Selected Publications

Hayashi, S., Abdulmalik, O., Peranteau, W.H., Ashizuka, S., Campagnoli, C. Chen, Q., Horiuchi, K., Asakura, T., and Flake, A.W: Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemlogolobinopathy. Exp. Hematol. 31: 176-184, 2003.

Iyamu, E.W. and Asakura, T. : Drug Therapy for sickle cell disease. Exp. Opin. Ther. Patents. 13: 807-813, 2003.

Iyamu, E.W., Adunyah, S.E., Fasold, H., Horiuchi, K. Baliga, S. Ohene-Frempong, K., Turner, E.A., and Asakura, T. : Combined Use of Non-myelosuppressive Nitrosourea Analogues with Hydroxyurea in the Induction of F-cells production in a Human Erythroleukemic cell line. Exp. Hematol. 31: 592-600, 2003.

Iyamu, E.W., Turner, E.A. and Asakura, T. : The naturally occurring antisickling agent, Nix-0699, prolongs the survival time of transgenic sickle cell mice exposed to acute severe hypoxic conditions. Brit J Haematol . 122: 1001-1008, 2003.

Abdulmalik, O., Martin, M., Yang, J., Chen, Q., Brugnara, C., Evans, G., Abraham, D. and Asakura, T.: In vitro and in vivo studies on 5-hydroxymethyl-2-furfural (5HMF): A new potent antisickling agent. American Society of Hematology 2003.

Iyamu W.E: In vitro effects of NIPRISAN (Nix-0699): a naturally occirring potent antisickling agent. Brit. J. Haematol. 118: 337-343, 2002.

Zhang, C., Li, X., Lian, L., Q. Chen, L.Q., Vassilev, V., C. Lai, C., Evans G, and Asakura, T: Antisickling effect of MX-1520, A prodrug of vanillin: an in vitro study using rats and transgenic sickle mice. The 26 th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract 2002.

sakura, T., Ballas, S., Ohene-Frempong, K., and Lian L. : Existence of two types of reversibly sickled cells in the blood of patients with sickle cell disease: their involvment in the clinical diversity among patients and initiation of vaso-occlusion. The 26th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract 2002.

Asakura, T., Lian, L., Chen, Q., Iyamu, W.E., Abdulmalik, O., Brugnara, C., and Evans, G. : Five-year summary report of screening screening new therapeutic agents for the treatment of sickle cell disease by the NIH Sickle Cell Disease Reference Laboratory. The 26th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract 2002.

Abdulmalik, O., Hayashi, S., Chen, Q., Asakura, T., and Flake, A. W. : Evaluation of the efficacy of mixed chimerism in transgenic sickle mice that were treated with in utero hematopoietic stem cell transplantation. The 26th Annual Meeting of the National Sickle Cell Disease Program. Proceeding. Abstract 2002.