Angela M DeMichele, MD MSCE

faculty photo
Alan and Jill Miller Professor in Breast Cancer Excellence
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-153
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-349-5730
Fax: 215-615-3349
Education:
B.A. (Biochemistry)
Brown University, 1988.
M.D. (Medicine)
Washington University School of Medicine, 1991.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, School of Medicine, 2001.
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Description of Research Expertise

breast cancer, biomarkers, clinical trials, pharmacogenetics, cytokines, host immunogenetics, cancer survivorship, molecular epidemiology

Description of Clinical Expertise

breast cancer, neoadjuvant therapy, menopausal symptoms related to cancer, cancer survivorship

Selected Publications

Clark AS, McAndrew NP, Troxel A, Feldman M, Lal P, Rosen M, Burrell J, Redlinger C, Gallgher M, Bradbury AR, Domchek SM, Fox KR, O'Dwyer PJ, DeMichele AM: Combination Paclitaxel and Palbociclib: Results of a Phase I Trial in Advanced Breast Cancer. Clinical Cancer Research Epub ahead of print, Jan 2019.

Demissei BG, Finkelman B, Hubbard RA, Zhang L, Smith AM, Sheline K, McDonald C, Narayan HK, Narayan V, Waxman AJ, Domchek SM, DeMichele A, Shah P, Clark AS, Bradbury A, Carver JR, Upshaw J, Armenian SH, Liu P, Ky B: Detailed phenotyping reveals distinct trajectories of cardiovascular function and symptoms with exposure to modern breast cancer therapy. Cancer In press 2019.

Lynch HF, Largent EA, Joffe S, DeMichele AM: Protecting clinical trial participants and study integrity in the age of social media. Cancer 124(24): 4610-4617, Dec 2018.

Maity A, Mick R, Huang AC, George SM, Farwell MD, Lukens JN, Berman AT, Mitchell TC, Bauml J, Schuchter LM, O'Hara M, Lin LL, Demichele A, Christodouleas JP, Haas NB, Patsch DM, Hahn SM, Minn AJ, Wherry EJ, Vonderheide RH: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. British Journal of Cancer 119(10), Nov 2018.

Turner NC, Slamon DJ, Ro J, Bondarenko I, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Loibl S, André F, Puyana Theall K, Huang X, Giorgetti C, Huang Bartlett C, Cristofanilli M: Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer. New England Journal of Medicine 379(20), Nov 2018.

Cristofanilli M, DeMichele A, Giorgetti C, Turner NC, Slamon DJ, Im SA, Masuda N, Verma S, Loi S, Colleoni M, Theall KP, Huang X, Liu Y, Bartlett CH: Predictors of prolonged benefit from palbociclib plus fulvestrant in women with endocrine-resistant hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer in PALOMA-3. European Journal of Cancer 104: 21-31, Nov 2018.

O'Shaughnessy Joyce, DeMichele Angela, Ma Cynthia X, Richards Paul, Yardley Denise A, Wright Gail Shaw, Kalinsky Kevin, Steis Ronald, Diab Sami, Kennealey Gerard, Geschwindt Ryan, Jiang Wei, Rugo Hope S: A randomized, double-blind, phase 2 study of ruxolitinib or placebo in combination with capecitabine in patients with advanced HER2-negative breast cancer and elevated C-reactive protein, a marker of systemic inflammation. Breast cancer research and treatment 170(3): 547-557, Aug 2018.

Banerjee Sagarika, Tian Tian, Wei Zhi, Shih Natalie, Feldman Michael D, Peck Kristen N, DeMichele Angela M, Alwine James C, Robertson Erle S: Distinct Microbial Signatures Associated With Different Breast Cancer Types. Frontiers in microbiology 9: 951, 2018.

Turner, N. C., Finn, R. S., Martin, M., Im, S. A., DeMichele, A., Ettl, J., Dieras, V., Moulder, S., Lipatov, O., Colleoni, M., Cristofanilli, M., Lu, D. R., Mori, A., Giorgetti, C., Iyer, S., Bartlett, C. H., Gelmon, K. A.: Clinical considerations of the role of palbociclib in the management of advanced breast cancer patients with and without visceral metastases. Ann Oncol 29(3): 669-680, 2018.

Sturgeon, K. M., Hackley, R., Fornash, A., Dean, L. T., Laudermilk, M., Brown, J. C., Sarwer, D. B., DeMichele, A. M., Troxel, A. B., Schmitz, K. H.: Strategic recruitment of an ethnically diverse cohort of overweight survivors of breast cancer with lymphedema. Cancer 124(1): 95-104, 2018.

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Last updated: 05/22/2019
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