David J. Vaughn, M.D.

faculty photo
GU Medical Oncology Professor
Attending Physician, Hospital of the University of Pennsylvania
Co-Leader, Abramson Cancer Center Genitourinary Cancer Program
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-114
3400 Civic Center Blvd
Philadelphia, PA 19104-4283
Office: 215-349-8140
Fax: 215-662-7804
A.B. (Spanish)
Dartmouth College, 1982.
M.D. (Medicine)
Harvard Medical School, 1987.
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Description of Research Expertise

New Drug Development for Urologic Cancer
Cancer Survivorship

Description of Clinical Expertise

Urologic Oncology
Bladder Cancer
Prostate Cancer
Testis Cancer
Cancer Survivorship

Selected Publications

Maxwell R, Chang Y, Paul C, Vaughn DJ, Christodouleas JP: Cancer control, toxicity, and second malignancy risks of proton radiation therapy doe stage I-IIB testicular seminoma. Advances in Radiation Oncology 8(5): 101259, May 2023.

Pyle LC, Kim J, Bradfield J, Damrauer SM, D'Andrea K, Einhorn LH, Godse R, Hakonarson H, Kanetsky PA, Kember RL, Jacobs LA, Maxwell KN, Rader DJ, Vaughn DJ, Weathers B, Wubbenhorst B, Regeneron Genetics Center Research Team, Cancer Genomics Research Laboratory, Greene MH, Nathanson KL, Stewart DR: Germline exome sequencing for men with testicular germ cell tumor reveals coding defects in chromosomal segregation and protein-targeting genes. European Urology 26: S0302-2838, May 2023 Notes: On line ahead of print.

Sanchez VA, Shuey MM, Dinh PC Jr, Monahan PO, Fosså SD, Sesso HD, Dolan ME, Einhorn LH, Vaughn DJ, Martin NE, Feldman DR, Kroenke K, Fung C, Frisina RD, Travis LB.: Patient-reported functional impairment due to hearing loss and tinnitus after cisplatin-based chemotherapy. Journal of Clinical Oncology 41(12): 2211-2226, Apr 2023.

Balar AV, Castellano DE, Grivas P, Vaughn DJ, Powles T, Vuky J, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Necchi A, Petrylak DP, Plimack ER, Xu JZ, Imai K, Moreno BH, Bellmunt J, de Wit R, O'Donnell PH.: Efficacy and safety of pembrolizumab in metastatic urothelial carcinoma: results from KEYNOTE-045 and KEYNOTE-052 after up to 5 years of follow-up. Annals of Oncology 34(3): 289-299, Mar 2023.

Shahbazi M, Zhang X, Dinh PC, Sanchez VA, Trendowski MR, Shuey MM, Nguyen T; Regeneron Genetics Center, Feldman DR, Vaughn DJ, Fung C, Kollmannsberger C, Martin NE, Einhorn LH, Cox NJ, Frisina RD, Travis LB, Dolan ME: Comprehensive association analysis of speech recognition thresholds after cisplatin-based chemotherapy in survivors of adult-onset cancer. Cancer Medicine 12(3): 2999-3012, Feb 2023.

Lauritsen J, Sauvé N, Tryakin A, Jiang DM, Huddart R, Heng DYC, Terbuch A, Winquist E, Chovanec M, Hentrich M, Fankhauser CD, Shamash J, Del Muro XG, Vaughn D, Heidenreich A, Sternberg CN, Sweeney C, Necchi A, Bokemeyer C, Bandak M, Jandari A, Collette L, Gillessen S, Beyer J, Daugaard G.: Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database. British Journal of Cancer 2023 Notes: Online ahead of print.

Adra N, Vaughn DJ, Einhorn LH, Hanna NH, Funt SA, Rosales M, Arozullah A, Feldman DR: A phase II study assessing the safety and efficacy of ASP1650 in male patients with relapsed refractory germ cell tumors Investigational New Drugs 40(5): 1087-1094, Oct 2022.

Roberson D, Jia H, Vaughn D, Miller C, Fogt F, Kovell RC: Effective control of recurrent and metastatic GU SCC by employing a multimodal approach in a patient with a history of radiation and transscrotal surgery for stage I seminoma. Urology Case Reports 45: 102223, Sep 2022.

Grasso C, Popovic M, Isaevska E, Lazzarato F, Fiano V, Zugna D, Pluta J, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Bishop DT, Chanock SJ, Chen C, Cortessis VK, Dalgaard MD, Daneshmand S, Ferlin A, Foresta C, Frone MN, Gamulin M, Gietema JA, Greene MH, Grotmol T, Hamilton RJ, Haugen TB, Hauser R, Karlsson R, Kiemeney LA, Lessel D, Lista P, Lothe RA, Loveday C, Meijer C, Nead KT, Nsengimana J, Skotheim RI, Turnbull C, Vaughn DJ, Wiklund F, Zheng T, Zitella A, Schwartz SM, McGlynn KA, Kanetsky PA, Nathanson KL, Richiardi L. : Association study between polymorphisms in DNA methylation-related genes and testicular germ cell tumor risk. Cancer Epidemiology Biomarkers Prevention 31(9): 1769-1779, Sep 2022.

Lin JK, Jacobs LA, Blauch A, Shulman LN, Vaughn DJ: Guideline discordant care in patients with metastatic germ cell tumors. Urologic Oncology: Seminars and Original Investigations 40(8): 385.e9-385.e17, Aug 2022.

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Last updated: 10/02/2023
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