Roland L. Dunbrack

faculty photo
Adjunct Professor of Biochemistry in Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations

Contact information
Institute for Cancer Reserach
Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111
Office: (215) 728-2434
Fax: (215) 728-2412
Ph.D. (Biophysics)
Harvard University, 1993.
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Description of Research Expertise

The Dunbrack group concentrates on research in computational structural biology, including homology modeling, fold recognition, molecular dynamics simulations, statistical analysis of the PDB, and bioinformatics. In developing these methods, we use methods from various areas of mathematics and computer science, including Bayesian statistics and computational geometry. We place an emphasis on large-scale benchmarking of new methods and comparison with existing methods. We are interested in applying comparative modeling to important problems in various areas of biology. Areas of particular interest include DNA repair, proteases and other peptide-binding protein families, and membrane proteins.

Selected Publications

Canutescu, A. A., Shelenkov, A. A., Dunbrack, R. L., Jr.: A graph-theory algorithm for rapid protein side-chain prediction. Protein Sci. 12: 2001-2014, 2003.

Wang, G., Dunbrack, R.L., Jr.: PISCES: a protein sequence culling server. Bioinformatics 19: 1589-91, 2003.

Canutescu, A.A., Dunbrack, R.L., Jr.: Cyclic coordinate descent: a new algorithm for loop closure in protein modeling. Protein Sci 12: 963-72, 2003.

Yi, J., Cheng, H., Andrake, M.D., Dunbrack, R.L., Jr., Roder, H., Skalka, A.M.: Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase. J. Biol. Chem. 277: 12164-12174, 2002.

Dunbrack, R.L., Jr.: Rotamer libraries in the 21st century. Curr. Opin. Struct. Biol. 12, 431-440 2002.

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Last updated: 08/25/2004
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