Paul A. Janmey, Ph.D.

faculty photo
Professor of Physiology
Member, Pennsylvania Muscle Institute, UPenn
Associate Director, Institute for Medicine and Engineering, UPenn
Department: Physiology

Contact information
Institute for Medicine and Engineering
University of Pennsylvania
1010 Vagelos Research Laboratories
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: 215 573-7380
Fax: 215 573-6815
A.B. (Chemistry and Philosophy)
Oberlin College, 1976.
Ph.D. (Physical Chemistry)
University of Wisconsin, 1982.
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Description of Research Expertise

Research Interests
cytoskeleton, phosphoinositide signalling, cell mechanics.

Key words: actin, PIP2, cytoskeleton, gel, astrocyte, fibrin, gelsolin.

Description of Research
Our lab studies several aspects of cell mechanics. In one project, we produce soft materials, usually hydrogels, to which cell adhesion proteins are linked to study how the stiffness of surfaces alters cell structure, function, and growth. Endothelial cells, fibroblasts, neurons and astrocytes each show unique dependence on substrate stiffness, and we seek to understand how they sense and respond to this mechanical cue. In related work we measure the structure and mechanics of cytoskeletal polymers using a variety of imaging, scattering, and rheologic methods. Further studies examine how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.

Rotation Projects
1. Image morphology and cytoskeletal changes in GFP-actin or GFP-vimentin expressing fibroblasts, endothelial cells, and other cell types grown of soft materials.

2. Fluorescence and atomic force microscopy of purified cytoskeletal polymers and associated motor proteins.

3. Use of fibrin gels as matrices for cell culture.

Lab personnel:
Fitzroy Byfield, Elisabeth Charrier, Ph.D., LiKang Chin, Ph.D., Katrina Cruz, Sarah Kim, Tongkeun Lee, Maria Murray, Ph.D., David Slochower, Anne Van Oosten, William Yang, Sameera Zaidi

Selected Publications

Parihar, Kshitiz, Nukpezah, Jonathan, Iwamoto, Daniel V., Janmey, Paul A., Radhakrishnan, Ravi: Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness. Iscience 25(8), 2022.

Chen, Xingyu, Chen, Dongning, Ban, Ehsan, Toussaint, Kimani C., Janmey, Paul A., Wells, Rebecca G., Shenoy, Vivek B.: Glycosaminoglycans modulate long-range mechanical communication between cells in collagen networks. Proceedings of the National Academy of Sciences of the United States of America 119(15), 2022.

Wu, Yufei, Pegoraro, Adrian M., Weitz, David, Janmey, Paul M., Sun, Sean: The correlation between cell and nucleus size is explained by an eukaryotic cell growth model. Plos Computational Biology 18(2), 2022.

Suprewicz, Lukasz, Tran, Kiet A., Piktel, Ewelina, Fiedoruk, Krzysztof, Janmey, Paul A., Galie, Peter A., Bucki, Robert: Recombinant human plasma gelsolin reverses increased permeability of the blood-brain barrier induced by the spike protein of the SARS-CoV-2 virus. Journal of neuroinflammation 19(1): 282-282, 2022.

Suprewicz, Lukasz, Swoger, Maxx, Gupta, Sarthak, Piktel, Ewelina, Byfield, Fitzroy J., Iwamoto, Daniel V., Germann, Danielle, Reszec, Joanna, Marcinczyk, Natalia, Carroll, Robert J., Lenart, Marzena, Pyre, Krzysztof, Janmey, Paul, Schwarz, J. M., Bucki, Robert, Patteson, Alison: Extracellular Vimentin as a Target Against SARS-CoV-2 Host Cell Invasion. Small 18(6), 2022.

Song, Dawei, Oberai, Assad A. A., Janmey, Paul A. A.: Hyperelastic continuum models for isotropic athermal fibrous networks. Interface Focus 12(6), 2022.

Song, Dawei, Janmey, Paul A.: Watching a cell sheet transform from soft to stiff. Biophysical Journal 121(8): 1349-1351, 2022.

Pogoda, Katarzyna, Byfield, Fitzroy, Deptula, Piotr, Ciesluk, Mateusz, Suprewicz, Lukasz, Sklodowski, Karol, Shivers, Jordan L., van Oosten, Anne, Cruz, Katrina, Tarasovetc, Ekaterina, Grishchuk, Ekaterina L., Mackintosh, Fred C., Bucki, Robert, Patteson, Alison E., Janmey, Paul A.: Unique Role of Vimentin Networks in Compression Stiffening of Cells and Protection of Nuclei from Compressive Stress. Nano Letters 22(12): 4725-4732, 2022.

Piktel, Ewelina, Wnorowska, Urszula, Depciuch, Joanna, Lysik, Dawid, Ciesluk, Mateusz, Fiedoruk, Krzysztof, Mystkowska, Joanna, Parlinska-Wojtan, Magdalena, Janmey, Paul A., Bucki, Robert: N-Acetyl-Cysteine Increases Activity of Peanut-Shaped Gold Nanoparticles Against Biofilms Formed by Clinical Strains of Pseudomonas aeruginosa Isolated from Sputum of Cystic Fibrosis Patients. Infection and Drug Resistance 15: 851-871, 2022.

Patteson, Alison E., Asp, Merrill E., Janmey, Paul A.: Materials science and mechanosensitivity of living matter. Applied Physics Reviews 9(1), 2022.

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Last updated: 11/28/2022
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