Description of Research Expertise

Dr. Raabe is a Research Assistant Professor at the Division of Translational Medicine and Human Genetics at the Department of Medicine. His lab is pioneering the derivation and characterization of adult mouse and human liver derived bipotent ductal organoids. These organoids can be cloned and passaged over many months in culture and can be readily genetically manipulated. The Raabe lab uses these organoids for liver cell/gene therapy as well as for liver disease modeling and drug screening. Recently, the Raabe lab discovered that bipotent ductal organoids can readily be derived from endstage NASH patient liver and have shown that they share many functional properties of the NASH liver they were derived from. This opens the new area of personalized functional analysis and medicine for NASH based on NASH patient liver derived organoids. In addition, the Raabe lab has strong expertise in CRISPR-mediated gene thargeting and collaborates with various researchers on CRISPR - generated knockin mouse models.