godellas C., Boughey JC., Isaacs C., Tripathy D., Lu J., Yung RL., Gallagher R., Wulfkuhle JD., Brown-Swigart L., Krings G., Chen YY., Potter DA., Stringer-Reasor E., Blair S., Asare SM., Wilson A., Hirst GL., Singhrao R., Buxton M., Clennell JL., Sanil A., Berry S., Asare AL., Matthews JB., DeMichele A., Hylton NM., Melisko M., Perlmutter J., Rugo HS., Symmans WF., Van't Veer LJ., Yee D., Berry DA., Esserman LJ: Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial-Efficacy and Biomarker Discovery. Clin Cancer Res Feb 2024.

Smith KL., Zhao F., Mayer IA., Tevaarwerk AJ., Garcia SF., Arteaga CL., Symmans WF., Park BH., Burnette BL., Makower DF., Block M., Morley KA., Jani CR., Mescher C., Shabana J Dewani SJ., Brown-Glaberman U., Flaum LE., Mayer EL., Sikov WM., Rodler ET., DeMichele A., Sparano JA., Wolff AC., Miller KD., Wagner LI : Adjuvant platinum versus capecitabine for residual, invasive, triple-negative breast cancer: Patient-reported outcomes in ECOG-ACRIN EA1131 Cancer Jan 2024.

Kyalwazi B, Yau C, Campbell MJ, Yoshimatsu TF, Chein AJ, Wallace AM, Forero-Torres A, Pusztai L, Ellis ED, Albain KS, Blaes AH, Haley BB, Boughey JC, Elias AD, Clark AS, Isaacs CJ, Nanda R, Han HS, Yung RL, Tripathy D, Edminston KK, Viscusi RK, Northfelt DW, Khan QJ, Asare SM, Wilson A, Hirst GL, Lu R, Symmans WF, Yee D, DeMichele A, Van't Veer LJ, Esserman LJ, Olopade OI: Race, Gene Expression Signatures, and Clinical Outcomes of Patients With High-Risk Early Breast Cancer. JAMA Network Open Dec 2023.

Albain KS, Yau C, Petricoin EF, Lang JE, Chein AJ, Haddad T, Forero-Torres A, Wallace AM, Kaplan H, Pusztai L, Euhus D, Nanda R, Elias AD, Clark AS, Godellas C, Boughey JC, Isaacs C, Tripathy D, Lu J, Yung RL, Gallagher RI, Wulfkuhle JD, Swigart LB, Krings G, Chen YY, Potter DA, Stringer-Reason E, Blair S, Asare SM, Wilson A, Hirst GL, Singhrao R, Buxton A, Clennell JL, Sanil A, Berry S, Asare AL, Matthews JB, DeMichele A, Hylton NM, Melisko M, Perlmutter J, Rugo HS, Symmans WF, Van't Veer LJ, Yee D, Berry DA, Esserman LJ: Neoadjuvant trebananib plus paclitaxel-based chemotherapy for stage II/III breast cancer in the adaptively randomized I-SPY2 trial - Efficacy and biomarker discovery. Clin Cancer Res Dec 2023.

Gallagher RI., Wulfkuhle J., Wolf DM., Brown-Swigart L., Yau C., O'Grady N., Amrita Basu A., Lu R., Campbell MJ., Magbanua MJ., Coppé JP., I-SPY 2 Investigators; Asare SM., Sit L., Matthews JB., Perlmutter J., Hylton N., Liu MC., Symmans WF., Rugo HS., Isaacs C., DeMichele A., Yee D., Pohlmann PR., Hirst GL., Esserman LJ., van 't Veer LJ., Petricoin EF : Protein signaling and drug target activation signatures to guide therapy prioritization: Therapeutic resistance and sensitivity in the I-SPY 2 Trial Cell Rep Med Dec 2023.

Curigliano G, Burstein HJ, Gnant M, Loibl S, Cameron D, Regan MM, Denkert C, Poortmans P, Weber WP, Thürlimann B; St Gallen Consensus Conference Panelists 2023.: Understanding breast cancer complexity to improve patient outcomes: The St Gallen International Consensus Conference for the Primary Therapy of Individuals with Early Breast Cancer 2023. Ann Oncol Sep 2023.

Villacampa G, Tung NM, Pernas S, Paré L, Bueno-Muiño C, Echavarría I, López-Tarruella S, Roche-Molina M, Del Monte-Millán M, Marín-Aguilera M, Brasó-Maristany F, Waks AG, Pascual T, Martínez-Sáez O, Vivancos A, Conte PF, Guarneri V, Vittoria Dieci M, Griguolo G, Cortés J, Llombart-Cussac A, Muñoz M, Vidal M, Adamo B, Wolff AC, DeMichele A, Villagrasa P, Parker JS, Perou CM, Fernandez-Martinez A, Carey LA, Mittendorf EA, Martín M, Prat A, Tolaney SM.: Association of HER2DX with pathological complete response and survival outcomes in HER2-positive breast cancer. Ann Oncol Sep 2023.

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Last updated: 05/07/2024
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