David J. Vaughn, M.D.

faculty photo
GU Medical Oncology Professor
Attending Physician, Hospital of the University of Pennsylvania
Co-Leader, Abramson Cancer Center Genitourinary Cancer Program
Vice Chief for Clinical Affairs, Division of Hematology/Oncology, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-114
3400 Civic Center Blvd
Philadelphia, PA 19104-4283
Office: 215-349-8140
Fax: 215-662-7804
A.B. (Spanish)
Dartmouth College, 1982.
M.D. (Medicine)
Harvard Medical School, 1987.
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Description of Research Expertise

New Drug Development for Urologic Cancer
Cancer Survivorship

Description of Clinical Expertise

Urologic Oncology
Bladder Cancer
Prostate Cancer
Testis Cancer
Cancer Survivorship

Selected Publications

Adra N, Vaughn DJ, Einhorn LH, Hanna NH, Funt SA, Rosales M, Arozullah A, Feldman DR: A phase II study assessing the safety and efficacy of ASP1650 in male patients with relapsed refractory germ cell tumors Investigational New Drugs 40(5): 1087-1094, Oct 2022.

Shahbazi M, Zhang X, Dinh PC, Sanchez VA, Trendowski MR, Shuey MM, Nguyen T; Regeneron Genetics Center, Feldman DR, Vaughn DJ, Fung C, Kollmannsberger C, Martin NE, Einhorn LH, Cox NJ, Frisina RD, Travis LB, Dolan ME: Comprehensive association analysis of speech recognition thresholds after cisplatin-based chemotherapy in survivors of adult-onset cancer. Cancer Medicine Sep 2022 Notes: Online ahead of print.

Grasso C, Popovic M, Isaevska E, Lazzarato F, Fiano V, Zugna D, Pluta J, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Bishop DT, Chanock SJ, Chen C, Cortessis VK, Dalgaard MD, Daneshmand S, Ferlin A, Foresta C, Frone MN, Gamulin M, Gietema JA, Greene MH, Grotmol T, Hamilton RJ, Haugen TB, Hauser R, Karlsson R, Kiemeney LA, Lessel D, Lista P, Lothe RA, Loveday C, Meijer C, Nead KT, Nsengimana J, Skotheim RI, Turnbull C, Vaughn DJ, Wiklund F, Zheng T, Zitella A, Schwartz SM, McGlynn KA, Kanetsky PA, Nathanson KL, Richiardi L. : Association study between polymorphisms in DNA methylation-related genes and testicular germ cell tumor risk. Cancer Epidemiology Biomarkers Prevention 31(9): 1769-1779, Sep 2022.

Roberson D, Jia H, Vaughn D, Miller C, Fogt F, Kovell RC: Effective control of recurrent and metastatic GU SCC by employing a multimodal approach in a patient with a history of radiation and transscrotal surgery for stage I seminoma. Urology Case Reports 45: 102223, Sep 2022.

Lin JK, Jacobs LA, Blauch A, Shulman LN, Vaughn DJ: Guideline discordant care in patients with metastatic germ cell tumors. Urologic Oncology: Seminars and Original Investigations Urol Oncol. 2022 Aug;40(8):385.e9-385.e17. 40(8): 385.e9-385.e17, Aug 2022.

Zhang X, Trendowski MR, Wilkinson E, Shahbazi M, Dinh PC, Shuey MM; Regeneron Genetics Center, Feldman DR, Hamilton RJ, Vaughn DJ, Fung C, Kollmannsberger C, Huddart R, Martin NE, Sanchez VA, Frisina RD, Einhorn LH, Cox NJ, Travis LB, Dolan ME.: Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy. Cancer Medicine 11(14): 2801-2816, Jul 2022.

Ardeshirrouhanifard S, Fossa SD, Huddart R, Monahan PO, Fung C, Song Y, Dolan ME, Feldman DR, Hamilton RJ, Vaughn D, Martin NE, Kollmannsberger C, Dinh P, Einhorn L, Frisina RD, Travis LB.: Ototoxicity after cisplatin-based chemotherapy: factors associated with discrepancies between patient-reported outcomes and audiometric assessments. Ear and Hearing 43(3): 794-807, May/Jun 2022.

Vaughn DJ, Jacobs LA: Approach to the care of long-term testicular cancer survivors. UpToDate 2022.

Vaughn DJ: Discovery and Healing: Reflections on Five Decades of Hematology/Oncology at the Perelman School of Medicine at the University of Pennsylvania. University of Pennsylvania Press, Philadelphia 2022.

Vaughn DJ: Testicular Cancer. Harrison's Principles of Internal Medicine, 21st Edition 2022.

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Last updated: 11/09/2022
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