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Zissimos Mourelatos, M.D.

Zissimos Mourelatos, M.D.

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Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Department of Pathology and Laboratory Medicine
Division of Neuropathology
613B Stellar Chance Labs
422 Curie Boulevard
Philadelphia, PA 19104-6100
Office: 215-746-0014
Fax: 215-746-0285
Aristotelian University of Thessaloniki - School of Medicine, Thessaloniki, Greece, 1991.
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Description of Research Expertise

Biochemical and genetic studies of Ribonucleoproteins (RNPs) with emphasis on
small regulatory RNPs such as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs).
Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration.

Description of Clinical Expertise

Surgical Neuropathology (Brain tumors; Brain biopsies; Muscle biopsies; Nerve biopsies)
Medical Neuropathology

Selected Publications

Couthouis J., Hart M.P., Erion R., King O.D., Diaz Z., Nakaya T., Ibrahim F., Kim H.J., Mojsilovic-Petrovic J., Panossian S., Kim C.E., Frackelton E.C., Solski J.A., Williams K.L., Clay-Falcone D., Elman L., McCluskey L., Greene R., Hakonarson H., Kalb R.G., Lee V-MY, Trojanowski J.Q., Nicholson G.A., Blair I.P., Bonini N.M., Van Deerlin V.M., Mourelatos Z. ,Shorter J and A.D. Gitler: Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics 21: 2899-911, 2012.

Liu X., Jin D-Y, McManus M.T. and Z. Mourelatos: Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals. Molecular Cell 46: 507-17, 2012.

Vourekas, A, Zheng Q., Kirino Y., Alexiou P., Maragkakis, M., Gregory B.D. and Z. Mourelatos : Target RNA repertoire of Mili and Miwi reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nature Structural & Molecular Biology 19: 773-81, 2012.

Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ : Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity. Journal of the Neurological Sciences 301(1-2): 112-5, Feb 2011.

Couthouis J., Erion R., Hart M.P., Oristano R.E., Liu X.A., Ramos D., Jethava N., Hosangadi D., Epstein J., Chiang A., Diaz Z., Nakaya T., Ibrahim F., King O.D., , Kim H.J., Panossian S., Kim C.E., Frackelton E.C., Geser F., Clay-Falcone D., Elman L., McCluskey L., Greene R., Lee V-MY, Trojanowski J.Q., Hakonarson H., Bonini N.M., Shorter J., Van Deerlin V.M., Mourelatos Z. and A.D. Gitler: A yeast functional screen predicts new candidate ALS disease genes. PNAS 108: 20881-90, 2011.

Venneti S., Boateng L.A., Friedman J.R, Baldwin D.A., Tobias J.W., Judkins A.R., Mourelatos Z. and L. Priti.: MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathology 22(4): 522-9, 2012.

Kirino Y, Vourekas A, Khandros E, Mourelatos Z: Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Molecular Biology 725: 281-93, 2011.

de Planell-Saguer M, Rodicio MC, Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nature Protocols 5(6): 1061-73, May 2010.

Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z: Arginine methylation of vasa protein is conserved across phyla. J Biol Chem 285(11): 8148-54, Mar 2010.

Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, and Mourelatos Z : Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA 16(1): 70-8, Jan 2010.

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Last updated: 03/15/2016
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