Jennifer L Orthmann-Murphy, MD, PhD
Assistant Professor of Neurology
Co-Director of Age Span Fellowship in MS/Neuroinflammatory Disorders, University of Pennsylvania
Faculty, Mahoney Institute for Neurosciences
Department: Neurology
Graduate Group Affiliations
Contact information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3606
Lab: 215-898-8282
Lab: 215-898-8282
Education:
B.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001.
Ph.D. (Neuroscience)
University of Pennsylvania Perelman School of Medicine, 2007.
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010.
Permanent linkB.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001.
Ph.D. (Neuroscience)
University of Pennsylvania Perelman School of Medicine, 2007.
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010.
Description of Research Expertise
Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination
Techniques: multiphoton imaging
Description of Clinical Expertise
Multiple Sclerosis, Neuroimmunology, Inherited White Matter DisordersSelected Publications
Kornbluh AB, Baldwin A, Fatemi A, Vanderver A, Adang LA, Van Haren K, Sampson J, Eichler FS, Sadjadi R, Engelen M, Orthmann-Murphy JL: Practical Approach to Longitudinal Neurologic Care of Adults With X-Linked Adrenoleukodystrophy and Adrenomyeloneuropathy. Neurology Genetics 10(5), October 2024.Laura A Adang, Joshua L Bonkowsky, Jaap Jan Boelens, Eric Mallack, Rebecca Ahrens-Nicklas, John A Bernat, Annette Bley, Barbara Burton, Alejandra Darling, Florian Eichler, Erik Eklund, Lisa Emrick, Maria Escolar, Ali Fatemi, Jamie L Fraser, Amy Gaviglio, Stephanie Keller, Marc C Patterson, Paul Orchard, Jennifer Orthmann-Murphy, Jonathan D Santoro, Ludger Schöls, Caroline Sevin, Isha N Srivastava, Deepa Rajan, Jennifer P Rubin, Keith Van Haren, Melissa Wasserstein, Ayelet Zerem, Francesca Fumagalli, Lucia Laugwitz, Adeline Vanderver: Consensus guidelines for the monitoring and management of metachromatic leukodystrophy in the United States. Cytotherapy 26 (7): 739-748, July 2024.
Anjana Sevagamoorthy, Adeline Vanderver, Jamie L. Fraser, and Jennifer Orthmann-Murphy: Glial Origins of Inherited White Matter Disorders. Additional Perspectives on Glia in Cold Spring Harb Perspect Biol. Beth Stevens, Kelly R. Monk, and Marc R. Freeman (eds.). in press 2024.
Aaron Baldwin, Juliette Copeland, Meron Azage, Laynie Dratch, Kelsey Johnson, Rachel A Paul, Defne A Amado, Michael Baer, Andres Deik, Lauren B Elman, Michael Guo, Ali G Hamedani, David J Irwin, Aaron Lasker, Jennifer Orthmann-Murphy, Colin C Quinn, Thomas F Tropea, Steven S Scherer, Russell T Shinohara, Roy H Hamilton, Colin A Ellis: Disparities in genetic testing for neurologic disorders. Neurology 102 (6): https://doi.org/10.1212/WNL.000000000020916, March 2024.
Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA. : Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurology 271 (2): 733-747, Feb 2024.
Rebecca L. Koch, Claudia Soler-Alfonso, Bridget T. Kiely, Akihiro Asai, Ariana L. Smith, Deeksha S. Bali, Peter B. Kang, Andrew P. Landstrom, H. Orhan Akman, T. Andrew Burrow, Jennifer L. Orthmann-Murphy, Deberah S. Goldman, Surekha Pendyal, Areeg H. El-Gharbawy, Stephanie L. Austin, Laura E. Case, Raphael Schiffmann, Michio Hirano, and Priya S. Kishnani: Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource. Molecular Genetics and Metabolism March 2023.
Felipe J.S. Jones and Jennifer Orthmann-Murphy: Clinical Reasoning: A 26-year-old woman with chronic progressive gait dysfunction Neurology October 2024.
Helman G, Orthmann-Murphy JL, Vanderver A: Approaches to diagnosis for individuals with a suspected inherited white matter disorder. Handb Clin Neurol 2024.
Jones FJ, Elser H, Mendez A, Fraser JL, Orthmann-Murphy J.: Neuroimage: Leukoencephalopathy With Calcifications and Cysts. Neurology September 2024.
Papapetropoulos S, Pontius A,Finger E, Karrenbauer V, Lynch DS, Brennan M, Zappia1 S, Koehler W, Schoels L, Hayer SN, Konno T, Ikeuchi T, Lund T, Orthmann-Murphy J, Eichler E and Wszolek ZK: Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development. Frontiers in Neurology Page: https://doi.org/10.3389/fneur.2021.788168, February 2022.
Jennifer Orthmann-Murphy*, Cody L Call*, Gian C Molina-Castro, Yu Chen Hsieh, Matthew N Rasband, Peter A Calabresi, Dwight E Bergles. *Co-first authors: Remyelination alters the pattern of myelin in the cerebral cortex. eLife 9: e56621, May 2020.
Guo MH, ardakjian TM, Brzozowski MR, Scherer SS, Quinn C, Elman L, Orthmann-Murphy JL, Tropea TF, Ellis CA, Gonzalez-Alegre P : Temporal trends and yield of clinical diagnostic genetic testing in adult neurology. American Journal of Medical Genetics 185(10): 2922-2928, Oct 2021 Notes: https://doi.org/10.1002/ajmg.a.62372.
Bloom MS, Orthmann-Murphy J. Grinspan JB: Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination ASN Neuro 14: doi: 10.1177/17590914221097510, Jan-Dec 2022.