John Matthew Maris, M.D.
Professor of Pediatrics
Member, Hematology/Oncology Fellowship Committee, Children's Hospital of Philadelphia,
University of Pennsylvania
Co-Chair, Genetics, Genomics and Pediatric Diseases Research Affinity Group, Children's Hospital of Philadelphia
Member, Abramson Family Cancer Research Institute, University of Pennsylvania
Giulio D'Angio Endowed Chair in Neuroblastoma Research, Children's Hospital of Philadelphia
Department: Pediatrics
Graduate Group Affiliations
Contact information
The Children's Hospital of Philadelphia
Division of Oncology
Colket Translational Research Building
3501 Civic Center Boulevard #3060
4399
Philadelphia, PA 19104-4318
Division of Oncology
Colket Translational Research Building
3501 Civic Center Boulevard #3060
4399
Philadelphia, PA 19104-4318
Office: 215 590 5244
Fax: 267 426 0685
Fax: 267 426 0685
Email:
MARIS@EMAIL.CHOP.EDU
MARIS@EMAIL.CHOP.EDU
Publications
Links
Search PubMed for articles
CCCR Faculty Profile
Abramson Family Cancer Research Institute webpage.
Maris Lab Website
Search PubMed for articles
CCCR Faculty Profile
Abramson Family Cancer Research Institute webpage.
Maris Lab Website
Education:
B.S. (Biology)
Wheeling College , 1983.
M.D. (Medicine)
University of Pennsylvania, 1989.
Permanent linkB.S. (Biology)
Wheeling College , 1983.
M.D. (Medicine)
University of Pennsylvania, 1989.
Selected Publications
Batra V, Samanta M, Makvandi M, Groff D, Martorano P, Elias J, Ranieri P, Tsang M, Hou C, Li Y, Pawel B, Martinez D, Vaidyanathan G, Carlin S, Pryma DA, Maris JM.: Preclinical development of [211At]meta-astatobenzylguanidine ([211At]MABG) as an alpha particle radiopharmaceutical therapy for neuroblastoma. Clinical Cancer Research July 2022 Notes: Online ahead of print.Desai AV, Gilman AL, Ozkaynak MF, Naranjo A, London WB, Tenney SC, Diccianni M, Hank JA, Parisi MT, Shulkin BL, Smith M, Moscow JA, Shimada H, Matthay KK, Cohn SL, Maris JM, Bagatell R, Sondel PM, Park JR, Yu AL.: Outcomes Following GD2-Directed Postconsolidation Therapy for Neuroblastoma After Cessation of Random Assignment on ANBL0032: A Report From the Children's Oncology Group. Journal of Clinical Oncology July 2022 Notes: Online ahead of print.
Chang X, Liu Y, Glessner J, Hou C, Qu H, Nguyen K, Sleiman P, Lee L, Diskin SJ, Maris JM, Hakonarson H.: Identification of Mitochondrial DNA Variants Associated With Risk of Neuroblastoma. J Natl Cancer Inst. 114(6): 910-913, June 2022 Notes: doi: 10.1093/jnci/djac012. Online ahead of print Feb 2022.
Yarmarkovich M, Marshall QF, Warrington JM, Premaratne R, Farrel A, Groff D, Li W, di Marco M, Runbeck E, Truong H, Toor JS, Tripathi S, Nguyen S, Shen H, Noel T, Church NL, Weiner A, Kendsersky N, Martinez D, Weisberg R, Christie M, Eisenlohr L, Bosse KR, Dimitrov DS, Stevanovic S, Sgourakis NG, Kiefel BR, Maris JM.: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs. Nature Nov 2021 Notes: doi: 10.1038/s41586-021-04061-6. Epub 2021 Nov 3.
Ferris MA, Smith AM, Heath SE, Duncavage EJ, Oberley MJ, Freyer D, Wynn R, Douzgou S, Maris JM, Reilly AF, Wu M, Choo F, Fiets RB, Koene S, Spencer DH, Miller CA, Shinawi M, Ley TJ.: DNMT3A Overgrowth Syndrome is associated with the development of hematopoietic malignancies in children and young adults. Blood Nov 2021.
Kawano A, Hazard FK, Chiu B, Naranjo A, LaBarre B, London WB, Hogarty MD, Cohn SL, Maris JM, Park JR, Gastier-Foster JM, Ikegaki N, Shimada H.: Stage 4S Neuroblastoma: Molecular, Histologic, and Immunohistochemical Characteristics and Presence of 2 Distinct Patterns of MYCN Protein Overexpression-A Report From the Children's Oncology Group. Am J Surg Pathol. 45(8): 1075-1081, Aug 2021 Notes: Epub 2021/03/20. doi: 10.1097/PAS.0000000000001647.
Shields CE, Potlapalli S, Cuya-Smith SM, Chappell SK, Chen D, Martinez D, Pogoriler J, Rathi KS, Patel SA, Oristian KM, Linardic CM, Maris JM, Haynes KA, Schnepp RW.: Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target. Mol Oncol. 15(8): 2156-2171, Aug 2021 Notes: doi: 10.1002/1878-0261.12914. Epub 2021 Mar 27.
Raman S, Buongervino SN, Lane MV, Zhelev DV, Zhu Z, Cui H, Martinez B, Martinez D, Wang Y, Upton K, Patel K, Rathi KS, Navia CT, Harmon DB, Li Y, Pawel B, Dimitrov DS, Maris JM, Julien JP, Bosse KR.: A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med. 2(7), Jul 2021.
Campbell BB, Galati MA, Stone SC, Riemenschneider AN, Edwards M, Sudhaman S, Siddaway R, Komosa M, Nunes NM, Nobre L, Morrissy AS, Zatzman M, Zapotocky M, Joksimovic L, Kalimuthu SN, Samuel D, Mason G, Bouffet E, Morgenstern DA, Aronson M, Durno C, Malkin D, Maris JM, Taylor MD, Shlien A, Pugh TJ, Ohashi PS, Hawkins CE, Tabori U.: Mutations in the RAS/MAPK pathway drive replication repair deficient hypermutated tumors and confer sensitivity to MEK inhibition. Cancer Discov. 11(6): 1454-1467, June 2021 Notes: doi: 10.1158/2159-8290.CD-20-1050. Epub 2021 Feb 9.
Dong Z, Yeo KS, Lopez G, Zhang C, Dankert Eggum EN, Rokita JL, Ung CY, Levee TM, Her ZP, Howe CJ, Hou X, van Ree JH, Li S, He S, Tao T, Fritchie K, Torres-Mora J, Lehman JS, Meves A, Razidlo GL, Rathi KS, Weroha SJ, Look AT, van Deursen JM, Li H, Westendorf JJ, Maris JM, Zhu S.: GAS7 Deficiency Promotes Metastasis in MYCN-driven Neuroblastoma. Cancer Res. 81(11): 2995-3007, June 2021 Notes: doi: 10.1158/0008-5472.CAN-20-1890. Epub 2021 Feb 18.