Jennifer L Orthmann-Murphy, MD, PhD

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Assistant Professor of Neurology
Co-Director of Age Span Fellowship in MS/Neuroinflammatory Disorders, University of Pennsylvania
Faculty, Mahoney Institute for Neurosciences
Department: Neurology
Graduate Group Affiliations

Contact information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3606
Lab: 215-898-8282
B.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001.
Ph.D. (Neuroscience)
University of Pennsylvania Perelman School of Medicine, 2007.
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010.
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Description of Research Expertise

Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.

Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination

Techniques: multiphoton imaging

Description of Clinical Expertise

Multiple Sclerosis, Neuroimmunology, Inherited White Matter Disorders

Selected Publications

Bloom MS, Orthmann-Murphy J. Grinspan JB: Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination ASN Neuro 14: doi: 10.1177/17590914221097510, Jan-Dec 2022.

Papapetropoulos S, Pontius A,Finger E, Karrenbauer V, Lynch DS, Brennan M, Zappia1 S, Koehler W, Schoels L, Hayer SN, Konno T, Ikeuchi T, Lund T, Orthmann-Murphy J, Eichler E and Wszolek ZK: Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development. Frontiers in Neurology Page:, 2022.

Guo MH, ardakjian TM, Brzozowski MR, Scherer SS, Quinn C, Elman L, Orthmann-Murphy JL, Tropea TF, Ellis CA, Gonzalez-Alegre P : Temporal trends and yield of clinical diagnostic genetic testing in adult neurology. American Journal of Medical Genetics 185(10): 2922-2928, Oct 2021 Notes:

Jennifer L. Orthmann-Murphy: An Undiagnosed White Matter Disorders Neurogenetics Clinic. ACTRIMS Virtual Meeting 2020 Poster P100 2021.

Jennifer Orthmann-Murphy*, Cody L Call*, Gian C Molina-Castro, Yu Chen Hsieh, Matthew N Rasband, Peter A Calabresi, Dwight E Bergles. *Co-first authors: Remyelination alters the pattern of myelin in the cerebral cortex. eLife 9: e56621, May 2020.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi PA, Bergles DE: Oligodendrogenesis following cortical demyelination generates a novel myelination pattern Platform Presentation at the American Academy of Neurology 71st Annual Meeting in Philadelphia, PA May 2019.

Mu W, Schiess N, Orthmann-Murphy JL, El-Hattab AW.: The utility of whole exome sequencing in diagnosing neurological disorders in adults from a highly consanguineous population. J Neurogenet 33(1): 21-26, Feb 2019.

Orthmann-Murphy JL, Call CL, Hughes EG, Calabresi P, Bergles DE.: Remyelination of specific axonal domains in the somatosensory cortex. Poster presentation at the American Neurological Association in Atlanta, GA October 2018.

Al Dhaibani MA, El-Hattab AW, Holroyd KB, Orthmann-Murphy J, Larson VA, Siddiqui KA, Szolics M, Schiess N: Novel mutation in the KCNJ10 gene in three siblings with seizures, ataxia and no electrolyte abnormalities. J Neurogenet 32(1): 1-5, May 2018.

Hughes EG*, Orthmann-Murphy JL*, Langseth AJ, Bergles DE: Myelin remodeling through experience dependent oligodendrogenesis in the adult somatosensory cortex. Nature Neuroscience 21(5): 696-706, May 2018.

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Last updated: 07/12/2022
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