Paul J.L. Zhang

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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Chief Physician, China Consultation Service, AP Division, Department of Pathology and laboratory Medicine, Hospital of the University of Pennsylvania
Consultant, Pennsylvania Hospital
Director, Bone and Soft Tissue Pathology Subspecialty Service, , AP Division, Department of Pathology and laboratory Medicine, Hospital of the University of Pennsylvania
Director, Breast Marker Service, AP Division, Department of Pathology and laboratory Medicine, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Lab Medicine
Division of Anatomic Pathology
University of Pennsylvania Medical Center
3400 Spruce Street – Six Founders
Philadelphia, PA 19104
Office: 484 802 9958 (cell)
Lab: 215-662-6503
Guangzhou Medical College, Canton, China, 1983.
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Description of Research Expertise

Various tumor markers in diagnostic and prognositc application. In-situ molecular morphometry in tumor diagnosis and prognosis.
Hypoxia in sarcoma. Translational research in sarcoma. Growth factors receptors in breast cancer. Mechanism of lymphangionesis and lymphatic invasion in cancer. The significance and determination of host immunoresponse on surgical specimen in cancer patients' prognosis.

Description of Clinical Expertise

Diagnostic pathology in soft tissue tumor, sarcoma and cancers of breast, GYN tract, pulmonary tract, ENT. Diagnostic immmunohistochemical and in-situ hybridization. Evaluation of tumor markers for personalized treatment in surgical specimen.

Selected Publications

Ase G, Parash TL, Zhang PJ.: WT1 is expressed in serous, but not in endometrioid, clear cell or mucinous carcinomas of the peritoneum, fallopian tube, ovaries and endometrium. Int J Gyn Pathol 23: 110-118, 2004.

Nasuti, JF, Zhang PJ, Feldman M, MD, PhD, Pasha TL, Khurana JS, Gorman J, Gorman R, Narula J, and Narula N : Fibrillin and Other Matrix Proteins in Mitral Valve Prolapse Syndrome. Annals of Thoracic Surgery 77: 532-535, 2004.

Fogt F, Pascha TL, Zhang PJ, Gausas RE, Rahemtulla A, Zimmerman RL: Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease. Int J Mol Med 13: 221-214, 2004.

Scobie JV, Acs G, Bandera CA, Blank SV, Wheeler JE, Pasha TL and Zhang PJ. : C-kit Immunoreactivity in Endometrial Adenocarcinomas and Its Clinicopathologic Significance. Int J Gyn Pathol 22(2): 149-155, 2003.

PJ Zhang, EM Genega, JE Tomaszewski, TL Pasha, VA LiVolsi. : The Role of Calretinin, Inhibin, Melan-A, BCL-2 and c-kit in differentiating Adrenal Cortical and Medullary Tumors, An Immunohistochemical Study. Mod Pathol 16(6): 591-597, 2003.

Zhang PJ, Goldblum JR, Pawel BR, Fisher C, Pasha TL, Barr FG. : Immunophenotype of Desmoplastic Small Round Cell Tumors as Detected in Cases with EWS-WT1 Gene Fusion Product. Mod Pathol 16(3): 229-235, 2003.

Geza. Acs, Lynn Wang, Puthiyaveettil N. Raghunath, Marilyn A. Salscheider and Paul J. Zhang. : The Role of Different Immunostaining Patterns In Herceptest Interpretation and Their Correlation with Gene Amplification as Determined by Fluorescence in Situ Hybridization. Applied Immunohistolochemistry & Molecular Morphology 13(3): 222-229, 2003.

Xu X, Tahan, SR and Zhang PJ. : Expression of Neurotrophin receptor Trk-C in nevi and melanomas, an immunohistochemical study. Journal of Cutaneous Pathology 30(5): 318-322, 2003.

Acs G, Zhang PJ, McGrath CM, Acs P, McBroom J, Mohyeldin A Liu S, Lu Huasheng and Verma A. : Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and tis potential role in cervical carcinogenesis and tumor progression. Am J Pathol 162(6): 1790-1806, 2003.

Zhang PJ, Liang HH, Pasha TL, Weber R, LiVolsi VA. : Various Growth Factors, Growth Factor Recptors in Juvenile Nasopharyngeal Angiofibroma; A Comparative Immunhistochemical Study with Nasal Polyps. Arch Pathol Lab Med. 127(11): 1480-1484, 2003.

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Last updated: 01/27/2022
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